Felodipine (BioDeep_00000018100)

   

human metabolite blood metabolite


代谢物信息卡片


4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester

化学式: C18H19Cl2NO4 (383.06910740000006)
中文名称: 非洛地平
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl
InChI: InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3

描述信息

Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

62 个代谢物同义名

4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester; (+-)-Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid; 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid; 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate ethyl methyl ester; (+-)-Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate; 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate; Pharmaceutica astra brand OF felodipine; CT-Arzneimittel brand OF felodipine; CT Arzneimittel brand OF felodipine; Pharmacia spain brand OF felodipine; AstraZeneca brand OF felodipine; Alphapharm brand OF felodipine; TheraPharm brand OF felodipine; Stadapharm brand OF felodipine; Ratiopharm brand OF felodipine; Merck dura brand OF felodipine; Azupharma brand OF felodipine; Betapharm brand OF felodipine; Alpharma brand OF felodipine; Aventis brand OF felodipine; Hoechst brand OF felodipine; Heumann brand OF felodipine; Promed brand OF felodipine; Wörwag brand OF felodipine; Aliud brand OF felodipine; Hexal brand OF felodipine; Astra brand OF felodipine; AbZ brand OF felodipine; 1a Brand OF felodipine; BC Brand OF felodipine; Felodipin-ratiopharm; Felodipin ratiopharm; Felodipin 1a pharma; Heumann, felodipin; Von CT, felodipin; Felodipin heumann; Felodipin von CT; Felodipin stada; Felodipin dura; Felo biochemie; DL-Felodipine; Felodipin azu; Felodipin abz; Felodipin al; Felodipinum; Felodipina; Felo puren; Felo-puren; felodipine; Felogamma; Perfudal; Felobeta; Munobal; Felodur; Plendil; Renedil; Felocor; Fensel; Flodil; Modip; Agon



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hong-Jaan Wang, Elise Chia-Hui Tan, Tzu-Yi Chiang, Wei-Ching Chen, Chien-Chang Shen, Yune-Fang Ueng. Effect of repeated Shengmai-San administration on nifedipine pharmacokinetics and the risk/benefit under co-treatment. Journal of food and drug analysis. 2022 03; 30(1):111-127. doi: 10.38212/2224-6614.3401. [PMID: 35647719]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Joscha Brinkmann, Frauke Rest, Christian Luebbert, Gabriele Sadowski. Solubility of Pharmaceutical Ingredients in Natural Edible Oils. Molecular pharmaceutics. 2020 07; 17(7):2499-2507. doi: 10.1021/acs.molpharmaceut.0c00215. [PMID: 32369379]
  • Aml A Emam, Ibrahim A Naguib, Eman S Hassan, Eglal A Abdelaleem. Development and Validation of RP-HPLC and an Ecofriendly HPTLC Method for Simultaneous Determination of Felodipine and Metoprolol Succinate, and their Major Metabolites in Human Spiked Plasma. Journal of AOAC International. 2020 Jul; 103(4):966-971. doi: 10.1093/jaoacint/qsz040. [PMID: 33241342]
  • Zi-Qing-Yun Yuan, Hong-Wen Zhang, Zi-Dan Yu, Yuan Tian, Lu-Ning Sun, Li-Jun Xie, Juan Chen, Ling Meng, Zun-Jian Zhang, Xue-Hui Zhang, Yong-Qing Wang. Impact of 14 types of genetic polymorphisms on antihypertensive efficacy of felodipine in healthy Chinese subjects
. International journal of clinical pharmacology and therapeutics. 2020 Jul; 58(7):375-386. doi: 10.5414/cp203686. [PMID: 32301702]
  • Yingmeng He, Chenglin Zhan, Chao Pi, Ying Zuo, Siyun Yang, Mei Hu, Yuntian Bai, Ling Zhao, Yumeng Wei. Enhanced Oral Bioavailability of Felodipine from Solid Lipid Nanoparticles Prepared Through Effervescent Dispersion Technique. AAPS PharmSciTech. 2020 Jun; 21(5):170. doi: 10.1208/s12249-020-01711-2. [PMID: 32529303]
  • Mads Hornum, Martin Iversen, Peter Oturai, Mads J Andersen, Mikhail Zemtsovski, Pia Bredahl, Nina H Bjarnason, Karl B Christensen, Jørn Carlsen, Christian H Møller, Bo Feldt-Rasmussen, Michael Perch. Felodipine and renal function in lung transplantation: A randomized placebo-controlled trial. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2020 06; 39(6):541-550. doi: 10.1016/j.healun.2020.01.1342. [PMID: 32061508]
  • Congwei Li, Pengfei Du, Meilin Zhou, Liuxin Yang, Haoyue Zhang, Jing Wang, Caiqin Yang. Spectroscopic Methodology and Molecular Docking Studies on Changes in Binding Interaction of Felodipine with Bovine Serum Albumin Induced by Cocrystallization with β-Resorcylic Acid. Chemical & pharmaceutical bulletin. 2020; 68(10):946-953. doi: 10.1248/cpb.c20-00212. [PMID: 32999146]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Farah H Siddiqi, Fiona M Menzies, Ana Lopez, Eleanna Stamatakou, Cansu Karabiyik, Rodrigo Ureshino, Thomas Ricketts, Maria Jimenez-Sanchez, Miguel Angel Esteban, Liangxue Lai, Micky D Tortorella, Zhiwei Luo, Hao Liu, Emmanouil Metzakopian, Hugo J R Fernandes, Andrew Bassett, Eric Karran, Bruce L Miller, Angeleen Fleming, David C Rubinsztein. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nature communications. 2019 04; 10(1):1817. doi: 10.1038/s41467-019-09494-2. [PMID: 31000720]
  • N H Salunkhe, N R Jadhav, S D Bhinge. Validated RP-HPLC method for quantification of felodipine in rabbit plasma: Application in a bioequivalence study. Annales pharmaceutiques francaises. 2019 Jan; 77(1):15-27. doi: 10.1016/j.pharma.2018.08.002. [PMID: 30243471]
  • Nian-Qiu Shi, Ying Jin, Yong Zhang, Xiao-Xia Che, Xiao Xiao, Gui-Hua Cui, Yu-Zhou Chen, Bo Feng, Zheng-Qiang Li, Xian-Rong Qi. The Influence of Cellulosic Polymer's Variables on Dissolution/Solubility of Amorphous Felodipine and Crystallization Inhibition from a Supersaturated State. AAPS PharmSciTech. 2018 Dec; 20(1):12. doi: 10.1208/s12249-018-1266-y. [PMID: 30560388]
  • Linda C Alskär, Janneke Keemink, Jenny Johannesson, Christopher J H Porter, Christel A S Bergström. Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations. Molecular pharmaceutics. 2018 10; 15(10):4733-4744. doi: 10.1021/acs.molpharmaceut.8b00699. [PMID: 30142268]
  • Wiebke Saal, Nicole Wyttenbach, Jochem Alsenz, Martin Kuentz. Interactions of dimethylaminoethyl methacrylate copolymer with non-acidic drugs demonstrated high solubilization in vitro and pronounced sustained release in vivo. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2018 Apr; 125(?):68-75. doi: 10.1016/j.ejpb.2018.01.006. [PMID: 29331439]
  • Morrie Lam, Natalia Mast, Irina A Pikuleva. Drugs and Scaffold That Inhibit Cytochrome P450 27A1 In Vitro and In Vivo. Molecular pharmacology. 2018 02; 93(2):101-108. doi: 10.1124/mol.117.110742. [PMID: 29192124]
  • George K Dresser, Brad L Urquhart, Julianne Proniuk, Alvin Tieu, David J Freeman, John Malcolm Arnold, David G Bailey. Coffee inhibition of CYP3A4 in vitro was not translated to a grapefruit-like pharmacokinetic interaction clinically. Pharmacology research & perspectives. 2017 10; 5(5):. doi: 10.1002/prp2.346. [PMID: 28971609]
  • Q Xiang, C Li, X Zhao, Y M Cui. The influence of CYP3A5*3 and BCRPC421A genetic polymorphisms on the pharmacokinetics of felodipine in healthy Chinese volunteers. Journal of clinical pharmacy and therapeutics. 2017 Jun; 42(3):345-349. doi: 10.1111/jcpt.12505. [PMID: 28244604]
  • Pius Fasinu, Yahya E Choonara, Pradeep Kumar, Lisa C du Toit, Divya Bijukumar, Riaz A Khan, Viness Pillay. Enhancement of the Oral Bioavailability of Felodipine Employing 8-Arm-Poly(Ethylene Glycol): In Vivo, In Vitro and In Silico Evaluation. AAPS PharmSciTech. 2017 Apr; 18(3):617-628. doi: 10.1208/s12249-016-0545-8. [PMID: 27173987]
  • Sameh Ahmed, Noha N Atia, Marwa Fathy Bakr Ali. Ultrasound assisted dispersive liquid-liquid microextraction coupled with high performance liquid chromatography designated for bioavailability studies of felodipine combinations in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Mar; 1046(?):200-210. doi: 10.1016/j.jchromb.2017.01.034. [PMID: 28189955]
  • Meiling Chen, Jiezhao Zhou, Le Mei, Fanglin Yu, Xiangyang Xie, Yan Liu, Yang Yang, Ying Li, Xingguo Mei. Simultaneous Determination of Felodipine and Metoprolol in Beagle Dog Plasma by Online SPE-LC-MS/MS and Its Application in a Pharmacokinetic Study. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2017; 33(7):755-759. doi: 10.2116/analsci.33.755. [PMID: 28690250]
  • David G Bailey, George K Dresser, Brad L Urquhart, David J Freeman, John Malcolm Arnold. Coffee-Antihypertensive Drug Interaction: A Hemodynamic and Pharmacokinetic Study With Felodipine. American journal of hypertension. 2016 12; 29(12):1386-1393. doi: 10.1093/ajh/hpw081. [PMID: 27481881]
  • Shiqing Zhao, Fanglin Yu, Nan Liu, Zhong Di, Kun Yan, Yan Liu, Ying Li, Hui Zhang, Yang Yang, Zhenbo Yang, Zhiping Li, Xingguo Mei. Synchronous delivery of felodipine and metoprolol tartrate using monolithic osmotic pump technology. Drug development and industrial pharmacy. 2016 Nov; 42(11):1723-31. doi: 10.3109/03639045.2016.1171332. [PMID: 27074758]
  • Li Wu, Lebing Wang, Shuxia Wang, Tiqiao Xiao, Min Chen, Qun Shao, Peter York, Vikaramjeet Singh, Xianzhen Yin, Jingkai Gu, Jiwen Zhang. Three dimensional structural insight of laser drilled orifices in osmotic pump tablets. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2016 Oct; 93(?):287-94. doi: 10.1016/j.ejps.2016.08.039. [PMID: 27562708]
  • Gino Seravalle, Gianmaria Brambilla, Daniela Prata Pizzalla, Anna Casati, Marta Riva, Cesare Cuspidi, Michele Bombelli, Giuseppe Mancia, Guido Grassi. Differential effects of enalapril-felodipine versus enalapril-lercanidipine combination drug treatment on sympathetic nerve traffic and metabolic profile in obesity-related hypertension. Journal of the American Society of Hypertension : JASH. 2016 Mar; 10(3):244-51. doi: 10.1016/j.jash.2016.01.006. [PMID: 26831124]
  • Yusra Habib Khan, Azmi Sarriff, Azreen Syazril Adnan, Amer Hayat Khan, Tauqeer Hussain Malhi, Fauziah Jummaat. Complications associated with End Stage Renal Disease. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2015 May; 25(5):392. doi: 05.2015/jcpsp.392392. [PMID: 26008675]
  • Abdel-Maaboud I Mohamed, Mahmoud A Omar, Mohamed A Hammad, Abobakr A Mohamed. Spectrofluorimetric and micelle-enhanced spectrofluorimetric methods for determination of Felodipine and Nimodipine in pharmaceutical preparations and human plasma. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2015; 149(?):934-40. doi: 10.1016/j.saa.2015.05.026. [PMID: 26005990]
  • Chao Wu, Zongzhe Zhao, Ying Zhao, Yanna Hao, Ying Liu, Chang Liu. Preparation of a push-pull osmotic pump of felodipine solubilized by mesoporous silica nanoparticles with a core-shell structure. International journal of pharmaceutics. 2014 Nov; 475(1-2):298-305. doi: 10.1016/j.ijpharm.2014.08.033. [PMID: 25148731]
  • Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Scientific reports. 2014 Sep; 4(?):6437. doi: 10.1038/srep06437. [PMID: 25257666]
  • Ben D Snyder, Andrew Rowland, Thomas M Polasek, John O Miners, Matthew P Doogue. Evaluation of felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions. European journal of clinical pharmacology. 2014 Sep; 70(9):1115-22. doi: 10.1007/s00228-014-1716-8. [PMID: 25028073]
  • Bhanu P Sahu, Malay K Das. Preparation and in vitro/in vivo evaluation of felodipine nanosuspension. European journal of drug metabolism and pharmacokinetics. 2014 Sep; 39(3):183-93. doi: 10.1007/s13318-013-0158-5. [PMID: 24198215]
  • V Sridhar, M Surya Sandeep, P Ravindra Babu, K Naveen Babu. Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using felodipine and hesperetin in combination in Wistar rats and everted rat gut sacs in vitro. Phytotherapy research : PTR. 2014 May; 28(5):699-705. doi: 10.1002/ptr.5040. [PMID: 23881850]
  • Sean H J Kim, Andre J Jackson, C Anthony Hunt. In silico, experimental, mechanistic model for extended-release felodipine disposition exhibiting complex absorption and a highly variable food interaction. PloS one. 2014; 9(9):e108392. doi: 10.1371/journal.pone.0108392. [PMID: 25268237]
  • Song Bai, Zheng-Gui Huang, Li Chen, Jiang-Tao Wang, Bo-Ping Ding. Effects of felodipine combined with puerarin on ACE2-Ang (1-7)-Mas axis in renovascular hypertensive rat. Regulatory peptides. 2013 Jun; 184(?):54-61. doi: 10.1016/j.regpep.2013.03.005. [PMID: 23523569]
  • Raja Reddy Kallem, Mullangi Ramesh, J V L N Seshagirirao. Validated LC-ESI-MS/MS method for simultaneous quantitation of felodipine and metoprolol in rat plasma: application to a pharmacokinetic study in rats. Biomedical chromatography : BMC. 2013 Jun; 27(6):784-91. doi: 10.1002/bmc.2861. [PMID: 23303553]
  • Zhen-Gui Huang, Song Bai, Li Chen, Jiang-Tao Wang, Bo-Ping Ding. [Effect of puerarin combined with felodipine on mRNA and protein expression of apelin and APJ in renovascular hypertensive rat]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Feb; 38(3):381-5. doi: ". [PMID: 23668014]
  • Luigi Petramala, Claudio Savoriti, Laura Zinnamosca, Cristiano Marinelli, Amina Settevendemmie, Camilla Calvieri, Marco Catani, Claudio Letizia. Primary aldosteronism with concurrent primary hyperparathyroidism in a patient with arrhythmic disorders. Internal medicine (Tokyo, Japan). 2013; 52(18):2071-5. doi: 10.2169/internalmedicine.52.8794. [PMID: 24042515]
  • Longquan Yang, Jing Yu, Ruixin Ma, Feng Zhao, Xin Lin, Peijun Liu, Hao Hu, Feng Bai. The effect of combined antihypertensive treatment (felodipine with either irbesartan or metoprolol) on erectile function: a randomized controlled trial. Cardiology. 2013; 125(4):235-41. doi: 10.1159/000350955. [PMID: 23816755]
  • Santosh Bhende, Namdeo Jadhav. Moringa coagulant as a stabilizer for amorphous solids: Part I. AAPS PharmSciTech. 2012 Jun; 13(2):400-10. doi: 10.1208/s12249-012-9755-x. [PMID: 22359158]
  • Emilie Hénin, Martin Bergstrand, Joseph F Standing, Mats O Karlsson. A mechanism-based approach for absorption modeling: the Gastro-Intestinal Transit Time (GITT) model. The AAPS journal. 2012 Jun; 14(2):155-63. doi: 10.1208/s12248-012-9324-y. [PMID: 22286919]
  • Ruixin Ma, Jing Yu, Dian Xu, Longquan Yang, Xin Lin, Feng Zhao, Feng Bai. Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension. Journal of hypertension. 2012 Jan; 30(1):210-6. doi: 10.1097/hjh.0b013e32834e1e2e. [PMID: 22134388]
  • Charline Gomo, Romain Coriat, Lionel Faivre, Olivier Mir, Stanislas Ropert, Bertrand Billemont, Alain Dauphin, Michel Tod, Francois Goldwasser, Benoit Blanchet. Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma. Investigational new drugs. 2011 Dec; 29(6):1511-4. doi: 10.1007/s10637-010-9514-3. [PMID: 20706860]
  • Chinna Reddy Palem, Ramesh Gannu, Shravan Kumar Yamsani, Vamshi Vishnu Yamsani, Madhusudan Rao Yamsani. Development of a high-performance liquid chromatography method for simultaneous determination of pioglitazone and felodipine in pig serum: application to pharmacokinetic study. Biomedical chromatography : BMC. 2011 Aug; 25(8):952-8. doi: 10.1002/bmc.1553. [PMID: 21058416]
  • Frans H H Leenen, Elizabeth Coletta. Pharmacokinetic and antihypertensive profile of amlodipine and felodipine-ER in younger versus older patients with hypertension. Journal of cardiovascular pharmacology. 2010 Dec; 56(6):669-75. doi: 10.1097/fjc.0b013e3181fc45bb. [PMID: 20881606]
  • Jun Chen, Jing Li, Zong-Ren Wang. [Therapeutic effect on essential hypertension treated with combined therapy of acupuncture and medication]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2010 Nov; 30(11):896-8. doi: NULL. [PMID: 21246843]
  • Yuquing Zhang, Xuezhong Zhang, Lisheng Liu, Alberto Zanchetti. Effects of individual risk factors on the residual risk of cardiovascular events in a population of treated Chinese patients with hypertension: data from the Felodipine Event Reduction (FEVER) study. Journal of hypertension. 2010 Oct; 28(10):2016-25. doi: 10.1097/hjh.0b013e32833cd338. [PMID: 20625319]
  • Dian Xu, Jing Yu, Pei-Jun Liu, Xue-Ya Guo, Hao Hu, Peng Chang, Feng Zhao, Xiu-Li Li, Xue-Hong Chen, Xi-Ping Shen, Yi Zhang, Feng Bai. [Effect between felodipine plus irbesartan and felodipine plus metoprolol regimen on the sexual function in young and middle-aged women with hypertension]. Zhonghua xin xue guan bing za zhi. 2010 Aug; 38(8):728-33. doi: NULL. [PMID: 21055142]
  • B B Matsubara, M Franco, J S Janicki, L S Matsubara. Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2010 May; 43(5):506-14. doi: 10.1590/s0100-879x2010007500037. [PMID: 20490436]
  • Y Uesawa, T Takeuchi, K Mohri. Publication bias on clinical studies of pharmacokinetic interactions between felodipine and grapefruit juice. Die Pharmazie. 2010 May; 65(5):375-8. doi: NULL. [PMID: 20503932]
  • A Rybczynska, A Jurska-Jasko, K Boblewski, A Lehmann, C Orlewska. Blockade of calcium channels and AT1 receptor prevents the hypertensive effect of calcilytic NPS 2143 in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2010 Apr; 61(2):163-70. doi: . [PMID: 20436216]
  • Mario Laganović. [Fixed combinations of antihypertensive medications--new opportunity in treatment of hypertension]. Lijecnicki vjesnik. 2010 Mar; 132(3-4):94-8. doi: NULL. [PMID: 20540436]
  • U S Mote, S L Bhattar, S R Patil, G B Kolekar. Interaction between felodipine and bovine serum albumin: fluorescence quenching study. Luminescence : the journal of biological and chemical luminescence. 2010 Jan; 25(1):1-8. doi: 10.1002/bio.1130. [PMID: 19424966]
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  • X-P Bi, H-W Tan, S-S Xing, M Zhong, Y Zhang, W Zhang. Felodipine downregulates serum interleukin-18 levels in rats with fructose-induced metabolic syndrome. Journal of endocrinological investigation. 2009 Apr; 32(4):303-7. doi: 10.1007/bf03345716. [PMID: 19636195]
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