2-Aminomethyl-4-t-butyl-6-iodophenol (BioDeep_00000181005)
human metabolite blood metabolite
代谢物信息卡片
化学式: C11H16INO (305.0276596)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)C1=CC(=C(C(=C1)I)O)CN
InChI: InChI=1S/C11H16INO/c1-11(2,3)8-4-7(6-13)10(14)9(12)5-8/h4-5,14H,6,13H2,1-3H3
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 119286
- HMDB: HMDB0254785
- ChEMBL: CHEMBL279581
- chemspider: 106552
- CAS: 58456-91-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- B Y Li, H Zhou, G F Qiao, L Wang, W H Li. Effects of MK-447 on platelet shape change, aggregation, and ATP release by collagen, ADP, and stable analogue of thromboxane A2 in rabbit platelets.
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1999 Jul; 20(7):627-30. doi:
NULL. [PMID: 10678127] - Y Takagi, A Kashiwagi, Y Tanaka, T Asahina, R Kikkawa, Y Shigeta. Significance of fructose-induced protein oxidation and formation of advanced glycation end product.
Journal of diabetes and its complications.
1995 Apr; 9(2):87-91. doi:
10.1016/1056-8727(94)00022-g. [PMID: 7599353] - B Y Li, Y Bai, G Z Li, W H Li, M Katori. Effects of MK-447 on thrombin-induced aggregation, secretion of ATP, and [Ca2+]i mobilization in rabbit platelets.
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1995 Mar; 16(2):108-13. doi:
NULL. [PMID: 7597907] - C P Bell-Quilley, Y S Lin, S D Hilchey, E D Drugge, J C McGiff. Renovascular actions of angiotensin II in the isolated kidney of the rat: relationship to lipoxygenases.
The Journal of pharmacology and experimental therapeutics.
1993 Nov; 267(2):676-82. doi:
NULL. [PMID: 8246141] - J S Stoddard, J H Steinbach, L Simchowitz. Whole cell Cl- currents in human neutrophils induced by cell swelling.
The American journal of physiology.
1993 Jul; 265(1 Pt 1):C156-65. doi:
10.1152/ajpcell.1993.265.1.c156. [PMID: 8338124] - M Kawamura, Y Harada, M Katori. Enhancement of endogenous prostaglandin I2 (prostacyclin) generation in vivo by a phenolic anti-inflammatory agent in the rabbit.
Japanese journal of pharmacology.
1991 Sep; 57(1):113-6. doi:
10.1254/jjp.57.113. [PMID: 1800794] - P A Johnston, S T Kau. Micropuncture evaluation of the site of action of 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol hydrochloride (MK447) in the rat kidney.
The Journal of pharmacology and experimental therapeutics.
1991 Feb; 256(2):587-91. doi:
NULL. [PMID: 1993996] - P A Johnston, K Leszczynska, C Yochim, S T Kau. Effect of route of administration on the relative efficacy and potency of 2-aminoethyl-4-(1,1-dimethylethyl)-6-iodophenol HCl (MK447) and furosemide.
Methods and findings in experimental and clinical pharmacology.
1990 Sep; 12(7):481-6. doi:
NULL. [PMID: 2087148] - K H Cheeseman, L G Forni. An investigation of the novel anti-inflammatory agents ONO-3144 and MK-447. Studies on their potential antioxidant activity.
Biochemical pharmacology.
1988 Nov; 37(21):4225-33. doi:
10.1016/0006-2952(88)90120-7. [PMID: 2847756] - M Hirafuji, Y Ogura. Lipid peroxidation modifies the effect of phenolic anti-inflammatory drugs on prostaglandin biosynthesis.
Biochemical pharmacology.
1985 Apr; 34(7):933-6. doi:
10.1016/0006-2952(85)90592-1. [PMID: 3921031] - Y Harada, K Tanaka, K Yamashita, M Ishibashi, H Miyazaki, M Katori. The anti-inflammatory mechanism of MK-447 in rat carrageenin-induced pleurisy.
Prostaglandins.
1983 Jul; 26(1):79-90. doi:
10.1016/0090-6980(83)90076-x. [PMID: 6635213] - H J Sugerman, C R Blocher, J I Hirsch, A M Strash, J L Tatum. Failure of various agents to decrease oleic acid pulmonary albumin leak.
The Journal of surgical research.
1983 May; 34(5):456-62. doi:
10.1016/0022-4804(83)90096-3. [PMID: 6843112] - A M Lefer, H Araki, S Okamatsu. Beneficial actions of a free radical scavenger in traumatic shock and myocardial ischemia.
Circulatory shock.
1981; 8(3):273-82. doi:
NULL. [PMID: 7249259] - B Odlind. Renal tubular secretion and effects of the alkaline diuretics amiloride, tizolemide (Hoe 740) and 2-aminomethyl-4(1,1-dimethylethyl)-6-iodophenol hydrochloride (MK-447).
Naunyn-Schmiedeberg's archives of pharmacology.
1981; 317(4):357-63. doi:
10.1007/bf00501319. [PMID: 6798474] - G E Stokker, R L Smith, E J Cragoe, C T Ludden, H F Russo, C S Sweet, L S Watson. 2-(Aminomethyl)phenols, a new class of saluretic agents. 2. Synthesis and pharmacological properties of the 5-aza isostere of 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol.
Journal of medicinal chemistry.
1981 Jan; 24(1):115-7. doi:
10.1021/jm00133a024. [PMID: 7205867] - R J Gryglewski. Evolution of ideas on the role of prostaglandins in inflammation.
Agents and actions. Supplements.
1980; 7(?):247-51. doi:
". [PMID: 7018200] - D J Tocco, F A deLuna, A E Duncan, R W Walker, B H Arison, W J Vandenheuvel. Physiological disposition and metabolism of 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol hydrochloride.
Drug metabolism and disposition: the biological fate of chemicals.
1979 Sep; 7(5):330-4. doi:
NULL. [PMID: 40776] - D T Lowenthal, G Onesti, M B Affrime, J J Schrogie, K E Kim, P Busby, C D Swartz. The diuretic response in normal volunteers to a new benzylamine, 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol HCl.
Journal of clinical pharmacology.
1978 Aug; 18(8-9):414-24. doi:
10.1002/j.1552-4604.1978.tb02458.x. [PMID: 690252]