Methyl 2-amino-3-(1H-indol-3-yl)propanoate (BioDeep_00000180823)

   

human metabolite blood metabolite


代谢物信息卡片


Methyl tryptophan monohydrochloride, (DL-TRP)-isomer

化学式: C12H14N2O2 (218.1055)
中文名称: 2-氨基-3-(1H-吲哚-3-基)丙酸甲酯
谱图信息: 最多检出来源 Homo sapiens(blood) 23.1%

分子结构信息

SMILES: COC(=O)C(CC1=CNC2=CC=CC=C21)N
InChI: InChI=1S/C12H14N2O2/c1-16-12(15)10(13)6-8-7-14-11-5-3-2-4-9(8)11/h2-5,7,10,14H,6,13H2,1H3



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Theodoros Eleftheriadis, Georgios Pissas, Georgios Filippidis, Vassilios Liakopoulos, Ioannis Stefanidis. The Role of Indoleamine 2,3-Dioxygenase in Renal Tubular Epithelial Cells Senescence under Anoxia or Reoxygenation. Biomolecules. 2021 10; 11(10):. doi: 10.3390/biom11101522. [PMID: 34680153]
  • Maite Duhalde Vega, José L Aparício, Lilia A Retegui. Levo-1-methyl tryptophan aggravates the effects of mouse hepatitis virus (MHV-A59) infection. International immunopharmacology. 2015 Feb; 24(2):377-382. doi: 10.1016/j.intimp.2014.12.031. [PMID: 25573404]
  • Todd D Merchen, Erika I Boesen, John R Gardner, Rachel Harbarger, Eiko Kitamura, Andrew Mellor, David M Pollock, Arina Ghaffari, Robert Podolsky, N Stanley Nahman. Indoleamine 2,3-dioxygenase inhibition alters the non-coding RNA transcriptome following renal ischemia-reperfusion injury. Transplant immunology. 2014 May; 30(4):140-4. doi: 10.1016/j.trim.2014.04.003. [PMID: 24751756]
  • Hong Soon Yim, Kyung Min Choi, Byoungjae Kim, In Duk Jung, Yeong-Min Park, Yoon Kyu Kang, Min-Goo Lee. Effect of 1-methyl-D-tryptophan and adoptive transfer of dendritic cells on polymicrobial sepsis induced by cecal content injection. Microbiology and immunology. 2013 Sep; 57(9):633-9. doi: 10.1111/1348-0421.12081. [PMID: 23841524]
  • Işık Perçin, Gözde Baydemir, Bahar Ergün, Adil Denizli. Macroporous PHEMA-based cryogel discs for bilirubin removal. Artificial cells, nanomedicine, and biotechnology. 2013 Jun; 41(3):172-7. doi: 10.3109/10731199.2012.712046. [PMID: 22947178]
  • Richard M Dunham, Shari N Gordon, Monica Vaccari, Michael Piatak, Yong Huang, Steven G Deeks, Jeffrey Lifson, Genoveffa Franchini, Joseph M McCune. Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase. AIDS research and human retroviruses. 2013 Feb; 29(2):207-14. doi: 10.1089/aid.2012.0162. [PMID: 22924680]
  • Jolanta Zuwała-Jagiello, Monika Pazgan-Simon, Krzysztof Simon, Maria Warwas. Picolinic acid in patients with chronic hepatitis C infection: a preliminary report. Mediators of inflammation. 2012; 2012(?):762863. doi: 10.1155/2012/762863. [PMID: 22701277]
  • Ariana Posadaz, N Mariano Correa, M Alicia Biasutti, Norman A García. A kinetic study of the photodynamic effect on tryptophan methyl ester and tryptophan octyl ester in DOPC vesicles. Photochemistry and photobiology. 2010 Jan; 86(1):96-103. doi: 10.1111/j.1751-1097.2009.00641.x. [PMID: 19930125]
  • Kanishka Mohib, Shuang Wang, Qiunong Guan, Andrew L Mellor, Hongtao Sun, Caigan Du, Anthony M Jevnikar. Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury. American journal of physiology. Renal physiology. 2008 Jul; 295(1):F226-34. doi: 10.1152/ajprenal.00567.2007. [PMID: 18480171]
  • Lee Jia, Karen Schweikart, Joseph Tomaszewski, John G Page, Patricia E Noker, Sarah A Buhrow, Joel M Reid, Matthew M Ames, David H Munn. Toxicology and pharmacokinetics of 1-methyl-d-tryptophan: absence of toxicity due to saturating absorption. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2008 Jan; 46(1):203-11. doi: 10.1016/j.fct.2007.07.017. [PMID: 17868966]
  • Anikó Takátsy, Judit Hodrea, Cornelia Majdik, Florin Dan Irimie, Ferenc Kilár. Role of chemical structure in molecular recognition by transferrin. Journal of molecular recognition : JMR. 2006 Jul; 19(4):270-4. doi: 10.1002/jmr.777. [PMID: 16703571]
  • Silvia Bozza, Francesca Fallarino, Lucia Pitzurra, Teresa Zelante, Claudia Montagnoli, Silvia Bellocchio, Paolo Mosci, Carmine Vacca, Paolo Puccetti, Luigina Romani. A crucial role for tryptophan catabolism at the host/Candida albicans interface. Journal of immunology (Baltimore, Md. : 1950). 2005 Mar; 174(5):2910-8. doi: 10.4049/jimmunol.174.5.2910. [PMID: 15728502]
  • F Yamane, H Okazawa, P Blier, M Diksic. Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan(2). Biochemical pharmacology. 2001 Dec; 62(11):1481-9. doi: 10.1016/s0006-2952(01)00798-5. [PMID: 11728384]
  • D C Chugani, O Muzik. Alpha[C-11]methyl-L-tryptophan PET maps brain serotonin synthesis and kynurenine pathway metabolism. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2000 Jan; 20(1):2-9. doi: 10.1097/00004647-200001000-00002. [PMID: 10616786]
  • F Kilár, S Fanali. Separation of tryptophan-derivative enantiomers with iron-free human serum transferrin by capillary zone electrophoresis. Electrophoresis. 1995 Aug; 16(8):1510-8. doi: 10.1002/elps.11501601250. [PMID: 8529623]
  • W BOLLAG, B J KOSZEWSKI. [Experimental kidney damage with methyl-tryptophan]. Virchows Archiv fur pathologische Anatomie und Physiologie und fur klinische Medizin. 1953; 324(4):428-37. doi: 10.1007/bf00954788. [PMID: 13169682]