5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide (BioDeep_00000180298)

   

human metabolite blood metabolite


代谢物信息卡片


5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide

化学式: C20H17F3N2O4S (438.08610780000004)
中文名称: 5-[(2,4-二氧代噻唑啉-5-基)甲基]-2-甲氧基-N-[[4-(三氟甲基)苯基]甲基]苯甲酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C(C=C1)CC2C(=O)NC(=O)S2)C(=O)NCC3=CC=C(C=C3)C(F)(F)F
InChI: InChI=1S/C20H17F3N2O4S/c1-29-15-7-4-12(9-16-18(27)25-19(28)30-16)8-14(15)17(26)24-10-11-2-5-13(6-3-11)20(21,22)23/h2-8,16H,9-10H2,1H3,(H,24,26)(H,25,27,28)

描述信息

同义名列表

4 个代谢物同义名

5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide; MK767 CPD; KRP-297; KRP 297



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yoshihiro Shibata, Katsuji Kagechika, Mitsuhiro Yamaguchi, Hideo Kubo, Hiroyuki Usui. Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1). Bioorganic & medicinal chemistry letters. 2012 Dec; 22(23):7075-9. doi: 10.1016/j.bmcl.2012.09.092. [PMID: 23084275]
  • Hiroyuki Miyachi. [Design and synthesis of subtype- and species-selective peroxisome proliferator-activated receptor (PPAR) alpha ligands]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2004 Nov; 124(11):803-13. doi: 10.1248/yakushi.124.803. [PMID: 15516807]
  • Thomas W Doebber, Linda J Kelly, Gaochao Zhou, Roger Meurer, Chhabi Biswas, Ying Li, Margaret S Wu, Marc C Ippolito, Yu-Sheng Chao, Pei-Ran Wang, Samuel D Wright, David E Moller, Joel P Berger. MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activities. Biochemical and biophysical research communications. 2004 May; 318(2):323-8. doi: 10.1016/j.bbrc.2004.04.032. [PMID: 15120604]
  • Ken Yajima, Hiroshi Hirose, Haruhisa Fujita, Yoshiko Seto, Hiroshi Fujita, Kaname Ukeda, Kiichi Miyashita, Toshihide Kawai, Yukihiro Yamamoto, Takeo Ogawa, Taketo Yamada, Takao Saruta. Combination therapy with PPARgamma and PPARalpha agonists increases glucose-stimulated insulin secretion in db/db mice. American journal of physiology. Endocrinology and metabolism. 2003 May; 284(5):E966-71. doi: 10.1152/ajpendo.00149.2002. [PMID: 12676649]
  • T Yamanouchi. [KRP-297, MCC-555]. Nihon rinsho. Japanese journal of clinical medicine. 2001 Nov; 59(11):2200-6. doi: NULL. [PMID: 11712408]
  • D A Brooks, G J Etgen, C J Rito, A J Shuker, S J Dominianni, A M Warshawsky, R Ardecky, J R Paterniti, J Tyhonas, D S Karanewsky, R F Kauffman, C L Broderick, B A Oldham, C Montrose-Rafizadeh, L L Winneroski, M M Faul, J R McCarthy. Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists. Journal of medicinal chemistry. 2001 Jun; 44(13):2061-4. doi: 10.1021/jm0155188. [PMID: 11405642]
  • K Murakami, T Ide, T Nakazawa, T Okazaki, T Mochizuki, T Kadowaki. Fatty-acyl-CoA thioesters inhibit recruitment of steroid receptor co-activator 1 to alpha and gamma isoforms of peroxisome-proliferator-activated receptors by competing with agonists. The Biochemical journal. 2001 Jan; 353(Pt 2):231-8. doi: 10.1042/0264-6021:3530231. [PMID: 11139385]
  • E Chaput, R Saladin, M Silvestre, A D Edgar. Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight. Biochemical and biophysical research communications. 2000 May; 271(2):445-50. doi: 10.1006/bbrc.2000.2647. [PMID: 10799317]
  • T Ide, T Nakazawa, T Mochizuki, K Murakami. Tissue-specific actions of antidiabetic thiazolidinediones on the reduced fatty acid oxidation in skeletal muscle and liver of Zucker diabetic fatty rats. Metabolism: clinical and experimental. 2000 Apr; 49(4):521-5. doi: 10.1016/s0026-0495(00)80019-0. [PMID: 10778879]
  • K Murakami, M Tsunoda, T Ide, M Ohashi, T Mochizuki. Amelioration by KRP-297, a new thiazolidinedione, of impaired glucose uptake in skeletal muscle from obese insulin-resistant animals. Metabolism: clinical and experimental. 1999 Nov; 48(11):1450-4. doi: 10.1016/s0026-0495(99)90158-0. [PMID: 10582556]
  • K Murakami, T Ide, M Suzuki, T Mochizuki, T Kadowaki. Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. Biochemical and biophysical research communications. 1999 Jul; 260(3):609-13. doi: 10.1006/bbrc.1999.0951. [PMID: 10403814]
  • K Murakami, K Tobe, T Ide, T Mochizuki, M Ohashi, Y Akanuma, Y Yazaki, T Kadowaki. A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. Diabetes. 1998 Dec; 47(12):1841-7. doi: 10.2337/diabetes.47.12.1841. [PMID: 9836514]