Methyl isocyanate (BioDeep_00000180845)

 

Secondary id: BioDeep_00001871329

human metabolite blood metabolite


代谢物信息卡片


Methylisocyanate 1 x 500mg neat

化学式: C2H3NO (57.021462799999995)
中文名称: 异氰酸甲酯
谱图信息: 最多检出来源 Homo sapiens(blood) 0.21%

分子结构信息

SMILES: CN=C=O
InChI: InChI=1S/C2H3NO/c1-3-2-4/h1H3

描述信息

D006401 - Hematologic Agents > D000986 - Antisickling Agents

同义名列表

12 个代谢物同义名

Methylisocyanate 1 x 500mg neat; Isocyanic acid de methyle; Methyl isocyanic acid; Isocyanate de methyle; Methyl carbonimide; Iso-cyanatomethane; Methyl isocyanide; Isocyanatomethane; Methylcarbylamine; Methyl isocyanate; Methylisocyanate; MIC



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • K E Zannat, S K Saha, S M Tanzim, A Afrin, B C Saha, J B Joynal, M Aktar, N H Nira, N Akhter, M A Hossain. Antibacterial Effects of Chloroform Henna (Lawsonia inermis) Leaf Extracts against Two Nosocomial Infection Causing Pathogens: Gram-positive Staphylococcus aureus and Gram-negative Klebsiella pneumoniae: A Comparative Study. Mymensingh medical journal : MMJ. 2023 Jul; 32(3):620-626. doi: . [PMID: 37391949]
  • Brandon M Kenwood, Pritha Bagchi, Luyu Zhang, Wanzhe Zhu, David M Chambers, Benjamin C Blount, Víctor R De Jesús. Characterization of US population levels of urinary methylcarbamoyl mercapturic acid, a metabolite of N,N-dimethylformamide and methyl isocyanate, in the National Health and Nutrition Examination Survey (NHANES) 2005-2006 and 2011-2016. Environmental science and pollution research international. 2021 Apr; 28(13):16781-16791. doi: 10.1007/s11356-020-12135-7. [PMID: 33398732]
  • Chinnu Sugavanam Senthilkumar, Tahir Mohi-Ud-Din Malla, Sameena Akhter, Nand Kishore Sah, Narayanan Ganesh. Susceptibility of the Bhopal-methyl isocyanate (MIC)-gas-tragedy survivors and their offspring to COVID-19: What we know, what we don't and what we should?. Ciencia & saude coletiva. 2020 Oct; 25(suppl 2):4225-4230. doi: 10.1590/1413-812320202510.2.28682020. [PMID: 33027359]
  • Raymond C Rancourt, Jacqueline S Rioux, Livia A Veress, Rhonda B Garlick, Claire R Croutch, Eric Peters, William Sosna, Carl W White. Methyl isocyanate inhalation induces tissue factor-dependent activation of coagulation in rats. Drug and chemical toxicology. 2019 May; 42(3):321-327. doi: 10.1080/01480545.2018.1517773. [PMID: 30426789]
  • Jerry Havens, Heather Walker, Tom Spicer. Bhopal atmospheric dispersion revisited. Journal of hazardous materials. 2012 Sep; 233-234(?):33-40. doi: 10.1016/j.jhazmat.2012.06.055. [PMID: 22819479]
  • Chinnu Sugavanam Senthilkumar, Nand Kishore Sah, Narayanan Ganesh. Methyl isocyanate and carcinogenesis: bridgeable gaps in scientific knowledge. Asian Pacific journal of cancer prevention : APJCP. 2012; 13(6):2429-35. doi: 10.7314/apjcp.2012.13.6.2429. [PMID: 22938400]
  • Lygia T Budnik, Dennis Nowak, Rolf Merget, Catherine Lemiere, Xaver Baur. Elimination kinetics of diisocyanates after specific inhalative challenges in humans: mass spectrometry analysis, as a basis for biomonitoring strategies. Journal of occupational medicine and toxicology (London, England). 2011 Mar; 6(1):9. doi: 10.1186/1745-6673-6-9. [PMID: 21447151]
  • Gianni Tognoni. [The Bhopal tragedy 25 (10+15) years after]. Assistenza infermieristica e ricerca : AIR. 2010 Apr; 29(2):94-103. doi: ". [PMID: 20828026]
  • Arpit Bhargava, Ram Prakash Punde, Neelam Pathak, Sunil Dabadghao, Prabha Desikan, Aruna Jain, Kewal Krishan Maudar, Pradyumna Kumar Mishra. Status of inflammatory biomarkers in the population that survived the Bhopal gas tragedy: a study after two decades. Industrial health. 2010; 48(2):204-8. doi: 10.2486/indhealth.48.204. [PMID: 20424351]
  • Alaa-Eldin F Nassar, Ivan King, Brandy L Paris, Lois Haupt, Florence Ndikum-Moffor, Rebecca Campbell, Etsuko Usuki, Jennifer Skibbe, Dan Brobst, Brian W Ogilvie, Andrew Parkinson. An in vitro evaluation of the victim and perpetrator potential of the anticancer agent laromustine (VNP40101M), based on reaction phenotyping and inhibition and induction of cytochrome P450 enzymes. Drug metabolism and disposition: the biological fate of chemicals. 2009 Sep; 37(9):1922-30. doi: 10.1124/dmd.109.027516. [PMID: 19520774]
  • Pradyumna K Mishra, Gorantla V Raghuram, Hariom Panwar, Deepika Jain, Hemant Pandey, Kewal K Maudar. Mitochondrial oxidative stress elicits chromosomal instability after exposure to isocyanates in human kidney epithelial cells. Free radical research. 2009 Aug; 43(8):718-28. doi: 10.1080/10715760903037699. [PMID: 19513903]
  • Pradyumna Kumar Mishra, Venkata Raghuram Gorantla, Nabila Akhtar, Priyanka Tamrakar, Subodh Kumar Jain, Kewal Krishan Maudar. Analysis of cellular response to isocyanate using N-succinimidyl N-methylcarbamate exposure in cultured mammalian cells. Environmental and molecular mutagenesis. 2009 May; 50(4):328-36. doi: 10.1002/em.20469. [PMID: 19197993]
  • Giuliana Bianco, Salvatore Abate, Cristiana Labella, Tommaso R I Cataldi. Identification and fragmentation pathways of caffeine metabolites in urine samples via liquid chromatography with positive electrospray ionization coupled to a hybrid quadrupole linear ion trap (LTQ) and Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2009 Apr; 23(7):1065-74. doi: 10.1002/rcm.3969. [PMID: 19260028]
  • Bret F Bessac, Michael Sivula, Christian A von Hehn, Ana I Caceres, Jasmine Escalera, Sven-Eric Jordt. Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2009 Apr; 23(4):1102-14. doi: 10.1096/fj.08-117812. [PMID: 19036859]
  • Heinz Kerger, Petroula Dodidou, Daniela Passani-Kruppa, Joachim Grüttner, Monika Birmelin, Alexander Volz, Klaus F Waschke. Excessive methaemoglobinaemia and multi-organ failure following 4-DMAP antidote therapy. Resuscitation. 2005 Aug; 66(2):231-5. doi: 10.1016/j.resuscitation.2005.02.008. [PMID: 15950359]
  • Edward Broughton. The Bhopal disaster and its aftermath: a review. Environmental health : a global access science source. 2005 May; 4(1):6. doi: 10.1186/1476-069x-4-6. [PMID: 15882472]
  • V Ramana Dhara, Thomas H Gassert. The Bhopal syndrome: persistent questions about acute toxicity and management of gas victims. International journal of occupational and environmental health. 2002 Oct; 8(4):380-6. doi: 10.1179/107735202800338731. [PMID: 12412857]
  • V Ramana Dhara, Rosaline Dhara. The Union Carbide disaster in Bhopal: a review of health effects. Archives of environmental health. 2002 Sep; 57(5):391-404. doi: 10.1080/00039890209601427. [PMID: 12641179]
  • V Ramana Dhara, Rosaline Dhara, Sushma D Acquilla, Paul Cullinan. Personal exposure and long-term health effects in survivors of the union carbide disaster at bhopal. Environmental health perspectives. 2002 May; 110(5):487-500. doi: 10.1289/ehp.02110487. [PMID: 12003752]
  • W S Beckett. Persistent respiratory effects in survivors of the Bhopal disaster. Thorax. 1998 Aug; 53 Suppl 2(?):S43-6. doi: 10.1136/thx.53.2008.s43. [PMID: 10193347]
  • P Cullinan, S Acquilla, V R Dhara. Respiratory morbidity 10 years after the Union Carbide gas leak at Bhopal: a cross sectional survey. The International Medical Commission on Bhopal. BMJ (Clinical research ed.). 1997 Feb; 314(7077):338-42. doi: 10.1136/bmj.314.7077.338. [PMID: 9040323]
  • M Gupta, V Prabha. Changes in brain and plasma amino acids of mice intoxicated with methyl isocyanate. Journal of applied toxicology : JAT. 1996 Nov; 16(6):469-73. doi: 10.1002/(sici)1099-1263(199611)16:6<469::aid-jat373>3.0.co;2-q. [PMID: 8956091]
  • K Jeevaratnam, S Sriramachari. Acute histopathological changes induced by methyl isocyanate in lungs, liver, kidneys & spleen of rats. The Indian journal of medical research. 1994 May; 99(?):231-5. doi: NULL. [PMID: 7927582]
  • I Guest, D R Varma. Inhibition of mouse embryonic, yolk sac, and limb-bud functions by the methyl isocyanate metabolite S-(N-methylcarbamoyl)glutathione. Canadian journal of physiology and pharmacology. 1994 Jan; 72(1):50-6. doi: 10.1139/y94-009. [PMID: 8012898]
  • D R Varma, I Guest. The Bhopal accident and methyl isocyanate toxicity. Journal of toxicology and environmental health. 1993 Dec; 40(4):513-29. doi: 10.1080/15287399309531816. [PMID: 8277516]
  • K Jeevaratnam, S Vidya, C S Vaidyanathan. Role of lipid peroxidation in impairment of mitochondrial function at complex I by methyl isocyanate treatment of rats in vivo. Biochemistry and molecular biology international. 1993 Jul; 30(3):411-7. doi: ". [PMID: 8401298]
  • J G Slatter, M R Davis, D H Han, P G Pearson, T A Baillie. Studies on the metabolic fate of caracemide, an experimental antitumor agent, in the rat. Evidence for the release of methyl isocyanate in vivo. Chemical research in toxicology. 1993 May; 6(3):335-40. doi: 10.1021/tx00033a013. [PMID: 8318655]
  • K Jeevaratnam, K Sugendran, C S Vaidyanathan. Do the hydrolysis products, methylamine and N,N'-dimethylurea, play any role in the methyl isocyanate-induced haematological and biochemical changes in rabbits?. Human & experimental toxicology. 1993 Mar; 12(2):135-9. doi: 10.1177/096032719301200207. [PMID: 8096711]
  • K Jeevaratnam, K Sugendran, C S Vaidyanathan. Influence of methylamine and N,N'-dimethylurea, the hydrolysis products of methyl isocyanate, on its systemic toxicity. Journal of applied toxicology : JAT. 1993 Jan; 13(1):15-8. doi: 10.1002/jat.2550130105. [PMID: 8440870]
  • K Jeevaratnam, S Vidya, C S Vaidyanathan. In vitro and in vivo effect of methyl isocyanate on rat liver mitochondrial respiration. Toxicology and applied pharmacology. 1992 Dec; 117(2):172-9. doi: 10.1016/0041-008x(92)90234-j. [PMID: 1471148]
  • R Dhara. Health effects of the Bhopal gas leak: a review. Epidemiologia e prevenzione. 1992 Sep; 14(52):22-31. doi: ". [PMID: 1306166]
  • I Guest, T A Baillie, D R Varma. Toxicity of the methyl isocyanate metabolite S-(N-methylcarbamoyl)GSH on mouse embryos in culture. Teratology. 1992 Jul; 46(1):61-7. doi: 10.1002/tera.1420460109. [PMID: 1641812]
  • K Jeevaratnam, C S Vaidyanathan. Acute toxicity of methyl isocyanate in rabbit: in vitro and in vivo effects on rabbit erythrocyte membrane. Archives of environmental contamination and toxicology. 1992 Apr; 22(3):300-4. doi: 10.1007/bf00212090. [PMID: 1535491]
  • K Jeevaratnam, R Bhattacharya, K Sugendran, C S Vaidyanathan. Acute toxicity of methyl isocyanate in mammals. IV. Biochemical and hematological changes in rabbits. Biomedical and environmental sciences : BES. 1991 Dec; 4(4):384-91. doi: . [PMID: 1781933]
  • R Kapoor. Fetal loss and contraceptive acceptance among the Bhopal gas victims. Social biology. 1991 Sep; 38(3-4):242-8. doi: 10.1080/19485565.1991.9988791. [PMID: 1801204]
  • P G Pearson, J G Slatter, M S Rashed, D H Han, T A Baillie. Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanate. Chemical research in toxicology. 1991 Jul; 4(4):436-44. doi: 10.1021/tx00022a007. [PMID: 1912331]
  • J G Slatter, M S Rashed, P G Pearson, D H Han, T A Baillie. Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities. Chemical research in toxicology. 1991 Mar; 4(2):157-61. doi: 10.1021/tx00020a006. [PMID: 1782345]
  • J S Ferguson, Y Alarie. Long term pulmonary impairment following a single exposure to methyl isocyanate. Toxicology and applied pharmacology. 1991 Feb; 107(2):253-68. doi: 10.1016/0041-008x(91)90207-u. [PMID: 1704645]
  • A K Saxena, B N Paul, M Sinha, K K Dutta, S N Das, P K Ray. A study on the B cell activity in protein deficient rats exposed to methyl isocyanate vapour. Immunopharmacology and immunotoxicology. 1991; 13(3):413-24. doi: 10.3109/08923979109019714. [PMID: 1940056]
  • B B Ghosh, S Sengupta, A Roy, S Maity, S Ghosh, G Talukder, A Sharma. Cytogenetic studies in human populations exposed to gas leak at Bhopal, India. Environmental health perspectives. 1990 Jun; 86(?):323-6. doi: 10.1289/ehp.9086323. [PMID: 2401269]
  • K Jeevaratnam, R Vijayaraghavan, M P Kaushik, C S Vaidyanathan. Acute toxicity of methyl isocyanate in mammals. II. Induction of hyperglycemia, lactic acidosis, uraemia, and hypothermia in rats. Archives of environmental contamination and toxicology. 1990 May; 19(3):314-8. doi: 10.1007/bf01054971. [PMID: 2353832]
  • D R Varma, I Guest, S Smith, S Mulay. Dissociation between maternal and fetal toxicity of methyl isocyanate in mice and rats. Journal of toxicology and environmental health. 1990 May; 30(1):1-14. doi: 10.1080/15287399009531405. [PMID: 2348477]
  • N Sethi, R Dayal, R K Singh. Acute and subacute toxicity study of inhaled methyl isocyanate in Charles Foster rats. Ecotoxicology and environmental safety. 1989 Aug; 18(1):68-74. doi: 10.1016/0147-6513(89)90092-4. [PMID: 2776690]
  • K Jeevarathinam, W Selvamurthy, U S Ray, S Mukhopadhyay, L Thakur. Acute toxicity of methyl isocyanate, administered subcutaneously in rabbits: changes in physiological, clinico-chemical and histological parameters. Toxicology. 1988 Oct; 51(2-3):223-40. doi: 10.1016/0300-483x(88)90152-7. [PMID: 3176030]
  • J S Ferguson, A L Kennedy, M F Stock, W E Brown, Y Alarie. Uptake and distribution of 14C during and following exposure to [14C]methyl isocyanate. Toxicology and applied pharmacology. 1988 Jun; 94(1):104-17. doi: 10.1016/0041-008x(88)90341-9. [PMID: 3376108]
  • R C Srivastava, B N Gupta, M Athar, J R Behari, R S Dwivedi, S K Hasan, R S Bharti, A Singh, M Misra, P K Ray. Effect of exposure to toxic gas on the population of Bhopal: Part III--Assessment of toxic manifestations in humans--haematological and biochemical studies. Indian journal of experimental biology. 1988 Mar; 26(3):165-72. doi: NULL. [PMID: 3397119]
  • G S Gupta, F N Jaffery, K K Dutta, P N Viswanathan, A Mishra, P K Ray. Inhalation toxicity studies on methyl isocyanate (MIC) in rats: Part II--Biochemical studies on hemolysates, lactate dehydrogenase, isoenzymes and lipid peroxidation. Indian journal of experimental biology. 1988 Mar; 26(3):183-6. doi: ". [PMID: 3397122]
  • D R Varma, J S Ferguson, Y Alarie. Inhibition of methyl isocyanate toxicity in mice by starvation and dexamethasone but not by sodium thiosulfate, atropine, and ethanol. Journal of toxicology and environmental health. 1988; 24(1):93-101. doi: 10.1080/15287398809531142. [PMID: 3373566]
  • M H Karol, S R Kamat. The antibody response to methyl isocyanate: experimental and clinical findings. Bulletin europeen de physiopathologie respiratoire. 1987 Nov; 23(6):591-7. doi: NULL. [PMID: 3453753]
  • H Weill. Disaster at Bhopal: the accident, early findings and respiratory health outlook in those injured. Bulletin europeen de physiopathologie respiratoire. 1987 Nov; 23(6):587-90. doi: ". [PMID: 3453752]
  • M H Karol, S Taskar, S Gangal, B F Rubanoff, S R Kamat. The antibody response to methyl isocyanate: experimental and clinical findings. Environmental health perspectives. 1987 Jun; 72(?):169-75. doi: 10.1289/ehp.8772169. [PMID: 3622432]
  • J R Bucher, B N Gupta, M Thompson, B Adkins, B A Schwetz. The toxicity of inhaled methyl isocyanate in F344/N rats and B6C3F1 mice. II. Repeated exposure and recovery studies. Environmental health perspectives. 1987 Jun; 72(?):133-8. doi: 10.1289/ehp.8772133. [PMID: 3622427]
  • W P Kolb, J R Savary, C M Troup, D E Dodd, J D Tamerius. Biological effects of short-term, high-concentration exposure to methyl isocyanate. VI. In vitro and in vivo complement activation studies. Environmental health perspectives. 1987 Jun; 72(?):189-95. doi: 10.1289/ehp.8772189. [PMID: 3622434]
  • D R Varma. Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy. Environmental health perspectives. 1987 Jun; 72(?):153-7. doi: 10.1289/ehp.8772153. [PMID: 3622430]
  • D R Varma, J S Ferguson, Y Alarie. Reproductive toxicity of methyl isocyanate in mice. Journal of toxicology and environmental health. 1987; 21(3):265-75. doi: 10.1080/15287398709531018. [PMID: 3586061]
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  • D Anderson, S D Blowers, B Nemery. Investigation by the Ames test of urine samples from rats exposed to methyl isocyanate. British journal of industrial medicine. 1986 Aug; 43(8):566-7. doi: 10.1136/oem.43.8.566. [PMID: 3730310]
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  • A G Salmon, M Kerr Muir, N Andersson. Acute toxicity of methyl isocyanate: a preliminary study of the dose response for eye and other effects. British journal of industrial medicine. 1985 Dec; 42(12):795-8. doi: 10.1136/oem.42.12.795. [PMID: 4074650]
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  • M H Karol, B A Hauth. Use of hexyl isocyanate antigen to detect antibodies to hexamethylene diisocyanate (HDI) in sensitized guinea pigs and in a sensitized worker. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1982 May; 2(3):108-13. doi: 10.1016/s0272-0590(82)80090-0. [PMID: 6821040]