Lanabecestat (BioDeep_00000180379)

   

human metabolite blood metabolite


代谢物信息卡片


4-methoxy-5-methyl-6-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3H-dispiro[cyclohexane-1,2-indene-1,2-imidazole]-4-amine

化学式: C26H28N4O (412.2262998)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 90.91%

分子结构信息

SMILES: CC#CC1=CC(=CN=C1)C2=CC3=C(CC4(C35N=C(C(=N5)N)C)CCC(CC4)OC)C=C2
InChI: InChI=1S/C26H28N4O/c1-4-5-18-12-21(16-28-15-18)19-6-7-20-14-25(10-8-22(31-3)9-11-25)26(23(20)13-19)29-17(2)24(27)30-26/h6-7,12-13,15-16,22H,8-11,14H2,1-3H3,(H2,27,30)

描述信息

同义名列表

3 个代谢物同义名

4-methoxy-5-methyl-6-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3H-dispiro[cyclohexane-1,2-indene-1,2-imidazole]-4-amine; 4-Methoxy-5-methyl-6-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3H-dispiro(cyclohexane-1,2-inden-1,2-imidazol)-4-amine; Lanabecestat



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Naidong Ye, Scott A Monk, Pankaj Daga, David M Bender, Laura B Rosen, Jamie Mullen, Margaret C Minkwitz, Alan R Kugler. Clinical Bioavailability of the Novel BACE1 Inhibitor Lanabecestat (AZD3293): Assessment of Tablet Formulations Versus an Oral Solution and the Impact of Gastric pH on Pharmacokinetics. Clinical pharmacology in drug development. 2018 03; 7(3):233-243. doi: 10.1002/cpdd.422. [PMID: 29319935]
  • Kei Sakamoto, Shunji Matsuki, Kyoko Matsuguma, Tatsuya Yoshihara, Naoki Uchida, Fumihiko Azuma, Muir Russell, Glen Hughes, Samantha Budd Haeberlein, Robert C Alexander, Susanna Eketjäll, Alan R Kugler. BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid Aβ Peptides. Journal of clinical pharmacology. 2017 Nov; 57(11):1460-1471. doi: 10.1002/jcph.950. [PMID: 28618005]
  • Yan Li, Paul H Severin, Mark R Hoffmann, Dennis L Miller, Scott A Monk, Alan R Kugler. Simultaneous quantitation of the BACE1 inhibitor AZD3293 and its metabolite AZ13569724 in human matrices by LC-MS/MS. Bioanalysis. 2017 May; 9(10):813-826. doi: 10.4155/bio-2017-0003. [PMID: 28434245]
  • Gvido Cebers, Robert C Alexander, Samantha Budd Haeberlein, David Han, Ronald Goldwater, Larry Ereshefsky, Tina Olsson, Naidong Ye, Laura Rosen, Muir Russell, Justine Maltby, Susanna Eketjäll, Alan R Kugler. AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2017; 55(3):1039-1053. doi: 10.3233/jad-160701. [PMID: 27767991]
  • J R Sims, K J Selzler, A M Downing, B A Willis, C D Aluise, J Zimmer, S Bragg, S Andersen, M Ayan-Oshodi, E Liffick, J Eads, A M Wessels, S Monk, J Schumi, J Mullen. Development Review of the BACE1 Inhibitor Lanabecestat (AZD3293/LY3314814). The journal of prevention of Alzheimer's disease. 2017; 4(4):247-254. doi: NULL. [PMID: 29181490]
  • Susanna Eketjäll, Juliette Janson, Karin Kaspersson, Anna Bogstedt, Fredrik Jeppsson, Johanna Fälting, Samantha Budd Haeberlein, Alan R Kugler, Robert C Alexander, Gvido Cebers. AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics. Journal of Alzheimer's disease : JAD. 2016; 50(4):1109-23. doi: 10.3233/jad-150834. [PMID: 26890753]