Loureirin A (BioDeep_00000180541)

   

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)propan-1-one

化学式: C17H18O4 (286.1205028)
中文名称: 龙血素A
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC(=C(C=C1)CCC(=O)C2=CC=C(C=C2)O)OC
InChI: InChI=1S/C17H18O4/c1-20-15-9-5-13(17(11-15)21-2)6-10-16(19)12-3-7-14(18)8-4-12/h3-5,7-9,11,18H,6,10H2,1-2H3

描述信息

Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.
Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.
Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.

同义名列表

2 个代谢物同义名

3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)propan-1-one; Loureirin A



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zi-Yi Xia, Ling Liu, Chiu-Fai Kuok, Xue-Li Wang, Dan Shi, Quan Ma, Xiao-Yang Cheng, Guo-Li Wang, Min-Jing Li, Qiu-Sheng Zheng, Xiao-Na Liu, De-Fang Li, Bo-Han Li. Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways. Biological & pharmaceutical bulletin. 2024 Feb; 47(2):486-498. doi: 10.1248/bpb.b23-00415. [PMID: 38199251]
  • Mohammad Rafi Khezri, Donya Moloodsouri, Darya Hodaei, Morteza Ghasemnejad-Berenji. Therapeutic potential of loureirin A against SARS-CoV-2 infection. Phytotherapy research : PTR. 2022 08; 36(8):3011-3012. doi: 10.1002/ptr.7453. [PMID: 35355342]
  • Mei-Yu Lin, Zhong-Lan Yuan, Dan-Dan Hu, Gan-Hai Hu, Ri-Li Zhang, Hua Zhong, Lan Yan, Yuan-Ying Jiang, Juan Su, Yan Wang. Effect of loureirin A against Candida albicans biofilms. Chinese journal of natural medicines. 2019 Aug; 17(8):616-623. doi: 10.1016/s1875-5364(19)30064-0. [PMID: 31472899]
  • Jiachun Li, Dongpo Li, Youzhi Pan, Jun-Hua Hu, Wenzhe Huang, Zhen-Zhong Wang, Wei Xiao, Yu Wang. Simultaneous determination of ten bioactive constituents of Sanjie Zhentong Capsule in rat plasma by ultra-high-performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Jun; 1054(?):20-26. doi: 10.1016/j.jchromb.2017.03.001. [PMID: 28415020]
  • Xiaoshuang Chen, Gaofeng Li, Shangfang Ma, Xujia Hu. A Rapid Centrifugation-Assisted Solid-Phase Extraction and Liquid Chromatography Method for Determination of Loureirin A and Loureirin B of Dragon's Blood Capsules in Rat Plasma and Urine After Oral Administration. Journal of chromatographic science. 2015 Jul; 53(6):979-85. doi: 10.1093/chromsci/bmu209. [PMID: 25575508]
  • Xu Chen, Kai Qian, Qin Chen. Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin. European journal of medicinal chemistry. 2015 Mar; 93(?):492-500. doi: 10.1016/j.ejmech.2015.02.025. [PMID: 25734332]
  • Hong-Zhen Hao, Ao-Di He, Dao-Chun Wang, Zhao Yin, Ya-Jun Zhou, Gang Liu, Ming-Lu Liang, Xing-Wen Da, Guang-Qiang Yao, Wen Xie, Ji-Zhou Xiang, Zhang-Yin Ming. Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies. European journal of pharmacology. 2015 Jan; 746(?):63-9. doi: 10.1016/j.ejphar.2014.10.059. [PMID: 25445049]
  • Jin-Long Cui, Chun-Lan Wang, Shun-Xing Guo, Pei-Gen Xiao, Meng-Liang Wang. Stimulation of dragon's blood accumulation in Dracaena cambodiana via fungal inoculation. Fitoterapia. 2013 Jun; 87(?):31-6. doi: 10.1016/j.fitote.2013.03.012. [PMID: 23518260]
  • Haiyan Zhao, Zilin Chen. An HPLC-ESI-MS method for analysis of loureirin A and B in dragon's blood and application in pharmacokinetics and tissue distribution in rats. Fitoterapia. 2013 Apr; 86(?):149-58. doi: 10.1016/j.fitote.2013.02.012. [PMID: 23458829]
  • Xueying Yang, Xufang Hu, Fei Li, Xinghong Wang, Qiue Cao. [Determination of loureirin A and loureirin B in dragon's blood by capillary zone electrophoresis]. Se pu = Chinese journal of chromatography. 2012 May; 30(5):501-6. doi: 10.3724/sp.j.1123.2011.12006. [PMID: 22934414]
  • Yun Li, Wei Xiao, Jianping Qin, Ying Guo, Qianqian Zhu. [Simultaneous determination of five active components in resina draconis and its extract by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Apr; 37(7):929-33. doi: . [PMID: 22792791]
  • Yushi Zhang, Yongzhi Li, Bo Chen, Yulin Deng, Yujuan Li. Simultaneous quantification of loureirin A and loureirin B in rat urine, feces, and bile by HPLC-MS/MS method and its application to excretion study. Analytical and bioanalytical chemistry. 2011 May; 400(4):1181-7. doi: 10.1007/s00216-011-4868-8. [PMID: 21431828]
  • Xing-Hong Wang, Changhe Zhang, Ling-Ling Yang, José Gomes-Laranjo. Production of dragon's blood in Dracaena cochinchinensis plants by inoculation of Fusarium proliferatum. Plant science : an international journal of experimental plant biology. 2011 Feb; 180(2):292-9. doi: 10.1016/j.plantsci.2010.09.007. [PMID: 21421373]
  • Suresh Awale, Tatsuya Miyamoto, Thein Zaw Linn, Feng Li, Nwet Nwet Win, Yasuhiro Tezuka, Hiroyasu Esumi, Shigetoshi Kadota. Cytotoxic constituents of Soymida febrifuga from Myanmar. Journal of natural products. 2009 Sep; 72(9):1631-6. doi: 10.1021/np9003323. [PMID: 19689125]