Lilly 117018 (BioDeep_00000180587)

   

human metabolite blood metabolite


代谢物信息卡片


6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl 4-[2-(1-pyrrolidinyl)ethoxy] phenyl ketone

化学式: C27H25NO4S (459.15042100000005)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCN(C1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
InChI: InChI=1S/C27H25NO4S/c29-20-7-3-19(4-8-20)27-25(23-12-9-21(30)17-24(23)33-27)26(31)18-5-10-22(11-6-18)32-16-15-28-13-1-2-14-28/h3-12,17,29-30H,1-2,13-16H2

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D020847 - Estrogen Receptor Modulators
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists

同义名列表

5 个代谢物同义名

6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl 4-[2-(1-pyrrolidinyl)ethoxy] phenyl ketone; 6-Hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl 4-(2-(1-pyrrolidinyl)ethoxy) phenyl ketone; 2-(4-hydroxyphenyl)-3-{4-[2-(pyrrolidin-1-yl)ethoxy]benzoyl}-1-benzothiophen-6-ol; Lilly 117018; LY-117018



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Caroline Jochems, Ulrika Islander, Anna Kallkopf, Marie Lagerquist, Claes Ohlsson, Hans Carlsten. Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis. Arthritis and rheumatism. 2007 Oct; 56(10):3261-70. doi: 10.1002/art.22873. [PMID: 17907171]
  • G Tulipano, C Bonfanti, C Poiesi, A Burattin, S Turazzi, G Barone, R Cozzi, A Bollati, D Valle, A Giustina. Effects of the selective estrogen receptor modulator LY117018 on growth hormone secretion: In vitro studies. Metabolism: clinical and experimental. 2004 May; 53(5):563-70. doi: 10.1016/j.metabol.2003.12.004. [PMID: 15131758]
  • G Hernández, J G Hernández-Jiménez, P Guelmes, J E Sánchez-Criado, C Bellido, J R Martínez-Morales, L Prieto, F Marín, C Glidewell-Kenney, F J López, R Alonso. Effect of treatment with the selective oestrogen receptor modulator LY117018-HCl on pituitary sensitivity to GnRH and subsequent ovulation. Reproduction (Cambridge, England). 2003 Apr; 125(4):597-606. doi: 10.1530/rep.0.1250597. [PMID: 12683930]
  • C Bellido, R Aguilar, J C Garrido-Gracia, J E Sánchez-Criado. Effects of progesterone (P) and antiprogestin RU486 on LH and FSH release by incubated pituitaries from rats treated with the SERM LY11701 8-HCl and/or recombinant human FSH. Journal of endocrinological investigation. 2002 Sep; 25(8):702-8. doi: 10.1007/bf03345104. [PMID: 12240902]
  • J C Russell, J D McKendrick, P J Dubé, P J Dolphin, M W Radomski. Effects of LY117018 and the estrogen analogue, 17alpha-ethinylestradiol, on vascular reactivity, platelet aggregation, and lipid metabolism in the insulin-resistant JCR:LA-cp male rat: role of nitric oxide. Journal of cardiovascular pharmacology. 2001 Jan; 37(1):119-28. doi: 10.1097/00005344-200101000-00014. [PMID: 11152369]
  • M A Richardson, D T Berg, D S Calnek, A V Ciaccia, D E Joyce, B W Grinnell. 17beta-estradiol, but not raloxifene, decreases thrombomodulin in the antithrombotic protein C pathway. Endocrinology. 2000 Oct; 141(10):3908-11. doi: 10.1210/endo.141.10.7798. [PMID: 11014248]
  • A R Genazzani, F Bernardi, M Stomati, P Monteleone, S Luisi, S Rubino, A Farzati, E Casarosa, M Luisi, F Petraglia. Effects of estradiol and raloxifene analog on brain, adrenal and serum allopregnanolone content in fertile and ovariectomized female rats. Neuroendocrinology. 2000 Sep; 72(3):162-70. doi: 10.1159/000054583. [PMID: 11025410]
  • Z Liu, E Graff, D Benayahu. Effect of raloxifene-analog (LY 117018-Hcl) on the bone marrow of ovariectomized mice. Journal of cellular biochemistry. 2000 Jan; 76(3):509-17. doi: 10.1002/(sici)1097-4644(20000301)76:3<509::aid-jcb17>3.0.co;2-r. [PMID: 10649447]
  • A R Genazzani, F Bernardi, M Stomati, S Rubino, L Giardina, S Luisi, P Monteleone, A D Genazzani, M Luisi, F Petraglia. Raloxifene analog LY 117018 effects on central and peripheral beta-endorphin. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 1999 Aug; 13(4):249-58. doi: 10.3109/09513599909167563. [PMID: 10533160]
  • X Li, M Takahashi, K Kushida, T Inoue. The preventive and interventional effects of raloxifene analog (LY117018 HCL) on osteopenia in ovariectomized rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 1998 Jun; 13(6):1005-10. doi: 10.1359/jbmr.1998.13.6.1005. [PMID: 9626632]
  • L D Apelgren, D L Bailey, R L Fouts, L Short, N Bryan, G F Evans, G E Sandusky, S H Zuckerman, A Glasebrook, T F Bumol. The effect of a selective estrogen receptor modulator on the progression of spontaneous autoimmune disease in MRL lpr/lpr mice. Cellular immunology. 1996 Oct; 173(1):55-63. doi: 10.1006/cimm.1996.0251. [PMID: 8871601]
  • A R Bowman, D A Sass, I Marshall, Y F Ma, H Liang, W S Jee, S Epstein. Raloxifene analog (LY117018 HCL) ameliorates cyclosporin A-induced osteopenia in oophorectomized rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 1996 Aug; 11(8):1191-8. doi: 10.1002/jbmr.5650110819. [PMID: 8854256]
  • Y Gong, G Ballejo, L C Murphy, L J Murphy. Differential effects of estrogen and antiestrogen on transforming growth factor gene expression in endometrial adenocarcinoma cells. Cancer research. 1992 Apr; 52(7):1704-9. doi: . [PMID: 1551100]
  • J R Pasqualini, C Sumida, N Giambiagi. Pharmacodynamic and biological effects of anti-estrogens in different models. Journal of steroid biochemistry. 1988 Oct; 31(4B):613-43. doi: 10.1016/0022-4731(88)90013-1. [PMID: 3059059]
  • I Weinstein, M Heimberg. Effects of the antiestrogen LY 117018 on the modulation by ethinyl estradiol of the metabolism of [1-14C]oleic acid by perfused livers from normal and ovariectomized rats. Biochemical pharmacology. 1988 Jan; 37(2):319-26. doi: 10.1016/0006-2952(88)90735-6. [PMID: 3342088]
  • E C Henry, R K Miller. The antiestrogen LY117018 is estrogenic in the fetal rat. Teratology. 1986 Aug; 34(1):59-63. doi: 10.1002/tera.1420340108. [PMID: 3764778]
  • M N Gordon, C V Mobbs, C E Finch. The antiestrogen LY117018 blocks effects of estradiol on pituitary glucose-6-phosphate dehydrogenase specific activity and on serum LH. Neuroendocrinology. 1985 May; 40(5):381-4. doi: 10.1159/000124102. [PMID: 4010886]