Iopromide (BioDeep_00000018064)
human metabolite
代谢物信息卡片
N-(2,3-dihydroxypropyl)-3-[(2,3-dihydroxypropyl)(methyl)carbamoyl]-5-[(1-hydroxy-2-methoxyethylidene)amino]-2,4,6-triiodobenzene-1-carboximidic acid
化学式: C18H24I3N3O8 (790.8697634)
中文名称: 碘普罗胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(CC(CO)O)C(=O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)NC(=O)COC)I
InChI: InChI=1S/C18H24I3N3O8/c1-24(4-9(28)6-26)18(31)12-13(19)11(17(30)22-3-8(27)5-25)14(20)16(15(12)21)23-10(29)7-32-2/h8-9,25-28H,3-7H2,1-2H3,(H,22,30)(H,23,29)
描述信息
Iopromide is a molecule used as a contrast medium. It is marketed under the name Ultravist which is produced by Bayer Healthcare. It is a low osmolar, non-ionic contrast agent for intravascular use.
V - Various > V08 - Contrast media > V08A - X-ray contrast media, iodinated > V08AB - Watersoluble, nephrotropic, low osmolar x-ray contrast media
D006133 - Growth Substances > D010937 - Plant Growth Regulators > D014283 - Triiodobenzoic Acids
同义名列表
11 个代谢物同义名
N-(2,3-dihydroxypropyl)-3-[(2,3-dihydroxypropyl)(methyl)carbamoyl]-5-[(1-hydroxy-2-methoxyethylidene)amino]-2,4,6-triiodobenzene-1-carboximidic acid; N,N-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetamido)-N-methylisophthalamide; Ultravist 300; Iopromidum; Ultravist; Clarograf; iopromide; Iopromida; Lopromid; Proscope; Iopromid
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:63578
- PubChem: 3736
- HMDB: HMDB0041910
- DrugBank: DB09156
- ChEMBL: CHEMBL1725
- Wikipedia: Iopromide
- chemspider: 3605
- CAS: 73334-07-3
- PMhub: MS000002037
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ji'an He, Mei Li, Yan Xu, Ning Fan, Chong Tian, Tianye Lv, Wenge Xing, Haipeng Yu. In vitro characteristics of Epirubicin-loaded thermosensitive liquid embolic agent.
Journal of cancer research and therapeutics.
2023 Dec; 19(6):1597-1602. doi:
10.4103/jcrt.jcrt_334_23. [PMID: 38156927] - Yiyu Feng, Guoping Qiu, Chengyun Xu, Zhibing Duan, Manting Wang, Lamei Wang, Wenjie Hu, Peifang Li, Hui Zhou. Iopromide and Iodixanol in the Development of Postoperative Contrast Nephropathy in Patients with Renal Insufficiency: A Meta-Analysis.
Journal of healthcare engineering.
2022; 2022(?):1469370. doi:
10.1155/2022/1469370. [PMID: 35422982] - Yuh-Feng Tsai, Jai-Sing Yang, Fuu-Jen Tsai, Yih-Dih Cheng, Yu-Jen Chiu, Shih-Chang Tsai. High Concentration of Iopromide Induces Apoptosis and Autophagy in Human Embryonic Kidney Cells via Activating a ROS-dependent Cellular Stress Pathway.
In vivo (Athens, Greece).
2021 Nov; 35(6):3221-3232. doi:
10.21873/invivo.12617. [PMID: 34697153] - Ian T Mark, Daniel E Maddox, Robert J McDonald, David F Kallmes, Jennifer S McDonald. Immunologic biomarker changes in patients exposed to intravenous iodinated contrast material.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2021 07; 127(1):135-136. doi:
10.1016/j.anai.2021.03.021. [PMID: 33781935] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Guanzhong Chen, Bowen Liu, Shiqun Chen, Huanqiang Li, Jin Liu, Ziling Mai, Enzhao Chen, Chunyun Zhou, Guoli Sun, Zhaodong Guo, Li Lei, Shanyi Huang, Liyao Zhang, Min Li, Ning Tan, Hong Li, Yulin Liao, Jia Liu, Jiyan Chen, Yong Liu. Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles.
International journal of biological sciences.
2021; 17(3):882-896. doi:
10.7150/ijbs.45294. [PMID: 33767596] - Dandong Fang, Yongbin Wang, Ziyue Zhang, Donghai Yang, Daqian Gu, Bo He, Xiaoqun Zhang, Duofen He, HongYong Wang, Pedro A Jose, Yu Han, Chunyu Zeng. Calorie Restriction Protects against Contrast-Induced Nephropathy via SIRT1/GPX4 Activation.
Oxidative medicine and cellular longevity.
2021; 2021(?):2999296. doi:
10.1155/2021/2999296. [PMID: 34712381] - Daqian Gu, Yu Shi, Zhengfan Gong, Tianyang Xia, Hongmei Ren, Duofen He, Jian Yang, Yu Han, Chunyu Zeng. AdipoRon, an adiponectin receptor agonist, protects contrast-induced nephropathy by suppressing oxidative stress and inflammation via activation of the AMPK pathway.
Clinical and experimental nephrology.
2020 Nov; 24(11):989-998. doi:
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Acta pharmacologica Sinica.
2020 Nov; 41(11):1457-1464. doi:
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Bioscience reports.
2020 02; 40(2):. doi:
10.1042/bsr20193253. [PMID: 31998952] - Zhenchao Tang, Dexin Yu, Tianjiao Ni, Tongtong Zhao, Ye Jin, Enqing Dong. Quantitative Analysis of Multiphase Contrast-Enhanced CT Images: A Pilot Study of Preoperative Prediction of Fat-Poor Angiomyolipoma and Renal Cell Carcinoma.
AJR. American journal of roentgenology.
2020 02; 214(2):370-382. doi:
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Clinical science (London, England : 1979).
2019 12; 133(23):2361-2378. doi:
10.1042/cs20190455. [PMID: 31763675] - Thomas E Kalogirou, Soultana Meditskou, Sotiria Davidopoulou, Ioannis Savvas, Apostolos G Pitoulias, Georgios A Pitoulias. Investigating the Possible Protective Role of Direct Intra-arterial Administration of Mannitol and N-Acetylcysteine and Per Os Administration of Simvastatin Against Contrast-Induced Nephropathy: An Experimental Study in a Rabbit Model.
Cardiovascular and interventional radiology.
2019 Dec; 42(12):1777-1785. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Yong Wang, Hong-Wei Zhao, Xiao-Jiao Zhang, Bao-Jun Chen, Guo-Ning Yu, Ai-Jie Hou, Bo Luan. CHA2DS2-VASC score as a preprocedural predictor of contrast-induced nephropathy among patients with chronic total occlusion undergoing percutaneous coronary intervention: a single-center experience.
BMC cardiovascular disorders.
2019 03; 19(1):74. doi:
10.1186/s12872-019-1060-0. [PMID: 30922230] - Katja Ribbers, Lutz Breuer, Rolf-Alexander Düring. Detection of artificial sweeteners and iodinated X-ray contrast media in wastewater via LC-MS/MS and their potential use as anthropogenic tracers in flowing waters.
Chemosphere.
2019 Mar; 218(?):189-196. doi:
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International journal of cardiology.
2018 Dec; 273(?):69-73. doi:
10.1016/j.ijcard.2018.08.097. [PMID: 30196995] - Giovanni Foti, Giuseppe Malleo, Niccolò Faccioli, Andrea Guerriero, Lino Furlani, Giovanni Carbognin. Characterization of adrenal lesions using MDCT wash-out parameters: diagnostic accuracy of several combinations of intermediate and delayed phases.
La Radiologia medica.
2018 Nov; 123(11):833-840. doi:
10.1007/s11547-018-0911-6. [PMID: 29923085] - Qian Su, Qian Wang, Honglei Zhang, Dexin Yu, Yanlei Wang, Zhiyan Liu, Xiaoming Zhang. Computed tomography findings of small bowel gastrointestinal stromal tumors with different histologic risks of progression.
Abdominal radiology (New York).
2018 10; 43(10):2651-2658. doi:
10.1007/s00261-018-1511-6. [PMID: 29492604] - Maria Redeker, Arne Wick, Björn Meermann, Thomas A Ternes. Anaerobic Transformation of the Iodinated X-ray Contrast Medium Iopromide, Its Aerobic Transformation Products, and Transfer to Further Iodinated X-ray Contrast Media.
Environmental science & technology.
2018 08; 52(15):8309-8320. doi:
10.1021/acs.est.8b01140. [PMID: 29998733] - Shang-Feng Yang, Ruey-Hsing Chou, Szu-Yuan Li, Shao-Sung Huang, Po-Hsun Huang. Serum Corin Level Is Associated With Subsequent Decline in Renal Function in Patients With Suspected Coronary Artery Disease.
Journal of the American Heart Association.
2018 05; 7(10):. doi:
10.1161/jaha.117.008157. [PMID: 29728370] - Junyi Zhang, Yufeng Jiang, Qing Rui, Min Chen, Nannan Zhang, Huajia Yang, Yafeng Zhou. Iodixanol versus iopromide in patients with renal insufficiency undergoing coronary angiography with or without PCI.
Medicine.
2018 May; 97(18):e0617. doi:
10.1097/md.0000000000010617. [PMID: 29718868] - Irene Terrenato, Francesca Sperati, Felice Musicco, Anna F Pozzi, Annunziata di Turi, Mauro Caterino, Elisabetta de Lutio di Castelguidone, Sergio V Setola, Massimo Bellomi, Carlo E Neumaier, Laura Conti, Giovanni Cigliana, Roberta Merola, Anna Antenucci, Giulia Orlandi, Antonio Giordano, Maddalena Barba, Stefano Canitano. Iodixanol versus iopromide in cancer patients: Evidence from a randomized clinical trial.
Journal of cellular physiology.
2018 Mar; 233(3):2572-2580. doi:
10.1002/jcp.26132. [PMID: 28777459] - Bin Zhang, Yuhao Dong, Baoliang Guo, Wenbo Chen, Fusheng Ouyang, Zhouyang Lian, Jing Liu, Shuixing Zhang. Application of noninvasive functional imaging to monitor the progressive changes in kidney diffusion and perfusion in contrast-induced acute kidney injury rats at 3.0 T.
Abdominal radiology (New York).
2018 03; 43(3):655-662. doi:
10.1007/s00261-017-1247-8. [PMID: 28677006] - Gerlig Widmann, Reto Bale, Hanno Ulmer, Daniel Putzer, Peter Schullian, Franz-Josef Wiedermann, Wolfgang Lederer. Systemic Hypotension Following Intravenous Administration of Nonionic Contrast Medium During Computed Tomography: Iopromide Versus Iodixanol.
Anesthesia and analgesia.
2018 03; 126(3):769-775. doi:
10.1213/ane.0000000000002346. [PMID: 28806208] - Chenchen Dai, Yingli Cao, Yan Jia, Yuqin Ding, Ruofan Sheng, Mengsu Zeng, Jianjun Zhou. Differentiation of renal cell carcinoma subtypes with different iodine quantification methods using single-phase contrast-enhanced dual-energy CT: areal vs. volumetric analyses.
Abdominal radiology (New York).
2018 03; 43(3):672-678. doi:
10.1007/s00261-017-1253-x. [PMID: 28721478] - Yuning Pan, Aiqin Song, Shizhong Bu, Zhaoqian Chen, Qiuli Huang, Aijing Li. The feasibility of low-concentration contrast and low tube voltage in computed tomography perfusion imaging: an animal study.
Bioscience reports.
2018 02; 38(1):. doi:
10.1042/bsr20170977. [PMID: 29208767] - Geng Qian, Yong-Qiang Yang, Wei Dong, Feng Cao, Yun-Dai Chen. Comparison of Iodixanol and Iopromide in Patients With Renal Insufficiency and Congestive Heart Failure Undergoing Coronary Angiography by Hemodynamic Monitoring.
Angiology.
2017 Nov; 68(10):907-913. doi:
10.1177/0003319717701868. [PMID: 28401790] - Philipp Lamby, Friedrich Jung, Stefanie Graf, Lotte Schellenberg, Johannes Falter, Natascha Platz-da-Silva, Stephan Schreml, Lukas Prantl, Ralf P Franke, Ernst M Jung. Effect of iodinated contrast media on renal perfusion: A randomized comparison study in pigs using quantitative contrast-enhanced ultrasound (CEUS).
Scientific reports.
2017 10; 7(1):13125. doi:
10.1038/s41598-017-13253-y. [PMID: 29030579] - Hao Cui, Martin Hrabě de Angelis, Peter Schröder. Iopromide exposure in Typha latifolia L.: Evaluation of uptake, translocation and different transformation mechanisms in planta.
Water research.
2017 10; 122(?):290-298. doi:
10.1016/j.watres.2017.06.004. [PMID: 28614741] - Maria-Malvina Tsamouri, Maria Rapti, Paraskevi Kouka, Charitini Nepka, Konstantinos Tsarouhas, Anestis Soumelidis, George Koukoulis, Aristides Tsatsakis, Demetrios Kouretas, Christina Tsitsimpikou. Histopathological evaluation and redox assessment in blood and kidney tissues in a rabbit contrast-induced nephrotoxicity model.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Oct; 108(Pt A):186-193. doi:
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Medical science monitor : international medical journal of experimental and clinical research.
2017 Sep; 23(?):4351-4359. doi:
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Medical science monitor : international medical journal of experimental and clinical research.
2017 Sep; 23(?):4299-4305. doi:
10.12659/msm.903255. [PMID: 28874655] - Gu-Mu-Yang Zhang, Bing Shi, Hao Sun, Zheng-Yu Jin, Hua-Dan Xue. Differentiating pheochromocytoma from lipid-poor adrenocortical adenoma by CT texture analysis: feasibility study.
Abdominal radiology (New York).
2017 09; 42(9):2305-2313. doi:
10.1007/s00261-017-1118-3. [PMID: 28357529] - Lucia Barbieri, Monica Verdoia, Matteo Nardin, Paolo Marino, Harry Suryapranata, Giuseppe De Luca. Gender Difference in the Risk of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography or Percutaneous Coronary Intervention.
Angiology.
2017 Jul; 68(6):542-546. doi:
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AJR. American journal of roentgenology.
2017 Jul; 209(1):W10-W17. doi:
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Angiology.
2017 May; 68(5):419-427. doi:
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Lancet (London, England).
2017 04; 389(10076):1312-1322. doi:
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Abdominal radiology (New York).
2017 01; 42(1):226-235. doi:
10.1007/s00261-016-0858-9. [PMID: 27503300] - D Fabbri, P Calza, D Dalmasso, P Chiarelli, V Santoro, C Medana. Iodinated X-ray contrast agents: Photoinduced transformation and monitoring in surface water.
The Science of the total environment.
2016 Dec; 572(?):340-351. doi:
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Heart and vessels.
2016 Nov; 31(11):1776-1782. doi:
10.1007/s00380-016-0809-y. [PMID: 26874946] - Yuan-Cheng Wang, Adrian Tang, Di Chang, Chun-Qiang Lu, Shi-Jun Zhang, Shenghong Ju. Long-Term Adverse Effects of Low-Osmolar Compared With Iso-Osmolar Contrast Media After Coronary Angiography.
The American journal of cardiology.
2016 Oct; 118(7):985-90. doi:
10.1016/j.amjcard.2016.07.017. [PMID: 27521223] - Hayriye Sayarlioglu, Ali Okuyucu, Abdulkerim Bedir, Osman Salis, Eser Yenen, Garip Bekfilavioglu, Coskun Kaya. Is there any role of epithelial to mesenchymal transition in the pathogenesis of contrast nephropathy?.
Renal failure.
2016 Sep; 38(8):1249-55. doi:
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Radiology.
2016 Apr; 279(1):254-61. doi:
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AJR. American journal of roentgenology.
2016 Apr; 206(4):764-74. doi:
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Nephrology (Carlton, Vic.).
2016 Apr; 21(4):295-300. doi:
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Contrast media & molecular imaging.
2015 Nov; 10(6):446-55. doi:
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European radiology.
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Journal of computer assisted tomography.
2015 Jul; 39(4):473-8. doi:
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Acta radiologica (Stockholm, Sweden : 1987).
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Environmental science & technology.
2015 Mar; 49(5):2983-90. doi:
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Cellular immunology.
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Angiology.
2015 Feb; 66(2):136-42. doi:
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Acta radiologica (Stockholm, Sweden : 1987).
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Radiology.
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Clinical radiology.
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Investigative radiology.
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Acta radiologica (Stockholm, Sweden : 1987).
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Investigative radiology.
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JACC. Cardiovascular interventions.
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Abdominal imaging.
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Journal of Korean medical science.
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Acta radiologica (Stockholm, Sweden : 1987).
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European journal of pharmacology.
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European radiology.
2014 Jan; 24(1):184-90. doi:
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PloS one.
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Diagnostic and interventional radiology (Ankara, Turkey).
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AJR. American journal of roentgenology.
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