Manassantin A (BioDeep_00000180640)

   

human metabolite blood metabolite natural product


代谢物信息卡片


1-(3,4-dimethoxyphenyl)-2-{4-[5-(4-{[1-(3,4-dimethoxyphenyl)-1-hydroxypropan-2-yl]oxy}-3-methoxyphenyl)-3,4-dimethyloxolan-2-yl]-2-methoxyphenoxy}propan-1-ol

化学式: C42H52O11 (732.3509442000001)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(OC1C2=CC(=C(C=C2)OC(C)C(C3=CC(=C(C=C3)OC)OC)O)OC)C4=CC(=C(C=C4)OC(C)C(C5=CC(=C(C=C5)OC)OC)O)OC)C
InChI: InChI=1S/C42H52O11/c1-23-24(2)42(30-14-18-34(38(22-30)50-10)52-26(4)40(44)28-12-16-32(46-6)36(20-28)48-8)53-41(23)29-13-17-33(37(21-29)49-9)51-25(3)39(43)27-11-15-31(45-5)35(19-27)47-7/h11-26,39-44H,1-10H3

描述信息

同义名列表

3 个代谢物同义名

1-(3,4-dimethoxyphenyl)-2-{4-[5-(4-{[1-(3,4-dimethoxyphenyl)-1-hydroxypropan-2-yl]oxy}-3-methoxyphenyl)-3,4-dimethyloxolan-2-yl]-2-methoxyphenoxy}propan-1-ol; Manassantin A; CID 10190528



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

24 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yibao Ma, Hae-Ki Min, Unsong Oh, Adam M Hawkridge, Wei Wang, Ahmed A Mohsin, Qun Chen, Arun Sanyal, Edward J Lesnefsky, Xianjun Fang. The lignan manassantin is a potent and specific inhibitor of mitochondrial complex I and bioenergetic activity in mammals. The Journal of biological chemistry. 2017 12; 292(51):20989-20997. doi: 10.1074/jbc.m117.812925. [PMID: 29046352]
  • Ji-Won Song, Chang-Seob Seo, Tae-In Kim, Og-Sung Moon, Young-Suk Won, Hwa-Young Son, Jong-Keun Son, Hyo-Jung Kwon. Protective Effects of Manassantin A against Ethanol-Induced Gastric Injury in Rats. Biological & pharmaceutical bulletin. 2016; 39(2):221-9. doi: 10.1248/bpb.b15-00642. [PMID: 26632199]
  • Su Jeong Kim, Yue Lu, Okyun Kwon, Kyoung Hwangbo, Chang-Seob Seo, Seung Ho Lee, Cheorl-Ho Kim, Young-Chae Chang, Jong Keun Son, Hyeun Wook Chang. Manassantin A isolated from Saururus chinensis inhibits 5-lipoxygenase-dependent leukotriene C4 generation by blocking mitogen-activated protein kinase activation in mast cells. Biological & pharmaceutical bulletin. 2011; 34(11):1769-72. doi: 10.1248/bpb.34.1769. [PMID: 22040894]
  • Oh Eok Kwon, Hyun Sun Lee, Seung Woong Lee, Mi Yeon Chung, Ki Hwan Bae, Mun-Chual Rho, Young-Kook Kim. Manassantin A and B isolated from Saururus chinensis inhibit TNF-alpha-induced cell adhesion molecule expression of human umbilical vein endothelial cells. Archives of pharmacal research. 2005 Jan; 28(1):55-60. doi: 10.1007/bf02975136. [PMID: 15742809]
  • Woo Song Lee, Dae-Woo Lee, Young-Il Baek, Sojin An, So-Jin An, Kyung-Hyun Cho, Yang-Kyu Choi, Hyoung-Chin Kim, Ho-Yong Park, Ki-Hwan Bae, Tae-Sook Jeong. Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis. Bioorganic & medicinal chemistry letters. 2004 Jun; 14(12):3109-12. doi: 10.1016/j.bmcl.2004.04.023. [PMID: 15149654]
  • Mun-Chual Rho, Oh Eok Kwon, Koanhoi Kim, Seung Woong Lee, Mi Yeon Chung, Young Ho Kim, Masahiko Hayashi, Hyun Sun Lee, Young-Kook Kim. Inhibitory effects of manassantin A and B isolated from the roots of Saururus chinensis on PMA-induced ICAM-1 expression. Planta medica. 2003 Dec; 69(12):1147-9. doi: 10.1055/s-2003-818007. [PMID: 14750033]