Lufironil (BioDeep_00000180559)

   

human metabolite blood metabolite


代谢物信息卡片


N2,N4-bis(2-methoxyethyl)pyridine-2,4-dicarboxamide

化学式: C13H19N3O4 (281.1375494)
中文名称: 鲁非罗尼
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COCCNC(=O)C1=CC(=NC=C1)C(=O)NCCOC
InChI: InChI=1S/C13H19N3O4/c1-19-7-5-15-12(17)10-3-4-14-11(9-10)13(18)16-6-8-20-2/h3-4,9H,5-8H2,1-2H3,(H,15,17)(H,16,18)

描述信息

C471 - Enzyme Inhibitor

同义名列表

5 个代谢物同义名

N2,N4-bis(2-methoxyethyl)pyridine-2,4-dicarboxamide; Pyridine-2,4-dicarboxylic-di-(2-methoxyethyl)amide; LUFIRONIL; HOE 077; HOE-077



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Y Matsumura, I Sakaida, K Uchida, T Kimura, T Ishihara, K Okita. Prolyl 4-hydroxylase inhibitor (HOE 077) inhibits pig serum-induced rat liver fibrosis by preventing stellate cell activation. Journal of hepatology. 1997 Jul; 27(1):185-92. doi: 10.1016/s0168-8278(97)80300-5. [PMID: 9252094]
  • I Sakaida, Y Matsumura, M Kubota, K Kayano, K Takenaka, K Okita. The prolyl 4-hydroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expression in rat liver fibrosis induced by choline-deficient L-amino acid-defined diet. Hepatology (Baltimore, Md.). 1996 Apr; 23(4):755-63. doi: 10.1053/jhep.1996.v23.pm0008666329. [PMID: 8666329]
  • I Sakaida, K Okita. New prolyl 4-hydroxylase inhibitor reduces procollagen gene expression and enzyme-altered lesions in rat liver cirrhosis. Journal of gastroenterology and hepatology. 1995; 10 Suppl 1(?):S63-4. doi: 10.1111/j.1440-1746.1995.tb01801.x. [PMID: 8589346]
  • E Baader, M Bickel, D Damm, H H Donaubauer, H W Fehlhaber, H Grötsch, V Günzler, V Teetz, M Volz. Interference in clinical laboratory tests, with special regard to the bilirubin assay: effects of a metabolite of the new prolyl 4-hydroxylase inhibitor, Lufironil. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. 1994 Jul; 32(7):515-20. doi: 10.1515/cclm.1994.32.7.515. [PMID: 7981331]
  • K Böker, G Schwarting, G Kaule, V Günzler, S Ohlendorf, E Schmidt. [Experimental studies of the inhibition of fibrogenesis]. Zeitschrift fur Gastroenterologie. 1992 Mar; 30 Suppl 1(?):43-5. doi: NULL. [PMID: 1333142]
  • H M Kellner, M Volz, E Badder, G U Kürzel, H G Eckert. Pharmacokinetics and metabolism of HOE 077. Preclinical studies. Journal of hepatology. 1991; 13 Suppl 3(?):S48-61; discussion S62. doi: 10.1016/0168-8278(91)90008-y. [PMID: 1667669]
  • K Böker, G Schwarting, G Kaule, V Günzler, E Schmidt. Fibrosis of the liver in rats induced by bile duct ligation. Effects of inhibition by prolyl 4-hydroxylase. Journal of hepatology. 1991; 13 Suppl 3(?):S35-40. doi: 10.1016/0168-8278(91)90006-w. [PMID: 1667667]
  • M Bickel, E Baader, D G Brocks, K Engelbart, V Günzler, H L Schmidts, G H Vogel. Beneficial effects of inhibitors of prolyl 4-hydroxylase in CCl4-induced fibrosis of the liver in rats. Journal of hepatology. 1991; 13 Suppl 3(?):S26-33; discussion S34. doi: 10.1016/0168-8278(91)90005-v. [PMID: 1667666]