N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide (BioDeep_00000180672)
human metabolite blood metabolite
代谢物信息卡片
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-yl)-N-{[4-(2-hydroxypropan-2-yl)furan-2-yl]sulphonyl}carbamimidic acid
化学式: C20H24N2O5S (404.1405854)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C1=COC(=C1)S(=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4)O
InChI: InChI=1S/C20H24N2O5S/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23)
描述信息
同义名列表
7 个代谢物同义名
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-yl)-N-{[4-(2-hydroxypropan-2-yl)furan-2-yl]sulphonyl}carbamimidic acid; N-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-N-{[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonyl}carbamimidic acid; N-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-N-[4-(2-hydroxypropan-2-yl)furan-2-ylsulfonyl]carbamimidic acid; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-yl)-N-{[4-(2-hydroxypropan-2-yl)furan-2-yl]sulphonyl}carbamimidate; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-yl)-N-{[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonyl}carbamimidate; N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide; MCC-950
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yeshu Liu, Xiaohu Yao, Yanqiu Yang, Yan Mi, Yingjie Wang, Shaowen Tan, Mingxia Fang, Qingqi Meng, Gang Chen, Ning Li, Yue Hou. Americanin B inhibits pyroptosis in lipopolysaccharide-induced septic encephalopathy mice through targeting NLRP3 protein.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155520. doi:
10.1016/j.phymed.2024.155520. [PMID: 38489892] - Lihua Cui, Caixia Li, Guixian Zhang, Lanqiu Zhang, Guowang Yao, Yuzhen Zhuo, Naiqiang Cui, Shukun Zhang. S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome.
Chemico-biological interactions.
2023 May; 380(?):110541. doi:
10.1016/j.cbi.2023.110541. [PMID: 37169277] - Qing Liu, Man-Man Zhang, Min-Xia Guo, Qiu-Ping Zhang, Na-Zhi Li, Jie Cheng, Shi-Le Wang, Guang-Hui Xu, Cheng-Fu Li, Ji-Xiao Zhu, Li-Tao Yi. Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.
2022 12; 17(3-4):503-514. doi:
10.1007/s11481-021-10037-0. [PMID: 34978026] - De-Wen Bi, Feng Xiong, Bin Cheng, Ya-Ling Zhou, Muhammad Aurang Zeb, Peng Tang, Wen-Hui Pang, Rui-Han Zhang, Xiao-Li Li, Xing-Jie Zhang, Wei-Lie Xiao. Callintegers A and B, Unusual Tricyclo[4.4.0.09,10]tetradecane Clerodane Diterpenoids from Callicarpa integerrima with Inhibitory Effects on NLRP3 Inflammasome Activation.
Journal of natural products.
2022 11; 85(11):2675-2681. doi:
10.1021/acs.jnatprod.2c00568. [PMID: 36286259] - Jenaro A Espitia-Corredor, Licia Shamoon, Francisco Olivares-Silva, Constanza Rimassa-Taré, Claudia Muñoz-Rodríguez, Claudio Espinoza-Pérez, Carlos F Sánchez-Ferrer, Concepción Peiró, Guillermo Díaz-Araya. Resolvin E1 attenuates doxorubicin-induced cardiac fibroblast senescence: A key role for IL-1β.
Biochimica et biophysica acta. Molecular basis of disease.
2022 11; 1868(11):166525. doi:
10.1016/j.bbadis.2022.166525. [PMID: 35987478] - Xiaobo Jiang, Fan Yang, Dengke Ou, Luyong Huang, Hongfei Li, Mingjian Lang. MCC950 ameliorates ventricular arrhythmia vulnerability induced by heart failure.
Bioengineered.
2022 04; 13(4):8593-8604. doi:
10.1080/21655979.2022.2053813. [PMID: 35287557] - Alejandra Palomino-Antolin, Paloma Narros-Fernández, Víctor Farré-Alins, Javier Sevilla-Montero, Celine Decouty-Pérez, Ana Belen Lopez-Rodriguez, Nuria Fernández, Luis Monge, Ana I Casas, María José Calzada, Javier Egea. Time-dependent dual effect of NLRP3 inflammasome in brain ischaemia.
British journal of pharmacology.
2022 04; 179(7):1395-1410. doi:
10.1111/bph.15732. [PMID: 34773639] - Yan Jiao, Jinshan Nan, Bo Mu, Yun Zhang, Nenghua Zhou, Shunhua Yang, Shanshan Zhang, Wanting Lin, Falu Wang, Anjie Xia, Zhixing Cao, Pei Chen, Zhiling Pan, Guifeng Lin, Shulei Pan, Huachao Bin, Linli Li, Shengyong Yang. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis.
European journal of medicinal chemistry.
2022 Mar; 232(?):114194. doi:
10.1016/j.ejmech.2022.114194. [PMID: 35183871] - Diego Pazos-Castro, Zulema Gonzalez-Klein, Alma Yuste Montalvo, Guadalupe Hernandez-Ramirez, Alejandro Romero-Sahagun, Vanesa Esteban, Maria Garrido-Arandia, Jaime Tome-Amat, Araceli Diaz-Perales. NLRP3 priming due to skin damage precedes LTP allergic sensitization in a mouse model.
Scientific reports.
2022 02; 12(1):3329. doi:
10.1038/s41598-022-07421-y. [PMID: 35228630] - Jakob A Østergaard, Jay C Jha, Arpeeta Sharma, Aozhi Dai, Judy S Y Choi, Judy B de Haan, Mark E Cooper, Karin Jandeleit-Dahm. Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease.
Clinical science (London, England : 1979).
2022 01; 136(2):167-180. doi:
10.1042/cs20210865. [PMID: 35048962] - Rittibet Yapasert, Patompong Khaw-On, Ratana Banjerdpongchai. Coronavirus Infection-Associated Cell Death Signaling and Potential Therapeutic Targets.
Molecules (Basel, Switzerland).
2021 Dec; 26(24):. doi:
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Neuroscience letters.
2021 11; 765(?):136290. doi:
10.1016/j.neulet.2021.136290. [PMID: 34644625] - Li Chen, Shi-Qi Cao, Ze-Min Lin, Shi-Jun He, Jian-Ping Zuo. NOD-like receptors in autoimmune diseases.
Acta pharmacologica Sinica.
2021 11; 42(11):1742-1756. doi:
10.1038/s41401-020-00603-2. [PMID: 33589796] - Guanghui Zheng, Jing Xu, Fenglian He, Juntao Hu, Weiwei Ge, Xianfei Ji, Changsheng Wang, Jennifer L Bradley, Mary Ann Peberdy, Joseph P Ornato, Stefano Toldo, Tong Wang, Wanchun Tang. Effects of NLRP3 inflammasome blockade on postresuscitation cerebral function in a rat model of cardiopulmonary resuscitation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Nov; 143(?):112093. doi:
10.1016/j.biopha.2021.112093. [PMID: 34474352] - Lei Zhang, Yue-Hua Jiang, Cundong Fan, Qian Zhang, Yong-Hao Jiang, Yan Li, Yi-Tao Xue. MCC950 attenuates doxorubicin-induced myocardial injury in vivo and in vitro by inhibiting NLRP3-mediated pyroptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Nov; 143(?):112133. doi:
10.1016/j.biopha.2021.112133. [PMID: 34474337] - Wenyun Zeng, Danbin Wu, Yingxin Sun, Yanrong Suo, Qun Yu, Miao Zeng, Qing Gao, Bin Yu, Xijuan Jiang, Yijing Wang. The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages.
Scientific reports.
2021 09; 11(1):19305. doi:
10.1038/s41598-021-98437-3. [PMID: 34588488] - Yan Wang, Dong Zhang, Tian Liu, Jun-Fei Wang, Jin-Xiang Wu, Ji-Ping Zhao, Jia-Wei Xu, Jin-Tao Zhang, Liang Dong. FSTL1 aggravates OVA-induced inflammatory responses by activating the NLRP3/IL-1β signaling pathway in mice and macrophages.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2021 Jul; 70(7):777-787. doi:
10.1007/s00011-021-01475-w. [PMID: 34076707] - Giuliana Guggino, Daniele Mauro, Aroldo Rizzo, Riccardo Alessandro, Stefania Raimondo, Anne-Sophie Bergot, M Arifur Rahman, Jonathan J Ellis, Simon Milling, Rik Lories, Dirk Elewaut, Matthew A Brown, Ranjeny Thomas, Francesco Ciccia. Inflammasome Activation in Ankylosing Spondylitis Is Associated With Gut Dysbiosis.
Arthritis & rheumatology (Hoboken, N.J.).
2021 07; 73(7):1189-1199. doi:
10.1002/art.41644. [PMID: 33452867] - Lian Liang, Guozhen Zhang, Hui Li, Cheng Cheng, Tao Jin, Chenglei Su, Yan Xiao, Jennifer Bradley, Mary A Peberdy, Joseph P Ornato, Martin J Mangino, Wanchun Tang. Combined Therapy With Polyethylene Glycol-20k and MCC950 Preserves Post-Resuscitated Myocardial Function in a Rat Model of Cardiac Arrest and Cardiopulmonary Resuscitation.
Journal of the American Heart Association.
2021 05; 10(9):e019177. doi:
10.1161/jaha.120.019177. [PMID: 33884887] - Ming Wu, Zhifen Yang, Chengyu Zhang, Yu Shi, Weixia Han, Shan Song, Lin Mu, Chunyang Du, Yonghong Shi. Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy.
Metabolism: clinical and experimental.
2021 05; 118(?):154748. doi:
10.1016/j.metabol.2021.154748. [PMID: 33675822] - Hu Li, Xinru Mao, Kai Liu, Jiahao Sun, Benrui Li, Rahmani Mohammad Malyar, Dandan Liu, Cuiling Pan, Fang Gan, Yunhuan Liu, Kehe Huang, Xingxiang Chen. Ochratoxin A induces nephrotoxicity in vitro and in vivo via pyroptosis.
Archives of toxicology.
2021 04; 95(4):1489-1502. doi:
10.1007/s00204-021-02993-6. [PMID: 33543323] - Yuan Gao, Guang Xu, Li Ma, Wei Shi, Zhilei Wang, Xiaoyan Zhan, Nan Qin, Tingting He, Yuming Guo, Ming Niu, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao. Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity.
Cell communication and signaling : CCS.
2021 02; 19(1):13. doi:
10.1186/s12964-020-00647-1. [PMID: 33573688] - S Li, Z Guo, Z Y Zhang. Protective effects of NLRP3 inhibitor MCC950 on sepsis-induced myocardial dysfunction.
Journal of biological regulators and homeostatic agents.
2021 Jan; 35(1):141-150. doi:
10.23812/20-662-a. [PMID: 33550789] - Guangning Zhao, Long Yang, Liming Li, Zhongqiang Fan. NaHS Alleviated Cell Apoptosis and Mitochondrial Dysfunction in Remote Lung Tissue after Renal Ischemia and Reperfusion via Nrf2 Activation-Mediated NLRP3 Pathway Inhibition.
BioMed research international.
2021; 2021(?):5598869. doi:
10.1155/2021/5598869. [PMID: 33954183] - Kun Li, Guoqi Shi, Yang Zhao, Yiwen Chen, Jie Gao, Lin Yao, Jiaying Zhao, Hongzhu Li, Ying Xu, Yongjun Chen. Electroacupuncture Ameliorates Neuroinflammation-Mediated Cognitive Deficits through Inhibition of NLRP3 in Presenilin1/2 Conditional Double Knockout Mice.
Neural plasticity.
2021; 2021(?):8814616. doi:
10.1155/2021/8814616. [PMID: 33505459] - Claire Hull, Ruta Dekeryte, Heather Buchanan, Sarah Kamli-Salino, Avril Robertson, Mirela Delibegovic, Bettina Platt. NLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementia.
Neuropharmacology.
2020 12; 180(?):108305. doi:
10.1016/j.neuropharm.2020.108305. [PMID: 32931815] - Fen Zheng, Chao Ye, Guo-Wei Wan, Bing Zhou, Ying Tong, Jian-Zhen Lei, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex.
Pflugers Archiv : European journal of physiology.
2020 11; 472(11):1577-1586. doi:
10.1007/s00424-020-02461-7. [PMID: 32915316] - Lei Niu, Shi Shi Luo, Yang Xu, Zhen Wang, Dan Luo, Hui Yang, Wei Li, Jie He, Xiao Lin Zhong, Zheng Hai Liu, Jia Yu Zeng, Wen Yu Cao, Wei Wan. The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice.
Neurobiology of learning and memory.
2020 11; 175(?):107301. doi:
10.1016/j.nlm.2020.107301. [PMID: 32882398] - Sameer Agarwal, Jignesh P Pethani, Hardik A Shah, Vismit Vyas, Santosh Sasane, Harsh Bhavsar, Debdutta Bandyopadhyay, Poonam Giri, Kasinath Viswanathan, Mukul R Jain, Rajiv Sharma. Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor.
Bioorganic & medicinal chemistry letters.
2020 11; 30(21):127571. doi:
10.1016/j.bmcl.2020.127571. [PMID: 32980515] - Min Jiang, Ben-Wen Cui, Yan-Ling Wu, Yu Zhang, Yue Shang, Jian Liu, Hong-Xu Yang, Chun-Ying Qiao, Zi-Ying Zhan, Huan Ye, Quan Jin, Ji-Xing Nan, Li-Hua Lian. P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells.
Toxicology letters.
2020 Oct; 333(?):22-32. doi:
10.1016/j.toxlet.2020.07.023. [PMID: 32721574] - Xun-Feng Zou, Jian-Hua Gu, Ji-Hui Duan, Zhan-Dong Hu, Zi-Lin Cui. The NLRP3 inhibitor Mcc950 attenuates acute allograft damage in rat kidney transplants.
Transplant immunology.
2020 08; 61(?):101293. doi:
10.1016/j.trim.2020.101293. [PMID: 32407873] - Mariusz Z Ratajczak, Magda Kucia. SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine 'storm' and risk factor for damage of hematopoietic stem cells.
Leukemia.
2020 07; 34(7):1726-1729. doi:
10.1038/s41375-020-0887-9. [PMID: 32483300] - Danbin Wu, Yefei Chen, Yingxin Sun, Qing Gao, Huhu Li, Zhengfei Yang, Yangxue Wang, Xijuan Jiang, Bin Yu. Target of MCC950 in Inhibition of NLRP3 Inflammasome Activation: a Literature Review.
Inflammation.
2020 Feb; 43(1):17-23. doi:
10.1007/s10753-019-01098-8. [PMID: 31646445] - Jung Hyun Park, Ji-Young Choi, Chulman Jo, Young Ho Koh. Involvement of ADAM10 in acrolein-induced astrocytic inflammation.
Toxicology letters.
2020 Jan; 318(?):44-49. doi:
10.1016/j.toxlet.2019.10.005. [PMID: 31639409] - Matthias Sendler, Cindy van den Brandt, Juliane Glaubitz, Anika Wilden, Janine Golchert, Frank Ulrich Weiss, Georg Homuth, Laura L De Freitas Chama, Neha Mishra, Ujjwal Mukund Mahajan, Lukas Bossaller, Uwe Völker, Barbara M Bröker, Julia Mayerle, Markus M Lerch. NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis.
Gastroenterology.
2020 01; 158(1):253-269.e14. doi:
10.1053/j.gastro.2019.09.040. [PMID: 31593700] - Tracey L Freeman, Talia H Swartz. Targeting the NLRP3 Inflammasome in Severe COVID-19.
Frontiers in immunology.
2020; 11(?):1518. doi:
10.3389/fimmu.2020.01518. [PMID: 32655582] - Nathanne Santos Ferreira, Thiago Bruder-Nascimento, Camila André Pereira, Camila Zillioto Zanotto, Douglas Silva Prado, Josiane Fernandes Silva, Diane Meyre Rassi, Maria Cristina Foss-Freitas, Jose Carlos Alves-Filho, Daniela Carlos, Rita de Cássia Tostes. NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus.
Cells.
2019 12; 8(12):. doi:
10.3390/cells8121595. [PMID: 31817997] - Shu Li, Qisheng Lin, Xinghua Shao, Shan Mou, Leyi Gu, Ling Wang, Zhen Zhang, Jianxiao Shen, Yijun Zhou, Chaojun Qi, Haijiao Jin, Huihua Pang, Zhaohui Ni. NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation.
Experimental cell research.
2019 10; 383(1):111488. doi:
10.1016/j.yexcr.2019.07.001. [PMID: 31276670] - Huihui Ti, Yang Zhou, Xue Liang, Runfeng Li, Ke Ding, Xin Zhao. Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs).
Journal of medicinal chemistry.
2019 07; 62(13):5944-5978. doi:
10.1021/acs.jmedchem.8b01520. [PMID: 30682248] - Shalini M Krishnan, Yeong H Ling, Brooke M Huuskes, Dorota M Ferens, Narbada Saini, Christopher T Chan, Henry Diep, Michelle M Kett, Chrishan S Samuel, Barbara K Kemp-Harper, Avril A B Robertson, Matthew A Cooper, Karlheinz Peter, Eicke Latz, Ashley S Mansell, Christopher G Sobey, Grant R Drummond, Antony Vinh. Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.
Cardiovascular research.
2019 03; 115(4):776-787. doi:
10.1093/cvr/cvy252. [PMID: 30357309] - Ben M Alberts, Connor Bruce, Kolitha Basnayake, Pietro Ghezzi, Kevin A Davies, Lisa M Mullen. Secretion of IL-1β From Monocytes in Gout Is Redox Independent.
Frontiers in immunology.
2019; 10(?):70. doi:
10.3389/fimmu.2019.00070. [PMID: 30761138] - Tianming Qiu, Pei Pei, Xiaofeng Yao, Liping Jiang, Sen Wei, Zhidong Wang, Jie Bai, Guang Yang, Ni Gao, Lei Yang, Shuangyue Qi, Rushan Yan, Xiaofang Liu, Xiance Sun. Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway.
Cell death & disease.
2018 09; 9(10):946. doi:
10.1038/s41419-018-1004-0. [PMID: 30237538] - H L Kammoun, T L Allen, D C Henstridge, S Barre, R C Coll, G I Lancaster, L Cron, S Reibe, J Y Chan, M Bensellam, D R Laybutt, M S Butler, A A B Robertson, L A O'Neill, M A Cooper, M A Febbraio. Evidence against a role for NLRP3-driven islet inflammation in db/db mice.
Molecular metabolism.
2018 04; 10(?):66-73. doi:
10.1016/j.molmet.2018.02.001. [PMID: 29478918] - Rong Fu, Chaohuan Guo, Shuang Wang, Yuefang Huang, Ou Jin, Haoqiang Hu, Jingxian Chen, Bihua Xu, Mianjing Zhou, Jijun Zhao, Sun-Sang J Sung, Hongyang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu. Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis.
Arthritis & rheumatology (Hoboken, N.J.).
2017 08; 69(8):1636-1646. doi:
10.1002/art.40155. [PMID: 28544564] - Auvro R Mridha, Alexander Wree, Avril A B Robertson, Matthew M Yeh, Casey D Johnson, Derrick M Van Rooyen, Fahrettin Haczeyni, Narci C-H Teoh, Christopher Savard, George N Ioannou, Seth L Masters, Kate Schroder, Matthew A Cooper, Ariel E Feldstein, Geoffrey C Farrell. NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.
Journal of hepatology.
2017 05; 66(5):1037-1046. doi:
10.1016/j.jhep.2017.01.022. [PMID: 28167322] - Isis Ludwig-Portugall, Eva Bartok, Ermanila Dhana, Beatrix D G Evers, Michael J Primiano, J Perry Hall, Bernardo S Franklin, Percy A Knolle, Veit Hornung, Gunther Hartmann, Peter Boor, Eicke Latz, Christian Kurts. An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice.
Kidney international.
2016 09; 90(3):525-39. doi:
10.1016/j.kint.2016.03.035. [PMID: 27262364]