LIPEGFILGRASTIM (BioDeep_00000180494)
human metabolite blood metabolite
代谢物信息卡片
2-({6-[(1-amino-1-carboxypropan-2-yl)oxy]-5-acetamido-3,4-dihydroxyoxan-2-yl}methoxy)-4-hydroxy-5-(2-{[(2-methoxyethoxy)carbonyl]amino}acetamido)-6-(1,2,3-trihydroxypropyl)oxane-2-carboxylic acid
化学式: C27H46N4O19 (730.2756125999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(C(=O)O)N)OC1C(C(C(C(O1)COC2(CC(C(C(O2)C(C(CO)O)O)NC(=O)CNC(=O)OCCOC)O)C(=O)O)O)O)NC(=O)C
InChI: InChI=1S/C27H46N4O19/c1-10(16(28)23(40)41)48-24-18(30-11(2)33)21(39)20(38)14(49-24)9-47-27(25(42)43)6-12(34)17(22(50-27)19(37)13(35)8-32)31-15(36)7-29-26(44)46-5-4-45-3/h10,12-14,16-22,24,32,34-35,37-39H,4-9,28H2,1-3H3,(H,29,44)(H,30,33)(H,31,36)(H,40,41)(H,42,43)
描述信息
L - Antineoplastic and immunomodulating agents > L03 - Immunostimulants > L03A - Immunostimulants > L03AA - Colony stimulating factors
D013501 - Surface-Active Agents > D011092 - Polyethylene Glycols
D001697 - Biomedical and Dental Materials
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Maria Nishimura, Midori Morita, Yuka Okuyama, Chise Matsui, Akira Watanabe, Erika Iguchi, Mie Oonishi, Rie Yasuoka, Koichi Sakaguchi, Tetsuya Taguchi. [A Case of Aortitis Caused by Pegfilgrastim Use during Neoadjuvant Chemotherapy for Treating Breast Cancer].
Gan to kagaku ryoho. Cancer & chemotherapy.
2022 May; 49(5):573-576. doi:
NULL. [PMID: 35578937] - Francesca Civoli, Barbara Finck, Helen Tang, Jennifer Hodge, Hillary O'Kelly, Vladimir Vexler. Biosimilar Pegfilgrastim-cbqv Demonstrated Similar Immunogenicity to Pegfilgrastim in Healthy Subjects Across Three Randomized Clinical Studies.
Advances in therapy.
2022 03; 39(3):1230-1246. doi:
10.1007/s12325-021-02024-x. [PMID: 35034311] - Vladan Vucinic, Madlen Jentzsch, Sabine Leiblein, Enrica Bach, Yvonne Remane, Kai Schulze-Forster, Michael Cross, Wolfram Pönisch, Sebastian Schwind, Georg-Nikolaus Franke, Uwe Platzbecker, Dietger Niederwieser. Stem-cell mobilization of healthy sibling donors with pegfilgrastim-A prospective open-label phase II trial (EudraCT no: 2005-004971-39).
Transfusion.
2022 01; 62(1):157-164. doi:
10.1111/trf.16761. [PMID: 34893987] - Sreekanth Gattu, Jessie Wang, Anne Bellon, Celine Schelcher, Roumen Nakov, Ramin Arani. Meta-analysis of Pharmacokinetic/Pharmacodynamic Results of 3 Phase 1 Studies with Biosimilar Pegfilgrastim.
Clinical pharmacology in drug development.
2021 10; 10(10):1130-1141. doi:
10.1002/cpdd.1005. [PMID: 34350732] - Chaoying Hu, Bingxin Ji, Xiao Hu, Cuicui Yang, Wanling Sun, Xiaowei Zhao, Lin Li, Xiaoying Li, Lan Zhang. Pharmacokinetics and Pharmacodynamics of Two Formulations of Pegylated Recombinant Human Granulocyte Colony-Stimulating Factor in Healthy Chinese Subjects: An Open-Label, Randomized, Parallel-Design Bioavailability Study.
Clinical pharmacology in drug development.
2021 03; 10(3):291-298. doi:
10.1002/cpdd.819. [PMID: 32567217] - Hillard M Lazarus, Robert Peter Gale. G-CSF and GM-CSF Are Different. Which One Is Better for COVID-19?.
Acta haematologica.
2021; 144(4):355-359. doi:
10.1159/000510352. [PMID: 32791509] - Inderjeet Singh, Anshul Attrey, Adarsh Garg, Ronak Patel, Vinu Jose. Single-Dose Pharmacokinetics, Pharmacodynamics and Immunogenicity, and Multiple-Dose Immunogenicity of INTP5 (Pegfilgrastim Biosimilar) Versus Reference Pegfilgrastim in Healthy Subjects.
Clinical drug investigation.
2021 Jan; 41(1):29-42. doi:
10.1007/s40261-020-00987-3. [PMID: 33236287] - John A Barrett, Jaehyuk Choi, Sribalaji Lakshmikanthan, Yu-Yon Kim, Douglas Greene, Prasad Kolli, Tae Hun Song, In Young Choi, Young Hoon Kim, Francois Lebel. Eflapegrastim's enhancement of efficacy compared with pegfilgrastim in neutropenic rats supports potential for same-day dosing.
Experimental hematology.
2020 12; 92(?):51-61. doi:
10.1016/j.exphem.2020.09.199. [PMID: 33002567] - Tao Xie, Hui Fang, Weiming Ouyang, Phillip Angart, Meng-Jung Chiang, Ashwinkumar A Bhirde, Faruk Sheikh, Patrick Lynch, Ankit B Shah, Sharadrao M Patil, Kang Chen, Meiyu Shen, Cyrus Agarabi, Raymond P Donnelly, Kurt Brorson, Sarah J Schrieber, Kristina E Howard, Sarah M Rogstad, David M Frucht. The ELISA Detectability and Potency of Pegfilgrastim Decrease in Physiological Conditions: Key Roles for Aggregation and Individual Variability.
Scientific reports.
2020 02; 10(1):2476. doi:
10.1038/s41598-020-59346-z. [PMID: 32051479] - Betre Legesse, Amandeep Kaur, Doreswamy Kenchegowda, Bernadette Hritzo, William E Culp, Maria Moroni. Neulasta Regimen for the Hematopoietic Acute Radiation Syndrome: Effects Beyond Neutrophil Recovery.
International journal of radiation oncology, biology, physics.
2019 03; 103(4):935-944. doi:
10.1016/j.ijrobp.2018.11.043. [PMID: 30496878] - Akira Kageyama, Yusuke Nakazawa, Naomi Ando, Dai Harada, Masaki Kitamura, Takashi Kawakubo, Koji Asano. [Identification of the Risk Factors for Cabazitaxel-Induced Neutropenia with Preventive Administration of Pegfilgrastim].
Gan to kagaku ryoho. Cancer & chemotherapy.
2019 Feb; 46(2):279-281. doi:
NULL. [PMID: 30914534] - Nicole L Watts, Marisa B Marques, Daniel B Peavey, Racquel Innis-Shelton, Ayman Saad, Stasi Ad, Donna Salzman, Lawrence S Lamb, Luciano J Costa. Mobilization of Hematopoietic Progenitor Cells for Autologous Transplantation Using Pegfilgrastim and Plerixafor: Efficacy and Cost Implications.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2019 02; 25(2):233-238. doi:
10.1016/j.bbmt.2018.09.005. [PMID: 30219699] - Roumen Nakov, Sreekanth Gattu, Jessie Wang, Maria Velinova, Gregor Schaffar, Andrej Skerjanec. Proposed biosimilar pegfilgrastim shows similarity in pharmacokinetics and pharmacodynamics to reference pegfilgrastim in healthy subjects.
British journal of clinical pharmacology.
2018 12; 84(12):2790-2801. doi:
10.1111/bcp.13731. [PMID: 30079636] - Hitomi Mori, Makoto Kubo, Masaya Kai, Kanako Kurata, Mai Yamada, Masafumi Nakamura. Efficacy and Safety of Bi-weekly Pegfilgrastim for Dose-dense Chemotherapy-induced Neutropenia in Breast Cancer Patients.
Anticancer research.
2018 Jul; 38(7):4381-4386. doi:
10.21873/anticanres.12740. [PMID: 29970577] - Mayumi Hatayama, Katsuya Ikuta, Masatomo Ishioh, Takeshi Saito, Yasumichi Toki, Masayo Yamamoto, Motohiro Shindo, Yoshihiro Torimoto, Toshikatsu Okumura. Pseudogout Attack after Pegfilgrastim Administration in Anaplastic Large Cell Lymphoma.
Internal medicine (Tokyo, Japan).
2018 Jun; 57(12):1779-1782. doi:
10.2169/internalmedicine.9362-17. [PMID: 29434148] - Cornelius F Waller, Renger G Tiessen, Tracey E Lawrence, Andrew Shaw, Mark Shiyao Liu, Rajiv Sharma, Mark Baczkowski, Mudgal A Kothekar, Catherine E Micales, Abhijit Barve, Gopinath M Ranganna, Eduardo J Pennella. A pharmacokinetics and pharmacodynamics equivalence trial of the proposed pegfilgrastim biosimilar, MYL-1401H, versus reference pegfilgrastim.
Journal of cancer research and clinical oncology.
2018 Jun; 144(6):1087-1095. doi:
10.1007/s00432-018-2643-3. [PMID: 29671069] - Sachi Morita, Toyone Kikumori, Nobuyuki Tsunoda, Takahiro Inaishi, Yayoi Adachi, Akiko Ota, Masahiro Shibata, Ayumu Matsuoka, Kenichi Nakanishi, Dai Takeuchi, Takefumi Mizutani, Tomoya Shimokata, Hironori Hayashi, Osamu Maeda, Yuichi Ando. Feasibility of dose-dense epirubicin and cyclophosphamide with subcutaneous pegfilgrastim 3.6 mg support: a single-center prospective study in Japan.
International journal of clinical oncology.
2018 Feb; 23(1):195-200. doi:
10.1007/s10147-017-1177-z. [PMID: 28791509] - Hatem Elabd, Rushi Nayak, Tarek Rashid, M Barry Stokes. The Case Acute kidney injury in a 78-year-old man with low-grade B-cell lymphoma.
Kidney international.
2018 01; 93(1):275-276. doi:
10.1016/j.kint.2017.07.001. [PMID: 29291825] - Jeffrey R Infante, Amita Patnaik, Claire F Verschraegen, Anthony J Olszanski, Montaser Shaheen, Howard A Burris, Anthony W Tolcher, Kyriakos P Papadopoulos, Muralidhar Beeram, Scott M Hynes, Jennifer Leohr, Aimee Bence Lin, Lily Q Li, Anna McGlothlin, Daphne L Farrington, Eric H Westin, Roger B Cohen. Two Phase 1 dose-escalation studies exploring multiple regimens of litronesib (LY2523355), an Eg5 inhibitor, in patients with advanced cancer.
Cancer chemotherapy and pharmacology.
2017 Feb; 79(2):315-326. doi:
10.1007/s00280-016-3205-5. [PMID: 28097385] - Arlene O Siefker-Radtke, Matthew T Campbell, Mark F Munsell, Deborah R Harris, Robert L Carolla, Lance C Pagliaro. Front-line Treatment with Gemcitabine, Paclitaxel, and Doxorubicin for Patients With Unresectable or Metastatic Urothelial Cancer and Poor Renal Function: Final Results from a Phase II Study.
Urology.
2016 Mar; 89(?):83-9. doi:
10.1016/j.urology.2015.12.007. [PMID: 26723185] - Oleg Gladkov, Vladimir Moiseyenko, Igor N Bondarenko, Yaroslav Shparyk, Steve Barash, Liat Adar, Noa Avisar. A Phase III Study of Balugrastim Versus Pegfilgrastim in Breast Cancer Patients Receiving Chemotherapy With Doxorubicin and Docetaxel.
The oncologist.
2016 Jan; 21(1):7-15. doi:
10.1634/theoncologist.2015-0152. [PMID: 26668251] - Oleg Gladkov, Vladimir Moiseyenko, Igor N Bondarenko, Yaroslav Shparyk, Steven Barash, Liat Adar, Peter Bias, Noa Avisar. Phase II dose-finding study of balugrastim in breast cancer patients receiving myelosuppressive chemotherapy.
Medical oncology (Northwood, London, England).
2015 Jun; 32(6):623. doi:
10.1007/s12032-015-0623-x. [PMID: 25966791] - Noa Avisar, Liat Adar, Jason Bock, Udo Müller, David Shen, Steve Barash, Laurie Pukac. First-in-human, phase I/IIa dose-escalation and safety study of balugrastim in breast cancer patients receiving myelosuppressive chemotherapy.
Cancer chemotherapy and pharmacology.
2015 May; 75(5):929-39. doi:
10.1007/s00280-015-2703-1. [PMID: 25740691] - Alena M Pfeil, Kim Allcott, Ruth Pettengell, Gunter von Minckwitz, Matthias Schwenkglenks, Zsolt Szabo. Efficacy, effectiveness and safety of long-acting granulocyte colony-stimulating factors for prophylaxis of chemotherapy-induced neutropenia in patients with cancer: a systematic review.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2015 Feb; 23(2):525-45. doi:
10.1007/s00520-014-2457-z. [PMID: 25284721] - Anton Buchner, Andreas Lammerich, Afsaneh Abdolzade-Bavil, Udo Müller, Peter Bias. Lipegfilgrastim: pharmacodynamics and pharmacokinetics for body-weight-adjusted and 6 mg fixed doses in two randomized studies in healthy volunteers.
Current medical research and opinion.
2014 Dec; 30(12):2523-33. doi:
10.1185/03007995.2014.962131. [PMID: 25251999] - Constantin Volovat, Oleg A Gladkov, Igor M Bondarenko, Steve Barash, Anton Buchner, Peter Bias, Liat Adar, Noa Avisar. Efficacy and safety of balugrastim compared with pegfilgrastim in patients with breast cancer receiving chemotherapy.
Clinical breast cancer.
2014 Apr; 14(2):101-8. doi:
10.1016/j.clbc.2013.10.001. [PMID: 24485296] - J Crown, M J Kennedy, P Tresca, M Marty, M Espie, H A Burris, M DeSilvio, M R Lau, D Kothari, K M Koch, V Diéras. Optimally tolerated dose of lapatinib in combination with docetaxel plus trastuzumab in first-line treatment of HER2-positive metastatic breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology.
2013 Aug; 24(8):2005-11. doi:
10.1093/annonc/mdt222. [PMID: 23878115] - Mar Llamas-Velasco, Patricia García-Martín, Javier Sánchez-Pérez, Javier Fraga, Amaro García-Diez. Sweet's syndrome with subcutaneous involvement associated with pegfilgrastim treatment: first reported case.
Journal of cutaneous pathology.
2013 Jan; 40(1):46-9. doi:
10.1111/cup.12042. [PMID: 23131080] - A M Farese, M V Cohen, R B Stead, W Jackson, T J Macvittie. Pegfilgrastim administered in an abbreviated schedule, significantly improved neutrophil recovery after high-dose radiation-induced myelosuppression in rhesus macaques.
Radiation research.
2012 Nov; 178(5):403-13. doi:
10.1667/rr2900.1. [PMID: 22991919] - Tobias Frank, Florian Klinker, Björn H Falkenburger, Rico Laage, Fred Lühder, Bettina Göricke, Armin Schneider, Hartmud Neurath, Herbert Desel, David Liebetanz, Mathias Bähr, Jochen H Weishaupt. Pegylated granulocyte colony-stimulating factor conveys long-term neuroprotection and improves functional outcome in a model of Parkinson's disease.
Brain : a journal of neurology.
2012 Jun; 135(Pt 6):1914-25. doi:
10.1093/brain/aws054. [PMID: 22427327] - Mitsunori Harada, Miho Ohuchi, Tatsuyuki Hayashi, Yasuki Kato. Prolonged circulation and in vivo efficacy of recombinant human granulocyte colony-stimulating factor encapsulated in polymeric micelles.
Journal of controlled release : official journal of the Controlled Release Society.
2011 Nov; 156(1):101-8. doi:
10.1016/j.jconrel.2011.06.024. [PMID: 21723892] - C Zwick, F Hartmann, S Zeynalova, V Pöschel, C Nickenig, M Reiser, E Lengfelder, N Peter, G Schlimok, J Schubert, N Schmitz, M Loeffler, M Pfreundschuh. Randomized comparison of pegfilgrastim day 4 versus day 2 for the prevention of chemotherapy-induced leukocytopenia.
Annals of oncology : official journal of the European Society for Medical Oncology.
2011 Aug; 22(8):1872-7. doi:
10.1093/annonc/mdq674. [PMID: 21292644] - Bing-Bing Yang, Anna Kido. Pharmacokinetics and pharmacodynamics of pegfilgrastim.
Clinical pharmacokinetics.
2011 May; 50(5):295-306. doi:
10.2165/11586040-000000000-00000. [PMID: 21456630] - Wolfgang Jelkmann. Biosimilar epoetins and other 'follow-on' biologics: update on the European experiences.
American journal of hematology.
2010 Oct; 85(10):771-80. doi:
10.1002/ajh.21805. [PMID: 20706990] - M Scholz, C Engel, D Apt, S L Sankar, E Goldstein, M Loeffler. Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony-stimulating factor derivative Maxy-G34 and pegfilgrastim in rats.
Cell proliferation.
2009 Dec; 42(6):823-37. doi:
10.1111/j.1365-2184.2009.00641.x. [PMID: 19780759] - M Scholz, M Ackermann, C Engel, F Emmrich, M Loeffler, M Kamprad. A pharmacokinetic model of filgrastim and pegfilgrastim application in normal mice and those with cyclophosphamide-induced granulocytopaenia.
Cell proliferation.
2009 Dec; 42(6):813-22. doi:
10.1111/j.1365-2184.2009.00638.x. [PMID: 19689472] - Nobuyuki Yamamoto, Ikuo Sekine, Kazuhiko Nakagawa, Minoru Takada, Masahiro Fukuoka, Yusuke Tanigawara, Nagahiro Saijo. A pharmacokinetic and dose escalation study of pegfilgrastim (KRN125) in lung cancer patients with chemotherapy-induced neutropenia.
Japanese journal of clinical oncology.
2009 Jul; 39(7):425-30. doi:
10.1093/jjco/hyp038. [PMID: 19395467] - G Kobbe, I Bruns, R Fenk, A Czibere, R Haas. Pegfilgrastim for PBSC mobilization and autologous haematopoietic SCT.
Bone marrow transplantation.
2009 May; 43(9):669-77. doi:
10.1038/bmt.2009.59. [PMID: 19308043] - Emilie Milano-Bausset, Jean Gaudart, Angelique Rome, Carole Coze, Jean Claude Gentet, Laetitia Padovani, Bruno Lacarelle, Nicolas André. Retrospective comparison of neutropenia in children with Ewing sarcoma treated with chemotherapy and granulocyte colony-stimulating factor (G-CSF) or pegylated G-CSF.
Clinical therapeutics.
2009; 31 Pt 2(?):2388-95. doi:
10.1016/j.clinthera.2009.11.013. [PMID: 20110048] - Bing-Bing Yang, Anna Kido, Margaret Salfi, Suzanne Swan, John T Sullivan. Pharmacokinetics and pharmacodynamics of pegfilgrastim in subjects with various degrees of renal function.
Journal of clinical pharmacology.
2008 Sep; 48(9):1025-31. doi:
10.1177/0091270008320318. [PMID: 18524995] - Patricia M LoRusso, Suzanne F Jones, Kevin M Koch, Nikita Arya, Ronald A Fleming, Jill Loftiss, Lini Pandite, Shirish Gadgeel, Barbara L Weber, Howard A Burris. Phase I and pharmacokinetic study of lapatinib and docetaxel in patients with advanced cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2008 Jun; 26(18):3051-6. doi:
10.1200/jco.2007.14.9633. [PMID: 18565892] - Frank Kroschinsky, Kristina Hölig, Gerhard Ehninger. The role of pegfilgrastim in mobilization of hematopoietic stem cells.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2008 Jun; 38(3):237-44. doi:
10.1016/j.transci.2008.04.007. [PMID: 18490197] - Bing-Bing Yang, Anna Kido, Atsuko Shibata. Serum pegfilgrastim concentrations during recovery of absolute neutrophil count in patients with cancer receiving pegfilgrastim after chemotherapy.
Pharmacotherapy.
2007 Oct; 27(10):1387-93. doi:
10.1592/phco.27.10.1387. [PMID: 17896894] - Ulrich J M Mey, Anna Maier, Ingo G H Schmidt-Wolf, Carsten Ziske, Helmut Forstbauer, Gamal-Andre Banat, Michael Reber, John W Strehl, Marcus Gorschlueter. Pegfilgrastim as hematopoietic support for dose-dense chemoimmunotherapy with R-CHOP-14 as first-line therapy in elderly patients with diffuse large B cell lymphoma.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2007 Jul; 15(7):877-84. doi:
10.1007/s00520-006-0201-z. [PMID: 17235504] - Daniel Ribeiro, Marlon R Veldwijk, Axel Benner, Stephanie Laufs, Frederik Wenz, Anthony D Ho, Stefan Fruehauf. Differences in functional activity and antigen expression of granulocytes primed in vivo with filgrastim, lenograstim, or pegfilgrastim.
Transfusion.
2007 Jun; 47(6):969-80. doi:
10.1111/j.1537-2995.2007.01241.x. [PMID: 17524085] - Roland Fenk, Nadine Hieronimus, Ulrich Steidl, Ingmar Bruns, Thorsten Graef, Fabian Zohren, Leilani Ruf, Rainer Haas, Guido Kobbe. Sustained G-CSF plasma levels following administration of pegfilgrastim fasten neutrophil reconstitution after high-dose chemotherapy and autologous blood stem cell transplantation in patients with multiple myeloma.
Experimental hematology.
2006 Oct; 34(10):1296-302. doi:
10.1016/j.exphem.2006.06.002. [PMID: 16982322] - Gerald Wendelin, Herwig Lackner, Wolfgang Schwinger, Petra Sovinz, Christian Urban. Once-per-cycle pegfilgrastim versus daily filgrastim in pediatric patients with Ewing sarcoma.
Journal of pediatric hematology/oncology.
2005 Aug; 27(8):449-51. doi:
10.1097/01.mph.0000175711.73039.63. [PMID: 16096530] - A-R Waladkhani. Pegfilgrastim: a recent advance in the prophylaxis of chemotherapy-induced neutropenia.
European journal of cancer care.
2004 Sep; 13(4):371-9. doi:
10.1111/j.1365-2354.2004.00503.x. [PMID: 15305906] - G Molineux. The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta).
Current pharmaceutical design.
2004; 10(11):1235-44. doi:
10.2174/1381612043452613. [PMID: 15078138] - S George, F Yunus, D Case, B B Yang, J Hackett, J E Shogan, L A Meza, T A Neumann, B C Liang. Fixed-dose pegfilgrastim is safe and allows neutrophil recovery in patients with non-Hodgkin's lymphoma.
Leukemia & lymphoma.
2003 Oct; 44(10):1691-6. doi:
10.1080/1042819031000063462. [PMID: 14692520] - Andrew Grigg, Philippe Solal-Celigny, Peter Hoskin, Kerry Taylor, Andrew McMillan, Roswitha Forstpointner, Pamela Bacon, Jennifer Renwick, Wolfgang Hiddemann. Open-label, randomized study of pegfilgrastim vs. daily filgrastim as an adjunct to chemotherapy in elderly patients with non-Hodgkin's lymphoma.
Leukemia & lymphoma.
2003 Sep; 44(9):1503-8. doi:
10.1080/1042819031000103953. [PMID: 14565651] - A M Farese, B-B Yang, L Roskos, R B Stead, T J MacVittie. Pegfilgrastim, a sustained-duration form of filgrastim, significantly improves neutrophil recovery after autologous marrow transplantation in rhesus macaques.
Bone marrow transplantation.
2003 Aug; 32(4):399-404. doi:
10.1038/sj.bmt.1704156. [PMID: 12900776] - Graham Molineux. Pegylation: engineering improved biopharmaceuticals for oncology.
Pharmacotherapy.
2003 Aug; 23(8 Pt 2):3S-8S. doi:
10.1592/phco.23.9.3s.32886. [PMID: 12921216] - Graham Molineux. Pegfilgrastim: using pegylation technology to improve neutropenia support in cancer patients.
Anti-cancer drugs.
2003 Apr; 14(4):259-64. doi:
10.1097/00001813-200304000-00002. [PMID: 12679729] - J M Vose, M Crump, H Lazarus, C Emmanouilides, D Schenkein, J Moore, S Frankel, I Flinn, W Lovelace, J Hackett, B C Liang. Randomized, multicenter, open-label study of pegfilgrastim compared with daily filgrastim after chemotherapy for lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2003 Feb; 21(3):514-9. doi:
10.1200/jco.2003.03.040. [PMID: 12560443] - Jeffrey Crawford. Neutrophil growth factors.
Current hematology reports.
2002 Nov; 1(2):95-102. doi:
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Annals of oncology : official journal of the European Society for Medical Oncology.
2002 Jun; 13(6):903-9. doi:
10.1093/annonc/mdf130. [PMID: 12123336] - Monique P Curran, Karen L Goa. Pegfilgrastim.
Drugs.
2002; 62(8):1207-13; discussion 1214. doi:
10.2165/00003495-200262080-00012. [PMID: 12010086] - Jeffrey Crawford. Pegfilgrastim administered once per cycle reduces incidence of chemotherapy-induced neutropenia.
Drugs.
2002; 62 Suppl 1(?):89-98. doi:
10.2165/00003495-200262001-00007. [PMID: 12479597] - E Johnston, J Crawford, S Blackwell, T Bjurstrom, P Lockbaum, L Roskos, B B Yang, S Gardner, M A Miller-Messana, D Shoemaker, J Garst, G Schwab. Randomized, dose-escalation study of SD/01 compared with daily filgrastim in patients receiving chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2000 Jul; 18(13):2522-8. doi:
10.1200/jco.2000.18.13.2522. [PMID: 10893282]