Meldonium (BioDeep_00000180959)
human metabolite blood metabolite
代谢物信息卡片
3-(2,2,2-trimethylhydrazin-2-ium-1-yl)propanoate
化学式: C6H14N2O2 (146.1055)
中文名称: 米屈肼
谱图信息:
最多检出来源 Homo sapiens(blood) 86%
分子结构信息
SMILES: C[N+](C)(C)NCCC(=O)[O-]
InChI: InChI=1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3
描述信息
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C26170 - Protective Agent > C2079 - Cardioprotective Agent
C - Cardiovascular system > C01 - Cardiac therapy
C78274 - Agent Affecting Cardiovascular System
D002317 - Cardiovascular Agents
D007155 - Immunologic Factors
C471 - Enzyme Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor[1][2].
同义名列表
20 个代谢物同义名
3-(2,2,2-trimethylhydrazin-2-ium-1-yl)propanoate; 3-(2,2,2-Trimethyldiazaniumyl)propanoic acid; 2-(2-Carboxyethyl)-1,1,1-trimethyldiazanium; 3-(2,2,2-Trimethylhydrazine)propionic acid; 3-(2,2,2-Trimethylhydrazinium)propionate; 3-(2,2,2-Trimethyldiazaniumyl)propanoate; 3-(2,2,2-Trimethylhydrazine)propionate; N-Trimethylhydrazine-3-propionate; Trimethylhydraziniumpropionate; Mildronic acid; Mildronate; Q-4224-IOS; Mindronate; Mildronat; Meldonium; Quaterin; Vasonat; 3-TMHP; MET-88; Mildronate
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:131843
- PubChem: 123868
- HMDB: HMDB0254733
- DrugBank: DB13723
- ChEMBL: CHEMBL2104708
- Wikipedia: Meldonium
- MetaCyc: CPD-10661
- chemspider: 110405
- CAS: 802032-35-5
- CAS: 76144-81-5
- medchemexpress: HY-B1836
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Fabian Piskol, Kerstin Neubauer, Maurice Eggers, Lisa Margarete Bode, Jan Jasper, Alan Slusarenko, Edward Reijerse, Wolfgang Lubitz, Dieter Jahn, Jürgen Moser. Two-component carnitine monooxygenase from Escherichia coli: functional characterization, inhibition and mutagenesis of the molecular interface.
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Fish physiology and biochemistry.
2022 Feb; 48(1):145-159. doi:
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2021 Dec; 23(1):. doi:
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