3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone (BioDeep_00000180677)
human metabolite blood metabolite
代谢物信息卡片
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one
化学式: C15H10Cl2N2O2S (351.98400200000003)
中文名称: 3-(2,4-二氯-5-甲氧基苯基)-2,3-二氢-2-硫代-4(1H)-喹唑啉酮
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl
InChI: InChI=1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
描述信息
同义名列表
6 个代谢物同义名
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanylidene-1H-quinazolin-4-one; 3-(2,4-Dichloro-5-methoxyphenyl)-2-sulphanyl-4(3H)-quinazolinone; 3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone; Mdivi-1 compound; Mdivi-1
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 3825829
- HMDB: HMDB0254371
- ChEMBL: CHEMBL1449747
- chemspider: 3052036
- CAS: 338967-87-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Li Li, Qingling Jia, Xiangxiang Wang, Yujiao Wang, Chenheng Wu, Jun Cong, Jianghong Ling. Chaihu Shugan San promotes gastric motility in rats with functional dyspepsia by regulating Drp-1-mediated ICC mitophagy.
Pharmaceutical biology.
2023 Dec; 61(1):249-258. doi:
10.1080/13880209.2023.2166966. [PMID: 36655341] - Yanhong Cao, Xin Chen, Fuqiang Pan, Mingyang Wang, Haowen Zhuang, Jiangna Chen, Lu Lu, Lingjun Wang, Ting Wang. Xinmaikang-mediated mitophagy attenuates atherosclerosis via the PINK1/Parkin signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Oct; 119(?):154955. doi:
10.1016/j.phymed.2023.154955. [PMID: 37572567] - Ying Yang, Wei Zhou, Yihao Wang, Yunxuan Ge, Zheng Fan, Qingquan Liu, Yue Gao. Bavachin induces liver injury and cell apoptosis by targeting Wnt/β-catenin/DRP1 signaling pathway mediated mitochondrial dysfunction.
Toxicology letters.
2023 Sep; 387(?):1-13. doi:
10.1016/j.toxlet.2023.09.006. [PMID: 37748667] - Linwei Zhang, Xuexue Xie, Jingxian Tao, Sizhe Wang, Miaoyang Hu, Xi Wang, Zheng Yu, Liuting Xu, Yuxin Lin, Weilan Wu, Jie Cheng, Linlin Wu, Wenwei Liu, Rong Gao, Jun Wang. Mystery of bisphenol F-induced nonalcoholic fatty liver disease-like changes: Roles of Drp1-mediated abnormal mitochondrial fission in lipid droplet deposition.
The Science of the total environment.
2023 Sep; 904(?):166831. doi:
10.1016/j.scitotenv.2023.166831. [PMID: 37683851] - Chen Ding, Chaofeng Zhang. Reducing myocardial infarction by combination of irisin and Dendrobium nobile Lindl through inhibiting nod-like receptor protein-3-related pyroptosis and activating PINK1/Parkin-mitophagy during aging.
The Chinese journal of physiology.
2023 Sep; 66(5):351-358. doi:
10.4103/cjop.cjop-d-23-00032. [PMID: 37929346] - Xu-Qing Chen, Long-Yun Zhou, Hua-An Ma, Ji-Yong Wu, Shu-Fen Liu, Yong-Jun Wu, Dao-Nan Yan. Mitochondrial dynamics modulate the allergic inflammation in a murine model of allergic rhinitis.
Immunity, inflammation and disease.
2023 09; 11(9):e1002. doi:
10.1002/iid3.1002. [PMID: 37773697] - Ze-da-Zhong Su, Chun-Qiu Li, Hua-Wei Wang, Min-Ming Zheng, Qing-Wei Chen. Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization.
Journal of translational medicine.
2023 06; 21(1):427. doi:
10.1186/s12967-023-04270-9. [PMID: 37386574] - Yuanyuan Chen, Chuan Yang, Mi Zou, Dan Wang, Ruilin Sheng, Meng Zhan, Qi Chen, Wenqin Yang, Xiao Liu, Shijun Xu. Inhibiting mitochondrial inflammation through Drp1/HK1/NLRP3 pathway: A mechanism of alpinetin attenuated aging-associated cognitive impairment.
Phytotherapy research : PTR.
2023 Feb; ?(?):. doi:
10.1002/ptr.7767. [PMID: 36772986] - Jian-Rong Huang, Ming-Hua Zhang, Ying-Jie Chen, Yu-Ling Sun, Zhi-Min Gao, Zhuo-Jia Li, Gui-Ping Zhang, Yuan Qin, Xiao-Yan Dai, Xi-Yong Yu, Xiao-Qian Wu. Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation.
Acta pharmacologica Sinica.
2023 Feb; 44(2):321-331. doi:
10.1038/s41401-022-00919-1. [PMID: 35655094] - Qingwen Yang, Junjie Yang, Xuesong Liu, Yi Zhang, Yue Li, Da Ao, Peng Zhong, Kang Yong. Crosstalk Between the Mitochondrial Dynamics and Oxidative Stress in Zinc-induced Cytotoxicity.
Biological trace element research.
2022 Nov; ?(?):. doi:
10.1007/s12011-022-03504-z. [PMID: 36445560] - Sisi Lei, Yuchao Feng, Peiying Huang, BoJun Chen, Kun Bao, Qihua Wu, Haobo Zhang, Xiaoyan Huang. Ophiopogonin D'-induced mitophagy and mitochondrial damage are associated with dysregulation of the PINK1/Parkin signaling pathway in AC16 cells.
Toxicology.
2022 07; 477(?):153275. doi:
10.1016/j.tox.2022.153275. [PMID: 35905946] - Xiaoqin Liu, Lijuan Song, Jiezhong Yu, Fang Huang, Yanhua Li, Cungen Ma. Mdivi-1: a promising drug and its underlying mechanisms in the treatment of neurodegenerative diseases.
Histology and histopathology.
2022 Jun; 37(6):505-512. doi:
10.14670/hh-18-443. [PMID: 35199329] - Xiaoqin Liu, Xiaojuan Zhang, Xiaojie Niu, Peijun Zhang, Qing Wang, Xiuhua Xue, Guobin Song, Jiezhong Yu, Guoping Xi, Lijuan Song, Yanhua Li, Cungen Ma. Mdivi-1 Modulates Macrophage/Microglial Polarization in Mice with EAE via the Inhibition of the TLR2/4-GSK3β-NF-κB Inflammatory Signaling Axis.
Molecular neurobiology.
2022 Jan; 59(1):1-16. doi:
10.1007/s12035-021-02552-1. [PMID: 34618332] - Hannah A Cooper, Stephanie Cicalese, Kyle J Preston, Tatsuo Kawai, Keisuke Okuno, Eric T Choi, Shingo Kasahara, Haruhito A Uchida, Nozomu Otaka, Rosario Scalia, Victor Rizzo, Satoru Eguchi. Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm.
Cardiovascular research.
2021 02; 117(3):971-982. doi:
10.1093/cvr/cvaa133. [PMID: 32384150] - Seon Min Woo, Kyoung-Jin Min, Taeg Kyu Kwon. Inhibition of Drp1 Sensitizes Cancer Cells to Cisplatin-Induced Apoptosis through Transcriptional Inhibition of c-FLIP Expression.
Molecules (Basel, Switzerland).
2020 Dec; 25(24):. doi:
10.3390/molecules25245793. [PMID: 33302576] - Xiaoling Zhang, Wenmin Huang, Qianhang Shao, Yuan Yang, Zhengxin Xu, Jing Chen, Xiaoyan Zhang, Xiaoqun Ge. Drp1, a potential therapeutic target for Parkinson's disease, is involved in olfactory bulb pathological alteration in the Rotenone-induced rat model.
Toxicology letters.
2020 Jun; 325(?):1-13. doi:
10.1016/j.toxlet.2020.02.009. [PMID: 32088201] - Songyun Deng, Lina Zhang, Yunan Mo, Yan Huang, Wenchao Li, Qianyi Peng, Li Huang, Yuhang Ai. Mdivi-1 attenuates lipopolysaccharide-induced acute lung injury by inhibiting MAPKs, oxidative stress and apoptosis.
Pulmonary pharmacology & therapeutics.
2020 06; 62(?):101918. doi:
10.1016/j.pupt.2020.101918. [PMID: 32251714] - Xue Wang, Jia-Qi Zhang, Cheng-Kui Xiu, Jing Yang, Jing-Yi Fang, Yan Lei. Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway.
Oxidative medicine and cellular longevity.
2020; 2020(?):7151946. doi:
10.1155/2020/7151946. [PMID: 32963699] - Ruijin Liu, Si-Cong Wang, Ming Li, Xiao-Hui Ma, Xiao-Nan Jia, Yue Bu, Lei Sun, Kai-Jiang Yu. An Inhibitor of DRP1 (Mdivi-1) Alleviates LPS-Induced Septic AKI by Inhibiting NLRP3 Inflammasome Activation.
BioMed research international.
2020; 2020(?):2398420. doi:
10.1155/2020/2398420. [PMID: 32733934] - Barbara Koch, Ana Traven. Mdivi-1 and mitochondrial fission: recent insights from fungal pathogens.
Current genetics.
2019 Aug; 65(4):837-845. doi:
10.1007/s00294-019-00942-6. [PMID: 30783741] - Yan-Hua Li, Fang Xu, Rodolfo Thome, Min-Fang Guo, Man-Luan Sun, Guo-Bin Song, Rui-Lan Li, Zhi Chai, Bogoljub Ciric, A M Rostami, Mark Curtis, Cun-Gen Ma, Guang-Xian Zhang. Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis.
Journal of neuroinflammation.
2019 Jul; 16(1):149. doi:
10.1186/s12974-019-1542-0. [PMID: 31324254] - Xiangyang Yu, Lili Jia, Wenli Yu, Hongyin Du. Dephosphorylation by calcineurin regulates translocation of dynamin-related protein 1 to mitochondria in hepatic ischemia reperfusion induced hippocampus injury in young mice.
Brain research.
2019 05; 1711(?):68-76. doi:
10.1016/j.brainres.2019.01.018. [PMID: 30659828] - Xu Luo, Ruimeng Liu, Zhihao Zhang, Zhugui Chen, Jian He, Youtan Liu. Mitochondrial Division Inhibitor 1 Attenuates Mitophagy in a Rat Model of Acute Lung Injury.
BioMed research international.
2019; 2019(?):2193706. doi:
10.1155/2019/2193706. [PMID: 31205936] - Xu-Gui Chen, Li-Hua Chen, Ru-Xiang Xu, Hong-Tian Zhang. Effect evaluation of methylprednisolone plus mitochondrial division inhibitor-1 on spinal cord injury rats.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery.
2018 08; 34(8):1479-1487. doi:
10.1007/s00381-018-3792-z. [PMID: 29682689] - Soon-Duck Ha, Ori Solomon, Masoud Akbari, Alp Sener, Sung Ouk Kim. Histone deacetylase 8 protects human proximal tubular epithelial cells from hypoxia-mimetic cobalt- and hypoxia/reoxygenation-induced mitochondrial fission and cytotoxicity.
Scientific reports.
2018 07; 8(1):11332. doi:
10.1038/s41598-018-29463-x. [PMID: 30054507] - Yanggang Yuan, Aiqing Zhang, Jia Qi, Hui Wang, Xi Liu, Min Zhao, Suyan Duan, Zhimin Huang, Chengning Zhang, Lin Wu, Bo Zhang, Aihua Zhang, Changying Xing. p53/Drp1-dependent mitochondrial fission mediates aldosterone-induced podocyte injury and mitochondrial dysfunction.
American journal of physiology. Renal physiology.
2018 05; 314(5):F798-F808. doi:
10.1152/ajprenal.00055.2017. [PMID: 28659272] - Songyun Deng, Yuhang Ai, Hua Gong, Qing Feng, Xiao Li, Caixia Chen, Zhiyong Liu, Yimin Wang, Qianyi Peng, Lina Zhang. Mitochondrial dynamics and protective effects of a mitochondrial division inhibitor, Mdivi-1, in lipopolysaccharide-induced brain damage.
Biochemical and biophysical research communications.
2018 02; 496(3):865-871. doi:
10.1016/j.bbrc.2018.01.136. [PMID: 29395086] - P Hemachandra Reddy, Maria Manczak, XiangLing Yin, Arubala P Reddy. Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer's Disease.
Journal of Alzheimer's disease : JAD.
2018; 62(4):1549-1565. doi:
10.3233/jad-170988. [PMID: 29400667] - Sehee Kim, Chanyang Kim, Seungjoon Park. Mdivi-1 Protects Adult Rat Hippocampal Neural Stem Cells against Palmitate-Induced Oxidative Stress and Apoptosis.
International journal of molecular sciences.
2017 Sep; 18(9):. doi:
10.3390/ijms18091947. [PMID: 28891994] - Jung-Hak Kim, Sun-Ji Park, Bokyung Kim, Young-Geun Choe, Dong-Seok Lee. Insulin-stimulated lipid accumulation is inhibited by ROS-scavenging chemicals, but not by the Drp1 inhibitor Mdivi-1.
PloS one.
2017; 12(10):e0185764. doi:
10.1371/journal.pone.0185764. [PMID: 28968439] - P Hemachandra Reddy, Maria Manczak, XiangLing Yin. Mitochondria-Division Inhibitor 1 Protects Against Amyloid-β induced Mitochondrial Fragmentation and Synaptic Damage in Alzheimer's Disease.
Journal of Alzheimer's disease : JAD.
2017; 58(1):147-162. doi:
10.3233/jad-170051. [PMID: 28409745] - Daniya Rakhmatullina, Anastasiya Ponomareva, Natalia Gazizova, Farida Minibayeva. Mitochondrial morphology and dynamics in Triticum aestivum roots in response to rotenone and antimycin A.
Protoplasma.
2016 Sep; 253(5):1299-308. doi:
10.1007/s00709-015-0888-0. [PMID: 26411562] - R S Al-Lamki, W Lu, P Manalo, J Wang, A Y Warren, A M Tolkovsky, J S Pober, J R Bradley. Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis.
Cell death & disease.
2016 06; 7(6):e2287. doi:
10.1038/cddis.2016.184. [PMID: 27362805] - Yoshihiro Suzuki-Karasaki, Kyoko Fujiwara, Kosuke Saito, Miki Suzuki-Karasaki, Toyoko Ochiai, Masayoshi Soma. Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization.
Oncotarget.
2015 Aug; 6(25):21572-88. doi:
10.18632/oncotarget.4268. [PMID: 26057632] - Xiaoying Li, Hua Tao, Kewei Xie, Zhaohui Ni, Yucheng Yan, Kai Wei, Peter Y Chuang, John Cijiang He, Leyi Gu. cAMP signaling prevents podocyte apoptosis via activation of protein kinase A and mitochondrial fusion.
PloS one.
2014; 9(3):e92003. doi:
10.1371/journal.pone.0092003. [PMID: 24642777] - Wan-Xin Tang, Wei-Hua Wu, Hong-Yu Qiu, Hong Bo, Song-Min Huang. Amelioration of rhabdomyolysis-induced renal mitochondrial injury and apoptosis through suppression of Drp-1 translocation.
Journal of nephrology.
2013 Nov; 26(6):1073-82. doi:
10.5301/jn.5000268. [PMID: 23553524] - Boa Kim, Ji-Seok Kim, Yisang Yoon, Mayra C Santiago, Michael D Brown, Joon-Young Park. Inhibition of Drp1-dependent mitochondrial division impairs myogenic differentiation.
American journal of physiology. Regulatory, integrative and comparative physiology.
2013 Oct; 305(8):R927-38. doi:
10.1152/ajpregu.00502.2012. [PMID: 23904108] - Yulia Kushnareva, Alexander Y Andreyev, Tomomi Kuwana, Donald D Newmeyer. Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes.
PLoS biology.
2012; 10(9):e1001394. doi:
10.1371/journal.pbio.1001394. [PMID: 23049480]