Meluadrine (BioDeep_00000180722)

   

human metabolite blood metabolite


Metabolite Card


1-(2-Chloro-4-hydroxyphenyl)-tert-butylaminoethanol hydrochloride

Formula: C12H18ClNO2 (243.1025998)
Chinese Names: HOKU-81
Spectrum Hits: Top Source () 0%

Molecular Structure

SMILES: CC(C)(C)NCC(C1=C(C=C(C=C1)O)Cl)O
InChI: InChI=1S/C12H18ClNO2/c1-12(2,3)14-7-11(16)9-5-4-8(15)6-10(9)13/h4-6,11,14-16H,7H2,1-3H3

Description

HOKU-81 (4-Hydroxytulobuterol) is one of the metabolites of Tulobuterol (HY-B1810). HOKU-81 is a potent and selective β2-adrenoceptor stimulant. HOKU-81 has bronchodilating effect[1][2].

Synonyms

8 synonym names

1-(2-Chloro-4-hydroxyphenyl)-tert-butylaminoethanol hydrochloride; 1-(2-Chloro-4-hydroxyphenyl)-tert-butylaminoethanol oxalate; 4-[2-(tert-butylamino)-1-hydroxyethyl]-3-chlorophenol; 1-(2-Chloro-4-hydroxyphenyl)-tert-butylaminoethanol; meluadrine; HOKU 81; HOKU-81; 4-Hydroxytulobuterol



Cross Reference

6 cross reference id

Classification Terms

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1 organism taxonomy source information

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Literature Reference

  • S Kubo, I Matsubara, M Yamazaki, S Kasamatsu, E Koshinaka, H Kato, Y Kase. Pharmacological studies of 1-(2-chloro-4-hydroxyphenyl)-2-t-butylaminoethanol (HOKU-81), a new bronchodilator. 1st Communication: Bronchodilator and cardiovascular actions. Arzneimittel-Forschung. 1980; 30(8):1272-8. doi: NULL. [PMID: 7192141]
  • M De Wolf, H J Hilderson, A Lagrou, W Dierick. Lipolytic enzymes in bovine thyroid tissue. III. Lysophospholipase activity. Archives internationales de physiologie et de biochimie. 1979 Feb; 87(1):1-18. doi: 10.3109/13813457909070481. [PMID: 92222]
  • K M Lovette, H Y Chuang, A F Mohammad, R G Mason. The subcellular distribution and partial characterization of cholinesterase activities of canine platelets. Biochimica et biophysica acta. 1976 Apr; 428(2):355-68. doi: 10.1016/0304-4165(76)90043-x. [PMID: 6047]