Methylenetanshinquinone (BioDeep_00000180888)
Main id: BioDeep_00000395584
human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
14-methyl-6-methylidene-12-oxatetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-1,7,9,11(15),13-pentaene-16,17-dione
化学式: C18H14O3 (278.0942894)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=COC2=C1C(=O)C(=O)C1=C3CCCC(=C)C3=CC=C21
InChI: InChI=1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h6-8H,1,3-5H2,2H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 226208 - Salvia miltiorrhiza:
- 587676 - Salvia paramiltiorrhiza: 10.3987/COM-94-6876
- 342065 - Salvia trijuga: 10.1021/NP100250W
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yiyang Jia, Dandan Yao, Hui Bi, Jing Duan, Wei Liang, Ziwei Jing, Mei Liu. Salvia miltiorrhiza Bunge (Danshen) based nano-delivery systems for anticancer therapeutics.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155521. doi:
10.1016/j.phymed.2024.155521. [PMID: 38489891] - Shikang Zhou, Xiaoqin Gao, Can Chen, Jinyun Zhang, Yi Zhang, Li Zhang, Xiaojing Yan. Porcine cardiac blood - Salvia miltiorrhiza root alleviates cerebral ischemia reperfusion injury by inhibiting oxidative stress induced apoptosis through PI3K/AKT/Bcl-2/Bax signaling pathway.
Journal of ethnopharmacology.
2023 Nov; 316(?):116698. doi:
10.1016/j.jep.2023.116698. [PMID: 37286116] - Xiao-Tian Jiang, Ye Qiu, Cong-Hua Li. Cryptotanshinone inhibits oral squamous cell carcinoma through the autophagic pathway.
Neoplasma.
2023 Feb; 70(1):114-122. doi:
10.4149/neo_2023_220924n957. [PMID: 36704921] - Hao-Shu Xiong, Yao-Yao Li, Kai-Xuan Zhang, Wan-Shun Zhao, Chen-Ming Li, Jin-Yong Cai, Jing Su, Yong-Hong Zhu, Kai-Jing Yan. [Research on batch-to-batch quality control of compound Danshen extract based on physical characterization and multivariate statistical analysis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 May; 47(9):2465-2473. doi:
10.19540/j.cnki.cjcmm.20210830.301. [PMID: 35531694] - Shan He, Tianqi Wang, Congwei Shi, Zhenguo Wang, Xianjun Fu. Network pharmacology-based approach to understand the effect and mechanism of Danshen against anemia.
Journal of ethnopharmacology.
2022 Jan; 282(?):114615. doi:
10.1016/j.jep.2021.114615. [PMID: 34509606] - Jiqing Bai, Xiaoping Wang, Shaobing Du, Pengfei Wang, Yaheng Wang, Lina Quan, Yundong Xie. Study on the protective effects of danshen-honghua herb pair (DHHP) on myocardial ischaemia/reperfusion injury (MIRI) and potential mechanisms based on apoptosis and mitochondria.
Pharmaceutical biology.
2021 Dec; 59(1):335-346. doi:
10.1080/13880209.2021.1893346. [PMID: 35086399] - Huilan Tang, Ningyi Qin, Chang Rao, Jiahui Zhu, Haiqiang Wang, Guang Hu. Screening of Potential Anti-Thrombotic Ingredients from Salvia miltiorrhiza in Zebrafish and by Molecular Docking.
Molecules (Basel, Switzerland).
2021 Nov; 26(22):. doi:
10.3390/molecules26226807. [PMID: 34833900] - Cheng-Ming Hsu, Ming-Yu Yang, Ming-Shao Tsai, Geng-He Chang, Yao-Hsu Yang, Yao-Te Tsai, Ching-Yuan Wu, Shun-Fu Chang. Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22168881. [PMID: 34445585] - Le Su, Yue Su, Zaiyong An, Ping Zhang, Qiulin Yue, Chen Zhao, Xin Sun, Song Zhang, Xinli Liu, Kunlun Li, Lin Zhao. Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice.
Scientific reports.
2021 08; 11(1):16210. doi:
10.1038/s41598-021-94594-7. [PMID: 34376708] - Tongxing Wang, Lu Liang, Chunlai Zhao, Jia Sun, Hairong Wang, Wenjia Wang, Jianping Lin, Yunhui Hu. Elucidating direct kinase targets of compound Danshen dropping pills employing archived data and prediction models.
Scientific reports.
2021 05; 11(1):9541. doi:
10.1038/s41598-021-89035-4. [PMID: 33953309] - Brahmam Kapalavavi, Ninad Doctor, Baohong Zhang, Yu Yang. Subcritical Water Extraction of Salvia miltiorrhiza.
Molecules (Basel, Switzerland).
2021 Mar; 26(6):. doi:
10.3390/molecules26061634. [PMID: 33804141] - Hefeng Wang, Wenhui Pang, Xingsheng Xu, Beian You, Cuijuan Zhang, Dan Li. Cryptotanshinone Attenuates Ischemia/Reperfusion-induced Apoptosis in Myocardium by Upregulating MAPK3.
Journal of cardiovascular pharmacology.
2021 03; 77(3):370-377. doi:
10.1097/fjc.0000000000000971. [PMID: 33662979] - Chee Wah Yuen, Vikneswaran Murugaiyah, Nazalan Najimudin, Ghows Azzam. Danshen (Salvia miltiorrhiza) water extract shows potential neuroprotective effects in Caenorhabditis elegans.
Journal of ethnopharmacology.
2021 Feb; 266(?):113418. doi:
10.1016/j.jep.2020.113418. [PMID: 32991971] - Tingting Ye, Yufei Li, Difeifei Xiong, Shuqing Gong, Luquan Zhang, Bailing Li, Jianyang Pan, Yi Wang, Jing Qian, Haibin Qu. Combination of Danshen and ligustrazine has dual anti-inflammatory effect on macrophages and endothelial cells.
Journal of ethnopharmacology.
2021 Feb; 266(?):113425. doi:
10.1016/j.jep.2020.113425. [PMID: 33010405] - Ying Ma, Guanghong Cui, Tong Chen, Xiaohui Ma, Ruishan Wang, Baolong Jin, Jian Yang, Liping Kang, Jinfu Tang, Changjiangsheng Lai, Yanan Wang, Yujun Zhao, Ye Shen, Wen Zeng, Reuben J Peters, Xiaoquan Qi, Juan Guo, Luqi Huang. Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza.
Nature communications.
2021 01; 12(1):685. doi:
10.1038/s41467-021-20959-1. [PMID: 33514704] - Yi-Zhen Wang, Lei Meng, Qi-Shuai Zhuang, Liang Shen. Screening Traditional Chinese Medicine Combination for Cotreatment of Alzheimer's Disease and Type 2 Diabetes Mellitus by Network Pharmacology.
Journal of Alzheimer's disease : JAD.
2021; 80(2):787-797. doi:
10.3233/jad-201336. [PMID: 33579846] - Yun Zhang, Jie Wang, Yong-Mei Liu, Yin-Ying Chen, Xiao-Chen Yang, Lian Duan. The Synergistic Effects of Astragalus mongholicus and Salvia miltiorrhiza on Coronary Heart Disease Identified by Network Pharmacology and Experiment.
Drug design, development and therapy.
2021; 15(?):4053-4069. doi:
10.2147/dddt.s326024. [PMID: 34611395] - Minjeong Ko, Goo Taeg Oh, Jiyong Park, Ho Jeong Kwon. Extract of high hydrostatic pressure-treated danshen (Salvia miltiorrhiza) ameliorates atherosclerosis via autophagy induction.
BMB reports.
2020 Dec; 53(12):652-657. doi:
10.5483/bmbrep.2020.53.12.184. [PMID: 33172543] - Kailin Yang, Liuting Zeng, Anqi Ge, Xiaoping Pan, Tingting Bao, Zhiyong Long, Qiaozhen Tong, Mengxia Yuan, Xiaofei Zhu, Jinwen Ge, Zhengde Huang. Integrating systematic biological and proteomics strategies to explore the pharmacological mechanism of danshen yin modified on atherosclerosis.
Journal of cellular and molecular medicine.
2020 12; 24(23):13876-13898. doi:
10.1111/jcmm.15979. [PMID: 33140562] - Shuang Wu, Qingyu Wang, Jinquan Wang, Baoyu Duan, Qihe Tang, Zhuojian Sun, Jinlong Han, Chenggang Shan, Zhifen Wang, Zhihui Hao. Protocatechuic aldehyde from Salvia miltiorrhiza exhibits an anti-inflammatory effect through inhibiting MAPK signalling pathway.
BMC complementary medicine and therapies.
2020 Nov; 20(1):347. doi:
10.1186/s12906-020-03090-4. [PMID: 33203388] - Liangyu Shao, Chaojie Sun, Wenjie Lu, Jiayi Chen, Dan Su, Song Gao, Shengqi Chen, Wenyou Fang, Yu Liu, Bin Wang, Rongfeng Hu. Effects of Borneol on the Release of Compound Danshen Colon-Specific Osmotic Pump Capsule In Vitro and Pharmacokinetics Study in Beagle Dogs.
AAPS PharmSciTech.
2020 Nov; 21(8):316. doi:
10.1208/s12249-020-01840-8. [PMID: 33174133] - Tsung-Jung Ho, Hsi Chin Wu, V Bharath Kumar, Wei-Wen Kuo, Yueh-Shan Weng, Yu-Lan Yeh, B Mahalakshmi, Cecilia Hsuan Day, Chi-Cheng Li, Chih-Yang Huang. Danshen (Salvia miltiorhiza) inhibits Leu27 IGF-II-induced hypertrophy in H9c2 cells.
Environmental toxicology.
2020 Oct; 35(10):1043-1049. doi:
10.1002/tox.22940. [PMID: 32415908] - Hua-Li Zuo, Ke-Gang Linghu, Ya-Li Wang, Kun-Meng Liu, Yan Gao, Hua Yu, Feng-Qing Yang, Yuan-Jia Hu. Interactions of antithrombotic herbal medicines with Western cardiovascular drugs.
Pharmacological research.
2020 09; 159(?):104963. doi:
10.1016/j.phrs.2020.104963. [PMID: 32497719] - Jianbo Guo, Shuang Dai, Yukun Ding, Haoqiang He, Hui Zhang, Wenchao Dan, Kun Qin, Hui Wang, Anqi Li, Peipei Meng, Shangjin Li, Qingyong He. A randomized controlled trial for gualou danshen granules in the treatment of unstable angina pectoris patients with phlegm-blood stasis syndrome.
Medicine.
2020 Aug; 99(33):e21593. doi:
10.1097/md.0000000000021593. [PMID: 32872012] - Yang Tan, Yuyan Li, Feng Zhou, Jinming Guo, Tao Wang, Yuhe Shi, Yantao Yang, Jiandong Lu, Gang Pei. Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora.
Journal of pharmacological sciences.
2020 Jul; 143(3):165-175. doi:
10.1016/j.jphs.2020.04.007. [PMID: 32387002] - YueTao Liu, QianQian Xue, AiPing Li, Ke Li, XueMei Qin. Mechanisms exploration of herbal pair of HuangQi-DanShen on cerebral ischemia based on metabonomics and network pharmacology.
Journal of ethnopharmacology.
2020 May; 253(?):112688. doi:
10.1016/j.jep.2020.112688. [PMID: 32101772] - Shuna Cui, Shanshan Chen, Qingqing Wu, Tingting Chen, Shihua Li. A network pharmacology approach to investigate the anti-inflammatory mechanism of effective ingredients from Salvia miltiorrhiza.
International immunopharmacology.
2020 Apr; 81(?):106040. doi:
10.1016/j.intimp.2019.106040. [PMID: 31818704] - Yujia Li, Hui Chen, Yating Yang, Menglan Niu, Jiaxin Wang, Yuanyuan Wu, Linhui Niu, Hongliang Liu, Dengke Bao. Danshen formula granule and salvianic acid A alleviate ethanol-induced neurotoxicity.
Journal of natural medicines.
2020 Mar; 74(2):399-408. doi:
10.1007/s11418-019-01379-4. [PMID: 31828593] - Sheng-Kuo Hsieh, Nan-Hei Lin, Ying-Jie Chen, Maw-Rong Lee, Wen-Ying Chen, Jason T C Tzen. Therapeutic Effects of Lithospermate B Complexed with Mg2+ or Zn2+ on Metabolic Syndrome Induced in Rats Fed with High-Fat Diet.
Molecules (Basel, Switzerland).
2020 Feb; 25(4):. doi:
10.3390/molecules25040983. [PMID: 32098371] - Jinjing Jia, Xiumei Mo, Junfeng Liu, Fenggen Yan, Ning Wang, Ying Lin, Hongyi Li, Yan Zheng, Dancan Chen. Mechanism of danshensu-induced inhibition of abnormal epidermal proliferation in psoriasis.
European journal of pharmacology.
2020 Feb; 868(?):172881. doi:
10.1016/j.ejphar.2019.172881. [PMID: 31866405] - Mingyang Qiu, Fengqin Xiao, Tianning Wang, Songlan Piao, Wu Zhao, Shuai Shao, Mingming Yan, Daqing Zhao. Protective effect of Hedansanqi Tiaozhi Tang against non-alcoholic fatty liver disease in vitro and in vivo through activating Nrf2/HO-1 antioxidant signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Feb; 67(?):153140. doi:
10.1016/j.phymed.2019.153140. [PMID: 31884405] - Cheng Qu, Ding-Qiao Xu, Shi-Jun Yue, Le-Fei Shen, Gui-Sheng Zhou, Yan-Yan Chen, Xiao-Ping Wang, Ji-Qing Bai, Feng Liu, Yu-Ping Tang, Bu-Chang Zhao, Jin-Ao Duan. Pharmacodynamics and pharmacokinetics of Danshen in isoproterenol-induced acute myocardial ischemic injury combined with Honghua.
Journal of ethnopharmacology.
2020 Jan; 247(?):112284. doi:
10.1016/j.jep.2019.112284. [PMID: 31604137] - Xiangjiang Nie, Bin Wang, Rongfeng Hu, Wenjie Lu, Jiayi Chen, Songlin Liu, Dong Jin, Chaojie Sun, Song Gao, Yuxing Guo, Wenyou Fang, Haiping Hao. Development and Evaluation of Controlled and Simultaneous Release of Compound Danshen Based on a Novel Colon-Specific Osmotic Pump Capsule.
AAPS PharmSciTech.
2020 Jan; 21(2):38. doi:
10.1208/s12249-019-1603-9. [PMID: 31897797] - Shiying Zhang, Zhiying Yuan, Huaying Wu, Weiqing Li, Liang Li, Huiyong Huang. Network Pharmacology-Based Strategy Reveals the Effects of Hedysarum multijugum Maxim.-Radix Salviae Compound on Oxidative Capacity and Cardiomyocyte Apoptosis in Rats with Diabetic Cardiomyopathy.
BioMed research international.
2020; 2020(?):8260703. doi:
10.1155/2020/8260703. [PMID: 33134388] - Guanhua Du, Junke Song, Lida Du, Li Zhang, Guifen Qiang, Shoubao Wang, Xiuying Yang, Lianhua Fang. Chemical and pharmacological research on the polyphenol acids isolated from Danshen: A review of salvianolic acids.
Advances in pharmacology (San Diego, Calif.).
2020; 87(?):1-41. doi:
10.1016/bs.apha.2019.12.004. [PMID: 32089230] - Yunzhen Hu, Jing Wang. Interactions between clopidogrel and traditional Chinese medicine.
Journal of thrombosis and thrombolysis.
2019 Oct; 48(3):491-499. doi:
10.1007/s11239-019-01945-3. [PMID: 31471773] - Xiao-Ping Wang, Peng-Fei Wang, Ji-Qing Bai, Su Gao, Ya-Heng Wang, Li-Na Quan, Fang Wang, Xiao-Ting Wang, Jin Wang, Yun-Dong Xie. Investigating the effects and possible mechanisms of danshen- honghua herb pair on acute myocardial ischemia induced by isoproterenol in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Oct; 118(?):109268. doi:
10.1016/j.biopha.2019.109268. [PMID: 31545239] - Xiao-Jing Han, Han Li, Chong-Bin Liu, Zhi-Rong Luo, Qiang-Li Wang, Fang-Fang Mou, Hai-Dong Guo. Guanxin Danshen Formulation improved the effect of mesenchymal stem cells transplantation for the treatment of myocardial infarction probably via enhancing the engraftment.
Life sciences.
2019 Sep; 233(?):116740. doi:
10.1016/j.lfs.2019.116740. [PMID: 31398416] - Weiguo Wang, Jinsong Li, Zhiyu Ding, Yuezhan Li, Jianlong Wang, Shijie Chen, Jinglei Miao. Tanshinone I inhibits the growth and metastasis of osteosarcoma via suppressing JAK/STAT3 signalling pathway.
Journal of cellular and molecular medicine.
2019 09; 23(9):6454-6465. doi:
10.1111/jcmm.14539. [PMID: 31293090] - Qian Zhang, Xifang Liu, Liang Yan, Rui Zhao, Jing An, Ciucui Liu, Hao Yang. Danshen extract (Salvia miltiorrhiza Bunge) attenuate spinal cord injury in a rat model: A metabolomic approach for the mechanism study.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Sep; 62(?):152966. doi:
10.1016/j.phymed.2019.152966. [PMID: 31132751] - Lixin Zhang, Xifang Liu, Hao Yang, Rui Zhao, Ciucui Liu, Rui Zhang, Qian Zhang. Comparative pharmacokinetic study on phenolic acids and flavonoids in spinal cord injury rats plasma by UPLC-MS/MS after single and combined oral administration of danshen and huangqin extract.
Journal of pharmaceutical and biomedical analysis.
2019 Aug; 172(?):103-112. doi:
10.1016/j.jpba.2019.04.024. [PMID: 31029799] - Lijun Ni, Fangfang Zhang, Mingyue Han, Liguo Zhang, Shaorong Luan, Wei Li, Haixing Deng, Zhuhui Lan, Zhongxiang Wu, Xiaofang Luo, Leslaw Mleczko. Qualitative analysis of the roots of Salvia miltiorrhiza and Salvia yunnanensis based on NIR, UHPLC and LC-MS-MS.
Journal of pharmaceutical and biomedical analysis.
2019 Jun; 170(?):295-304. doi:
10.1016/j.jpba.2019.01.010. [PMID: 30951995] - Danqing Wang, Shuangshuang Zhang, Han Tang, Cuiping Jiang, Bingwei Wang, Jianping Liu. Development of sustained-release pellets to modulate the in vivo processes of the main active components of Danshen: A pharmacokinetic and pharmacodynamic evaluation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 May; 58(?):152793. doi:
10.1016/j.phymed.2018.12.016. [PMID: 31005724] - Fuu-Jen Tsai, Chi-Fung Cheng, Chao-Jung Chen, Chih-Ying Lin, Yi-Fang Wu, Te-Mao Li, Po-Heng Chuang, Yang-Chang Wu, Chih-Ho Lai, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Jung-Chun Lin, Chih-Chien Lin, Wen-Miin Liang, Ying-Ju Lin. Effects of Chinese herbal medicine therapy on survival and hepatic outcomes in patients with hepatitis C virus infection in Taiwan.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Apr; 57(?):30-38. doi:
10.1016/j.phymed.2018.09.237. [PMID: 30668320] - Xian Zhou, Valentina Razmovski-Naumovski, Antony Kam, Dennis Chang, Chun Guang Li, Kelvin Chan, Alan Bensoussan. Synergistic study of a Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination on cell survival in EA.hy926 cells.
BMC complementary and alternative medicine.
2019 Feb; 19(1):50. doi:
10.1186/s12906-019-2458-z. [PMID: 30791910] - Jianyong Zhang, Rixin Liang, Lan Wang, Bin Yang. Effects and mechanisms of Danshen-Shanzha herb-pair for atherosclerosis treatment using network pharmacology and experimental pharmacology.
Journal of ethnopharmacology.
2019 Jan; 229(?):104-114. doi:
10.1016/j.jep.2018.10.004. [PMID: 30312741] - Mingyong Zhang, Yue Liu, Min Liu, Biying Liu, Na Li, Xin Dong, Zhanying Hong, Yifeng Chai. UHPLC-QTOF/MS-based metabolomics investigation for the protective mechanism of Danshen in Alzheimer's disease cell model induced by Aβ1-42.
Metabolomics : Official journal of the Metabolomic Society.
2019 01; 15(2):13. doi:
10.1007/s11306-019-1473-x. [PMID: 30830431] - Min Shi, Fenfen Huang, Changping Deng, Yao Wang, Guoyin Kai. Bioactivities, biosynthesis and biotechnological production of phenolic acids in Salvia miltiorrhiza.
Critical reviews in food science and nutrition.
2019; 59(6):953-964. doi:
10.1080/10408398.2018.1474170. [PMID: 29746788] - Sen Sun, Rong Wang, Jie Fan, Guoqing Zhang, Hai Zhang. Effects of Danshen tablets on pharmacokinetics of atorvastatin calcium in rats and its potential mechanism.
Pharmaceutical biology.
2018 Dec; 56(1):104-108. doi:
10.1080/13880209.2018.1424209. [PMID: 29322864] - Zhenyu Xu, Lu Chen, Zhangang Xiao, Yanhong Zhu, Hui Jiang, Yan Jin, Cheng Gu, Yilai Wu, Lin Wang, Wen Zhang, Jian Zuo, Dexi Zhou, Jiajie Luan, Jing Shen. Potentiation of the anticancer effect of doxorubicinin drug-resistant gastric cancer cells by tanshinone IIA.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Dec; 51(?):58-67. doi:
10.1016/j.phymed.2018.05.012. [PMID: 30466628] - Hung-Yu Lin, Ting-Sian Lin, Han-Ju Chien, Yu-Min Juang, Chao-Jung Chen, Chang-Sheng Wang, Chien-Chen Lai. A rapid, simple, and high-throughput UPLC-MS/MS method for simultaneous determination of bioactive constituents in Salvia miltiorrhiza with positive/negative ionization switching.
Journal of pharmaceutical and biomedical analysis.
2018 Nov; 161(?):94-100. doi:
10.1016/j.jpba.2018.08.027. [PMID: 30145454] - Lili Sun, Hongmei Jia, Liyan Ma, Meng Yu, Yong Yang, Yang Liu, Hongwu Zhang, Zhongmei Zou. Metabolic profiling of hypoxia/reoxygenation injury in H9c2 cells reveals the accumulation of phytosphingosine and the vital role of Dan-Shen in Xin-Ke-Shu.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Oct; 49(?):83-94. doi:
10.1016/j.phymed.2018.06.026. [PMID: 30217265] - Li Yu, Haofang Wan, Weifeng Jin, Jiehong Yang, Chang Li, Liuling Dai, Lijun Ge, Huifen Zhou, Haitong Wan, Yu He. Protective effects of effective ingredients of Danshen (Radix Salviae Miltiorrhizae) and Honghua (Flos Carthami) compatibility after rat hippocampal neurons induced by hypoxia injury.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2018 10; 38(5):685-697. doi:
. [PMID: 32185985] - Lorenzo Di Cesare Mannelli, Marialuisa Piccolo, Francesco Maione, Maria Grazia Ferraro, Carlo Irace, Vincenzo De Feo, Carla Ghelardini, Nicola Mascolo. Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Sep; 105(?):1042-1049. doi:
10.1016/j.biopha.2018.06.047. [PMID: 30021339] - Guojun Yan, Zhitao Zhu, Liliang Jin, Jun Chen, Hui Xie, Jackelyn Miozzi, Feifei Lei, Xuchao Wei, Jinhuo Pan. Study on the Quality Evaluation of Compound Danshen Preparations Based on the xCELLigence Real-Time Cell-Based Assay and Pharmacodynamic Authentication.
Molecules (Basel, Switzerland).
2018 Aug; 23(9):. doi:
10.3390/molecules23092090. [PMID: 30134517] - Yu-Qing Wang, Guo Zhuang, Shu-Jiao Li. Multiple on-line screening and identification methods for hydroxyl radical scavengers in Yudanshen.
Journal of pharmaceutical and biomedical analysis.
2018 Jul; 156(?):278-283. doi:
10.1016/j.jpba.2018.04.043. [PMID: 29730337] - Mei-Juan Xu, Li-Feng Jiang, Ting Wu, Ji-Hong Chu, Yi-Dan Wei, Ji-Ye Aa, Guang-Ji Wang, Hai-Ping Hao, Wen-Zheng Ju, Ping Li. Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2.
Chemico-biological interactions.
2018 Jun; 289(?):15-22. doi:
10.1016/j.cbi.2018.04.011. [PMID: 29689254] - Qian Zhang, Cheng-Ning Tan, Ya-Li Wang, Wen-Jing Liu, Feng-Qing Yang, Hua Chen, Zhi-Ning Xia. Adsorbed hollow fiber-based biological fingerprinting for the discovery of platelet aggregation inhibitors from Danshen-Honghua decoction.
Journal of separation science.
2018 Jun; 41(12):2651-2660. doi:
10.1002/jssc.201701434. [PMID: 29573136] - Xuyang Liu, Zhan-Guo Gao, Yiran Wu, Raymond C Stevens, Kenneth A Jacobson, Suwen Zhao. Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors.
Scientific reports.
2018 05; 8(1):8084. doi:
10.1038/s41598-018-26577-0. [PMID: 29795391] - Xilin Xu, Hang Lv, Xiaodong Li, Hui Su, Xiaofeng Zhang, Jun Yang. Danshen attenuates cartilage injuries in osteoarthritis in vivo and in vitro by activating JAK2/STAT3 and AKT pathways.
Experimental animals.
2018 May; 67(2):127-137. doi:
10.1538/expanim.17-0062. [PMID: 29093428] - Zhuo-Ming Li, Suo-Wen Xu, Pei-Qing Liu. Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics.
Acta pharmacologica Sinica.
2018 May; 39(5):802-824. doi:
10.1038/aps.2017.193. [PMID: 29698387] - Huan-Huan Pang, Mei-Fang Jiang, Qin-Hui Wang, Xiao-Ye Wang, Wei Gao, Zhi-Hao Tian, Jian-Mei Huang. Metabolic profile of danshen in rats by HPLC-LTQ-Orbitrap mass spectrometry.
Journal of Zhejiang University. Science. B.
2018 Mar; 19(3):227-244. doi:
10.1631/jzus.b1700105. [PMID: 29504316] - Yang Wang, Kun Jiang, Lijun Wang, Dongqi Han, Guo Yin, Jue Wang, Bin Qin, Shaoping Li, Tiejie Wang. Identification of Salvia species using high-performance liquid chromatography combined with chemical pattern recognition analysis.
Journal of separation science.
2018 Feb; 41(3):609-617. doi:
10.1002/jssc.201701066. [PMID: 29105962] - Naoya Kishikawa, Akiko Yamanouchi, Mahmoud Hamed El-Maghrabey, Kaname Ohyama, Naotaka Kuroda. Determination of Tanshinones in Danshen (Salvia miltiorrhiza) by High-Performance Liquid Chromatography with Fluorescence Detection after pre-Column Derivatisation.
Phytochemical analysis : PCA.
2018 Jan; 29(1):112-117. doi:
10.1002/pca.2719. [PMID: 28895217] - Simeng Gu, Yao Ma, Kemin Ge, Ruifang Nie, Erxi Wu, Yang Li. Danshen-Honghua Ameliorates Stress-Induced Menopausal Depression in Rats.
Neural plasticity.
2018; 2018(?):6589608. doi:
10.1155/2018/6589608. [PMID: 29853846] - Jian Fang, Peter J Little, Suowen Xu. Atheroprotective Effects and Molecular Targets of Tanshinones Derived From Herbal Medicine Danshen.
Medicinal research reviews.
2018 01; 38(1):201-228. doi:
10.1002/med.21438. [PMID: 28295428] - X L Dong, W X Yu, C M Li, S He, L P Zhou, C W Poon, M S Wong. Danshen (Salvia miltiorrhiza) protects ovariectomized rats fed with high-saturated fat-sucrose diet from bone loss.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2018 01; 29(1):223-235. doi:
10.1007/s00198-017-4254-2. [PMID: 29058051] - Cheng-Yu Yang, Cheng-Chih Hsieh, Chih-Kung Lin, Chun-Shu Lin, Bo Peng, Gu-Jiun Lin, Huey-Kang Sytwu, Wen-Liang Chang, Yuan-Wu Chen. Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells.
BMC complementary and alternative medicine.
2017 Dec; 17(1):555. doi:
10.1186/s12906-017-2063-y. [PMID: 29284481] - Muhammad Naveed, Li Wenhua, Wang Gang, Imran Shair Mohammad, Muhammad Abbas, Xiaoqian Liao, Mengqi Yang, Li Zhang, Xiaolin Liu, Xiaoming Qi, Yineng Chen, Lv Jiadi, Linlan Ye, Wang Zhijie, Chen Ding Ding, Yu Feng, Zhou Xiaohui. A novel ventricular restraint device (ASD) repetitively deliver Salvia miltiorrhiza to epicardium have good curative effects in heart failure management.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Nov; 95(?):701-710. doi:
10.1016/j.biopha.2017.07.126. [PMID: 28886530] - Haoshi Gao, Hongzhang Huang, Aini Zheng, Nuojun Yu, Ning Li. Determination of quantitative retention-activity relationships between pharmacokinetic parameters and biological effectiveness fingerprints of Salvia miltiorrhiza constituents using biopartitioning and microemulsion high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Nov; 1067(?):10-17. doi:
10.1016/j.jchromb.2017.09.018. [PMID: 28985481] - David Wing-Shing Cheung, Chi-Man Koon, Pui-Han Wong, Ka-Chun Yau, Elaine Wat, Angela Sze-Man Hung, Yan-Ping Wang, Kit-Man Lau, Chun-Hay Ko, Judy Yuet-Wa Chan, Mary Miu-Yee Waye, Kwok-Pui Fung. Evaluating Efficacy and Safety of Combination Medication of Atorvastatin and a Herbal Formula Containing Salvia miltiorrhiza and Pueraria lobata on Hyperlipidemia.
Phytotherapy research : PTR.
2017 Oct; 31(10):1579-1589. doi:
10.1002/ptr.5888. [PMID: 28840970] - Si-Si Cao, Miao Yan, Zhen-Yan Hou, Ying Chen, Yun-Sheng Jiang, Xin-Rong Fan, Ping-Fei Fang, Bi-Kui Zhang. Danshen modulates Nrf2-mediated signaling pathway in cisplatin-induced renal injury.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
2017 Oct; 37(5):761-765. doi:
10.1007/s11596-017-1801-1. [PMID: 29058292] - Nguyen Huu Tung, Kensuke Nakajima, Takuhiro Uto, Nguyen Thanh Hai, Dinh Doan Long, Tomoe Ohta, Shigeru Oiso, Hiroko Kariyazono, Yukihiro Shoyama. Bioactive Triterpenes from the Root of Salvia miltiorrhiza Bunge.
Phytotherapy research : PTR.
2017 Sep; 31(9):1457-1460. doi:
10.1002/ptr.5877. [PMID: 28766764] - Yu-Xiang Fei, Si-Qi Wang, Li-Jian Yang, Yan-Ying Qiu, Yi-Ze Li, Wen-Yuan Liu, Tao Xi, Wei-Rong Fang, Yun-Man Li. Salvia miltiorrhiza Bunge (Danshen) extract attenuates permanent cerebral ischemia through inhibiting platelet activation in rats.
Journal of ethnopharmacology.
2017 Jul; 207(?):57-66. doi:
10.1016/j.jep.2017.06.023. [PMID: 28645780] - Ching-Yuan Wu, Yao-Hsu Yang, Yin-Yin Lin, Feng-Che Kuan, Yu-Shin Lin, Wei-Yu Lin, Ming-Yen Tsai, Jia-Jing Yang, Yu-Ching Cheng, Li-Hsin Shu, Ming-Chu Lu, Yun-Ju Chen, Kuan-Der Lee, Hong-Yo Kang. Anti-cancer effect of danshen and dihydroisotanshinone I on prostate cancer: targeting the crosstalk between macrophages and cancer cells via inhibition of the STAT3/CCL2 signaling pathway.
Oncotarget.
2017 Jun; 8(25):40246-40263. doi:
10.18632/oncotarget.14958. [PMID: 28157698] - Mengqi Huo, Zhixin Wang, Dongxue Wu, Yanling Zhang, Yanjiang Qiao. Using Coexpression Protein Interaction Network Analysis to Identify Mechanisms of Danshensu Affecting Patients with Coronary Heart Disease.
International journal of molecular sciences.
2017 Jun; 18(6):. doi:
10.3390/ijms18061298. [PMID: 28629174] - Lingyan Wang, Jiahui Yu, Patrick Asare Fordjour, Xiaoxue Xing, Hui Gao, Yanyan Li, Lingyan Li, Yan Zhu, Xiumei Gao, Guanwei Fan. Danshen injection prevents heart failure by attenuating post-infarct remodeling.
Journal of ethnopharmacology.
2017 Jun; 205(?):22-32. doi:
10.1016/j.jep.2017.04.027. [PMID: 28465251] - Tom Fleischer, Tung-Ti Chang, Jen-Huai Chiang, Mao-Feng Sun, Hung-Rong Yen. Improved Survival With Integration of Chinese Herbal Medicine Therapy in Patients With Acute Myeloid Leukemia: A Nationwide Population-Based Cohort Study.
Integrative cancer therapies.
2017 06; 16(2):156-164. doi:
10.1177/1534735416664171. [PMID: 27531548] - Wei Wei, Yiwei Liu, Qiang Zhang, Yangming Wang, Xiaoling Zhang, Hao Zhang. Danshen-Enhanced Cardioprotective Effect of Cardioplegia on Ischemia Reperfusion Injury in a Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Model.
Artificial organs.
2017 May; 41(5):452-460. doi:
10.1111/aor.12801. [PMID: 27925238] - Jia-Rui Wu, Shi Liu, Xiao-Meng Zhang, Bing Zhang. Danshen injection as adjuvant treatment for unstable angina pectoris: A systematic review and meta-analysis.
Chinese journal of integrative medicine.
2017 Apr; 23(4):306-311. doi:
10.1007/s11655-016-2272-0. [PMID: 27921196] - Wenyi Liang, Wenjing Chen, Lingfang Wu, Shi Li, Qi Qi, Yaping Cui, Linjin Liang, Ting Ye, Lanzhen Zhang. Quality Evaluation and Chemical Markers Screening of Salvia miltiorrhiza Bge. (Danshen) Based on HPLC Fingerprints and HPLC-MSn Coupled with Chemometrics.
Molecules (Basel, Switzerland).
2017 Mar; 22(3):. doi:
10.3390/molecules22030478. [PMID: 28304365] - Keqiu Jiang, Peng Huang, Lianjun Luan, Kai Fan, Wenbo Guo, Zhihui Zhao, Yongjiang Wu, Zheng Han. Iron (II, III) oxide/multi-walled carbon nanotube composite as solid-phase extraction sorbent followed by ultra-high performance liquid chromatography tandem mass spectrometry for simultaneous determination of zearalenone and type A trichothecenes in Salviae miltiorrhizae Radix et Rhizoma (Danshen).
Journal of chromatography. A.
2017 Jan; 1482(?):1-10. doi:
10.1016/j.chroma.2016.12.058. [PMID: 28017565] - L He, Q Q Zhang, X Y Lü, X X Li. [Effects of water extract of salvia miltiorrhiza aganst renal injury on rats exposed to cadmium].
Zhonghua yi xue za zhi.
2017 Jan; 97(1):57-61. doi:
10.3760/cma.j.issn.0376-2491.2017.01.014. [PMID: 28056293] - Lei Ding, Like Wo, Zhongyan Du, Lihua Tang, Zhenyuan Song, Xiaobing Dou. Danshen protects against early-stage alcoholic liver disease in mice via inducing PPARα activation and subsequent 4-HNE degradation.
PloS one.
2017; 12(10):e0186357. doi:
10.1371/journal.pone.0186357. [PMID: 29020055] - Wei Chen, Guoxun Chen. Danshen (Salvia miltiorrhiza Bunge): A Prospective Healing Sage for Cardiovascular Diseases.
Current pharmaceutical design.
2017; 23(34):5125-5135. doi:
10.2174/1381612823666170822101112. [PMID: 28828985] - Lili Wang, Rufeng Ma, Chenyue Liu, Haixia Liu, Ruyuan Zhu, Shuzhen Guo, Minke Tang, Yu Li, Jianzhao Niu, Min Fu, Sihua Gao, Dongwei Zhang. Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases.
Current pharmaceutical design.
2017; 23(7):1077-1097. doi:
10.2174/1381612822666161010105242. [PMID: 27748194] - Ren Guibing, Zhang Xiping, Ding Xiaowen, Zou Dehong, Yang Hongjiang, Meng Xiaoru, Mo Wenju, He Xiangming, Zhao Shuai. EFFECTS OF SALVIA MILTIORRHIZAE ON THE KIDNEY OF RATS WITH SEVERE ACUTE PANCREATITIS AND OBSTRUTIVE JAUNDICE.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2017; 14(2):103-124. doi:
10.21010/ajtcam.v14i2.12. [PMID: 28573227] - Ling Gong, Chunhong Di, Xiaofang Xia, Jie Wang, Gongying Chen, Junping Shi, Pengshuai Chen, Hui Xu, Weibing Zhang. AKT/mTOR signaling pathway is involved in salvianolic acid B-induced autophagy and apoptosis in hepatocellular carcinoma cells.
International journal of oncology.
2016 Dec; 49(6):2538-2548. doi:
10.3892/ijo.2016.3748. [PMID: 27779641] - Kai-Jing Yan, Yang Chu, Jian-Hua Huang, Miao-Miao Jiang, Wei Li, Yue-Fei Wang, Hui-Yong Huang, Yu-Hui Qin, Xiao-Hui Ma, Shui-Ping Zhou, Henry Sun, Wei Wang. Qualitative and quantitative analyses of Compound Danshen extract based on 1H NMR method and its application for quality control.
Journal of pharmaceutical and biomedical analysis.
2016 Nov; 131(?):183-187. doi:
10.1016/j.jpba.2016.08.017. [PMID: 27596830] - Wen-Bing Peng, Qiu-Hua Zeng, Dan-Ping Li, Tian-Ming Ding, Jing-Ling Tan, Xiao-Ping Ding. Multiple on-line HPLC coupled with biochemical detection methods to evaluate bioactive compounds in Danshen injection.
Biomedical chromatography : BMC.
2016 Nov; 30(11):1854-1860. doi:
10.1002/bmc.3772. [PMID: 27229445] - Yong Zhang, Pingyao Xie, Xiuchun Guo, Wenyi Kang. Procoagulant Substance and Mechanism of Myristica fragrans.
Journal of medicinal food.
2016 Nov; 19(11):1065-1073. doi:
10.1089/jmf.2016.3700. [PMID: 27845864] - Zhanli Liu, Xunyang Zheng, Yanlei Guo, Weihan Qin, Lei Hua, Yong Yang. Quantitatively metabolic profiles of salvianolic acids in rats after gastric-administration of Salvia miltiorrhiza extract.
Fitoterapia.
2016 Sep; 113(?):27-34. doi:
10.1016/j.fitote.2016.06.017. [PMID: 27370098] - Wan-yang Sun, Ling Tong, Dong-xiang Li, Kai-shun Bi. [Bioactive consistency evaluation of cardiotonic pill using marker genes].
Yao xue xue bao = Acta pharmaceutica Sinica.
2016 08; 51(8):1290-6. doi:
. [PMID: 29906022] - Li Shen, Zhaohuan Lou, Guangshun Zhang, Guanhua Xu, Guangji Zhang. Diterpenoid Tanshinones, the extract from Danshen (Radix Salviae Miltiorrhizae) induced apoptosis in nine human cancer cell lines.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2016 08; 36(4):514-21. doi:
10.1016/s0254-6272(16)30069-3. [PMID: 28459519] - Zhi-Xing Sun, Yu-Chun Zhou, Tao Liu, Qian Fan, Xin-Fei Huang, Jian Huang, Qing Wang, Liang-Yu Ni, Jian-Guo Xue, Ke-Qin Ning. [Modified Jujing No.2 Decoction for varicocele-induced male infertility].
Zhonghua nan ke xue = National journal of andrology.
2016 07; 22(7):645-648. doi:
". [PMID: 28965385] - Chia-Chi Chang, Yu-Chen Lee, Che-Chen Lin, Chin-Hsien Chang, Cheng-Di Chiu, Li-Wei Chou, Mao-Feng Sun, Hung-Rong Yen. Characteristics of traditional Chinese medicine usage in patients with stroke in Taiwan: A nationwide population-based study.
Journal of ethnopharmacology.
2016 Jun; 186(?):311-321. doi:
10.1016/j.jep.2016.04.018. [PMID: 27090345] - Liang Dai, Linda L D Zhong, Yan Cao, Wei Chen, Ying Cheng, Xiu-Fang Lin, Zhao-Xiang Bian, Ai-Ping Lu. Efficacy and safety of Yirui capsule in patients with hyperlipidemia: study protocol for a multicenter, randomized, double-blind, placebo-controlled trial.
Trials.
2016 06; 17(1):291. doi:
10.1186/s13063-016-1419-9. [PMID: 27316679] - Tao Guo, Wei-Hong Feng, Xiao-Qian Liu, Hui-Min Gao, Zhi-Min Wang, Liang-Liang Gao. Fourier transform mid-infrared spectroscopy (FT-MIR) combined with chemometrics for quantitative analysis of dextrin in Danshen (Salvia miltiorrhiza) granule.
Journal of pharmaceutical and biomedical analysis.
2016 May; 123(?):16-23. doi:
10.1016/j.jpba.2015.11.021. [PMID: 26859611] - Qing-Qing Liu, Jun Han, Guo-Ying Zuo, Gen-Chun Wang, Hua-Shu Tang. Potentiation activity of multiple antibacterial agents by Salvianolate from the Chinese medicine Danshen against methicillin-resistant Staphylococcus aureus (MRSA).
Journal of pharmacological sciences.
2016 May; 131(1):13-7. doi:
10.1016/j.jphs.2015.10.009. [PMID: 26639445]