Medroxalol (BioDeep_00000180705)

   

human metabolite blood metabolite


代谢物信息卡片


5-(2-((3-(1,3-Benzodioxol-5-yl)-1-methylpropyl)amino)-1-hydroxyethyl)-2-hydroxybenzamide

化学式: C20H24N2O5 (372.1685134)
中文名称: 美沙洛尔
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CCC1=CC2=C(C=C1)OCO2)NCC(C3=CC(=C(C=C3)O)C(=O)N)O
InChI: InChI=1S/C20H24N2O5/c1-12(2-3-13-4-7-18-19(8-13)27-11-26-18)22-10-17(24)14-5-6-16(23)15(9-14)20(21)25/h4-9,12,17,22-24H,2-3,10-11H2,1H3,(H2,21,25)

描述信息

C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents

同义名列表

9 个代谢物同义名

5-(2-((3-(1,3-Benzodioxol-5-yl)-1-methylpropyl)amino)-1-hydroxyethyl)-2-hydroxybenzamide; 5-(2-{[4-(2H-1,3-benzodioxol-5-yl)butan-2-yl]amino}-1-hydroxyethyl)-2-hydroxybenzamide; 5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]salicylamide; Medroxalol monohydrochloride, (S-(r*,r*))-isomer; Medroxalol monohydrochloride, (R-(r*,s*))-isomer; Medroxalol monohydrochloride, (R-(r*,r*))-isomer; Medroxalol monohydrochloride, (S-(r*,s*))-isomer; Medroxalol monohydrochloride; MEDROXALOL



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • E M Bargar. Application of column switching in high-performance liquid chromatographic analysis of medroxalol in plasma. Journal of chromatography. 1987 Jun; 417(1):143-50. doi: 10.1016/0378-4347(87)80100-7. [PMID: 2887579]
  • J D Wallin, P Jones, W M O'Neill, R J Kuzma, R J Morgan, M Morgan, C Rolf. Effects of medroxalol on renal function and the renin-angiotensin-aldosterone axis. Clinical pharmacology and therapeutics. 1984 Aug; 36(2):169-73. doi: 10.1038/clpt.1984.158. [PMID: 6146422]
  • H L Elliott, P A Meredith, D J Sumner, J L Reid. Comparison of the clinical pharmacokinetics and concentration-effect relationships for medroxalol and labetalol. British journal of clinical pharmacology. 1984 May; 17(5):573-8. doi: 10.1111/j.1365-2125.1984.tb02392.x. [PMID: 6145441]
  • R M Graham. Selective alpha 1-adrenergic antagonists: therapeutically relevant antihypertensive agents. The American journal of cardiology. 1984 Jan; 53(3):16A-20A. doi: 10.1016/0002-9149(84)90829-4. [PMID: 6141721]
  • K D Haegele, P Jaillon, G Cheymol, R G Alken, P J Schechter, J Koch-Weser. Kinetics of medroxalol, a beta- and alpha-adrenoceptor antagonist. Clinical pharmacology and therapeutics. 1983 Dec; 34(6):785-91. doi: 10.1038/clpt.1983.250. [PMID: 6641094]
  • J Weissenburger, J Heckle, J M Juliard, M Biour, K Haegele, G Cheymol. [Hemodynamic effects of medroxalol in the anesthetized dog. Relation between adrenolytic properties and plasma concentration]. Journal de pharmacologie. 1983 Oct; 14(4):413-23. doi: NULL. [PMID: 6142982]
  • N D Vlachakis, M Valasquez, N Alexander, R F Maronde. Medroxalol combined with hydrochlorothiazide in the treatment of hypertension. Journal of clinical pharmacology. 1983 Oct; 23(10):419-27. doi: 10.1002/j.1552-4604.1983.tb01785.x. [PMID: 6139390]
  • F J Keeley, D L Weiner, R A Okerholm. Bioavailability of medroxalol in man. Biopharmaceutics & drug disposition. 1983 Oct; 4(4):305-9. doi: 10.1002/bdd.2510040402. [PMID: 6661511]
  • P Jaillon, J Weissenburger, M Biour, G Cheymol, K Haegele, P J Schechter, J Koch-Weser. beta- and alpha-Adrenoceptor antagonism by medroxalol in healthy volunteers: relationship to dose and plasma concentration. Journal of cardiovascular pharmacology. 1982 Sep; 4(5):705-13. doi: 10.1097/00005344-198209000-00003. [PMID: 6182399]