N-[2-[4-[[3-Butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methyl-2-thiophenecarboxamide (BioDeep_00000180316)

   

human metabolite blood metabolite


代谢物信息卡片


N-{[4-({3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-4,5-dihydro-1H-1,2,4-triazol-4-yl}methyl)-[1,1-biphenyl]-2-yl]sulfonyl}-3-methylthiophene-2-carboxamide

化学式: C32H29F3N4O4S2 (654.158223)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 47.06%

分子结构信息

SMILES: CCCCC1=NN(C(=O)N1CC1=CC=C(C=C1)C1=CC=CC=C1S(=O)(=O)NC(=O)C1=C(C)C=CS1)C1=CC=CC=C1C(F)(F)F
InChI: InChI=1S/C32H29F3N4O4S2/c1-3-4-13-28-36-39(26-11-7-6-10-25(26)32(33,34)35)31(41)38(28)20-22-14-16-23(17-15-22)24-9-5-8-12-27(24)45(42,43)37-30(40)29-21(2)18-19-44-29/h5-12,14-19H,3-4,13,20H2,1-2H3,(H,37,40)

描述信息

同义名列表

4 个代谢物同义名

N-{[4-({3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-4,5-dihydro-1H-1,2,4-triazol-4-yl}methyl)-[1,1-biphenyl]-2-yl]sulfonyl}-3-methylthiophene-2-carboxamide; N-[4-({3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl}methyl)-[1,1-biphenyl]-2-ylsulfonyl]-3-methylthiophene-2-carboxamide; N-[2-[4-[[3-Butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulphonyl-3-methyl-2-thiophenecarboxamide; N-[2-[4-[[3-Butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methyl-2-thiophenecarboxamide



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Liang Chen, Xianglei Wu, Jun Zhong, Dongqing Li. L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels. BMC musculoskeletal disorders. 2017 Nov; 18(1):462. doi: 10.1186/s12891-017-1819-3. [PMID: 29145862]
  • Ning Li, Limin Zhang, Yanpeng An, Lulu Zhang, Yipeng Song, Yulan Wang, Huiru Tang. Antagonist of prostaglandin E2 receptor 4 induces metabolic alterations in liver of mice. Journal of proteome research. 2015 Mar; 14(3):1566-73. doi: 10.1021/pr501236y. [PMID: 25669961]
  • Eva H C Tang, Yin Cai, Chi Kin Wong, Viviane Z Rocha, Galina K Sukhova, Koichi Shimizu, Ge Xuan, Paul M Vanhoutte, Peter Libby, Aimin Xu. Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue. Journal of lipid research. 2015 Feb; 56(2):358-68. doi: 10.1194/jlr.m054817. [PMID: 25510249]
  • Chenglin Mo, Ruonan Zhao, Julian Vallejo, Orisa Igwe, Lynda Bonewald, Lori Wetmore, Marco Brotto. Prostaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation. Cell cycle (Georgetown, Tex.). 2015; 14(10):1507-16. doi: 10.1080/15384101.2015.1026520. [PMID: 25785867]
  • Tamer Coskun, Libbey S O'Farrell, Samreen K Syed, Daniel A Briere, Lisa S Beavers, Susan L Dubois, Mervyn D Michael, Jeffry B Franciskovich, David G Barrett, Alexander M Efanov. Activation of prostaglandin E receptor 4 triggers secretion of gut hormone peptides GLP-1, GLP-2, and PYY. Endocrinology. 2013 Jan; 154(1):45-53. doi: 10.1210/en.2012-1446. [PMID: 23142807]
  • Agnes Rasmuson, Anna Kock, Ole Martin Fuskevåg, Björn Kruspig, Jaione Simón-Santamaría, Vladimir Gogvadze, John Inge Johnsen, Per Kogner, Baldur Sveinbjörnsson. Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma. PloS one. 2012; 7(1):e29331. doi: 10.1371/journal.pone.0029331. [PMID: 22276108]
  • Ulla C Kopp, Michael Z Cicha, Lori A Smith, Jan Mulder, Tomas Hökfelt. Renal sympathetic nerve activity modulates afferent renal nerve activity by PGE2-dependent activation of alpha1- and alpha2-adrenoceptors on renal sensory nerve fibers. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 Oct; 293(4):R1561-72. doi: 10.1152/ajpregu.00485.2007. [PMID: 17699565]
  • Lamine Aoudjit, Anna Potapov, Tomoko Takano. Prostaglandin E2 promotes cell survival of glomerular epithelial cells via the EP4 receptor. American journal of physiology. Renal physiology. 2006 Jun; 290(6):F1534-42. doi: 10.1152/ajprenal.00267.2005. [PMID: 16396944]