MAP5 (BioDeep_00000180647)

   

human metabolite blood metabolite


代谢物信息卡片


1-[(anthracen-9-yl)methyl]-4-({[34-({1-[(anthracen-9-yl)methyl]-1H-1,2,3-triazol-4-yl}methoxy)-9,14,20,25,27,29,30,32-octamethoxyhexacyclo[21.2.2.2^{3,6}.2^{8,11}.2^{13,16}.2^{18,21}]pentatriaconta-1(25),3(35),4,6(34),8,10,13,15,18,20,23,26,28,30,32-pentadecaen-4-yl]oxy}methyl)-1H-1,2,3-triazole

化学式: C79H72N6O10 (1264.5309651999999)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC2=C(C=C1CC3=CC(=C(CC4=CC(=C(CC5=C(C=C(CC6=C(C=C(C2)C(=C6)OC)OC)C(=C5)OCC7=CN(N=N7)CC8=C9C=CC=CC9=CC1=CC=CC=C18)OCC1=CN(N=N1)CC1=C2C=CC=CC2=CC2=CC=CC=C21)C=C4OC)OC)C=C3OC)OC)OC
InChI: InChI=1S/C79H72N6O10/c1-86-70-34-54-28-56-36-76(92-7)58(38-74(56)90-5)30-60-40-79(95-47-63-43-85(83-81-63)45-69-66-23-15-11-19-50(66)26-51-20-12-16-24-67(51)69)61(41-78(60)94-46-62-42-84(82-80-62)44-68-64-21-13-9-17-48(64)25-49-18-10-14-22-65(49)68)31-59-39-75(91-6)57(37-77(59)93-8)29-55-35-71(87-2)53(33-73(55)89-4)27-52(70)32-72(54)88-3/h9-26,32-43H,27-31,44-47H2,1-8H3

描述信息

同义名列表

9 个代谢物同义名

1-[(anthracen-9-yl)methyl]-4-({[34-({1-[(anthracen-9-yl)methyl]-1H-1,2,3-triazol-4-yl}methoxy)-9,14,20,25,27,29,30,32-octamethoxyhexacyclo[21.2.2.2^{3,6}.2^{8,11}.2^{13,16}.2^{18,21}]pentatriaconta-1(25),3(35),4,6(34),8,10,13,15,18,20,23,26,28,30,32-pentadecaen-4-yl]oxy}methyl)-1H-1,2,3-triazole; 1-(anthracen-9-ylmethyl)-4-{[(34-{[1-(anthracen-9-ylmethyl)-1,2,3-triazol-4-yl]methoxy}-9,14,20,25,27,29,30,32-octamethoxyhexacyclo[21.2.2.2^{3,6}.2^{8,11}.2^{13,16}.2^{18,21}]pentatriaconta-1(25),3(35),4,6(34),8,10,13,15,18,20,23,26,28,30,32-pentadecaen-4-yl)oxy]methyl}-1,2,3-triazole; 1-(Anthracen-9-ylmethyl)-4-[[34-[[1-(anthracen-9-ylmethyl)triazol-4-yl]methoxy]-9,14,19,24,26,28,30,32-octamethoxy-4-hexacyclo[21.2.2.23,6.28,11.213,16.218,21]pentatriaconta-1(26),3(35),4,6(34),8,10,13,15,18(29),19,21(28),23(27),24,30,32-pentadecaenyl]oxymethyl]triazole; Microtubule-associated protein 1b; MAP1.2; MAP1.x; MAP1b; MAP1X; MAP5



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yahel Segal, Felix Bukstein, Michal Raz, Orna Aizenstein, Yifat Alcalay, Avi Gadoth. PD-1-inhibitor-induced PCA-2 (MAP1B) Autoimmunity in a Patient with Renal Cell Carcinoma. Cerebellum (London, England). 2022 Apr; 21(2):328-331. doi: 10.1007/s12311-021-01298-9. [PMID: 34176072]
  • Jaeyoung Kwon, Keebeom Ko, Lijun Zhang, Dong Zhao, Hyun Ok Yang, Hak Cheol Kwon. An Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis. Molecules (Basel, Switzerland). 2019 Dec; 24(24):. doi: 10.3390/molecules24244489. [PMID: 31817934]
  • Avi Gadoth, Thomas J Kryzer, Jim Fryer, Andrew McKeon, Vanda A Lennon, Sean J Pittock. Microtubule-associated protein 1B: Novel paraneoplastic biomarker. Annals of neurology. 2017 Feb; 81(2):266-277. doi: 10.1002/ana.24872. [PMID: 28074593]
  • Vann Bennett, Kathryn Walder. Evolution in action: giant ankyrins awake. Developmental cell. 2015 Apr; 33(1):1-2. doi: 10.1016/j.devcel.2015.03.017. [PMID: 25850669]
  • Markus Gödel, Dunja Temerinac, Florian Grahammer, Björn Hartleben, Oliver Kretz, Beat M Riederer, Friedrich Propst, Stefan Kohl, Tobias B Huber. Microtubule Associated Protein 1b (MAP1B) Is a Marker of the Microtubular Cytoskeleton in Podocytes but Is Not Essential for the Function of the Kidney Filtration Barrier in Mice. PloS one. 2015; 10(10):e0140116. doi: 10.1371/journal.pone.0140116. [PMID: 26448484]
  • Marine Hovakimyan, Karola Weinreich, Stefan Jean-Pierre Haas, Elena Cattaneo, Arndt Rolfs, Andreas Wree. In vitro characterization of embryionic ST14A-cells. The International journal of neuroscience. 2008 Nov; 118(11):1489-501. doi: 10.1080/00207450701769257. [PMID: 18853328]
  • Hui Sun, Xiang-Qun Hu, Michel B Emerit, Jeffrey C Schoenebeck, Cassin E Kimmel, Robert W Peoples, Angela Miko, Li Zhang. Modulation of 5-HT3 receptor desensitization by the light chain of microtubule-associated protein 1B expressed in HEK 293 cells. The Journal of physiology. 2008 Feb; 586(3):751-62. doi: 10.1113/jphysiol.2007.136440. [PMID: 18063656]
  • Chikara Kitamura, Kyoko Shirai, Madoka Inoue, Tomoko Tashiro. Changes in the subcellular distribution of microtubule-associated protein 1B during synaptogenesis of cultured rat cortical neurons. Cellular and molecular neurobiology. 2007 Feb; 27(1):57-73. doi: 10.1007/s10571-006-9117-x. [PMID: 17151949]
  • Ze-Jian Wang, Bao-Ming Nie, Hong-Zhuan Chen, Yang Lu. Panaxynol induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms. Chemico-biological interactions. 2006 Jan; 159(1):58-64. doi: 10.1016/j.cbi.2005.09.003. [PMID: 16219303]
  • Lyudmila V Dergunova, Natalja M Raevskaya, Irina P Vladychenskaya, Svetlana A Limborska. Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region. Biomolecular engineering. 2003 Mar; 20(3):91-6. doi: 10.1016/s1389-0344(03)00003-0. [PMID: 12684070]
  • Yoko Uchida. Overexpression of full-length but not N-terminal truncated isoform of microtubule-associated protein (MAP) 1B accelerates apoptosis of cultured cortical neurons. The Journal of biological chemistry. 2003 Jan; 278(1):366-71. doi: 10.1074/jbc.m210091200. [PMID: 12376528]
  • L Chen, S W Yun, J Seto, W Liu, M Toth. The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences. Neuroscience. 2003; 120(4):1005-17. doi: 10.1016/s0306-4522(03)00406-8. [PMID: 12927206]
  • Stefan Jean-Pierre Haas, Andreas Wree. Dopaminergic differentiation of the Nurr1-expressing immortalized mesencephalic cell line CSM14.1 in vitro. Journal of anatomy. 2002 Jul; 201(1):61-9. doi: 10.1046/j.1469-7580.2002.00072.x. [PMID: 12171477]
  • Jukka Peltola, Jukka Hellman, Kati Hakkarainen, Aulis Marttinen, Esa Soppi, Gabor K Molnara. Naturally occurring human autoantibodies recognize a fetal brain antigen identified as microtubulus associated protein 1B. Life sciences. 2002 Jan; 70(8):887-92. doi: 10.1016/s0024-3205(01)01462-x. [PMID: 11853226]
  • R Franzen, S L Tanner, S M Dashiell, C A Rottkamp, J A Hammer, R H Quarles. Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein. The Journal of cell biology. 2001 Dec; 155(6):893-8. doi: 10.1083/jcb.200108137. [PMID: 11733546]
  • S Sanchez, C L Sayas, F Lim, J Diaz-Nido, J Avila, F Wandosell. The inhibition of phosphatidylinositol-3-kinase induces neurite retraction and activates GSK3. Journal of neurochemistry. 2001 Aug; 78(3):468-81. doi: 10.1046/j.1471-4159.2001.00453.x. [PMID: 11483649]
  • M Schwab, I Antonow-Schlorke, B Kühn, T Müller, H Schubert, B Walter, U Sliwka, P W Nathanielsz. Effect of antenatal betamethasone treatment on microtubule-associated proteins MAP1B and MAP2 in fetal sheep. The Journal of physiology. 2001 Feb; 530(Pt 3):497-506. doi: 10.1111/j.1469-7793.2001.0497k.x. [PMID: 11158279]
  • D Billups, J G Hanley, M Orme, D Attwell, S J Moss. GABAC receptor sensitivity is modulated by interaction with MAP1B. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Dec; 20(23):8643-50. doi: 10.1523/jneurosci.20-23-08643.2000. [PMID: 11102469]
  • S L Tanner, R Franzen, H Jaffe, R H Quarles. Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein. Journal of neurochemistry. 2000 Aug; 75(2):553-62. doi: 10.1046/j.1471-4159.2000.0750553.x. [PMID: 10899930]
  • M Pignatelli, M Cortés-Canteli, A Santos, A Perez-Castillo. Involvement of the NGFI-A gene in the differentiation of neuroblastoma cells. FEBS letters. 1999 Nov; 461(1-2):37-42. doi: 10.1016/s0014-5793(99)01420-9. [PMID: 10561492]
  • F Féron, A Mackay-Sim, J L Andrieu, K I Matthaei, A Holley, G Sicard. Stress induces neurogenesis in non-neuronal cell cultures of adult olfactory epithelium. Neuroscience. 1999 Jan; 88(2):571-83. doi: 10.1016/s0306-4522(98)00233-4. [PMID: 10197776]
  • D A Tonge, J P Golding, P R Gordon-Weeks. Expression of a developmentally regulated, phosphorylated isoform of microtubule-associated protein 1B in sprouting and regenerating axons in vitro. Neuroscience. 1996 Jul; 73(2):541-51. doi: 10.1016/0306-4522(96)00077-2. [PMID: 8783269]
  • R Takemura, S Okabe, T Umeyama, Y Kanai, N J Cowan, N Hirokawa. Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B, MAP2 or tau. Journal of cell science. 1992 Dec; 103 ( Pt 4)(?):953-64. doi: 10.1242/jcs.103.4.953. [PMID: 1487506]
  • Y Tanaka, K Kawahata, T Nakata, N Hirokawa. Chronological expression of microtubule-associated proteins (MAPs) in EC cell P19 after neuronal induction by retinoic acid. Brain research. 1992 Nov; 596(1-2):269-78. doi: 10.1016/0006-8993(92)91557-u. [PMID: 1467987]
  • J Díaz-Nido, R Armas-Portela, I Correas, J E Dominguez, E Montejo, J Avila. Microtubule protein phosphorylation in neuroblastoma cells and neurite growth. Journal of cell science. Supplement. 1991; 15(?):51-9. doi: 10.1242/jcs.1991.supplement_15.8. [PMID: 1824107]