levo-tetrahydropalmatine (BioDeep_00000180449)

   

human metabolite blood metabolite


代谢物信息卡片


9,10-Dimethoxy-5,6,13,13a-tetrahydro-8H-dibenzo[a,g]quinolizine

化学式: C19H21NO2 (295.1572206)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C2=C(CC3C4=CC=CC=C4CCN3C2)C=C1)OC
InChI: InChI=1S/C19H21NO2/c1-21-18-8-7-14-11-17-15-6-4-3-5-13(15)9-10-20(17)12-16(14)19(18)22-2/h3-8,17H,9-12H2,1-2H3



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Lian-Zhi Cheng, Jia-Mei Zhou, Jun-Long Ma, Fan-Jing Wang, Kai Cheng, Qian Chen, Hui-Lun Yuan, Ai-Juan Jiang. [Tetrahydropalmatine alleviated diabetic neuropathic pain by inhibiting activation of microglia via p38 MAPK signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 May; 47(9):2533-2540. doi: 10.19540/j.cnki.cjcmm.20220119.702. [PMID: 35531701]
  • Yaodong Yi, Liping Li, Feifeng Song, Ping Li, Mingyang Chen, Shixin Ni, Hengbin Zhang, Hui Zhou, Su Zeng, Huidi Jiang. L-tetrahydropalmatine reduces oxaliplatin accumulation in the dorsal root ganglion and mitochondria through selectively inhibiting the transporter-mediated uptake thereby attenuates peripheral neurotoxicity. Toxicology. 2021 07; 459(?):152853. doi: 10.1016/j.tox.2021.152853. [PMID: 34252480]
  • Yajie Deng, Xianhui Li, Wei Xiao, Zhenzhong Wang, Zhili Xiong, Longshan Zhao. UPLC-MS/MS simultaneous determination of seven active ingredients of Yaobitong capsule in rat plasma and its integrated pharmacokinetic application. Biomedical chromatography : BMC. 2020 Sep; 34(9):e4866. doi: 10.1002/bmc.4866. [PMID: 32330998]
  • Cui Li, Liping Li, Yaodong Yi, Wei Wang, Jingqun Yuan, Fuqing Tan, Danbo Fang, Su Zeng, Hui Zhou, Huidi Jiang. L-tetrahydropalmatine attenuates cisplatin-induced nephrotoxicity via selective inhibition of organic cation transporter 2 without impairing its antitumor efficacy. Biochemical pharmacology. 2020 07; 177(?):114021. doi: 10.1016/j.bcp.2020.114021. [PMID: 32389634]
  • Lin Zhi, Shangqi Yang, Jiekun Chen, Yuli Lu, Jiahong Chen, Zixi Qin, Xiao-Mei Tang. Tetrahydropalmatine has a therapeutic effect in a lipopolysaccharide-induced disseminated intravascular coagulation model. The Journal of international medical research. 2020 Jun; 48(6):300060519889430. doi: 10.1177/0300060519889430. [PMID: 31830839]
  • Yan Du, Hongliang Su, Jie Cao, Zhiwen Wei, Yujin Wang, Keming Yun. Pharmacokinetic Effects of l-Tetrahydropalmatine on Ketamine in Rat Plasma by Ultraperformance Liquid Chromatography Tandem Mass Spectrometry. BioMed research international. 2020; 2020(?):9259683. doi: 10.1155/2020/9259683. [PMID: 32724819]
  • Wang Ping, Zhang Tinglan, Yu Guohua, Li Mengjie, Su Jin, Zhang Jiaqi, Li Ke, Fu Yan, Xu Haiyu, Yang Hongjun. Poly-pharmacokinetic strategy-delineated metabolic fate of bioactive compounds in a traditional Chinese medicine formula, Yuanhu Zhitong tablets, using parallel reaction monitoring mode. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Feb; 53(?):53-61. doi: 10.1016/j.phymed.2018.09.026. [PMID: 30668412]
  • Liwei Chai, Paul Owusu Donkor, Kun Wang, Yingjie Sun, Mahmood Brobbey Oppong, Kai Wang, Liqin Ding, Feng Qiu. Metabolic profiles of corydaline in rats by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Xenobiotica; the fate of foreign compounds in biological systems. 2019 Jan; 49(1):80-89. doi: 10.1080/00498254.2017.1416207. [PMID: 29235899]
  • Caihua Sun, Zhiyun Chen, Hui Wang, Ke Ding. Tetrahydropalmatine Prevents High-Fat Diet-Induced Hyperlipidemia in Golden Hamsters (Mesocricetus Auratus). Medical science monitor : international medical journal of experimental and clinical research. 2018 Sep; 24(?):6564-6572. doi: 10.12659/msm.910578. [PMID: 30226834]
  • Hongbing Zhang, Xin Wu, Jun Xu, Suxiao Gong, Yanqi Han, Tiejun Zhang, Changxiao Liu. The comparative pharmacokinetic study of Yuanhu Zhitong prescription based on five quality-markers. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 May; 44(?):148-154. doi: 10.1016/j.phymed.2018.02.005. [PMID: 29523382]
  • Qiang Yu, Tong Liu, Sainan Li, Jiao Feng, Liwei Wu, Wenwen Wang, Kan Chen, Yujing Xia, Peiqin Niu, Ling Xu, Fan Wang, Weiqi Dai, Yingqun Zhou, Chuanyong Guo. The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling. Mediators of inflammation. 2018; 2018(?):4032484. doi: 10.1155/2018/4032484. [PMID: 30622431]
  • Weihui Wang, Jing Liu, Xiaoning Zhao, Yan Peng, Nannan Wang, David Y W Lee, Ronghua Dai. Simultaneous determination of l-tetrahydropalmatine and its active metabolites in rat plasma by a sensitive ultra-high-performance liquid chromatography with tandem mass spectrometry method and its application in a pharmacokinetic study. Biomedical chromatography : BMC. 2017 Jun; 31(6):. doi: 10.1002/bmc.3903. [PMID: 27868218]
  • Dujun Wang, Kai Wang, Danjuan Sui, Zhen Ouyang, Haiyu Xu, Yuan Wei. Effects of tetrahydroberberine and tetrahydropalmatine on hepatic cytochrome P450 expression and their toxicity in mice. Chemico-biological interactions. 2017 Apr; 268(?):47-52. doi: 10.1016/j.cbi.2017.02.019. [PMID: 28257954]
  • Inas A Abdallah, Peng Huang, Jing Liu, David Y Lee, Lee-Yuan Liu-Chen, Hazem E Hassan. Development and validation of a high performance liquid chromatography quantification method of levo-tetrahydropalmatine and its metabolites in plasma and brain tissues: application to a pharmacokinetic study. Biomedical chromatography : BMC. 2017 Apr; 31(4):. doi: 10.1002/bmc.3850. [PMID: 27606501]
  • Jian Wu, Ying Xie, Zheng Xiang, Canjian Wang, Hua Zhou, Liang Liu. Simultaneous Determination of Multiple Components in Guanjiekang in Rat Plasma via the UPLC-MS/MS Method and Its Application in Pharmacokinetic Study. Molecules (Basel, Switzerland). 2016 Dec; 21(12):. doi: 10.3390/molecules21121732. [PMID: 27999285]
  • Weibin Xiao, Guolin Shen, Xiaomei Zhuang, Xiaorong Ran, Mingshe Zhu, Hua Li. Characterization of human metabolism and disposition of levo-tetrahydropalmatine: Qualitative and quantitative determination of oxidative and conjugated metabolites. Journal of pharmaceutical and biomedical analysis. 2016 Sep; 128(?):371-381. doi: 10.1016/j.jpba.2016.06.015. [PMID: 27343900]
  • L P Li, F F Song, Y Y Weng, X Yang, K Wang, H M Lei, J Ma, H Zhou, H D Jiang. Role of OCT2 and MATE1 in renal disposition and toxicity of nitidine chloride. British journal of pharmacology. 2016 08; 173(16):2543-54. doi: 10.1111/bph.13537. [PMID: 27324234]
  • Yong Zhao, Aihua Liang, Yushi Zhang, Chunying Li, Yan Yi, Odd Georg Nilsen. Impact of Tetrahydropalmatine on the Pharmacokinetics of Probe Drugs for CYP1A2, 2D6 and 3A Isoenzymes in Beagle Dogs. Phytotherapy research : PTR. 2016 Jun; 30(6):906-14. doi: 10.1002/ptr.5608. [PMID: 26990021]
  • Son Cao Tran, Nguyen Dinh Duc, Nguyen-Thach Tung. Pharmacokinetic analysis of levo-tetrahydropalmatine in rabbit plasma by rapid sample preparation and liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jan; 1008(?):81-86. doi: 10.1016/j.jchromb.2015.11.033. [PMID: 26638032]
  • Wuhong Li, Liang Zhao, Jian Le, Yinying Zhang, Yinli Liu, Guoqing Zhang, Yifeng Chai, Zhanying Hong. Evaluation of Tetrahydropalmatine Enantiomers on the Activity of Five Cytochrome P450 Isozymes in Rats Using a Liquid Chromatography / Mass Spectrometric Method and a Cocktail Approach. Chirality. 2015 Aug; 27(8):551-6. doi: 10.1002/chir.22469. [PMID: 26032585]
  • Ji Won Jung, Yong Sam Kwon, Jin Seok Jeong, Miwon Son, Hee Eun Kang. Pharmacokinetics and brain distribution of tetrahydropalmatine and tetrahydroberberine after oral administration of DA-9701, a new botanical gastroprokinetic agent, in rats. Biological & pharmaceutical bulletin. 2015; 38(2):285-91. doi: 10.1248/bpb.b14-00678. [PMID: 25747988]
  • Xiurong Zhang, Jiao Guan, Heyun Zhu, Tingting Niu. Simultaneous determination of scutellarin and tetrahydropalmatine of Deng-yan granule in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Nov; 971(?):126-32. doi: 10.1016/j.jchromb.2014.09.026. [PMID: 25289789]
  • Mingming Yu, Hazem E Hassan, Ahmed Ibrahim, Kenneth S Bauer, Deanna L Kelly, Jia Bei Wang. Simultaneous determination of L-tetrahydropalmatine and cocaine in human plasma by simple UPLC-FLD method: application in clinical studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Aug; 965(?):39-44. doi: 10.1016/j.jchromb.2014.06.020. [PMID: 24996068]
  • Xiaochen Huang, Shulan Su, Wenxia Cui, Pei Liu, Jin-Ao Duan, Jianming Guo, Zhenhao Li, Erxin Shang, Dawei Qian, Zhijun Huang. Simultaneous determination of paeoniflorin, albiflorin, ferulic acid, tetrahydropalmatine, protopine, typhaneoside, senkyunolide I in Beagle dogs plasma by UPLC-MS/MS and its application to a pharmacokinetic study after Oral Administration of Shaofu Zhuyu Decoction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Jul; 962(?):75-81. doi: 10.1016/j.jchromb.2014.05.032. [PMID: 24907546]
  • Yinying Zhang, Xin Dong, Jian Le, Jun Wen, Zebin Lin, Yinli Liu, Ziyang Lou, Yifeng Chai, Zhanying Hong. A practical strategy for characterization of the metabolic profile of chiral drugs using combinatory liquid chromatography-mass spectrometric techniques: application to tetrahydropalmatine enantiomers and their metabolites in rat urine. Journal of pharmaceutical and biomedical analysis. 2014 Jun; 94(?):152-62. doi: 10.1016/j.jpba.2014.01.045. [PMID: 24598170]
  • Yuan-yuan Lin, Yin-ping Wang, Hao-yang Lu, Xiu-cai Guo, Xia Liu, Chuan-bin Wu, Yue-hong Xu. Plasma pharmacokinetics and lung distribution of tetrahydropalmatine after topical application of cold asthma recipe extract: Feishu (BL 13) versus Non-Feishu acupoint. Journal of ethnopharmacology. 2014 Apr; 153(2):454-60. doi: 10.1016/j.jep.2014.03.009. [PMID: 24632014]
  • Weibin Xiao, Xiaomei Zhuang, Guolin Shen, Yuhuan Zhong, Mei Yuan, Hua Li. Simultaneous quantification of L-tetrahydropalmatine and its urine metabolites by ultra high performance liquid chromatography with tandem mass spectrometry. Journal of separation science. 2014 Mar; 37(6):696-703. doi: 10.1002/jssc.201301352. [PMID: 24453165]
  • Qing Tang, Fanghong Shang, Xiaocui Wang, Yang Yang, Gang Chen, Yi Chen, Jifen Zhang, Xiaoyu Xu. Combination use of ferulic acid, ligustrazine and tetrahydropalmatine inhibits the growth of ectopic endometrial tissue: a multi-target therapy for endometriosis rats. Journal of ethnopharmacology. 2014 Feb; 151(3):1218-1225. doi: 10.1016/j.jep.2013.12.047. [PMID: 24389027]
  • Wei Xu, Yujun Wang, Zhongze Ma, Yi-Ting Chiu, Peng Huang, Khampaseuth Rasakham, Ellen Unterwald, David Y-W Lee, Lee-Yuan Liu-Chen. L-isocorypalmine reduces behavioral sensitization and rewarding effects of cocaine in mice by acting on dopamine receptors. Drug and alcohol dependence. 2013 Dec; 133(2):693-703. doi: 10.1016/j.drugalcdep.2013.08.021. [PMID: 24080315]
  • Shuping Wang, Lei Liu, Lingling Wang, Peng Jiang, Li Xiang, Weidong Zhang, Runhui Liu. Development and validation of liquid chromatography-tandem mass spectrometry method for simultaneous determination of four tertiary alkaloids in rat plasma and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2013 Jan; 72(?):80-8. doi: 10.1016/j.jpba.2012.09.001. [PMID: 23146230]
  • Siyuan Sun, Zhongjian Chen, Liping Li, Dongli Sun, Ye Tian, Hao Pan, Huichang Bi, Min Huang, Su Zeng, Huidi Jiang. The two enantiomers of tetrahydropalmatine are inhibitors of P-gp, but not inhibitors of MRP1 or BCRP. Xenobiotica; the fate of foreign compounds in biological systems. 2012 Dec; 42(12):1197-205. doi: 10.3109/00498254.2012.702247. [PMID: 22900779]
  • Zhanying Hong, Guojun Cai, Wentao Ma, Jun Wen, Yifeng Chai, Guorong Fan. Rapid determination and comparative pharmacokinetics of tetrahydropalmatine in spontaneously hypertensive rats and normotensive rats. Biomedical chromatography : BMC. 2012 Jun; 26(6):749-53. doi: 10.1002/bmc.1724. [PMID: 22991695]
  • Zhiying Dou, Kefeng Li, Ping Wang, Liu Cao. Effect of wine and vinegar processing of Rhizoma Corydalis on the tissue distribution of tetrahydropalmatine, protopine and dehydrocorydaline in rats. Molecules (Basel, Switzerland). 2012 Jan; 17(1):951-70. doi: 10.3390/molecules17010951. [PMID: 22258341]
  • Yi Han, Wen Zhang, Yan Tang, Wenli Bai, Fan Yang, Liping Xie, Xiaozhen Li, Suming Zhou, Shiyang Pan, Qi Chen, Albert Ferro, Yong Ji. l-Tetrahydropalmatine, an active component of Corydalis yanhusuo W.T. Wang, protects against myocardial ischaemia-reperfusion injury in rats. PloS one. 2012; 7(6):e38627. doi: 10.1371/journal.pone.0038627. [PMID: 22715398]
  • Li Chao-Wu, Zhang Shuo, Gao Hai-Qing, Zhang Xiu-Mei. Determination of L-tetrahydropalmatine in human plasma by HPLC and pharmacokinetics of its disintegrating tablets in healthy Chinese. European journal of drug metabolism and pharmacokinetics. 2011 Dec; 36(4):257-62. doi: 10.1007/s13318-011-0045-x. [PMID: 21633914]
  • Mingyong Zhang, Jian Le, Jun Wen, Yifeng Chai, Guorong Fan, Zhanying Hong. Simultaneous determination of tetrahydropalmatine and tetrahydroberberine in rat urine using dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography. Journal of separation science. 2011 Nov; 34(22):3279-86. doi: 10.1002/jssc.201100588. [PMID: 22028314]
  • Dong-Li Sun, Shan-Ding Huang, Pei-Sheng Wu, Jia Li, Ya-Ju Ye, Hui-Di Jiang. Stereoselective protein binding of tetrahydropalmatine enantiomers in human plasma, HSA, and AGP, but not in rat plasma. Chirality. 2010 Jun; 22(6):618-23. doi: 10.1002/chir.20808. [PMID: 19927376]
  • Zheng-Gen Liao, Xin-Li Liang, Jing-Yun Zhu, Guo-Wei Zhao, Ming Yang, Guang-Fa Wang, Qie-Ying Jiang, Xu-Long Chen. Correlation between synergistic action of Radix Angelica dahurica extracts on analgesic effects of Corydalis alkaloid and plasma concentration of dl-THP. Journal of ethnopharmacology. 2010 May; 129(1):115-20. doi: 10.1016/j.jep.2010.03.005. [PMID: 20307640]
  • Zhanying Hong, Jun Wen, Quanlong Zhang, Guorong Fan, Yifeng Chai, Yutian Wu. Study on the stereoselective excretion of tetrahydropalmatine enantiomers in rats and identification of in vivo metabolites by liquid chromatography-tandem mass spectrometry. Chirality. 2010 Mar; 22(3):355-60. doi: 10.1002/chir.20750. [PMID: 19544352]
  • Ling Zhou, Zhao-shu Sun, De-qiang Dou, Ai-min Cao, Ting-guo Kang. [Comparison of pharmacokinetics about ermiao capsules and ermiao pellet]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2010 Feb; 33(2):246-9. doi: NULL. [PMID: 20575422]
  • Xin-Li Liang, Zheng-Gen Liao, Guang-Fa Wang, Guo-Wei Zhao, Chun-Lan Dai, Xiao-Hui Zhang. [Influence of combination of extractum Angelicae Dahuricae Siccum and total alkaloids of Rhizoma Corydalis on pharmacokinetics of tetrahydropalmatine in rats]. Yao xue xue bao = Acta pharmaceutica Sinica. 2009 Jun; 44(6):645-50. doi: NULL. [PMID: 19806898]
  • Xiaoxia Wu, Juan Peng, Bin Fan, Youhua Yu. [Pharmacokinetics of three alkaloids in Huanglianjiedu decoction in rat serum by LC-MS-MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 May; 34(10):1276-80. doi: NULL. [PMID: 19673395]
  • Hongda Ma, Yongjun Wang, Tao Guo, Zhonggui He, Xinyu Chang, Xiaohui Pu. Simultaneous determination of tetrahydropalmatine, protopine, and palmatine in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2009 Feb; 49(2):440-6. doi: 10.1016/j.jpba.2008.11.019. [PMID: 19121909]
  • Li Lin, Jian-Xun Liu, Ying Zhang, Cheng-Ren Lin, Chang-Ling Duan. [Pharmacokinetic studies of tetrahydropalmatine and dehydrocorydaline in rat after oral administration of yanhusuo extraction by LC-MS/MS method]. Yao xue xue bao = Acta pharmaceutica Sinica. 2008 Nov; 43(11):1123-7. doi: . [PMID: 19239032]
  • Yating Deng, Qiongfeng Liao, Suhua Li, Kaishun Bi, Biyan Pan, Zhiyong Xie. Simultaneous determination of berberine, palmatine and jatrorrhizine by liquid chromatography-tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of coptis-evodia herb couple. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Mar; 863(2):195-205. doi: 10.1016/j.jchromb.2007.12.028. [PMID: 18258496]
  • Zhanying Hong, Jian Le, Mei Lin, Guorong Fan, Yifeng Chai, Xueping Yin, Yutian Wu. Comparative studies on pharmacokinetic fates of tetrahydropalmatine enantiomers in different chemical environments in rats. Chirality. 2008 Feb; 20(2):119-24. doi: 10.1002/chir.20507. [PMID: 18074336]
  • Zhi-ying Dou, Wei Sun, Xiao-lan Mi, Li-ping Yao. [Comparison of pharmacokinetics of tetrahydropalmatine monomer and extractive of corydalis and corydalis processed with vinegar]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2007 Dec; 30(12):1499-501. doi: NULL. [PMID: 18422179]
  • Ai-ying Zeng, En-yuan Tu, Zun-yi Han, Guang-tian Yang. [Effects of rotundine injection on nitric oxide synthase in tissues of different organs after ischemia/reperfusion of brain in rats]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. 2007 Jun; 19(6):361-4. doi: . [PMID: 17577446]
  • Zhanying Hong, Guorong Fan, Jian Le, Yifeng Chai, Xueping Yin, Yutian Wu. Brain pharmacokinetics and tissue distribution of tetrahydropalmatine enantiomers in rats after oral administration of the racemate. Biopharmaceutics & drug disposition. 2006 Apr; 27(3):111-7. doi: 10.1002/bdd.489. [PMID: 16400711]
  • Qing Min, Yu-Ting Bai, Si-Jie Shu, Ping Ren. [Protective effect of dl-tetrahydropalmatine on liver injury induced by carbon tetrachloride in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Mar; 31(6):483-4, 521. doi: . [PMID: 16722379]
  • Li Li, Min Ye, Kaishun Bi, Dean Guo. Liquid chromatography-tandem mass spectrometry for the identification of L-tetrahydropalmatine metabolites in Penicillium janthinellum and rats. Biomedical chromatography : BMC. 2006 Jan; 20(1):95-100. doi: 10.1002/bmc.534. [PMID: 15959869]
  • Z Y Hong, G R Fan, Y F Chai, X P Yin, J Wen, Y T Wu. Chiral liquid chromatography resolution and stereoselective pharmacokinetic study of tetrahydropalmatine enantiomers in dogs. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Nov; 826(1-2):108-13. doi: 10.1016/j.jchromb.2005.08.012. [PMID: 16165405]
  • Zhan-Ying Hong, Guo-Rong Fan, Yi-Feng Chai, Jun Wen, Xue-Ping Yin, Yu-Tian Wu. [Stereoselective pharmacokinetics of tetrahydropalmatine in rats]. Yao xue xue bao = Acta pharmaceutica Sinica. 2005 Aug; 40(8):746-9. doi: NULL. [PMID: 16268511]
  • Zhanying Hong, Guorong Fan, Yifeng Chai, Xueping Yin, Yutian Wu. Stereoselective pharmacokinetics of tetrahydropalmatine after oral administration of (-)-enantiomer and the racemate. Chirality. 2005 May; 17(5):293-6. doi: 10.1002/chir.20161. [PMID: 15846827]
  • C K Lai, A Y Chan. Tetrahydropalmatine poisoning: diagnoses of nine adult overdoses based on toxicology screens by HPLC with diode-array detection and gas chromatography-mass spectrometry. Clinical chemistry. 1999 Feb; 45(2):229-36. doi: 10.1093/clinchem/45.2.229. [PMID: 9931045]
  • W Zhu, Z Xu. [Alterations of plasma beta-EP and cortisol contents in thyroidectomy under acupuncture anesthesia and acupuncture anesthesia combined with tetrahydropalmatine]. Zhen ci yan jiu = Acupuncture research. 1996; 21(1):15-7. doi: . [PMID: 9387349]
  • B Xuan, D X Li, W Wang. [Protective effects of tetrahydroprotoberberines on experimental myocardial infarction in rats]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1992 Mar; 13(2):167-71. doi: . [PMID: 1598835]
  • B HSU, K C KIN. FURTHER STUDIES ON THE PHARMACOLOGY OF TETRAHYDROPALMATINE AND ITS ANALOGS. International journal of neuropharmacology. 1963 Dec; 2(?):283-90. doi: 10.1016/0028-3908(63)90004-2. [PMID: 14119489]