Fluorometholone (BioDeep_00000018095)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C22H29FO4 (376.205)
中文名称: 氟米龙
谱图信息:
最多检出来源 Homo sapiens(blood) 16.04%
分子结构信息
SMILES: CC(=O)C1(O)CCC2C3CC(C)C4=CC(=O)C=CC4(C)C3(F)C(O)CC21C
InChI: InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3
描述信息
Fluorometholone is only found in individuals that have used or taken this drug. It is a glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Their primary target is the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07X - Corticosteroids, other combinations > D07XB - Corticosteroids, moderately potent, other combinations
S - Sensory organs > S01 - Ophthalmologicals > S01C - Antiinflammatory agents and antiinfectives in combination > S01CB - Corticosteroids/antiinfectives/mydriatics in combination
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AB - Corticosteroids, moderately potent (group ii)
D - Dermatologicals > D10 - Anti-acne preparations > D10A - Anti-acne preparations for topical use > D10AA - Corticosteroids, combinations for treatment of acne
C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AA - Corticosteroids
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BA - Corticosteroids, plain
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents
D018926 - Anti-Allergic Agents
同义名列表
39 个代谢物同义名
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one; 9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-11b,17-dihydroxy-6a-methylpregna-1,4-diene-3,20-dione; Pharm-allergan brand OF fluorometholone; Pharm allergan brand OF fluorometholone; Pharmascience brand OF fluorometholone; Allergan brand 2 OF fluorometholone; Allergan brand 1 OF fluorometholone; Allergan brand 3 OF fluorometholone; Ursapharm brand OF fluorometholone; Novartis brand OF fluorometholone; Winzer brand OF fluorometholone; Isdin brand OF fluorometholone; Alcon brand OF fluorometholone; PMS-Fluorometholone; PMS Fluorometholone; Fluorometholonum; Fluoromethalone; Fluorometholone; Fluorometolona; Flucon, isopto; Fluormetholone; Fluorometholon; Fluormetholon; FML Liquifilm; Fluoro-ophtal; Fluoro ophtal; Isopto flucon; Efflumidex; Fluoropos; Cortisdin; FML Forte; NSC 33001; Fluor OP; Fluor-OP; Oxylone; Flucon; Fml
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:31625
- PubChem: 3384
- PubChem: 9878
- HMDB: HMDB0014469
- DrugBank: DB00324
- ChEMBL: CHEMBL1200600
- ChEMBL: CHEMBL1716015
- Wikipedia: Fluorometholone
- MeSH: Fluorometholone
- chemspider: 9494
- CAS: 3918-13-6
- CAS: 426-13-1
- PMhub: MS000002422
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
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Cell reports.
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