Methyl paraoxon (BioDeep_00000180898)
human metabolite blood metabolite
代谢物信息卡片
Phosphoric acid dimethyl ester 4-nitro-phenyl ester
化学式: C8H10NO6P (247.024573)
中文名称: 甲基对氧磷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COP(=O)(OC)OC1=CC=C(C=C1)N(=O)=O
InChI: InChI=1S/C8H10NO6P/c1-13-16(12,14-2)15-8-5-3-7(4-6-8)9(10)11/h3-6H,1-2H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alper Coban, Russell L Carr, Howard W Chambers, Kenneth O Willeford, Janice E Chambers. Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase.
Toxicology letters.
2016 Apr; 248(?):39-45. doi:
10.1016/j.toxlet.2016.03.002. [PMID: 26965078] - Rezeda V Shamagsumova, Dmitry N Shurpik, Pavel L Padnya, Ivan I Stoikov, Gennady A Evtugyn. Acetylcholinesterase biosensor for inhibitor measurements based on glassy carbon electrode modified with carbon black and pillar[5]arene.
Talanta.
2015 Nov; 144(?):559-68. doi:
10.1016/j.talanta.2015.07.008. [PMID: 26452862] - Hong-Bo Jiang, Wei Dou, Pei-An Tang, Jin-Jun Wang. Transcription and induction profiles of three novel P450 genes in Liposcelis bostrychophila (Psocoptera: Liposcelididae).
Journal of economic entomology.
2012 Apr; 105(2):560-72. doi:
10.1603/ec11324. [PMID: 22606828] - Mustafa Alp Cetinkaya, Emine Baydan. Investigation of in vitro effects of ethephon and chlorpyrifos, either alone or in combination, on rat intestinal muscle contraction.
Interdisciplinary toxicology.
2010 Mar; 3(1):35-9. doi:
10.2478/v10102-010-0002-6. [PMID: 21217869] - N Aurbek, H Thiermann, F Eyer, P Eyer, F Worek. Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.
Toxicology.
2009 May; 259(3):133-9. doi:
10.1016/j.tox.2009.02.014. [PMID: 19428953] - Zhuo-Kun Li, Ying-Yue Zhu, Xiang-Gang Yin, Chi-Fang Peng, Wei Chen, Li-Qiang Liu, Li-Mei Yin, Chuan-Lai Xu. Development of an indirect enzyme-linked immunosorbent assay for the organophosphorus pesticide paraoxon-methyl.
Immunological investigations.
2009; 38(6):510-25. doi:
10.1080/08820130902803689. [PMID: 19811409] - Axel Muttray, Gerhard Bäcker, Detlev Jung, Georg Hill, Stephan Letzel. External and internal exposure of wine growers spraying methyl parathion.
Toxicology letters.
2006 Apr; 162(2-3):219-24. doi:
10.1016/j.toxlet.2005.09.013. [PMID: 16242869] - J B Salles, V L F Cunha Bastos, M V Silva Filho, O L T Machado, C M C Salles, S Giovanni de Simone, J Cunha Bastos. A novel butyrylcholinesterase from serum of Leporinus macrocephalus, a Neotropical fish.
Biochimie.
2006 Jan; 88(1):59-68. doi:
10.1016/j.biochi.2005.06.017. [PMID: 16085351] - Eric S Peeples, Lawrence M Schopfer, Ellen G Duysen, Reggie Spaulding, Troy Voelker, Charles M Thompson, Oksana Lockridge. Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry.
Toxicological sciences : an official journal of the Society of Toxicology.
2005 Feb; 83(2):303-12. doi:
10.1093/toxsci/kfi023. [PMID: 15525694] - Subramanya Karanth, Jing Liu, Kenneth Olivier, Carey Pope. Interactive toxicity of the organophosphorus insecticides chlorpyrifos and methyl parathion in adult rats.
Toxicology and applied pharmacology.
2004 Apr; 196(2):183-90. doi:
10.1016/j.taap.2003.12.014. [PMID: 15081265] - A W Abu-Qare, M B Abou-Donia. Inhibition and recovery of maternal and fetal cholinesterase enzyme activity following a single cutaneous dose of methyl parathion and diazinon, alone and in combination, in pregnant rats.
Journal of applied toxicology : JAT.
2001 Jul; 21(4):307-16. doi:
10.1002/jat.761. [PMID: 11481665] - M L Parker, M I Goldstein. Differential toxicities of organophosphate and carbamate insecticides in the nestling European starling (Sturnus vulgaris).
Archives of environmental contamination and toxicology.
2000 Aug; 39(2):233-42. doi:
10.1007/s002440010100. [PMID: 10871426] - A W Abu-Qare, A A Abdel-Rahman, A M Kishk, M B Abou-Donia. Placental transfer and pharmacokinetics of a single dermal dose of [14C]methyl parathion in rats.
Toxicological sciences : an official journal of the Society of Toxicology.
2000 Jan; 53(1):5-12. doi:
10.1093/toxsci/53.1.5. [PMID: 10653515] - Y S Huang, L Woods, L G Sultatos. Solubilization and purification of A-esterase from mouse hepatic microsomes.
Biochemical pharmacology.
1994 Sep; 48(6):1273-80. doi:
10.1016/0006-2952(94)90165-1. [PMID: 7945421] - E De Schryver, L De Reu, F Belpaire, J Willems. Toxicokinetics of methyl paraoxon in the dog.
Archives of toxicology.
1987 Feb; 59(5):319-22. doi:
10.1007/bf00295082. [PMID: 3579595] - E P De Schryver, L De Reu, J L Willems. Determination of methyl paraoxon in dog plasma by reversed-phase high-performance liquid chromatography.
Journal of chromatography.
1985 Mar; 338(2):389-95. doi:
10.1016/0378-4347(85)80109-2. [PMID: 3998025] - E Reiner, V Simeon, M Skrinjarić-Spoljar. Hydrolysis of O,O-dimethyl-2,2-dichlorovinyl phosphate (DDVP) by esterases in parasitic helminths, and in vertebrate plasma and erythrocytes.
Comparative biochemistry and physiology. C: Comparative pharmacology.
1980; 66(2):149-52. doi:
10.1016/0306-4492(80)90116-1. [PMID: 6107198]