Lemildipine (BioDeep_00000180415)

   

human metabolite blood metabolite


代谢物信息卡片


{[4-(2,3-dichlorophenyl)-5-(methoxycarbonyl)-6-methyl-3-[(propan-2-yloxy)carbonyl]-1,4-dihydropyridin-2-yl]methoxy}carboximidic acid

化学式: C20H22Cl2N2O6 (456.0854852)
中文名称: 来米地平
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(C(=C(N1)COC(=O)N)C(=O)OC(C)C)C2=C(C(=CC=C2)Cl)Cl)C(=O)OC
InChI: InChI=1S/C20H22Cl2N2O6/c1-9(2)30-19(26)16-13(8-29-20(23)27)24-10(3)14(18(25)28-4)15(16)11-6-5-7-12(21)17(11)22/h5-7,9,15,24H,8H2,1-4H3,(H2,23,27)

描述信息

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

5 个代谢物同义名

{[4-(2,3-dichlorophenyl)-5-(methoxycarbonyl)-6-methyl-3-[(propan-2-yloxy)carbonyl]-1,4-dihydropyridin-2-yl]methoxy}carboximidic acid; {[4-(2,3-dichlorophenyl)-5-(methoxycarbonyl)-6-methyl-3-[(propan-2-yloxy)carbonyl]-1,4-dihydropyridin-2-yl]methoxy}carboximidate; 1,4-Dihydropyridine; Dihydropyridine; Lemildipine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Tamer Z Attia, Mahmoud A Abdelmajed, Mahmoud A Omar, Khalid M Badr El-Din. Selective Spectrofluorimetric Protocol for Determination of Commonly Used Gram-negative Bactericidal Drug in Combined Pharmaceutical Dosage Forms and Human Plasma. Journal of fluorescence. 2022 Mar; 32(2):603-612. doi: 10.1007/s10895-021-02862-6. [PMID: 35013853]
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  • Minghua Yang, Fang Zhang, Yuting Hou, Yue Su, Yinlong Guo. Screening of illegally adulterated 1,4-dihydropyridine calcium antagonists in traditional Chinese medicines by a high-performance liquid chromatography electrospray ionization in-source collision-induced dissociation triple quadrupole mass spectrometric method. Rapid communications in mass spectrometry : RCM. 2018 04; 32(8):672-676. doi: 10.1002/rcm.8076. [PMID: 29420846]
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  • Göknur Aktay, Memet Hanifi Emre, Alaadin Polat. Influence of dihydropyridine calcium antagonist nitrendipine on benzo(a)pyrene-induced oxidative stress. Archives of pharmacal research. 2011 Jul; 34(7):1171-5. doi: 10.1007/s12272-011-0715-x. [PMID: 21811924]
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  • Miguel A Piñeros, Mark Tester. Calcium inhibits dihydropyridine-stimulated increases in opening and unitary conductance of a plant Ca²+ channel. The Journal of membrane biology. 2011 Mar; 240(1):13-20. doi: 10.1007/s00232-011-9338-x. [PMID: 21274523]
  • Tomislava Lovaković, Marija Poljak-Blazi, Gunars Duburs, Ana Cipak, Marina Cindrić, Brigita Vigante, Egils Bisenieks, Morana Jaganjac, Lidija Mrakovcić, Azra Dedić, Neven Zarković. Growth modulation of human cells in vitro by mild oxidative stress and 1,4-dihydropyridine derivative antioxidants. Collegium antropologicum. 2011 Mar; 35(1):137-41. doi: ". [PMID: 21661362]
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