Mefruside (BioDeep_00000180706)

   

human metabolite blood metabolite


代谢物信息卡片


4-chloro-1-N-Methyl-1-N-[(2-methyloxolan-2-yl)methyl]benzene-1,3-disulphonamide

化学式: C13H19ClN2O5S2 (382.0423874)
中文名称: 美夫西特
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(CCCO1)CN(C)S(=O)(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N
InChI: InChI=1S/C13H19ClN2O5S2/c1-13(6-3-7-21-13)9-16(2)23(19,20)10-4-5-11(14)12(8-10)22(15,17)18/h4-5,8H,3,6-7,9H2,1-2H3,(H2,15,17,18)

描述信息

C - Cardiovascular system > C03 - Diuretics > C03B - Low-ceiling diuretics, excl. thiazides > C03BA - Sulfonamides, plain
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics

同义名列表

5 个代谢物同义名

4-chloro-1-N-Methyl-1-N-[(2-methyloxolan-2-yl)methyl]benzene-1,3-disulphonamide; 4-Chloro-N1-methyl-N1-[(2-methyloxolan-2-yl)methyl]benzene-1,3-disulphonamide; 4-chloro-N1-methyl-N1-[(2-methyloxolan-2-yl)methyl]benzene-1,3-disulfonamide; mefruside; Baycaron



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Jochen Beyer, Anabelle Bierl, Frank T Peters, Hans H Maurer. Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation. Therapeutic drug monitoring. 2005 Aug; 27(4):509-20. doi: 10.1097/01.ftd.0000160719.96445.91. [PMID: 16044110]
  • Volker Perst, Martin Hassler, Joachim Greven. Transport of anionic drugs across the basolateral membrane of proximal S2 segments of the rabbit kidney. Inverse relationship between the affinity to the p-aminohippurate transport system and the transport rate. Arzneimittel-Forschung. 2002; 52(12):896-902. doi: 10.1055/s-0031-1299987. [PMID: 12572530]
  • K Landmark, M Forsman, K Lindberg, T Ryman, K Martmann-Moe, S Haaverstad, S Wiel. Nitrendipine and mefruside in elderly hypertensives: effects on blood pressure, cardiac output, cerebral blood flow and metabolic parameters. Journal of human hypertension. 1995 Apr; 9(4):281-5. doi: NULL. [PMID: 7595911]
  • S Shintani, T Shiigai, H Tsukagoshi. Marked hypokalemic rhabdomyolysis with myoglobinuria due to diuretic treatment. European neurology. 1991; 31(6):396-8. doi: 10.1159/000116702. [PMID: 1756765]
  • A Notghi, J L Anderton. Effect of nifedipine and mefruside on renal reserve in hypertensive patients. Postgraduate medical journal. 1988 Nov; 64(757):856-9. doi: 10.1136/pgmj.64.757.856. [PMID: 3255934]
  • K L Schulte, W Meyer-Sabellek, L Röcker, R Gotzen, A Distler. Effects of diltiazem alone and combined with mefruside on cardiovascular response at rest and during exercise, carbohydrate metabolism and serum lipoproteins in patients with systemic hypertension. The American journal of cardiology. 1987 Oct; 60(10):826-31. doi: 10.1016/0002-9149(87)91031-9. [PMID: 3661396]
  • F Saito, G Kimura, Y Shimozaki, T Fujii, T Ishii, K Yoshida, H Abe, M Kawamura, F Deguchi, Y Kawano. [Mechanism of hypotensive action of a diuretic, mefruside, based on the pressure-natriuresis relationship]. Nihon Jinzo Gakkai shi. 1987 Apr; 29(4):461-7. doi: NULL. [PMID: 3656703]
  • J R M'Buyamba-Kabangu, R Fagard, P Lijnen, J Staessen, W Lissens, M Ditu, B Lepira, K A Tshiani, A Amery. Calcium entry blockade or beta-blockade in long-term management of hypertension in blacks. Clinical pharmacology and therapeutics. 1987 Jan; 41(1):45-54. doi: 10.1038/clpt.1987.7. [PMID: 3802705]
  • A Notghi, C E Fiskerstrand, M E Burnet, J L Anderton. Effect of nifedipine and mefruside on renal function and platelet function in hypertensive patients. Current medical research and opinion. 1987; 10(7):441-9. doi: 10.1185/03007998709112402. [PMID: 3621989]
  • K L Schulte, W Meyer-Sabellek, R Gotzen. Effects of acebutolol combined with mefruside on total-body and serum potassium in essential hypertensive patients. International journal of clinical pharmacology, therapy, and toxicology. 1984 Aug; 22(8):438-40. doi: NULL. [PMID: 6490227]
  • C Fossati. [Diuretics. I]. La Clinica terapeutica. 1981 Nov; 99(3):313-36. doi: NULL. [PMID: 7030589]
  • H L Fleuren, C P Verwey-Van Wissen, J M Van Rossum. Quantitative gas chromatographic determination of two oxidized metabolites of the diuretic mefruside in human urine, plasma and red blood cells. Journal of chromatography. 1980 May; 182(2):179-90. doi: 10.1016/s0378-4347(00)81622-9. [PMID: 7380910]
  • N C Henningsen, B Bergengren, O Malmborg, O Pihl, K Renmarker, L Strand. Effects of mefruside treatment in hypertension. Acta medica Scandinavica. 1980; 208(4):272-8. doi: NULL. [PMID: 7446207]
  • G Oesterhelt, E Eschenhof. [Gas liquid chromatographic analysis for quantitative determination of mefruside and oxomefruside in blood plasma (author's transl)]. Arzneimittel-Forschung. 1979; 29(4):607-10. doi: NULL. [PMID: 582754]
  • H L Fleuren, C P Verwey-van Wissen, J M van Rossum. Quantitative gas chromatographic determination of mefruside in body fluids by extractive methylation and nitrogen detection. Arzneimittel-Forschung. 1979; 29(7):1041-7. doi: NULL. [PMID: 582996]
  • C Fuchs, D H Hunneman, F Scheler. [Hyperreninism without hyperaldosteronism in diuretic abuse: a report of a case with identification of mefruside and ethacrynic acid in urine (author's transl)]. Deutsche medizinische Wochenschrift (1946). 1977 Sep; 102(37):1319-22. doi: 10.1055/s-0028-1105500. [PMID: 902598]
  • C J Little, A D Dale, D A Ord, T R Marten. Determination of mefruside and its metabolites in urine by high performance liquid chromatography. Analytical chemistry. 1977 Aug; 49(9):1311-3. doi: 10.1021/ac50017a007. [PMID: 196519]
  • R Jagenburg, S Landahl, B Steen. [Blood pressure and serum potassium during 6 months of mefruside treatment]. Lakartidningen. 1977 Jul; 74(27-28):2509-11. doi: NULL. [PMID: 875560]
  • W Bartsch, H J Horst, H Becker, G Nehse. Sex hormone binding globulin binding capacity, testosterone, 5alpha-dihydrotestosterone, oestradiol and prolactin in plasma of patients with prostatic carcinoma under various types of hormonal treatment. Acta endocrinologica. 1977 Jul; 85(3):650-64. doi: 10.1530/acta.0.0850650. [PMID: 325982]
  • C Beretta-Piccoli, P Weidmann, R de Châtel, D Hirsch, F C Reubi. [Correlations between blood pressure, blood volume and plasma renin during therapy with diuretics in essential hypertension. Comparison between the mineralocorticoid antagonist spironolactone and the 'loop' diuretic mefruside]. Schweizerische medizinische Wochenschrift. 1977 Jan; 107(4):104-15. doi: NULL. [PMID: 834983]
  • S Bevegård, J Castenfors, M Danielson, J Bergström. Effect of saluretic therapy on muscle content of water and electrolytes in relation to hemodynamic variables. Acta medica Scandinavica. 1977; 202(5):379-84. doi: 10.1111/j.0954-6820.1977.tb16847.x. [PMID: 920262]