Methyl diethyldithiocarbamate (BioDeep_00000180837)
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
化学式: C6H13NS2 (163.0489378)
中文名称: 二乙基二硫代氨基甲酸甲酯
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: CCN(CC)C(=S)SC
InChI: InChI=1S/C6H13NS2/c1-4-7(5-2)6(8)9-3/h4-5H2,1-3H3
描述信息
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- M G Pike, D C Mays, D W Macomber, J J Lipsky. Metabolism of a disulfiram metabolite, S-methyl N,N-diethyldithiocarbamate, by flavin monooxygenase in human renal microsomes.
Drug metabolism and disposition: the biological fate of chemicals.
2001 Feb; 29(2):127-32. doi:
. [PMID: 11159801] - A Madan, M D Faiman. Characterization of diethyldithiocarbamate methyl ester sulfine as an intermediate in the bioactivation of disulfiram.
The Journal of pharmacology and experimental therapeutics.
1995 Feb; 272(2):775-80. doi:
NULL. [PMID: 7853193] - B W Hart, M D Faiman. In vivo pharmacodynamic studies of the disulfiram metabolite S-methyl N,N-diethylthiolcarbamate sulfoxide: inhibition of liver aldehyde dehydrogenase.
Alcoholism, clinical and experimental research.
1994 Apr; 18(2):340-5. doi:
10.1111/j.1530-0277.1994.tb00023.x. [PMID: 8048736] - B Johansson, H R Angelo, J K Christensen, I W Møller, P Rønsted. Dose-effect relationship of disulfiram in human volunteers. II: A study of the relation between the disulfiram-alcohol reaction and plasma concentrations of acetaldehyde, diethyldithiocarbamic acid methyl ester, and erythrocyte aldehyde dehydrogenase activity.
Pharmacology & toxicology.
1991 Mar; 68(3):166-70. doi:
10.1111/j.1600-0773.1991.tb01216.x. [PMID: 1647526] - B Scappaticci, J Soubeyrand, M Rousseau-Tsangaris, M Desage, J L Brazier, B Coquet. Determination of sodium diethyldithiocarbamate (Imuthiol) and its S-methyl metabolite by gas chromatography-mass spectrometry. Use of deuteromethyl iodide derivatization.
Journal of chromatography.
1990 Dec; 534(?):57-66. doi:
10.1016/s0378-4347(00)82148-9. [PMID: 1965596] - B Johansson. Plasma protein binding of disulfiram and its metabolite diethylthiocarbamic acid methyl ester.
The Journal of pharmacy and pharmacology.
1990 Nov; 42(11):806-7. doi:
10.1111/j.2042-7158.1990.tb07028.x. [PMID: 1982309] - B W Hart, J J Yourick, M D Faiman. S-methyl-N,N-diethylthiolcarbamate: a disulfiram metabolite and potent rat liver mitochondrial low Km aldehyde dehydrogenase inhibitor.
Alcohol (Fayetteville, N.Y.).
1990 Mar; 7(2):165-9. doi:
10.1016/0741-8329(90)90079-r. [PMID: 2158327] - E N Petersen. Pharmacological effects of diethylthiocarbamic acid methyl ester, the active metabolite of disulfiram?.
European journal of pharmacology.
1989 Aug; 166(3):419-25. doi:
10.1016/0014-2999(89)90354-3. [PMID: 2806369] - B Johansson, E N Petersen, E Arnold. Diethylthiocarbamic acid methyl ester. A potent inhibitor of aldehyde dehydrogenase found in rats treated with disulfiram or diethyldithiocarbamic acid methyl ester.
Biochemical pharmacology.
1989 Apr; 38(7):1053-9. doi:
10.1016/0006-2952(89)90248-7. [PMID: 2539814] - J J Yourick, M D Faiman. Comparative aspects of disulfiram and its metabolites in the disulfiram-ethanol reaction in the rat.
Biochemical pharmacology.
1989 Feb; 38(3):413-21. doi:
10.1016/0006-2952(89)90380-8. [PMID: 2537080] - B Johansson, Z Stankiewicz. Inhibition of erythrocyte aldehyde dehydrogenase activity and elimination kinetics of diethyldithiocarbamic acid methyl ester and its monothio analogue after administration of single and repeated doses of disulfiram to man.
European journal of clinical pharmacology.
1989; 37(2):133-8. doi:
10.1007/bf00558220. [PMID: 2551696] - B Johansson. Rapid and sensitive on-line precolumn purification and high-performance liquid chromatographic assay for disulfiram and its metabolites.
Journal of chromatography.
1986 Jun; 378(2):419-29. doi:
10.1016/s0378-4347(00)80737-9. [PMID: 3016011] - M D Faiman, L Artman, T Maziasz. Diethyldithiocarbamic acid-methyl ester distribution, elimination, and LD50 in the rat after intraperitoneal administration.
Alcoholism, clinical and experimental research.
1983; 7(3):307-11. doi:
10.1111/j.1530-0277.1983.tb05466.x. [PMID: 6312830]