levo-tetrahydropalmatine (BioDeep_00000180449)
human metabolite blood metabolite
代谢物信息卡片
化学式: C19H21NO2 (295.1572206)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C2=C(CC3C4=CC=CC=C4CCN3C2)C=C1)OC
InChI: InChI=1S/C19H21NO2/c1-21-18-8-7-14-11-17-15-6-4-3-5-13(15)9-10-20(17)12-16(14)19(18)22-2/h3-8,17H,9-12H2,1-2H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Lian-Zhi Cheng, Jia-Mei Zhou, Jun-Long Ma, Fan-Jing Wang, Kai Cheng, Qian Chen, Hui-Lun Yuan, Ai-Juan Jiang. [Tetrahydropalmatine alleviated diabetic neuropathic pain by inhibiting activation of microglia via p38 MAPK signaling pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 May; 47(9):2533-2540. doi:
10.19540/j.cnki.cjcmm.20220119.702
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Toxicology.
2021 07; 459(?):152853. doi:
10.1016/j.tox.2021.152853
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Biomedical chromatography : BMC.
2020 Sep; 34(9):e4866. doi:
10.1002/bmc.4866
. [PMID: 32330998] - Cui Li, Liping Li, Yaodong Yi, Wei Wang, Jingqun Yuan, Fuqing Tan, Danbo Fang, Su Zeng, Hui Zhou, Huidi Jiang. L-tetrahydropalmatine attenuates cisplatin-induced nephrotoxicity via selective inhibition of organic cation transporter 2 without impairing its antitumor efficacy.
Biochemical pharmacology.
2020 07; 177(?):114021. doi:
10.1016/j.bcp.2020.114021
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The Journal of international medical research.
2020 Jun; 48(6):300060519889430. doi:
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BioMed research international.
2020; 2020(?):9259683. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Feb; 53(?):53-61. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2019 Jan; 49(1):80-89. doi:
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Medical science monitor : international medical journal of experimental and clinical research.
2018 Sep; 24(?):6564-6572. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
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Mediators of inflammation.
2018; 2018(?):4032484. doi:
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Biomedical chromatography : BMC.
2017 Jun; 31(6):. doi:
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Chemico-biological interactions.
2017 Apr; 268(?):47-52. doi:
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Biomedical chromatography : BMC.
2017 Apr; 31(4):. doi:
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Molecules (Basel, Switzerland).
2016 Dec; 21(12):. doi:
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Journal of pharmaceutical and biomedical analysis.
2016 Sep; 128(?):371-381. doi:
10.1016/j.jpba.2016.06.015
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British journal of pharmacology.
2016 08; 173(16):2543-54. doi:
10.1111/bph.13537
. [PMID: 27324234] - Yong Zhao, Aihua Liang, Yushi Zhang, Chunying Li, Yan Yi, Odd Georg Nilsen. Impact of Tetrahydropalmatine on the Pharmacokinetics of Probe Drugs for CYP1A2, 2D6 and 3A Isoenzymes in Beagle Dogs.
Phytotherapy research : PTR.
2016 Jun; 30(6):906-14. doi:
10.1002/ptr.5608
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jan; 1008(?):81-86. doi:
10.1016/j.jchromb.2015.11.033
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Chirality.
2015 Aug; 27(8):551-6. doi:
10.1002/chir.22469
. [PMID: 26032585] - Ji Won Jung, Yong Sam Kwon, Jin Seok Jeong, Miwon Son, Hee Eun Kang. Pharmacokinetics and brain distribution of tetrahydropalmatine and tetrahydroberberine after oral administration of DA-9701, a new botanical gastroprokinetic agent, in rats.
Biological & pharmaceutical bulletin.
2015; 38(2):285-91. doi:
10.1248/bpb.b14-00678
. [PMID: 25747988] - Xiurong Zhang, Jiao Guan, Heyun Zhu, Tingting Niu. Simultaneous determination of scutellarin and tetrahydropalmatine of Deng-yan granule in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Nov; 971(?):126-32. doi:
10.1016/j.jchromb.2014.09.026
. [PMID: 25289789] - Mingming Yu, Hazem E Hassan, Ahmed Ibrahim, Kenneth S Bauer, Deanna L Kelly, Jia Bei Wang. Simultaneous determination of L-tetrahydropalmatine and cocaine in human plasma by simple UPLC-FLD method: application in clinical studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Aug; 965(?):39-44. doi:
10.1016/j.jchromb.2014.06.020
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jul; 962(?):75-81. doi:
10.1016/j.jchromb.2014.05.032
. [PMID: 24907546] - Yinying Zhang, Xin Dong, Jian Le, Jun Wen, Zebin Lin, Yinli Liu, Ziyang Lou, Yifeng Chai, Zhanying Hong. A practical strategy for characterization of the metabolic profile of chiral drugs using combinatory liquid chromatography-mass spectrometric techniques: application to tetrahydropalmatine enantiomers and their metabolites in rat urine.
Journal of pharmaceutical and biomedical analysis.
2014 Jun; 94(?):152-62. doi:
10.1016/j.jpba.2014.01.045
. [PMID: 24598170] - Yuan-yuan Lin, Yin-ping Wang, Hao-yang Lu, Xiu-cai Guo, Xia Liu, Chuan-bin Wu, Yue-hong Xu. Plasma pharmacokinetics and lung distribution of tetrahydropalmatine after topical application of cold asthma recipe extract: Feishu (BL 13) versus Non-Feishu acupoint.
Journal of ethnopharmacology.
2014 Apr; 153(2):454-60. doi:
10.1016/j.jep.2014.03.009
. [PMID: 24632014] - Weibin Xiao, Xiaomei Zhuang, Guolin Shen, Yuhuan Zhong, Mei Yuan, Hua Li. Simultaneous quantification of L-tetrahydropalmatine and its urine metabolites by ultra high performance liquid chromatography with tandem mass spectrometry.
Journal of separation science.
2014 Mar; 37(6):696-703. doi:
10.1002/jssc.201301352
. [PMID: 24453165] - Qing Tang, Fanghong Shang, Xiaocui Wang, Yang Yang, Gang Chen, Yi Chen, Jifen Zhang, Xiaoyu Xu. Combination use of ferulic acid, ligustrazine and tetrahydropalmatine inhibits the growth of ectopic endometrial tissue: a multi-target therapy for endometriosis rats.
Journal of ethnopharmacology.
2014 Feb; 151(3):1218-1225. doi:
10.1016/j.jep.2013.12.047
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Drug and alcohol dependence.
2013 Dec; 133(2):693-703. doi:
10.1016/j.drugalcdep.2013.08.021
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Journal of pharmaceutical and biomedical analysis.
2013 Jan; 72(?):80-8. doi:
10.1016/j.jpba.2012.09.001
. [PMID: 23146230] - Siyuan Sun, Zhongjian Chen, Liping Li, Dongli Sun, Ye Tian, Hao Pan, Huichang Bi, Min Huang, Su Zeng, Huidi Jiang. The two enantiomers of tetrahydropalmatine are inhibitors of P-gp, but not inhibitors of MRP1 or BCRP.
Xenobiotica; the fate of foreign compounds in biological systems.
2012 Dec; 42(12):1197-205. doi:
10.3109/00498254.2012.702247
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Biomedical chromatography : BMC.
2012 Jun; 26(6):749-53. doi:
10.1002/bmc.1724
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Molecules (Basel, Switzerland).
2012 Jan; 17(1):951-70. doi:
10.3390/molecules17010951
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PloS one.
2012; 7(6):e38627. doi:
10.1371/journal.pone.0038627
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European journal of drug metabolism and pharmacokinetics.
2011 Dec; 36(4):257-62. doi:
10.1007/s13318-011-0045-x
. [PMID: 21633914] - Mingyong Zhang, Jian Le, Jun Wen, Yifeng Chai, Guorong Fan, Zhanying Hong. Simultaneous determination of tetrahydropalmatine and tetrahydroberberine in rat urine using dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography.
Journal of separation science.
2011 Nov; 34(22):3279-86. doi:
10.1002/jssc.201100588
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Chirality.
2010 Jun; 22(6):618-23. doi:
10.1002/chir.20808
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Journal of ethnopharmacology.
2010 May; 129(1):115-20. doi:
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Chirality.
2010 Mar; 22(3):355-60. doi:
10.1002/chir.20750
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Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2010 Feb; 33(2):246-9. doi:
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2009 Jun; 44(6):645-50. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2009 May; 34(10):1276-80. doi:
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Journal of pharmaceutical and biomedical analysis.
2009 Feb; 49(2):440-6. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Mar; 863(2):195-205. doi:
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Chirality.
2008 Feb; 20(2):119-24. doi:
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Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
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Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
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Biopharmaceutics & drug disposition.
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
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Chirality.
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