7-Aminoclonazepam (BioDeep_00000018084)

   

human metabolite Endogenous


代谢物信息卡片


7-amino-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2-ol

化学式: C15H12ClN3O (285.0668852)
中文名称: 7-氨基氯硝西泮
谱图信息: 最多检出来源 () 0%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

7-Aminoclonazepam. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/7-aminoclonazepam (retrieved 2024-11-25) (BioDeep RN: BioDeep_00000018084). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C(=O)NC2=C(C=C(C=C2)N)C(=N1)C3=CC=CC=C3Cl
InChI: InChI=1S/C15H12ClN3O/c16-12-4-2-1-3-10(12)15-11-7-9(17)5-6-13(11)19-14(20)8-18-15/h1-7H,8,17H2,(H,19,20)

描述信息

7-aminoclonazepam belongs to the family of Benzodiazepines. These are organic compounds containing a benzene ring fused to either isomers of diazepine(unsaturated seven-member heterocycle with two nitrogen atoms replacing two carbon atoms).

同义名列表

6 个代谢物同义名

7-amino-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2-ol; Ro-05-46197-aminoclonazepam; 7-Aminoclonazepam; Aminoclonazepam; Chloraminazepam; 7-ACLZ



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Stacy E F Melanson, David Griggs, Ida Bixho, Tahira Khaliq, James G Flood. 7-aminoclonazepam is superior to clonazepam for detection of clonazepam use in oral fluid by LC-MS/MS. Clinica chimica acta; international journal of clinical chemistry. 2016 Apr; 455(?):128-33. doi: 10.1016/j.cca.2016.01.027. [PMID: 26826393]
  • L W Storhaug, A Enger, K Hjelmeland, E L Øiestad, V Vindenes. Prolonged excretion of 7-aminoclonazepam in urine after repeated ingestion of clonazepam: a case report. Forensic science international. 2012 Oct; 222(1-3):e33-5. doi: 10.1016/j.forsciint.2012.06.018. [PMID: 22819278]
  • Stephanie J Marin, Gwendolyn A McMillin. LC-MS/MS analysis of 13 benzodiazepines and metabolites in urine, serum, plasma, and meconium. Methods in molecular biology (Clifton, N.J.). 2010; 603(?):89-105. doi: 10.1007/978-1-60761-459-3_9. [PMID: 20077062]
  • Josh Gunn, Scott Kriger, Andrea R Terrell. Simultaneous determination and quantification of 12 benzodiazepines in serum or whole blood using UPLC/MS/MS. Methods in molecular biology (Clifton, N.J.). 2010; 603(?):107-19. doi: 10.1007/978-1-60761-459-3_10. [PMID: 20077063]
  • Hua Kuang, Qiusheng Li, Chongyu Shen, Jinzhong Xu, Yuan Yuan, Chuanlai Xu, Wuyang Wang. A highly sensitive method for the determination of 7-aminonitrazepam, a metabolite of nitrazepam, in human urine using high-performance electrospray liquid chromatography tandem mass spectrometry. Biomedical chromatography : BMC. 2009 Jul; 23(7):740-4. doi: 10.1002/bmc.1178. [PMID: 19319833]
  • Wei Chen, Chifang Peng, Zhengyue Jin, Ruirui Qiao, Wuyang Wang, Shuifang Zhu, Libing Wang, Qinhui Jin, Chuanlai Xu. Ultrasensitive immunoassay of 7-aminoclonazepam in human urine based on CdTe nanoparticle bioconjugations by fabricated microfluidic chip. Biosensors & bioelectronics. 2009 Mar; 24(7):2051-6. doi: 10.1016/j.bios.2008.10.015. [PMID: 19058957]
  • Marjorie Chèze, Marion Villain, Gilbert Pépin. Determination of bromazepam, clonazepam and metabolites after a single intake in urine and hair by LC-MS/MS. Application to forensic cases of drug facilitated crimes. Forensic science international. 2004 Oct; 145(2-3):123-30. doi: 10.1016/j.forsciint.2004.04.066. [PMID: 15451083]
  • Adam Negrusz, Andrew M Bowen, Christine M Moore, Sheila M Dowd, Mary Jane Strong, Philip G Janicak. Elimination of 7-aminoclonazepam in urine after a single dose of clonazepam. Analytical and bioanalytical chemistry. 2003 Aug; 376(8):1198-204. doi: 10.1007/s00216-003-2050-7. [PMID: 12845398]
  • Albert A Elian. ELISA detection of clonazepam and 7-aminoclonazepam in whole blood and urine. Forensic science international. 2003 Jun; 134(1):54-6. doi: 10.1016/s0379-0738(03)00099-9. [PMID: 12842358]
  • J H Edge, P D Walson, A Rane. Clonazepam and 7-aminoclonazepam in human plasma. Therapeutic drug monitoring. 1991 Jul; 13(4):363-8. doi: 10.1097/00007691-199107000-00014. [PMID: 1780971]
  • R L Heazlewood, R W Lemass. Simple high-performance liquid chromatographic assay for the routine monitoring of clonazepam in plasma. Journal of chromatography. 1984 Dec; 336(1):229-33. doi: 10.1016/s0378-4347(00)85145-2. [PMID: 6526921]
  • I Petters, D R Peng, A Rane. Quantitation of clonazepam and its 7-amino and 7-acetamido metabolites in plasma by high-performance liquid chromatography. Journal of chromatography. 1984 Mar; 306(?):241-8. doi: 10.1016/s0378-4347(00)80886-5. [PMID: 6715463]
  • S M Rocha, E L Angerami. [Study of urine pH and density in the rehydration of infants. Introduction to nursing care]. Boletin de la Oficina Sanitaria Panamericana. Pan American Sanitary Bureau. 1978 Feb; 84(2):146-56. doi: NULL. [PMID: 24456]