Meptazinol (BioDeep_00000180744)

   

human metabolite blood metabolite


代谢物信息卡片


Cahill may roberts brand OF meptazinol hydrochloride

化学式: C15H23NO (233.17795479999998)
中文名称: 美普他酚
谱图信息: 最多检出来源 Mus musculus(blood) 33.33%

分子结构信息

SMILES: CCC1(CCCCN(C)C1)C1=CC(O)=CC=C1
InChI: InChI=1S/C15H23NO/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13/h6-8,11,17H,3-5,9-10,12H2,1-2H3

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D009292 - Narcotic Antagonists
D002491 - Central Nervous System Agents > D000700 - Analgesics
N - Nervous system > N02 - Analgesics > N02A - Opioids

同义名列表

7 个代谢物同义名

Cahill may roberts brand OF meptazinol hydrochloride; Riemser brand OF meptazinol hydrochloride; Shire brand OF meptazinol hydrochloride; 3-(3-ethyl-1-methylazepan-3-yl)phenol; Meptazinol hydrochloride; Meptazinol; Meptid



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Faxue Zhao, Lin Zhao, Yan Zhou, Xiaofang Tan, Yang Yang, Wenwen Ni, Wei Zheng, Hongzhuan Chen, Yu Qiu, Juan Li. A Multifunctional (-)-Meptazinol-Serotonin Hybrid Ameliorates Oxidative Stress-Associated Apoptotic Neuronal Death and Memory Deficits via Activating the Nrf2/Antioxidant Enzyme Pathway. Oxidative medicine and cellular longevity. 2023; 2023(?):6935947. doi: 10.1155/2023/6935947. [PMID: 36819782]
  • Shaobing Cheng, Wei Zheng, Ping Gong, Qiang Zhou, Qiong Xie, Lining Yu, Peiyi Zhang, Liangkang Chen, Juan Li, Jianxing Chen, Hailin Chen, Hongzhuan Chen. (-)-Meptazinol-melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-β aggregation with high antioxidant potency for Alzheimer's therapy. Bioorganic & medicinal chemistry. 2015 Jul; 23(13):3110-8. doi: 10.1016/j.bmc.2015.04.084. [PMID: 26025073]
  • Ying Xie, Pan Jiang, Xinxing Ge, Hao Wang, Biyun Shao, Qiong Xie, Zhuibai Qiu, Hongzhuan Chen. Determination of a novel carbamate AChE inhibitor meserine in mouse plasma, brain and rat plasma by LC-MS/MS: application to pharmacokinetic study after intravenous and subcutaneous administration. Journal of pharmaceutical and biomedical analysis. 2014 Aug; 96(?):156-61. doi: 10.1016/j.jpba.2014.03.025. [PMID: 24747147]
  • Zhaoxi Zheng, Yabin Tang, Haoyu Lv, Jianrong Xu, Hengyi Zhao, Qiong Xie, Zhuibai Qiu, Hongzhuan Chen, Hao Wang. Determination of Meserine, a new candidate for Alzheimer's disease in mice brain by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic and tissue distribution study. Analytical and bioanalytical chemistry. 2014 May; 406(14):3451-8. doi: 10.1007/s00216-014-7779-7. [PMID: 24756818]
  • Xin-xing Ge, Xiao-lin Wang, Pan Jiang, Ying Xie, Tao Jiang, Zheng-xing Rong, Qi-zhi Zhang, Qiong Xie, Zhui-bai Qiu, Hao Wang, Hong-zhuan Chen. Determination of Bis(9)-(-)-Meptazinol, a bis-ligand for Alzheimer's disease, in rat plasma by liquid chromatography-tandem mass spectrometry: application to pharmacokinetics study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jan; 881-882(?):126-30. doi: 10.1016/j.jchromb.2011.12.010. [PMID: 22204875]
  • Peter D Maskell, Giorgia De Paoli, L Nitin Seetohul, Derrick J Pounder. Meptazinol and ethanol: a fatal intoxication. Journal of analytical toxicology. 2012 Jan; 36(1):69-73. doi: 10.1093/jat/bkr005. [PMID: 22290756]
  • Jian Qiao, Zhirong Tan, Weiyong Li, Lu Huang, Miaomiao Ge. Liquid chromatography/positive ion electrospray tandem mass spectrometry method for the quantification of hydrochloride meptazinol in human plasma: application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Nov; 877(30):3787-91. doi: 10.1016/j.jchromb.2009.08.051. [PMID: 19819764]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Zhenqi Shi, Qizhi Zhang, Xinguo Jiang. Pharmacokinetic behavior in plasma, cerebrospinal fluid and cerebral cortex after intranasal administration of hydrochloride meptazinol. Life sciences. 2005 Sep; 77(20):2574-83. doi: 10.1016/j.lfs.2005.02.025. [PMID: 15993428]
  • Zhen-qi Shi, Qi-zhi Zhang, Xin-guo Jiang. Enhancement of systemic and CNS delivery of meptazinol hydrochloride by intranasal administration to rats. Yao xue xue bao = Acta pharmaceutica Sinica. 2005 Aug; 40(8):754-7. doi: NULL. [PMID: 16268513]
  • Zhenqi Shi, Qizhi Zhang, Xinguo Jiang. A novel method to calculate the extent and amount of drug transported into CSF after intranasal administration. International journal of pharmaceutics. 2005 Jan; 289(1-2):159-66. doi: 10.1016/j.ijpharm.2004.11.006. [PMID: 15652208]
  • A Galli, E Ranaudo, L Giannini, C Costagli. Reversible inhibition of cholinesterases by opioids: possible pharmacological consequences. The Journal of pharmacy and pharmacology. 1996 Nov; 48(11):1164-8. doi: 10.1111/j.2042-7158.1996.tb03914.x. [PMID: 8961166]
  • C Rudolphi, G Blaschke. Determination of the stereoselective aspects in in-vitro and in-vivo metabolism of the analgesic meptazinol by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. 1995 Jan; 663(2):315-26. doi: 10.1016/0378-4347(94)00466-i. [PMID: 7735479]
  • G R Murray, G M Whiffin, R A Franklin, J A Henry. Quantitative aspects of the urinary excretion of meptazinol and its metabolites in human volunteers. Xenobiotica; the fate of foreign compounds in biological systems. 1989 Jun; 19(6):669-75. doi: 10.3109/00498258909042304. [PMID: 2669363]
  • G R Murray, D Evans, T Lind, R A Franklin, D F Graham. The disposition of meptazinol after single and multiple intravenous administration to pregnant and non-pregnant women. European journal of clinical pharmacology. 1989; 36(3):273-7. doi: 10.1007/bf00558159. [PMID: 2744067]
  • G R Murray, O Petitjean, R A Franklin, D F Graham, J H Trouvin, C Jacquot. The systemic availability of meptazinol in man after oral and rectal doses. European journal of clinical pharmacology. 1989; 36(3):279-82. doi: 10.1007/bf00558160. [PMID: 2744068]
  • A Galli, A Mazri. Protection against diisopropylfluorophosphate intoxication by meptazinol. Toxicology and applied pharmacology. 1988 Sep; 95(3):388-96. doi: 10.1016/0041-008x(88)90357-2. [PMID: 3188007]
  • R A Franklin. The clinical pharmacokinetics and metabolism of the analgesic meptazinol. Xenobiotica; the fate of foreign compounds in biological systems. 1988 Jan; 18(1):105-12. doi: 10.3109/00498258809055141. [PMID: 3354226]
  • T Manner, J Kanto, H Scheinin, M Scheinin. Meptazinol and pentazocine: plasma catecholamines and other effects in healthy volunteers. British journal of clinical pharmacology. 1987 Dec; 24(6):689-97. doi: 10.1111/j.1365-2125.1987.tb03233.x. [PMID: 3440093]
  • T Manner, J Kanto, H Scheinin, O Viinamäki, M Scheinin. Meptazinol and pentazocine: effects on prolactin, growth hormone and vasopressin levels in plasma. Pharmacology & toxicology. 1987 Nov; 61(5):301-4. doi: 10.1111/j.1600-0773.1987.tb01823.x. [PMID: 3438224]
  • C Verborgh, D Van der Auwera, F Camu. Meptazinol for postoperative pain relief in man. Comparison of extradural and i.m. administration. British journal of anaesthesia. 1987 Sep; 59(9):1134-9. doi: 10.1093/bja/59.9.1134. [PMID: 2444241]
  • A K Dhiri, J Sanford, M G Wyllie. Disposition and pharmacokinetics of meptazinol in the CSF. Studies after intrathecal administration in the non-human primate Erythrocebus patas. British journal of anaesthesia. 1987 Sep; 59(9):1140-6. doi: 10.1093/bja/59.9.1140. [PMID: 3663435]
  • A Bottoncetti, A Galli. Prevention of physostigmine-induced lethality by the opioid analgesic meptazinol in the mouse. British journal of pharmacology. 1987 Jun; 91(2):299-306. doi: 10.1111/j.1476-5381.1987.tb10284.x. [PMID: 3607358]
  • G G Birnie, G G Thompson, T Murray, G Watkinson, M J Brodie. Enhanced oral bioavailability of meptazinol in cirrhosis. Gut. 1987 Mar; 28(3):248-54. doi: 10.1136/gut.28.3.248. [PMID: 3570028]
  • E Gepts, W A Sonck, F Camu, A Vercruysse. Pharmacokinetics of intravenously administered meptazinol during general anaesthesia in man. European journal of anaesthesiology. 1987 Jan; 4(1):35-43. doi: NULL. [PMID: 3582376]
  • A E Jacobson. Biological evaluation of compounds for their physical dependence potential and abuse liability. X. Drug testing programs of the Committee on Problems of Drug Dependence, Inc. (1986). NIDA research monograph. 1987; 76(?):370-91. doi: NULL. [PMID: 2893982]
  • R J Flanagan, N M Ward. HPLC measurement of meptazinol in plasma using electrochemical oxidation detection. Biomedical chromatography : BMC. 1986 Aug; 1(4):180-2. doi: 10.1002/bmc.1130010411. [PMID: 3506833]
  • G C Storey, R Schootstra, J A Henry. Measurement of meptazinol in plasma by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. 1985 May; 341(1):223-7. doi: 10.1016/s0378-4347(00)84033-5. [PMID: 4019690]
  • H M Norbury, R A Franklin, D F Graham, B Sinha. Pharmacokinetics of meptazinol after single and multiple oral administration to elderly patients. European journal of clinical pharmacology. 1984; 27(2):223-6. doi: 10.1007/bf00544049. [PMID: 6499901]
  • H M Norbury, R A Franklin, D F Graham. Pharmacokinetics of the new analgesic, meptazinol, after oral and intravenous administration to volunteers. European journal of clinical pharmacology. 1983; 25(1):77-80. doi: 10.1007/bf00544019. [PMID: 6617729]
  • P S Dowell, D M Pierce, R A Franklin, P J Robson, M B Jackson. Routes of meptazinol conjugation in the neonate. British journal of clinical pharmacology. 1982 Nov; 14(5):748-50. doi: 10.1111/j.1365-2125.1982.tb04970.x. [PMID: 7138758]
  • G Davies, A J Sinclair, S J Warrington, R Franklin, T Frost, A Latham, P J Robson. Pharmacokinetics of meptazinol in man following repeated intramuscular administration. European journal of clinical pharmacology. 1982; 23(6):535-8. doi: 10.1007/bf00637502. [PMID: 7160422]
  • T Frost. Determination of meptazinol in plasma by high-performance liquid chromatography with fluorescence detection. The Analyst. 1981 Sep; 106(1266):999-1000. doi: 10.1039/an9810600999. [PMID: 7294367]