Met-glu-his-phe-arg-trp-gly (BioDeep_00000180769)

   

human metabolite blood metabolite


代谢物信息卡片


4-[2-amino-4-(methylsulfanyl)butanamido]-4-({1-[(1-{[1-({1-[(carboxymethyl)carbamoyl]-2-(1H-indol-3-yl)ethyl}carbamoyl)-4-[(diaminomethylidene)amino]butyl]carbamoyl}-2-phenylethyl)carbamoyl]-2-(1H-imidazol-5-yl)ethyl}carbamoyl)butanoic acid

化学式: C44H59N13O10S (961.4228354)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CSCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)O)N
InChI: InChI=1S/C44H59N13O10S/c1-68-17-15-29(45)38(62)53-32(13-14-36(58)59)41(65)57-35(20-27-22-48-24-52-27)43(67)55-33(18-25-8-3-2-4-9-25)42(66)54-31(12-7-16-49-44(46)47)40(64)56-34(39(63)51-23-37(60)61)19-26-21-50-30-11-6-5-10-28(26)30/h2-6,8-11,21-22,24,29,31-35,50H,7,12-20,23,45H2,1H3,(H,48,52)(H,51,63)(H,53,62)(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,59)(H,60,61)(H4,46,47,49)

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents

同义名列表

16 个代谢物同义名

4-[2-amino-4-(methylsulfanyl)butanamido]-4-({1-[(1-{[1-({1-[(carboxymethyl)carbamoyl]-2-(1H-indol-3-yl)ethyl}carbamoyl)-4-[(diaminomethylidene)amino]butyl]carbamoyl}-2-phenylethyl)carbamoyl]-2-(1H-imidazol-5-yl)ethyl}carbamoyl)butanoic acid; 4-[2-amino-4-(methylsulfanyl)butanamido]-4-{[1-({1-[(1-{[1-(carboxymethylcarbamoyl)-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-[(diaminomethylidene)amino]butyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-(3H-imidazol-4-yl)ethyl]carbamoyl}butanoic acid; ACTH (4-10), zinc phosphate (1:1) salt; ACTH (4-10), (D-alpha glu)-isomer; Met-glu-his-phe-arg-trp-gly; ACTH (4-10), (D-arg)-isomer; ACTH (4-10), (D-met)-isomer; Corticotropin (4-10); Porcine acth (4-10); Corticotropin 4-10; Human acth (4-10); ACTH-MSH (4-10); MSH-ACTH (4-10); ACTH (4-10); ACTH(4-10); 4-10-SEMAX



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Heng-Keang Lim, Yuan Cao, Xi Qiu, Jose Silva, David C Evans. A nonradioactive approach to investigate the metabolism of therapeutic peptides by tagging with 127i and using inductively-coupled plasma mass spectrometry analysis. Drug metabolism and disposition: the biological fate of chemicals. 2015 Jan; 43(1):17-26. doi: 10.1124/dmd.114.059774. [PMID: 25315343]
  • Yu A Zolotarev, O V Dolotov, L S Inozemtseva, A K Dadayan, E M Dorokhova, L A Andreeva, L Yu Alfeeva, I A Grivennikov, N F Myasoedov. Degradation of the ACTH(4-10) analog Semax in the presence of rat basal forebrain cell cultures and plasma membranes. Amino acids. 2006 Jun; 30(4):403-8. doi: 10.1007/s00726-006-0328-8. [PMID: 16773243]
  • Manfred Hallschmid, Rüdiger Smolnik, Gerard McGregor, Jan Born, Horst L Fehm. Overweight humans are resistant to the weight-reducing effects of melanocortin4-10. The Journal of clinical endocrinology and metabolism. 2006 Feb; 91(2):522-5. doi: 10.1210/jc.2005-0906. [PMID: 16317061]
  • M J Hoogduijn, S McGurk, N P M Smit, P H Nibbering, J Ancans, A van der Laarse, A J Thody. Ligand-dependent activation of the melanocortin 5 receptor: cAMP production and ryanodine receptor-dependent elevations of [Ca(2+)](I). Biochemical and biophysical research communications. 2002 Jan; 290(2):844-50. doi: 10.1006/bbrc.2001.6283. [PMID: 11785979]
  • V G Bashkatova, V B Koshelev, O E Fadyukova, A A Alexeev, A F Vanin, K S Rayevsky, I P Ashmarin, D M Armstrong. Novel synthetic analogue of ACTH 4-10 (Semax) but not glycine prevents the enhanced nitric oxide generation in cerebral cortex of rats with incomplete global ischemia. Brain research. 2001 Mar; 894(1):145-9. doi: 10.1016/s0006-8993(00)03324-2. [PMID: 11245825]
  • H L Fehm, R Smolnik, W Kern, G P McGregor, U Bickel, J Born. The melanocortin melanocyte-stimulating hormone/adrenocorticotropin(4-10) decreases body fat in humans. The Journal of clinical endocrinology and metabolism. 2001 Mar; 86(3):1144-8. doi: 10.1210/jcem.86.3.7298. [PMID: 11238499]
  • R A Adan, J Oosterom, G Ludvigsdottir, J H Brakkee, J P Burbach, W H Gispen. Identification of antagonists for melanocortin MC3, MC4 and MC5 receptors. European journal of pharmacology. 1994 Nov; 269(3):331-7. doi: 10.1016/0922-4106(94)90041-8. [PMID: 7895772]
  • V N Potaman, L Y Alfeeva, A A Kamensky, V N Nezavibatko. Degradation of ACTH/MSH(4-10) and its synthetic analog semax by rat serum enzymes: an inhibitor study. Peptides. 1993 May; 14(3):491-5. doi: 10.1016/0196-9781(93)90137-6. [PMID: 8392718]
  • V N Potaman, L V Antonova, V A Dubynin, D A Zaitzev, A A Kamensky, N F Myasoedov, V N Nezavibatko. Entry of the synthetic ACTH(4-10) analogue into the rat brain following intravenous injection. Neuroscience letters. 1991 Jun; 127(1):133-6. doi: 10.1016/0304-3940(91)90912-d. [PMID: 1652713]
  • V N Potaman, L Y Alfeeva, A A Kamensky, N G Levitzkaya, V N Nezavibatko. N-terminal degradation of ACTH(4-10) and its synthetic analog semax by the rat blood enzymes. Biochemical and biophysical research communications. 1991 Apr; 176(2):741-6. doi: 10.1016/s0006-291x(05)80247-5. [PMID: 1851003]
  • U Bickel, J Born, H L Fehm, M Distler, K H Voigt. The behaviorally active peptide ACTH 4-10: measurement in plasma and pharmacokinetics in man. European journal of clinical pharmacology. 1988; 35(4):371-7. doi: 10.1007/bf00561367. [PMID: 2848706]
  • J Born, W Bräuninger, G Fehm-Wolfsdorf, K H Voigt, P Pauschinger, H L Fehm. Dose-dependent influences on electrophysiological signs of attention in humans after neuropeptide ACTH 4-10. Experimental brain research. 1987; 67(1):85-92. doi: 10.1007/bf00269456. [PMID: 3040455]
  • L Korányi, E Endröczi. Changes in serum corticosterone and testosterone during induced maternal behavior in rats. Acta physiologica Hungarica. 1987; 69(1):33-42. doi: NULL. [PMID: 3035872]
  • L Stárka, R Hampl, A Simecková, J Obenberger, R Drouhault. Changes induced in rabbit plasma and aqueous humour by ACTH4-10 and ACTH1-24. Endocrinologia experimentalis. 1985 Mar; 19(1):25-8. doi: NULL. [PMID: 2985354]
  • K A Gruber, M F Callahan, R F Kirby, A K Johnson, J R Lymangrover. Natriuretic and hypertensinogenic pro-opiomelanocortin derived peptides. Regulatory peptides. Supplement. 1985; 4(?):118-23. doi: NULL. [PMID: 2997849]
  • K A Gruber, M C Klein, J R Lymangrover. Natriuretic peptides derived from pro-opiocortin. Progress in clinical and biological research. 1985; 192(?):213-20. doi: NULL. [PMID: 3001754]
  • R Drouhault, D Valéro, A Baghdiantz, P Blanquet. In-vivo hypocalcaemic, hypophosphataemic and hyperlipaemic activities in the common peptide sequence of adrenocorticotrophin, melanocyte-stimulating hormone and lipotrophin. The Journal of endocrinology. 1983 Jun; 97(3):447-52. doi: 10.1677/joe.0.0970447. [PMID: 6306130]
  • H D Veldhuis, E R De Kloet. Significance of ACTH4-10 in the control of hippocampal corticosterone receptor capacity of hypophysectomized rats. Neuroendocrinology. 1982; 34(5):374-80. doi: 10.1159/000123331. [PMID: 6281678]
  • T van Wimersma Greidanus. MSH/ACTH4-10: a tool to differentiate between the role of vasopressin in memory consolidation or retrieval processes. Peptides. 1982 Jan; 3(1):7-11. doi: 10.1016/0196-9781(82)90133-4. [PMID: 6281748]
  • L V Antonova, G Sh Burbaeva, A A Kamenskiĭ, I P Ashmarin. [Learning ability of white rats following immunization with a conjugate of the oligopeptide ACTH 4-10 with albumin; absence of immunotolerance to ACTH 4-10]. Doklady Akademii nauk SSSR. 1981; 258(6):1477-80. doi: NULL. [PMID: 6266798]
  • W P Smotherman, S Levine. ACTH4--10 affects behavior but not plasma corticosterone levels in a conditioned taste aversion situation. Peptides. 1980; 1(3):207-10. doi: 10.1016/0196-9781(80)90055-8. [PMID: 6262738]
  • A Gecse, A Ottlecz, M Faragó, T Forster, G Telegdy. Effects of ACTH on the synthesis and metabolism of prostaglandin in rat kidney. Acta physiologica Academiae Scientiarum Hungaricae. 1980; 55(2):107-12. doi: NULL. [PMID: 6254326]