Landiolol (BioDeep_00000180383)
human metabolite blood metabolite
代谢物信息卡片
化学式: C25H39N3O8 (509.2737014)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C)OCC(COC(=O)CCC2=CC=C(OCC(O)CNCCNC(=O)N3CCOCC3)C=C2)O1
InChI: InChI=1S/C25H39N3O8/c1-25(2)35-18-22(36-25)17-34-23(30)8-5-19-3-6-21(7-4-19)33-16-20(29)15-26-9-10-27-24(31)28-11-13-32-14-12-28/h3-4,6-7,20,22,26,29H,5,8-18H2,1-2H3,(H,27,31)
描述信息
同义名列表
4 个代谢物同义名
N-(2-{[3-(4-{3-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-3-oxopropyl}phenoxy)-2-hydroxypropyl]amino}ethyl)morpholine-4-carboximidate; (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-{4-[2-hydroxy-3-({2-[(morpholine-4-carbonyl)amino]ethyl}amino)propoxy]phenyl}propanoate; Landiololhydrochloride; Landiolol
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qun He, Meiyun Shi, Xidong Liu, Yantong Sun, Lianghai Hu, Yan Yang, J Paul Fawcett, Jingkai Gu, Limei Zhao. Determination of landiolol, an ultra-short-acting β₁-receptor antagonist, in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Apr; 891-892(?):7-11. doi:
10.1016/j.jchromb.2011.12.024. [PMID: 22418070] - Masashi Fujii, Yasuyo Kawabata, Tomoko Hayashi, Hiroji Nishimae, Shinya Masuko. [Hyperlactemia during undiagnosed pheochromocytoma resection under laparoscopy].
Masui. The Japanese journal of anesthesiology.
2012 Feb; 61(2):197-9. doi:
. [PMID: 22413446] - Naoki Matsumoto, Tohru Aomori, Masafumi Kanamoto, Tadashi Usui, Tatsuya Shiga, Koujirou Yamamoto, Shigeru Saito. Influence of hemodynamic variations on the pharmacokinetics of landiolol in patients undergoing cardiovascular surgery.
Biological & pharmaceutical bulletin.
2012; 35(10):1655-60. doi:
10.1248/bpb.b110727. [PMID: 22864018] - Satoki Inoue, Ryuichi Abe, Masahiko Kawaguchi, Hiroshi Kobayashi, Hitoshi Furuya. Metoclopramide does not prolong duration of action of landiolol attenuating the hemodynamic response to induction of anesthesia and tracheal intubation.
Journal of anesthesia.
2010 Aug; 24(4):649-52. doi:
10.1007/s00540-010-0945-y. [PMID: 20454811] - Masahiko Kawaguchi, Kouji Utada, Kenji Yoshitani, Hiroyuki Uchino, Yoshimasa Takeda, Kenichi Masui, Takefumi Sakabe. Effects of a short-acting [beta]1 receptor antagonist landiolol on hemodynamics and tissue injury markers in patients with subarachnoid hemorrhage undergoing intracranial aneurysm surgery.
Journal of neurosurgical anesthesiology.
2010 Jul; 22(3):230-9. doi:
10.1097/ana.0b013e3181d0c2e4. [PMID: 20118792] - Masahiro Uraoka, Yoshiki Nakajima, Tadayoshi Kurita, Akira Suzuki, Kotaro Takata, Shigehito Sato. Landiolol, an ultra short acting beta1-blocker, improves pulmonary edema after cardiopulmonary resuscitation with epinephrine in rats.
Journal of anesthesia.
2010 Feb; 24(1):67-72. doi:
10.1007/s00540-009-0834-4. [PMID: 20039077] - Nao Tamada, Yohei Kasuya, Tomoko Yorozu, Takehiko Iijima, Yasuhide Iwao. [Case of thyroid crisis with persistent tachycardia diagnosed postoperatively].
Masui. The Japanese journal of anesthesiology.
2009 Dec; 58(12):1541-4. doi:
NULL. [PMID: 20055204] - Manabu Suno, Takayuki Kunisawa, Akio Yamagishi, Takashi Ono, Joe Yamamoto, Takehiro Yamada, Yoshikazu Tasaki, Keiko Shimizu, Hiroshi Iwasaki, Kazuo Matsubara. Detection of landiolol using high-performance liquid chromatography/fluorescence: a blood esterase-sensitive ultra-short-acting beta(1)-receptor antagonist.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Jun; 877(16-17):1705-8. doi:
10.1016/j.jchromb.2009.04.017. [PMID: 19409865] - Satoshi Hagiwara, Hideo Iwasaka, Hayato Maeda, Takayuki Noguchi. Landiolol, an ultrashort-acting beta1-adrenoceptor antagonist, has protective effects in an LPS-induced systemic inflammation model.
Shock (Augusta, Ga.).
2009 May; 31(5):515-20. doi:
10.1097/shk.0b013e3181863689. [PMID: 18791493] - Etienne de Montmollin, Jerome Aboab, Arnaud Mansart, Djillali Annane. Bench-to-bedside review: Beta-adrenergic modulation in sepsis.
Critical care (London, England).
2009; 13(5):230. doi:
10.1186/cc8026. [PMID: 19863760] - Saori Kimura-Kurosawa, Noriaki Kanaya, Noriko Kamada, Naoyuki Hirata, Masayasu Nakayama, Akiyoshi Namiki. Cardioprotective effect and mechanism of action of landiolol on the ischemic reperfused heart.
Journal of anesthesia.
2007; 21(4):480-9. doi:
10.1007/s00540-007-0558-2. [PMID: 18008115] - Makiko Sakanashi, Mayuko Sakanashi, Kazuhiro Sugahara, Matao Sakanashi. Effects of landiolol on mechanical and metabolic changes in rat reperfused ischaemic hearts.
Clinical and experimental pharmacology & physiology.
2007 Jan; 34(1-2):55-60. doi:
10.1111/j.1440-1681.2007.04543.x. [PMID: 17201736] - Daisuke Takizawa, Shigeru Saito, Eri Sato, Haruhiko Hiraoka, Fumio Kunimoto, Fumio Goto. Influence of landiolol on the dose requirement of propofol for induction of anesthesia.
Fundamental & clinical pharmacology.
2005 Oct; 19(5):597-9. doi:
10.1111/j.1472-8206.2005.00351.x. [PMID: 16176340] - Takenori Takahata, Norio Yasui-Furukori, Juichi Sakamoto, Koji Suto, Toshiyuki Suto, Tomonori Tateishi, Akihiro Munakata. Influence of hepatic impairment on the pharmacokinetics and pharmacodynamics of landiolol hydrochloride, an ultra-short-acting beta1-blocker.
Drugs in R&D.
2005; 6(6):385-94. doi:
10.2165/00126839-200506060-00006. [PMID: 16274261] - Sachiko Imamura, Kyung-ho Chang, Yuuichiro Saitoh, Erika Sano, Tooru Akune, Kazuo Hanaoka. [The successful anesthetic management of a patient with pheochromocytoma using prostaglandin E1 and a novel, short-acting beta-adrenergic blocker: landiolol hydrochloride].
Masui. The Japanese journal of anesthesiology.
2004 Jul; 53(7):806-9. doi:
. [PMID: 15298253]