Methylenecyclopropylglycine (BioDeep_00000180884)
human metabolite blood metabolite
代谢物信息卡片
alpha-Amino-2-methylene-cyclopropaneacetic acid
化学式: C6H9NO2 (127.0633)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 3.88%
分子结构信息
SMILES: C=C(C(=O)O)NC1CC1
InChI: InChI=1S/C6H9NO2/c1-4(6(8)9)7-5-2-3-5/h5,7H,1-3H2,(H,8,9)
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Anna Maria Engel, Ahmed H El-Khatib, Fenja Klevenhusen, Michael Weiss, Sabine Aboling, Benjamin Sachse, Bernd Schäfer, Stefan Weigel, Robert Pieper, Carola Fischer-Tenhagen. Detection of Hypoglycin A and MCPrG Metabolites in the Milk and Urine of Pasture Dairy Cows after Intake of Sycamore Seedlings.
Journal of agricultural and food chemistry.
2023 Jul; ?(?):. doi:
10.1021/acs.jafc.3c01248. [PMID: 37419492] - Ahmed H El-Khatib, Julika Lamp, Stefan Weigel. A sensitive LC-MS/MS method for the quantification of the plant toxins hypoglycin A and methylenecyclopropylglycine and their metabolites in cow's milk and urine and application to farm milk samples from Germany.
Analytical and bioanalytical chemistry.
2023 Mar; ?(?):. doi:
10.1007/s00216-023-04607-9. [PMID: 36877265] - Mandy Bochnia, Eva Ziemssen, Johannes Sander, Birgit Stief, Annette Zeyner. Methylenecyclopropylglycine and hypoglycin A intoxication in three Pére David's Deers (Elaphurus davidianus) with atypical myopathy.
Veterinary medicine and science.
2021 05; 7(3):998-1005. doi:
10.1002/vms3.406. [PMID: 33314647] - Jiali Yang, Xiangrong Zhu, Pei Zhang, Yinhong Wang, Yangyang Xiao, Bao Yang, Hongxia Qu, Yueming Jiang. Detection of toxic methylenecyclopropylglycine and hypoglycin A in litchi aril of three Chinese cultivars.
Food chemistry.
2020 Oct; 327(?):127013. doi:
10.1016/j.foodchem.2020.127013. [PMID: 32454275] - Sukesh Narayan Sinha, Ungarala Venkat Ramakrishna, P K Sinha, C P Thakur. A recurring disease outbreak following litchi fruit consumption among children in Muzaffarpur, Bihar-A comprehensive investigation on factors of toxicity.
PloS one.
2020; 15(12):e0244798. doi:
10.1371/journal.pone.0244798. [PMID: 33382820] - Mandy Bochnia, Johannes Sander, Joerg Ziegler, Michael Terhardt, Stefanie Sander, Nils Janzen, Jessika-M V Cavalleri, Aleksandra Zuraw, Monika Wensch-Dorendorf, Annette Zeyner. Detection of MCPG metabolites in horses with atypical myopathy.
PloS one.
2019; 14(2):e0211698. doi:
10.1371/journal.pone.0211698. [PMID: 30721263] - Aimee A Sanford, Samantha L Isenberg, Melissa D Carter, Mike A Mojica, Thomas P Mathews, Sarah Laughlin, Jerry D Thomas, James L Pirkle, Rudolph C Johnson. Quantification of hypoglycin A and methylenecyclopropylglycine in human plasma by HPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Sep; 1095(?):112-118. doi:
10.1016/j.jchromb.2018.07.017. [PMID: 30056267] - Aakash Shrivastava, Anil Kumar, Jerry D Thomas, Kayla F Laserson, Gyan Bhushan, Melissa D Carter, Mala Chhabra, Veena Mittal, Shashi Khare, James J Sejvar, Mayank Dwivedi, Samantha L Isenberg, Rudolph Johnson, James L Pirkle, Jon D Sharer, Patricia L Hall, Rajesh Yadav, Anoop Velayudhan, Mohan Papanna, Pankaj Singh, D Somashekar, Arghya Pradhan, Kapil Goel, Rajesh Pandey, Mohan Kumar, Satish Kumar, Amit Chakrabarti, P Sivaperumal, A Ramesh Kumar, Joshua G Schier, Arthur Chang, Leigh Ann Graham, Thomas P Mathews, Darryl Johnson, Liza Valentin, Kathleen L Caldwell, Jeffery M Jarrett, Leslie A Harden, Gary R Takeoka, Suxiang Tong, Krista Queen, Clinton Paden, Anne Whitney, Dana L Haberling, Ram Singh, Ravi Shankar Singh, Kenneth C Earhart, A C Dhariwal, L S Chauhan, S Venkatesh, Padmini Srikantiah. Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study.
The Lancet. Global health.
2017 04; 5(4):e458-e466. doi:
10.1016/s2214-109x(17)30035-9. [PMID: 28153514] - Samantha L Isenberg, Melissa D Carter, Leigh Ann Graham, Thomas P Mathews, Darryl Johnson, Jerry D Thomas, James L Pirkle, Rudolph C Johnson. Quantification of metabolites for assessing human exposure to soapberry toxins hypoglycin A and methylenecyclopropylglycine.
Chemical research in toxicology.
2015 Sep; 28(9):1753-9. doi:
10.1021/acs.chemrestox.5b00205. [PMID: 26328472] - K Melde, S Jackson, K Bartlett, H S Sherratt, S Ghisla. Metabolic consequences of methylenecyclopropylglycine poisoning in rats.
The Biochemical journal.
1991 Mar; 274 ( Pt 2)(?):395-400. doi:
10.1042/bj2740395. [PMID: 2006907] - S Ghisla, K Melde, H D Zeller, W Boschert. Mechanisms of enzyme inhibition by hypoglycin, methylenecyclopropylglycine and their metabolites.
Progress in clinical and biological research.
1990; 321(?):185-92. doi:
NULL. [PMID: 2326291] - K Melde, H Buettner, W Boschert, H P Wolf, S Ghisla. Mechanism of hypoglycaemic action of methylenecyclopropylglycine.
The Biochemical journal.
1989 May; 259(3):921-4. doi:
10.1042/bj2590921. [PMID: 2730593]
