luzindole (BioDeep_00000180579)

   

human metabolite blood metabolite


代谢物信息卡片


N-[2-(2-benzyl-1H-indol-3-yl)ethyl]acetamide

化学式: C19H20N2O (292.157555)
中文名称: N-乙酰基-2-苄基色胺
谱图信息: 最多检出来源 Homo sapiens(blood) 75%

分子结构信息

SMILES: CC(=O)NCCC1=C(CC2=CC=CC=C2)NC2=CC=CC=C12
InChI: InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)

描述信息

同义名列表

6 个代谢物同义名

N-[2-(2-benzyl-1H-indol-3-yl)ethyl]acetamide; 2-Benzyl-N-acetyltryptamine; N-Acetyl-2-benzyltryptamine; Luzindole; N 0774; N-0774



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hyeon Hwa Nam, Ji Hye Lee, Seung Mok Ryu, Sueun Lee, Sungyu Yang, Pureum Noh, Byung Cheol Moon, Joong Sun Kim, Yun-Soo Seo. Gekko gecko extract attenuates airway inflammation and mucus hypersecretion in a murine model of ovalbumin-induced asthma. Journal of ethnopharmacology. 2022 Jan; 282(?):114574. doi: 10.1016/j.jep.2021.114574. [PMID: 34461187]
  • Yisheng Luo, Yongqiang Yang, Yi Shen, Longjiang Li, Jiayi Huang, Li Tang, Li Zhang. Luzindole attenuates LPS/d-galactosamine-induced acute hepatitis in mice. Innate immunity. 2020 05; 26(4):319-327. doi: 10.1177/1753425919890912. [PMID: 31779498]
  • Boxian Huang, Chunfeng Qian, Chenyue Ding, Qingxia Meng, Qinyan Zou, Hong Li. Fetal liver mesenchymal stem cells restore ovarian function in premature ovarian insufficiency by targeting MT1. Stem cell research & therapy. 2019 11; 10(1):362. doi: 10.1186/s13287-019-1490-8. [PMID: 31783916]
  • Lu Zhang, Fang Li, Xiaomin Su, Yue Li, Yining Wang, Ruonan Fang, Yingying Guo, Tongzhu Jin, Huitong Shan, Xiaoguang Zhao, Rui Yang, Hongli Shan, Haihai Liang. Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction. Experimental & molecular medicine. 2019 07; 51(7):1-12. doi: 10.1038/s12276-019-0273-8. [PMID: 31273199]
  • Zhendong Zhu, Rongnan Li, Yinghua Lv, Wenxian Zeng. Melatonin protects rabbit spermatozoa from cryo-damage via decreasing oxidative stress. Cryobiology. 2019 06; 88(?):1-8. doi: 10.1016/j.cryobiol.2019.04.009. [PMID: 31034812]
  • Yong Seok Han, Sang Min Kim, Jun Hee Lee, Sang Hun Lee. Co-Administration of Melatonin Effectively Enhances the Therapeutic Effects of Pioglitazone on Mesenchymal Stem Cells Undergoing Indoxyl Sulfate-Induced Senescence through Modulation of Cellular Prion Protein Expression. International journal of molecular sciences. 2018 May; 19(5):. doi: 10.3390/ijms19051367. [PMID: 29734669]
  • Shou-Long Deng, Tie-Cheng Sun, Kun Yu, Zhi-Peng Wang, Bao-Lu Zhang, Yan Zhang, Xiu-Xia Wang, Zheng-Xing Lian, Yi-Xun Liu. Melatonin reduces oxidative damage and upregulates heat shock protein 90 expression in cryopreserved human semen. Free radical biology & medicine. 2017 12; 113(?):347-354. doi: 10.1016/j.freeradbiomed.2017.10.342. [PMID: 29051117]
  • M Suhaib Azim, Nidhi B Agarwal, Divya Vohora. Effects of agomelatine on pentylenetetrazole-induced kindling, kindling-associated oxidative stress, and behavioral despair in mice and modulation of its actions by luzindole and 1-(m-chlorophenyl) piperazine. Epilepsy & behavior : E&B. 2017 07; 72(?):140-144. doi: 10.1016/j.yebeh.2017.03.019. [PMID: 28578215]
  • Jianying Tao, Juanxiu Lv, Weisheng Li, Pengjie Zhang, Caiping Mao, Zhice Xu. Exogenous melatonin reduced blood pressure in late-term ovine fetus via MT1/MT2 receptor pathways. Reproductive biology. 2016 Sep; 16(3):212-217. doi: 10.1016/j.repbio.2016.06.001. [PMID: 27692363]
  • Fuju Chen, Aikebaier Reheman, Jing Cao, Zixu Wang, Yulan Dong, Yuxian Zhang, Yaoxing Chen. Effect of melatonin on monochromatic light-induced T-lymphocyte proliferation in the thymus of chickens. Journal of photochemistry and photobiology. B, Biology. 2016 Aug; 161(?):9-16. doi: 10.1016/j.jphotobiol.2016.05.001. [PMID: 27203566]
  • Bei-bei Rui, Hao Chen, Lei Jang, Zhen Li, Jing-mo Yang, Wei-ping Xu, Wei Wei. Melatonin Upregulates the Activity of AMPK and Attenuates Lipid Accumulation in Alcohol-induced Rats. Alcohol and alcoholism (Oxford, Oxfordshire). 2016 Jan; 51(1):11-9. doi: 10.1093/alcalc/agv126. [PMID: 26564773]
  • M Juszczak, M Roszczyk, E Kowalczyk, B Stempniak. The influence od melatonin receptors antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT), on melatonin-dependent vasopressin and adrenocorticotropic hormone (ACTH) release from the rat hypothalamo-hypophysial system. In vitro and in vivo studies. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2014 Dec; 65(6):777-84. doi: NULL. [PMID: 25554981]
  • Tracy A Bedrosian, Kamillya L Herring, James C Walton, Laura K Fonken, Zachary M Weil, Randy J Nelson. Evidence for feedback control of pineal melatonin secretion. Neuroscience letters. 2013 May; 542(?):123-5. doi: 10.1016/j.neulet.2013.03.021. [PMID: 23528860]
  • Eleonora Regueira, Alina Grisel Sassone, María Florencia Scaia, María Clara Volonteri, Nora Raquel Ceballos. Seasonal changes and regulation of the glucocorticoid receptor in the testis of the toad Rhinella arenarum. Journal of experimental zoology. Part A, Ecological genetics and physiology. 2013 Jan; 319(1):39-52. doi: 10.1002/jez.1772. [PMID: 23203422]
  • Ugurlu M Umit, Terzioglu Berna, Kaya Handan, Erbarut Ipek, Yegen Berrak, Erzik Can, Gulluoglu M Bahadir. Role of melatonin and luzindole in rat mammary cancer. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2012 Dec; 25(6):345-53. doi: 10.3109/08941939.2012.665570. [PMID: 23215791]
  • Ina Bähr, Eckhard Mühlbauer, Elke Albrecht, Elmar Peschke. Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the Gαq protein-coupled and PI3K signaling pathways. Journal of pineal research. 2012 Nov; 53(4):390-8. doi: 10.1111/j.1600-079x.2012.01009.x. [PMID: 22672634]
  • Venkataramanujam Srinivasan, Asma H Ahmad, Mahaneem Mohamed, Rahimah Zakaria. Melatonin effects on Plasmodium life cycle: new avenues for therapeutic approach. Recent patents on endocrine, metabolic & immune drug discovery. 2012 May; 6(2):139-47. doi: 10.2174/187221412800604635. [PMID: 22537380]
  • Diego M Presman, Valeria Levi, Omar P Pignataro, Adali Pecci. Melatonin inhibits glucocorticoid-dependent GR-TIF2 interaction in newborn hamster kidney (BHK) cells. Molecular and cellular endocrinology. 2012 Feb; 349(2):214-21. doi: 10.1016/j.mce.2011.10.026. [PMID: 22079433]
  • Gene Chi-Wai Man, William Wei-Jun Wang, Benson Hiu-Yan Yeung, Simon Kwong-Man Lee, Bobby Kin-Ah Ng, Wing-Yin Hung, Jack Ho Wong, Tzi-Bun Ng, Yong Qiu, Jack Chun-Yiu Cheng. Abnormal proliferation and differentiation of osteoblasts from girls with adolescent idiopathic scoliosis to melatonin. Journal of pineal research. 2010 Aug; 49(1):69-77. doi: 10.1111/j.1600-079x.2010.00768.x. [PMID: 20524972]
  • Flavia Radogna, Silvia Nuccitelli, Fabio Mengoni, Lina Ghibelli. Neuroprotection by melatonin on astrocytoma cell death. Annals of the New York Academy of Sciences. 2009 Aug; 1171(?):509-13. doi: 10.1111/j.1749-6632.2009.04900.x. [PMID: 19723097]
  • Shawon Lahiri, Pratibha Singh, Sarvesh Singh, Naila Rasheed, Gautam Palit, K K Pant. Melatonin protects against experimental reflux esophagitis. Journal of pineal research. 2009 Mar; 46(2):207-13. doi: 10.1111/j.1600-079x.2008.00650.x. [PMID: 19067786]
  • Alexander M Mathes, Darius Kubulus, Lina Waibel, Julia Weiler, Paul Heymann, Beate Wolf, Hauke Rensing. Selective activation of melatonin receptors with ramelteon improves liver function and hepatic perfusion after hemorrhagic shock in rat. Critical care medicine. 2008 Oct; 36(10):2863-70. doi: 10.1097/ccm.0b013e318187b863. [PMID: 18766086]
  • Flavia Radogna, Silvia Cristofanon, Laura Paternoster, Maria D'Alessio, Milena De Nicola, Claudia Cerella, Mario Dicato, Marc Diederich, Lina Ghibelli. Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2. Journal of pineal research. 2008 Apr; 44(3):316-25. doi: 10.1111/j.1600-079x.2007.00532.x. [PMID: 18339127]
  • Pura J Requintina, Gregory F Oxenkrug. Effect of luzindole and other melatonin receptor antagonists on iron- and lipopolysaccharide-induced lipid peroxidation in vitro. Annals of the New York Academy of Sciences. 2007 Dec; 1122(?):289-94. doi: 10.1196/annals.1403.021. [PMID: 18077581]
  • Flavia Radogna, Laura Paternoster, Maria Cristina Albertini, Claudia Cerella, Augusto Accorsi, Anahi Bucchini, Gilberto Spadoni, Giuseppe Diamantini, Giorgio Tarzia, Milena De Nicola, Maria D'Alessio, Lina Ghibelli. Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cells. Journal of pineal research. 2007 Sep; 43(2):154-62. doi: 10.1111/j.1600-079x.2007.00455.x. [PMID: 17645693]
  • Veronika Butterweck, Axel Brattstroem, Oliver Grundmann, Uwe Koetter. Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice. The Journal of pharmacy and pharmacology. 2007 Apr; 59(4):549-52. doi: 10.1211/jpp.59.4.0009. [PMID: 17430638]
  • Maria D Maldonado, Andrew W Siu, Marina Sánchez-Hidalgo, Dario Acuna-Castroviejo, Germaine Escames. Melatonin and lipid uptake by murine fibroblasts: clinical implications. Neuro endocrinology letters. 2006 Oct; 27(5):601-8. doi: ". [PMID: 17186997]
  • I C Sumaya, M I Masana, M L Dubocovich. The antidepressant-like effect of the melatonin receptor ligand luzindole in mice during forced swimming requires expression of MT2 but not MT1 melatonin receptors. Journal of pineal research. 2005 Sep; 39(2):170-7. doi: 10.1111/j.1600-079x.2005.00233.x. [PMID: 16098095]
  • Rafal A Derlacz, Piotr Poplawski, Malgorzata Napierala, Adam K Jagielski, Jadwiga Bryla. Melatonin-induced modulation of glucose metabolism in primary cultures of rabbit kidney-cortex tubules. Journal of pineal research. 2005 Apr; 38(3):164-9. doi: 10.1111/j.1600-079x.2004.00188.x. [PMID: 15725337]
  • Gabriel F Anhê, Luciana C Caperuto, Marcio Pereira-Da-Silva, Lilian C Souza, A Emiko Hirata, Lício A Velloso, José Cipolla-Neto, Carla R O Carvalho. In vivo activation of insulin receptor tyrosine kinase by melatonin in the rat hypothalamus. Journal of neurochemistry. 2004 Aug; 90(3):559-66. doi: 10.1111/j.1471-4159.2004.02514.x. [PMID: 15255933]
  • Jolanta Jaworek, Katarzyna Nawrot, Stanisław J Konturek, Anna Leja-Szpak, Piotr Thor, Wiesław W Pawlik. Melatonin and its precursor, L-tryptophan: influence on pancreatic amylase secretion in vivo and in vitro. Journal of pineal research. 2004 Apr; 36(3):155-64. doi: 10.1046/j.1600-079x.2003.00110.x. [PMID: 15009505]
  • P Montilla, M Feijóo, M C Muñoz, J R Muñoz-Castañeda, I Bujalance, I Túnez. Effect of melatonin on the oxidative stress in N1E-115 cells is not mediated by mt1 receptors. Journal of physiology and biochemistry. 2003 Dec; 59(4):263-8. doi: 10.1007/bf03179883. [PMID: 15164945]
  • J Jaworek, S J Konturek, A Leja-Szpak, K Nawrot, J Bonior, R Tomaszewska, J Stachura, W W Pawlik. Role of endogenous melatonin and its MT2 receptor in the modulation of caerulein-induced pancreatitis in the rat. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2002 Dec; 53(4 Pt 2):791-804. doi: NULL. [PMID: 12510864]
  • Iwona Brzozowska, Peter C Konturek, Tomasz Brzozowski, Stanislaw J Konturek, Slawomir Kwiecien, Robert Pajdo, Danuta Drozdowicz, Michal Pawlik, Agata Ptak, Eckhart G Hahn. Role of prostaglandins, nitric oxide, sensory nerves and gastrin in acceleration of ulcer healing by melatonin and its precursor, L-tryptophan. Journal of pineal research. 2002 Apr; 32(3):149-62. doi: 10.1034/j.1600-079x.2002.1o811.x. [PMID: 12074098]
  • A García-Pergañeda, J M Guerrero, M Rafii-El-Idrissi, M Paz Romero, D Pozo, J R Calvo. Characterization of membrane melatonin receptor in mouse peritoneal macrophages: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein. Journal of neuroimmunology. 1999 Mar; 95(1-2):85-94. doi: 10.1016/s0165-5728(98)00268-9. [PMID: 10229118]
  • S Conway, J E Drew, S J Canning, P Barrett, R Jockers, A D Strosberg, B Guardiola-Lemaitre, P Delagrange, P J Morgan. Identification of Mel1a melatonin receptors in the human embryonic kidney cell line HEK293: evidence of G protein-coupled melatonin receptors which do not mediate the inhibition of stimulated cyclic AMP levels. FEBS letters. 1997 Apr; 407(1):121-6. doi: 10.1016/s0014-5793(97)00315-3. [PMID: 9141494]