5,6-Dihydro-4-(2-methylpropyl)amino-4H-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide (BioDeep_00000180999)

   

human metabolite blood metabolite


代谢物信息卡片


4-[(2-methylpropyl)amino]-1,1-dioxo-2H,3H,4H-1lambda6-thieno[2,3-b]thiopyran-6-sulfonamide

化学式: C11H18N2O4S3 (338.0428668)
中文名称: 司佐胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CNC1CCS(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N
InChI: InChI=1S/C11H18N2O4S3/c1-7(2)6-13-9-3-4-19(14,15)11-8(9)5-10(18-11)20(12,16)17/h5,7,9,13H,3-4,6H2,1-2H3,(H2,12,16,17)



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • V Lyall, R I Alam, D Q Phan, G L Ereso, T H Phan, S A Malik, M H Montrose, S Chu, G L Heck, G M Feldman, J A DeSimone. Decrease in rat taste receptor cell intracellular pH is the proximate stimulus in sour taste transduction. American journal of physiology. Cell physiology. 2001 Sep; 281(3):C1005-13. doi: 10.1152/ajpcell.2001.281.3.c1005. [PMID: 11502578]
  • C W Conroy. Sulfonamides do not reach the retina in therapeutic amounts after topical application to the cornea. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 1997 Oct; 13(5):465-72. doi: 10.1089/jop.1997.13.465. [PMID: 9326728]
  • J H Lin, T H Lin, H Cheng. Uptake and stereoselective binding of the enantiomers of MK-927, a potent carbonic anhydrase inhibitor, by human erythrocytes in vitro. Pharmaceutical research. 1992 Mar; 9(3):339-44. doi: 10.1023/a:1015886717974. [PMID: 1614967]
  • G Durand-Cavagna, R A Owen, L R Gordon, C P Peter, C Boussiquet-Leroux. Urothelial hyperplasia induced by carbonic anhydrase inhibitors (CAIs) in animals and its relationship to urinary Na and pH. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1992 Jan; 18(1):137-43. doi: NULL. [PMID: 1601202]
  • T Buclin, J Biollaz, E A Lippa, F Brunner-Ferber, G van Melle, A Munafo, C Clineschmidt, J L Schelling. Absence of metabolic effects of the topical carbonic anhydrase inhibitors MK-927 and sezolamide during two-week ocular administration to normal subjects. Clinical pharmacology and therapeutics. 1991 Jun; 49(6):665-73. doi: 10.1038/clpt.1991.84. [PMID: 2060255]
  • J H Lin, I W Chen, F A deLuna. Dose-dependent pharmacokinetics of MK-417, a potent carbonic anhydrase inhibitor, in experimental polycythemic and anemic rats. Pharmaceutical research. 1991 May; 8(5):608-14. doi: 10.1023/a:1015804707206. [PMID: 1866376]
  • B K Matuszewski, M L Constanzer, G A Hessey, W F Bayne. Development of direct stereoselective and non-stereoselective assays in biological fluids for the enantiomers of a thieno[2,3-b]thiopyran-2-sulfonamide, a topically effective carbonic anhydrase inhibitor. Journal of chromatography. 1990 Apr; 526(2):461-73. doi: 10.1016/s0378-4347(00)82528-1. [PMID: 2361985]
  • T H Maren, A Bar-Ilan, C W Conroy, W F Brechue. Chemical and pharmacological properties of MK-927, a sulfonamide carbonic anhydrase inhibitor that lowers intraocular pressure by the topical route. Experimental eye research. 1990 Jan; 50(1):27-36. doi: 10.1016/0014-4835(90)90007-h. [PMID: 2307193]