(3-{[3-(2-Amino-2-Oxoethyl)-1-Benzyl-2-Ethyl-1h-Indol-5-Yl]oxy}propyl)phosphonic Acid (BioDeep_00000180584)

   

human metabolite blood metabolite


代谢物信息卡片


(3-{[3-(2-Amino-2-Oxoethyl)-1-Benzyl-2-Ethyl-1h-Indol-5-Yl]oxy}propyl)phosphonic Acid

化学式: C22H27N2O5P (430.16575020000005)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 99.57%

分子结构信息

SMILES: CCC1=C(C2=C(N1CC3=CC=CC=C3)C=CC(=C2)OCCCP(=O)(O)O)CC(=O)N
InChI: InChI=1S/C22H27N2O5P/c1-2-20-19(14-22(23)25)18-13-17(29-11-6-12-30(26,27)28)9-10-21(18)24(20)15-16-7-4-3-5-8-16/h3-5,7-10,13H,2,6,11-12,14-15H2,1H3,(H2,23,25)(H2,26,27,28)

描述信息

LY-311727 is a potent secretory non-pancreatic phospholipase A2 (sPLA2) inhibitor (IC50 <1 μM for group IIA sPLA2). sPLA2 is an important proinflammatory enzyme[1][2].

同义名列表

4 个代谢物同义名

(3-{[3-(2-Amino-2-Oxoethyl)-1-Benzyl-2-Ethyl-1h-Indol-5-Yl]oxy}propyl)phosphonic Acid; 2-[1-benzyl-2-ethyl-5-(3-phosphonopropoxy)-1H-indol-3-yl]ethanimidic acid; 2-[1-benzyl-2-ethyl-5-(3-phosphonopropoxy)indol-3-yl]ethanimidic acid; LY-311727



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yu Maw Htwe, Huashan Wang, Patrick Belvitch, Lucille Meliton, Mounica Bandela, Eleftheria Letsiou, Steven M Dudek. Group V Phospholipase A2 Mediates Endothelial Dysfunction and Acute Lung Injury Caused by Methicillin-Resistant Staphylococcus Aureus. Cells. 2021 07; 10(7):. doi: 10.3390/cells10071731. [PMID: 34359901]
  • Denis Blache, Thomas Gautier, Uwe J F Tietge, Laurent Lagrost. Activated platelets contribute to oxidized low-density lipoproteins and dysfunctional high-density lipoproteins through a phospholipase A2-dependent mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 Feb; 26(2):927-37. doi: 10.1096/fj.11-191593. [PMID: 22042222]
  • Maren Luchtefeld, Nele Bandlow, Uwe J F Tietge, Karsten Grote, Josef Pfeilschifter, Marietta Kaszkin, Sabine Beck, Helmut Drexler, Bernhard Schieffer. Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation. Atherosclerosis. 2007 Sep; 194(1):62-70. doi: 10.1016/j.atherosclerosis.2006.09.024. [PMID: 17069818]
  • Ursula A Kessen, Ralph H Schaloske, Daren L Stephens, Karin Killermann Lucas, Edward A Dennis. PGE2 release is independent of upregulation of Group V phospholipase A2 during long-term stimulation of P388D1 cells with LPS. Journal of lipid research. 2005 Nov; 46(11):2488-96. doi: 10.1194/jlr.m500325-jlr200. [PMID: 16150819]
  • Norbert Degousee, Farideh Ghomashchi, Eva Stefanski, Alan Singer, Brian P Smart, Niels Borregaard, Reinhardt Reithmeier, Thomas F Lindsay, Cornelia Lichtenberger, Walter Reinisch, Gerard Lambeau, Jonathan Arm, Jay Tischfield, Michael H Gelb, Barry B Rubin. Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. The Journal of biological chemistry. 2002 Feb; 277(7):5061-73. doi: 10.1074/jbc.m109083200. [PMID: 11741884]
  • M Triggiani, F Granata, A Oriente, V De Marino, M Gentile, C Calabrese, C Palumbo, G Marone. Secretory phospholipases A2 induce beta-glucuronidase release and IL-6 production from human lung macrophages. Journal of immunology (Baltimore, Md. : 1950). 2000 May; 164(9):4908-15. doi: 10.4049/jimmunol.164.9.4908. [PMID: 10779801]
  • P G Hains, K L Sung, A Tseng, K W Broady. Functional characteristics of a phospholipase A(2) inhibitor from Notechis ater serum. The Journal of biological chemistry. 2000 Jan; 275(2):983-91. doi: 10.1074/jbc.275.2.983. [PMID: 10625636]
  • O L Brekke, E Sagen, K S Bjerve. Specificity of endogenous fatty acid release during tumor necrosis factor-induced apoptosis in WEHI 164 fibrosarcoma cells. Journal of lipid research. 1999 Dec; 40(12):2223-33. doi: 10.1016/s0022-2275(20)32097-6. [PMID: 10588948]
  • L Arbibe, K Koumanov, D Vial, C Rougeot, G Faure, N Havet, S Longacre, B B Vargaftig, G Béréziat, D R Voelker, C Wolf, L Touqui. Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction. The Journal of clinical investigation. 1998 Sep; 102(6):1152-60. doi: 10.1172/jci3236. [PMID: 9739049]
  • E Hurt-Camejo, S Andersen, R Standal, B Rosengren, P Sartipy, E Stadberg, B Johansen. Localization of nonpancreatic secretory phospholipase A2 in normal and atherosclerotic arteries. Activity of the isolated enzyme on low-density lipoproteins. Arteriosclerosis, thrombosis, and vascular biology. 1997 Feb; 17(2):300-9. doi: 10.1161/01.atv.17.2.300. [PMID: 9081685]
  • J H Fleisch, C T Armstrong, C R Roman, E D Mihelich, S M Spaethe, W T Jackson, J L Bobbitt, S Draheim, N J Bach, R D Dillard, M Martinelli, R Fouts, D W Snyder. Recombinant human secretory phospholipase A2 released thromboxane from guinea pig bronchoalveolar lavage cells: in vitro and ex vivo evaluation of a novel secretory phospholipase A2 inhibitor. The Journal of pharmacology and experimental therapeutics. 1996 Jul; 278(1):252-7. doi: ". [PMID: 8764358]