methiothepin (BioDeep_00000180801)

   

human metabolite blood metabolite


代谢物信息卡片


1-methyl-4-[6-(methylsulfanyl)-2-thiatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3(8),4,6,11,13-hexaen-9-yl]piperazine

化学式: C20H24N2S2 (356.1380824)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)SC
InChI: InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist

同义名列表

13 个代谢物同义名

1-methyl-4-[6-(methylsulfanyl)-2-thiatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3(8),4,6,11,13-hexaen-9-yl]piperazine; (+-)-1-(10,11-Dihydro-8-(methylthio)dibenzo(b,F)thiepin-10-yl)-4-methylpiperazine; (+-)-10-(4-Methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,F)thiepin; 1-Methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,F]thiepin-10-yl]piperazine; 1-(10,11-Dihydro-8-(methylthio)dibenzo(b,F)thiepin-10-yl)-4-methylpiperazine; (+-)-8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,F)thiepin; Maleate, methiothepin; METHIOTHEPIN MALEATE; Methiothepine; methiothepin; Metitepinum; Metitepine; Metitepina



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Valeria Itzel Reyes-Pérez, Vinicio Granados-Soto, Manuel Rangel-Grimaldo, Myrna Déciga-Campos, Rachel Mata. Pharmacological Analysis of the Anti-inflammatory and Antiallodynic Effects of Zinagrandinolide E from Zinnia grandiflora in Mice. Journal of natural products. 2021 03; 84(3):713-723. doi: 10.1021/acs.jnatprod.0c00793. [PMID: 32870011]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ha Thi Thanh Nguyen, Hai Thanh Nguyen, Md Zahorul Islam, Takeshi Obi, Pitchaya Pothinuch, Phyu Phyu Khine Zar, De Xing Hou, Thanh Van Nguyen, Tuong Manh Nguyen, Cuong Van Dao, Mitsuya Shiraishi, Atsushi Miyamoto. Pharmacological characteristics of Artemisia vulgaris L. in isolated porcine basilar artery. Journal of ethnopharmacology. 2016 Apr; 182(?):16-26. doi: 10.1016/j.jep.2016.02.009. [PMID: 26875644]
  • Katarzyna Kucwaj-Brysz, Dawid Warszycki, Sabina Podlewska, Jagna Witek, Karolina Witek, Andrea González Izquierdo, Grzegorz Satała, María I Loza, Annamaria Lubelska, Gniewomir Latacz, Andrzej J Bojarski, Marián Castro, Katarzyna Kieć-Kononowicz, Jadwiga Handzlik. Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation. European journal of medicinal chemistry. 2016 Apr; 112(?):258-269. doi: 10.1016/j.ejmech.2016.02.024. [PMID: 26900658]
  • Kevin M Wood, Anisa Zeqja, H Frederik Nijhout, Michael C Reed, Janet Best, Parastoo Hashemi. Voltammetric and mathematical evidence for dual transport mediation of serotonin clearance in vivo. Journal of neurochemistry. 2014 Aug; 130(3):351-9. doi: 10.1111/jnc.12733. [PMID: 24702305]
  • Yi Zhang, Jeanne L Benton, Barbara S Beltz. 5-HT receptors mediate lineage-dependent effects of serotonin on adult neurogenesis in Procambarus clarkii. Neural development. 2011 Jan; 6(?):2. doi: 10.1186/1749-8104-6-2. [PMID: 21205292]
  • Jessica A Knight, Carol Smith, Nicole Toohey, Michael T Klein, Milt Teitler. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. Molecular pharmacology. 2009 Feb; 75(2):374-80. doi: 10.1124/mol.108.052084. [PMID: 18996971]
  • Jonas Lindblom, Ramona Petrovska, Mathias Hallberg, Kristina Magnusson, Fred Nyberg, Staffan Uhlén. Nandrolone treatment decreases the alpha1B-adrenoceptor mRNA level in rat kidney, but not the density of alpha1B-adrenoceptors in cultured MDCK-D1 kidney cells. European journal of pharmacology. 2005 Dec; 527(1-3):157-62. doi: 10.1016/j.ejphar.2005.09.062. [PMID: 16309668]
  • David R Thomas, Christopher G Larminie, Helen R Lyons, Andrew Fosberry, Matthew J Hill, Philip D Hayes. Cloning and pharmacological characterisation of the guinea pig 5-ht5A receptor. European journal of pharmacology. 2004 Jun; 494(2-3):91-9. doi: 10.1016/j.ejphar.2004.04.027. [PMID: 15212962]
  • Elsa Maria Gouveia, Celso Rodrigues Franci. Involvement of serotonin 5HT1 and 5HT2 receptors and nitric oxide synthase in the medial preoptic area on gonadotropin secretion. Brain research bulletin. 2004 Apr; 63(3):243-51. doi: 10.1016/j.brainresbull.2004.03.002. [PMID: 15145143]
  • Julie Y Crider, Gary W Williams, Colene D Drace, Parvaneh Katoli, Michelle Senchyna, Najam A Sharif. Pharmacological characterization of a serotonin receptor (5-HT7) stimulating cAMP production in human corneal epithelial cells. Investigative ophthalmology & visual science. 2003 Nov; 44(11):4837-44. doi: 10.1167/iovs.02-1292. [PMID: 14578406]
  • Giuseppe Campiani, Stefania Butini, Sandra Gemma, Vito Nacci, Caterina Fattorusso, Bruno Catalanotti, Gianluca Giorgi, Alfredo Cagnotto, Mara Goegan, Tiziana Mennini, Patrizia Minetti, M Assunta Di Cesare, Domenico Mastroianni, Nazzareno Scafetta, Bruno Galletti, M Antonietta Stasi, Massimo Castorina, Licia Pacifici, Orlando Ghirardi, Ornella Tinti, Paolo Carminati. Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies. Journal of medicinal chemistry. 2002 Jan; 45(2):344-59. doi: 10.1021/jm010982y. [PMID: 11784139]
  • N M Rajamannan, N Caplice, F Anthikad, T J Sebo, T A Orszulak, W D Edwards, J Tajik, R S Schwartz. Cell proliferation in carcinoid valve disease: a mechanism for serotonin effects. The Journal of heart valve disease. 2001 Nov; 10(6):827-31. doi: NULL. [PMID: 11767194]
  • T J Berndt, M Liang, G M Tyce, F G Knox. Intrarenal serotonin, dopamine, and phosphate handling in remnant kidneys. Kidney international. 2001 Feb; 59(2):625-30. doi: 10.1046/j.1523-1755.2001.059002625.x. [PMID: 11168943]
  • Jennifer M Gross, Theresa J Berndt, Franklyn G Knox. Effect of serotonin receptor antagonist on phosphate excretion. Journal of the American Society of Nephrology : JASN. 2000 Jun; 11(6):1002-1007. doi: 10.1681/asn.v1161002. [PMID: 10820163]
  • G A Lambert, T Shimomura, P M Boers, V Gordon, C Donaldson, A S Zagami. Serotonin infusions inhibit sensory input from the dural vasculature. Cephalalgia : an international journal of headache. 1999 Sep; 19(7):639-50. doi: 10.1046/j.1468-2982.1999.019007639.x. [PMID: 10524657]
  • M M Iravani, R Muscat, Z L Kruk. MK-801 interaction with the 5-HT transporter: a real-time study in brain slices using fast cyclic voltammetry. Synapse (New York, N.Y.). 1999 Jun; 32(3):212-24. doi: 10.1002/(sici)1098-2396(19990601)32:3<212::aid-syn7>3.0.co;2-m. [PMID: 10340631]
  • J M Zgombick, T A Branchek. Native 5-HT1B receptors expressed in OK cells display dual coupling to elevation of intracellular calcium concentrations and inhibition of adenylate cyclase. Naunyn-Schmiedeberg's archives of pharmacology. 1998 Nov; 358(5):503-8. doi: 10.1007/pl00005285. [PMID: 9840417]
  • S R Bailey, J Elliott. Plasma 5-hydroxytryptamine constricts equine digital blood vessels in vitro: implications for pathogenesis of acute laminitis. Equine veterinary journal. 1998 Mar; 30(2):124-30. doi: 10.1111/j.2042-3306.1998.tb04471.x. [PMID: 9535068]
  • F G Boess, F J Monsma, V Meyer, C Zwingelstein, A J Sleight. Interaction of tryptamine and ergoline compounds with threonine 196 in the ligand binding site of the 5-hydroxytryptamine6 receptor. Molecular pharmacology. 1997 Sep; 52(3):515-23. doi: 10.1124/mol.52.3.515. [PMID: 9284367]
  • N Adham, J A Bard, J M Zgombick, M M Durkin, S Kucharewicz, R L Weinshank, T A Branchek. Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog. Neuropharmacology. 1997 Apr; 36(4-5):569-76. doi: 10.1016/s0028-3908(97)00020-8. [PMID: 9225282]
  • J E Leysen, W Gommeren, L Heylen, W H Luyten, I Van de Weyer, P Vanhoenacker, G Haegeman, A Schotte, P Van Gompel, R Wouters, A S Lesage. Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. Molecular pharmacology. 1996 Dec; 50(6):1567-80. doi: . [PMID: 8967979]
  • P Schoeffter, I Bobirnac. 5-Hydroxytryptamine 5-HT1D receptors mediating inhibition of cyclic AMP accumulation in Madin-Darby canine kidney (MDCK) cells. Naunyn-Schmiedeberg's archives of pharmacology. 1995 Sep; 352(3):256-62. doi: 10.1007/bf00168555. [PMID: 8584040]
  • P J Pauwels, C Palmier. Functional effects of the 5-HT1D receptor antagonist GR 127,935 at human 5-HT1D alpha, 5-HT1D beta, 5-HT1A and opossum 5-HT1B receptors. European journal of pharmacology. 1995 Jul; 290(2):95-103. doi: 10.1016/0922-4106(95)90021-7. [PMID: 8575538]
  • N Adham, P J Vaysse, R L Weinshank, T A Branchek. The cloned human 5-HT1E receptor couples to inhibition and activation of adenylyl cyclase via two distinct pathways in transfected BS-C-1 cells. Neuropharmacology. 1994 Mar; 33(3-4):403-10. doi: 10.1016/0028-3908(94)90070-1. [PMID: 7984278]
  • Y Shen, F J Monsma, M A Metcalf, P A Jose, M W Hamblin, D R Sibley. Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. The Journal of biological chemistry. 1993 Aug; 268(24):18200-4. doi: . [PMID: 8394362]
  • N Adham, H T Kao, L E Schecter, J Bard, M Olsen, D Urquhart, M Durkin, P R Hartig, R L Weinshank, T A Branchek. Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America. 1993 Jan; 90(2):408-12. doi: 10.1073/pnas.90.2.408. [PMID: 8380639]
  • G McAllister, A Charlesworth, C Snodin, M S Beer, A J Noble, D N Middlemiss, L L Iversen, P Whiting. Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. Proceedings of the National Academy of Sciences of the United States of America. 1992 Jun; 89(12):5517-21. doi: 10.1073/pnas.89.12.5517. [PMID: 1608964]
  • R A Bond, D A Craig, K G Charlton, A G Ornstein, D E Clarke. Partial agonistic activity of GR43175 at the inhibitory prejunctional 5-HT1-like receptor in rat kidney. Journal of autonomic pharmacology. 1989 Jun; 9(3):201-10. doi: 10.1111/j.1474-8673.1989.tb00211.x. [PMID: 2545718]
  • T J Murphy, D B Bylund. Oxymetazoline inhibits adenylate cyclase by activation of serotonin-1 receptors in the OK cell, an established renal epithelial cell line. Molecular pharmacology. 1988 Jul; 34(1):1-7. doi: . [PMID: 2839761]
  • G A Jahn, R P Deis. A possible dual regulation of prolactin release by the serotoninergic system in rats at pro-oestrus and during late pregnancy: role of ovarian hormones. The Journal of endocrinology. 1987 Mar; 112(3):367-74. doi: 10.1677/joe.0.1120367. [PMID: 2951475]
  • M S Hudecki, C M Pollina, A K Bhargava, R S Hudecki. Screening of antiserotoninergic drugs with the genetically dystrophic chicken. Archives of neurology. 1980 Sep; 37(9):545-50. doi: 10.1001/archneur.1980.00500580041005. [PMID: 6448038]
  • D L Nelson, A Herbet, L Pichat, J Glowinski, M Hamon. In vitro and in vivo disposition of 3H-methiothepin in brain tissues. Relationship to the effects of acute treatment with methiothepin on central serotoninergic receptors. Naunyn-Schmiedeberg's archives of pharmacology. 1979 Dec; 310(1):25-33. doi: 10.1007/bf00499871. [PMID: 530311]
  • A Masala, L Devilla, G Delitala, S Alagna, P P Rovasio, G L Capitanio. Action of the serotoninergic and dopaminergic antagonist methiothepin maleate on serum prolactin and growth hormone levels in man. Panminerva medica. 1979 Apr; 21(2):65-8. doi: NULL. [PMID: 554040]
  • E Eschenhof, W Meister, G Oesterhelt, W Vetter. [Metabolism of methiothepin in the rat, dog and man]. Arzneimittel-Forschung. 1976 Feb; 26(2):262-71. doi: NULL. [PMID: 947211]
  • D M Lawson, R R Gala. The interaction of dopaminergic and serotonergic drugs on plasma prolactin in ovariectomized, estrogen-treated rats. Endocrinology. 1976 Jan; 98(1):42-7. doi: 10.1210/endo-98-1-42. [PMID: 1248448]
  • J H Jacoby, H Shabshelowitz, J D Fernstrom, R J Wurtman. The mechanism by which methiothepin, a putative serotonin receptor antagonist, icnreses brain 5-hydroxyindole levels. The Journal of pharmacology and experimental therapeutics. 1975 Nov; 195(2):257-64. doi: NULL. [PMID: 241843]