Pregabalin (BioDeep_00000018028)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(3S)-3-(aminomethyl)-5-methylhexanoic acid

化学式: C8H17NO2 (159.1259222)
中文名称: 3-(氨甲基)-5-甲基己酸, 3-氨甲基-5-甲基己酸, 普瑞巴林
谱图信息: 最多检出来源 Homo sapiens(blood) 12.7%

分子结构信息

SMILES: CC(C)CC(CC(=O)O)CN
InChI: InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)

描述信息

Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Pregabalin is marketed by Pfizer under the trade name Lyrica. It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S. [Wikipedia]
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
N - Nervous system > N02 - Analgesics > N02B - Other analgesics and antipyretics > N02BF - Gabapentinoids
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators

同义名列表

12 个代谢物同义名

(3S)-3-(aminomethyl)-5-methylhexanoic acid; (S)-3-(Aminomethyl)-5-methylhexanoic acid; 3-(aminomethyl)-5-methylhexanoic acid; 3-(ammoniomethyl)-5-methylhexanoate; (R-)-3-Isobutyl gaba; (S+)-3-isobutyl gaba; (S)-3-Isobutyl gaba; GABA, 3-isobutyl; 3-Isobutyl gaba; 3 Isobutyl gaba; Pregabalin; Lyrica



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Li-Mian Hong, Jian-Min Liu, Lei Lin, Chun-Chun Huang, Rui Chen, Wei-Wei Lin. Modeling an evaluation of the efficacy of the novel neuroanalgesic drug mirogabalin for diabetic peripheral neuropathic pain and postherpetic neuralgia therapy. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024 Jun; 197(?):106777. doi: 10.1016/j.ejps.2024.106777. [PMID: 38649099]
  • Jiayu Tang, Yunchao Zhang, Chenxin Liu, Anqi Zeng, Linjiang Song. Therapeutic Strategies for Postherpetic Neuralgia: Mechanisms, Treatments, and Perspectives. Current pain and headache reports. 2023 Jul; ?(?):. doi: 10.1007/s11916-023-01146-x. [PMID: 37493871]
  • Xiaohua Shen, Xingying Chen, Yanyan He, Hui Xu, Jia Zhu. Efficacy and safety of pregabalin in eye pain: A systematic review. Medicine. 2023 Feb; 102(6):e32875. doi: 10.1097/md.0000000000032875. [PMID: 36820573]
  • Qian Wang, Jing Dong, Xin Ye, Yi-Feng Ren. A Meta-Analysis Showing the Quantitative Evidence Base of Preemptive Pregabalin for Postoperative Pain from Cancer-Related Surgery. Medicina (Kaunas, Lithuania). 2023 Jan; 59(2):. doi: 10.3390/medicina59020280. [PMID: 36837482]
  • Yi Zhou, Xiaoyan Liu, Chuan Ding, Bingyan Xiang, Ling Yan. Positive Preemptive Analgesia Effectiveness of Pregabalin Combined with Celecoxib in Total Knee Arthroplasty: A Prospective Controlled Randomized Study. Pain research & management. 2023; 2023(?):7088004. doi: 10.1155/2023/7088004. [PMID: 36686371]
  • Isha Gupta, Syeda Nashvia Adin, Mohd Aqil, Mohd Mujeeb, Yasmin Sultana. Quality by design-based development and validation of an HPLC method for simultaneous estimation of pregabalin and piperine in dual drug-loaded liposomes. Biomedical chromatography : BMC. 2023 Jan; 37(1):e5510. doi: 10.1002/bmc.5510. [PMID: 36100737]
  • Sijin He, Qigang Chen, Zhicong Jing, Lihua Gu, Kaixuan Luo. Avellis syndrome with ipsilateral prosopalgia, glossopharyngeal neuralgia, and central post-stroke pain: A case report and literature review. Medicine. 2022 Sep; 101(39):e30669. doi: 10.1097/md.0000000000030669. [PMID: 36181064]
  • Qiyun Lu, Benjian Chen, Qingshun Liang, Liyan Wu, Lulu Luo, Anxiang Li, Wenwei Ouyang, Zehuai Wen, Yunwei Liu, Jiayan Lu, Yunyi Liu, Guanjie Fan, Zhenjie Liu. Xiaoketongbi Formula vs pregabalin for painful diabetic neuropathy: A single-center, randomized, single-blind, double-dummy, and parallel controlled clinical trial. Journal of diabetes. 2022 Aug; 14(8):551-561. doi: 10.1111/1753-0407.13306. [PMID: 36040201]
  • Anam Asghar, Muhammad Naeem Aamir, Fatima Akbar Sheikh, Naveed Ahmad, Mervat A Elsherif, Syed Nasir Abbas Bukhari. Co-Combination of Pregabalin and Withaniacoagulans-Extract-Loaded Topical Gel Alleviates Allodynia and Hyperalgesia in the Chronic Sciatic Nerve Constriction Injury for Neuropathic Pain in Animal Model. Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144433. [PMID: 35889307]
  • Jonathan L Fu, Michael D Perloff. Pharmacotherapy for Spine-Related Pain in Older Adults. Drugs & aging. 2022 07; 39(7):523-550. doi: 10.1007/s40266-022-00946-x. [PMID: 35754070]
  • Flory T Muanda, Matthew A Weir, Fatemeh Ahmadi, Jessica M Sontrop, Andrea Cowan, Jamie L Fleet, Peter G Blake, Amit X Garg. Higher-Dose Gabapentinoids and the Risk of Adverse Events in Older Adults With CKD: A Population-Based Cohort Study. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2022 07; 80(1):98-107.e1. doi: 10.1053/j.ajkd.2021.11.007. [PMID: 34979160]
  • Terttu Lamminen, Anne Doedée, Minja Hyttilä-Hopponen, Janne Kaskinoro. Pharmacokinetics of single and repeated oral doses of pregabalin oral solution formulation in cats. Journal of veterinary pharmacology and therapeutics. 2022 Jul; 45(4):385-391. doi: 10.1111/jvp.13061. [PMID: 35466408]
  • Tomoyuki Yamada, Satoru Mitsuboshi, Junko Makino, Kaoru Suzuki, Masami Nishihara, Masashi Neo. Risk of Pregabalin-Induced Hypoglycemia: Analysis of the Japanese Adverse Drug Event Report Database. Journal of clinical pharmacology. 2022 06; 62(6):756-761. doi: 10.1002/jcph.2009. [PMID: 34817883]
  • Daniel Tassinari Felber, Rafael Tamborena Malheiros, Victor Novo Tentardini, Andréia Caroline Fernandes Salgueiro, Francisco José Cidral-Filho, Morgana Duarte da Silva. Dry needling increases antioxidant activity and grip force in a rat model of muscle pain. Acupuncture in medicine : journal of the British Medical Acupuncture Society. 2022 06; 40(3):241-248. doi: 10.1177/09645284211056941. [PMID: 34894763]
  • Kaustubh Mundada, Amit Goel, Vimal Kumar Paliwal, Thakur Prashant Singh, Praveer Rai, Rakesh Aggarwal. Short course of low-dose pregabalin is effective for the treatment of restless leg syndrome in patients with cirrhosis: A pilot study. Journal of gastroenterology and hepatology. 2022 May; 37(5):933-937. doi: 10.1111/jgh.15803. [PMID: 35174537]
  • Dani C Mata, John F Davis. Simultaneous quantitative analysis of 39 common toxicological drugs for increased efficiency in an ante- and postmortem laboratory. Forensic science international. 2022 May; 334(?):111246. doi: 10.1016/j.forsciint.2022.111246. [PMID: 35276541]
  • Burcak Akin, Bayram Kelle, Erkan Kozanoglu. The Effect of Pregabalin on Bone Metabolism. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. 2022 Apr; 25(2):223-229. doi: 10.1016/j.jocd.2021.05.001. [PMID: 34120834]
  • Alvaro Henrique Bernardo de Lima Silva, Debora Rasec Radulski, Gabriela Saidel Pereira, Alexandra Acco, Janaina Menezes Zanoveli. A single injection of pregabalin induces short- and long-term beneficial effects on fear memory and anxiety-like behavior in rats with experimental type-1 diabetes mellitus. Metabolic brain disease. 2022 04; 37(4):1095-1110. doi: 10.1007/s11011-022-00936-3. [PMID: 35239142]
  • Omnia I Ismail, Eman S Shaltout, Nora Z Abdellah, Diab F Hetta, Wael M A Abd El-Ghani, Lobna A Abdelzaher, Ahmed Mohamed Mohamed Mahmoud, Asmaa M Hasan, Noha A Rashed, Noha Esmael Ebrahem. The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study. BMC pharmacology & toxicology. 2022 01; 23(1):4. doi: 10.1186/s40360-021-00546-2. [PMID: 34986900]
  • Josée Bouchard, Christopher Yates, Diane P Calello, Sophie Gosselin, Darren M Roberts, Valéry Lavergne, Robert S Hoffman, Marlies Ostermann, Ai Peng, Marc Ghannoum. Extracorporeal Treatment for Gabapentin and Pregabalin Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2022 01; 79(1):88-104. doi: 10.1053/j.ajkd.2021.06.027. [PMID: 34799138]
  • Ke-Yu Chen, Ruo-Yang Li. Efficacy and safety of different antidepressants and anticonvulsants in central poststroke pain: A network meta-analysis and systematic review. PloS one. 2022; 17(10):e0276012. doi: 10.1371/journal.pone.0276012. [PMID: 36227855]
  • Shumao Zheng, Mingjun Lei, Fan Bai, Zan Tian, Hua Wang. The Curative Effect of Pregabalin in the Treatment of Postherpetic Neuralgia Analyzed by Deep Learning-Based Brain Resting-State Functional Magnetic Resonance Images. Contrast media & molecular imaging. 2022; 2022(?):2250621. doi: 10.1155/2022/2250621. [PMID: 35615728]
  • Mark S Wallace. Effect of Pregabalin on the Median Effective Plasma Concentration of Intravenous Alfentanil in Capsaicin-Induced Pain. Pain medicine (Malden, Mass.). 2021 Dec; 22(12):3072-3079. doi: 10.1093/pm/pnab222. [PMID: 34329455]
  • Seol Ju Moon, Ji-Young Jeon, Yeji Lim, Taewon An, Seong Bok Jang, Sohee Kim, Woon-Sook Na, Sun Young Lee, Min-Gul Kim. Pharmacokinetics of a New, Once-Daily, Sustained-release Pregabalin Tablet in Healthy Male Volunteers. Clinical therapeutics. 2021 08; 43(8):1381-1391.e1. doi: 10.1016/j.clinthera.2021.06.010. [PMID: 34256964]
  • Sinan Pektas, Canan Gursoy, Semra Gumus Demirbilek. The use of Pregabalin in Intensive Care Unit in the Treatment of Covid-19-related Pain and Cough. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2021 Jul; 31(7):143. doi: 10.29271/jcpsp.2021.supp2.s143. [PMID: 34271819]
  • H Asci, O Ozmen, Y Erzurumlu, H B Savas, E N Temel, P Icten, N Hasseyid. Ameliorative effects of pregabalin on LPS induced endothelial and cardiac toxicity. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2021 Jul; 96(5):364-375. doi: 10.1080/10520295.2020.1810315. [PMID: 32921172]
  • Rafaela F Rodrigues, Taila Kawano, Rodrigo V Placido, Lellis H Costa, Marcia H M C Podesta, Rafaela S Santos, Giovane Galdino, Carlos M Barros, Vanessa B Boralli. Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats. Pain physician. 2021 07; 24(4):E511-E520. doi: NULL. [PMID: 34213877]
  • Einat Peles, Anat Sason, Shaul Schreiber, Miriam Adelson. Pregabalin Misuse: Motives, Pattern, and Knowledge about Its Risks among Patients in Methadone Maintenance Treatment. Journal of psychoactive drugs. 2021 Jul; 53(3):238-246. doi: 10.1080/02791072.2020.1861392. [PMID: 33357129]
  • Andy Kuo, Laura Corradini, Janet R Nicholson, Maree T Smith. Assessment of the Anti-Allodynic and Anti-Hyperalgesic Efficacy of a Glycine Transporter 2 Inhibitor Relative to Pregabalin, Duloxetine and Indomethacin in a Rat Model of Cisplatin-Induced Peripheral Neuropathy. Biomolecules. 2021 06; 11(7):. doi: 10.3390/biom11070940. [PMID: 34202809]
  • Cornelius Hess, Sandra Zeidler, Joerg Roehrich. Forensic application and evaluation of a commercially available pregabalin immunoassay test in serum on an Olympus AU480. Drug testing and analysis. 2021 Jun; 13(6):1216-1218. doi: 10.1002/dta.2994. [PMID: 33377304]
  • Ibrahim A Naguib, Nesma A Ali, Fadwa A Elroby, Mohamed R Elghobashy. Green HPLC-DAD and HPTLC Methods for Quantitative Determination of Binary Mixture of Pregabalin and Amitriptyline Used for Neuropathic Pain Management. Journal of chromatographic science. 2021 May; 59(6):536-547. doi: 10.1093/chromsci/bmab031. [PMID: 33778855]
  • Ibrahim A Naguib, Nesma A Ali, Fadwa A Elroby, Mohamed R El Ghobashy, Fatma F Abdallah. Ecologically evaluated and FDA-validated HPTLC method for assay of pregabalin and tramadol in human biological fluids. Biomedical chromatography : BMC. 2021 Apr; 35(4):e5023. doi: 10.1002/bmc.5023. [PMID: 33169415]
  • Valeria Itzel Reyes-Pérez, Vinicio Granados-Soto, Manuel Rangel-Grimaldo, Myrna Déciga-Campos, Rachel Mata. Pharmacological Analysis of the Anti-inflammatory and Antiallodynic Effects of Zinagrandinolide E from Zinnia grandiflora in Mice. Journal of natural products. 2021 03; 84(3):713-723. doi: 10.1021/acs.jnatprod.0c00793. [PMID: 32870011]
  • José Luis Díaz, Félix Cuevas, Gonzalo Pazos, Paula Álvarez-Bercedo, Ana I Oliva, M Ángeles Sarmentero, Daniel Font, Agustín Jiménez-Aquino, María Morón, Adriana Port, Rosalía Pascual, Albert Dordal, Enrique Portillo-Salido, Raquel F Reinoso, José Miguel Vela, Carmen Almansa. Bicyclic Diazepinones as Dual Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter. Journal of medicinal chemistry. 2021 02; 64(4):2167-2185. doi: 10.1021/acs.jmedchem.0c01867. [PMID: 33591743]
  • Reem Odi, Valentina Franco, Emilio Perucca, Meir Bialer. Bioequivalence and switchability of generic antiseizure medications (ASMs): A re-appraisal based on analysis of generic ASM products approved in Europe. Epilepsia. 2021 02; 62(2):285-302. doi: 10.1111/epi.16802. [PMID: 33426641]
  • Kristina Friedland, Giacomo Silani, Anita Schuwald, Carola Stockburger, Egon Koch, Michael Nöldner, Walter E Müller. Neurotrophic Properties of Silexan, an Essential Oil from the Flowers of Lavender-Preclinical Evidence for Antidepressant-Like Properties. Pharmacopsychiatry. 2021 Jan; 54(1):37-46. doi: 10.1055/a-1293-8585. [PMID: 33254260]
  • Dina A Shokry, Naglaa El Nabrawy, Hanan D Yassa, Shereen S Gaber, Gaber El-Saber Batiha, Nermeen N Welson. Pregabalin induced reproductive toxicity and body weight changes by affecting caspase3 and leptin expression: Protective role of wheat germ oil. Life sciences. 2020 Nov; 260(?):118344. doi: 10.1016/j.lfs.2020.118344. [PMID: 32853651]
  • Mohammad Zafar Imam, Andy Kuo, Janet R Nicholson, Laura Corradini, Maree T Smith. Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain. Pharmacological reports : PR. 2020 Oct; 72(5):1418-1425. doi: 10.1007/s43440-020-00145-8. [PMID: 32715433]
  • Rajkumar Chinnadurai, Smeeta Sinha, Aoife C Lowney, Mary Miller. Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians. BMC nephrology. 2020 09; 21(1):403. doi: 10.1186/s12882-020-02067-2. [PMID: 32948131]
  • Philipp A Schmierer, Julia Tünsmeyer, Andrea Tipold, Sonja Hartnack-Wilhelm, Piotr Lesczuk, Sabine B R Kästner. Randomized controlled trial of pregabalin for analgesia after surgical treatment of intervertebral disc disease in dogs. Veterinary surgery : VS. 2020 Jul; 49(5):905-913. doi: 10.1111/vsu.13411. [PMID: 32329092]
  • Zeinab M Awwad, Samar O El-Ganainy, Ahmed I ElMallah, Shaimaa M Khedr, Mahmoud M Khattab, Aiman S El-Khatib. Assessment of Pregabalin-Induced Cardiotoxicity in Rats: Mechanistic Role of Angiotensin 1-7. Cardiovascular toxicology. 2020 06; 20(3):301-311. doi: 10.1007/s12012-019-09553-6. [PMID: 31720995]
  • Yunguang Qiu, Lu Huang, Jie Fu, Chenxia Han, Jing Fang, Ping Liao, Zhuo Chen, Yiqing Mo, Peihua Sun, Daqing Liao, Linghui Yang, Jing Wang, Qiansen Zhang, Jin Liu, Feng Liu, Tingting Liu, Wei Huang, Huaiyu Yang, Ruotian Jiang. TREK Channel Family Activator with a Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation. Journal of medicinal chemistry. 2020 04; 63(7):3665-3677. doi: 10.1021/acs.jmedchem.9b02163. [PMID: 32162512]
  • Shaza Deeb, Fiona M Wylie, Hazel J Torrance, Karen S Scott. An Insight into Gabapentin and Pregabalin in Scottish Prisoners. Journal of analytical toxicology. 2020 Apr; 44(5):504-513. doi: 10.1093/jat/bkz105. [PMID: 31897471]
  • Manal Hassanien, Abdelraheem Elawamy, Emad Zarief Kamel, Walaa A Khalifa, Ghada Mohamed Abolfadl, Al Shimaa Ismael Roushdy, Randa A El Zohne, Yasmine S Makarem. Perineural Platelet-Rich Plasma for Diabetic Neuropathic Pain, Could It Make a Difference?. Pain medicine (Malden, Mass.). 2020 04; 21(4):757-765. doi: 10.1093/pm/pnz140. [PMID: 31298289]
  • Ahmed Soliman, Ahmed Wahid, Mayssaa M Wahby, Ahmad Bassiouny. Study of the possible synergistic protective effects of Melatonin and Pregabalin in Vincristine induced peripheral neuropathy Wistar Albino rats. Life sciences. 2020 Mar; 244(?):117095. doi: 10.1016/j.lfs.2019.117095. [PMID: 31816326]
  • Qin Zhang, Xia-Feng Lu, Yan Zhang, Xiao-Ling Tang, Ren-Chao Zheng, Yu-Guo Zheng. Development of a robust nitrilase by fragment swapping and semi-rational design for efficient biosynthesis of pregabalin precursor. Biotechnology and bioengineering. 2020 02; 117(2):318-329. doi: 10.1002/bit.27203. [PMID: 31631320]
  • Salina P Waddy, Adan Z Becerra, Julia B Ward, Kevin E Chan, Chyng-Wen Fwu, Paul W Eggers, Kevin C Abbott, Paul L Kimmel. Concomitant Use of Gabapentinoids with Opioids Is Associated with Increased Mortality and Morbidity among Dialysis Patients. American journal of nephrology. 2020; 51(6):424-432. doi: 10.1159/000507725. [PMID: 32428902]
  • Xiaoxia Yang, Yan Zhang, Huijin Yu, Jundi Sun, Yanhong He. Efficacy of Pregabalin in Neuropathic Pain after Spinal Cord Injury. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2020 Jan; 30(1):106-107. doi: 10.29271/jcpsp.2020.01.106. [PMID: 31931947]
  • Kyung Hun Kim, Seo Hyun Lim, Cho Rok Shim, Junsung Park, Woo Heon Song, Min Chang Kwon, Jong Hyuk Lee, Jun Sang Park, Han-Gon Choi. Development of a Novel Controlled-Release Tablet of Pregabalin: Formulation Variation and Pharmacokinetics in Dogs and Humans. Drug design, development and therapy. 2020; 14(?):445-456. doi: 10.2147/dddt.s222505. [PMID: 32099329]
  • R A Kalekin, O V Saltykova, G M Rodionova, V I Gegechkori, A M Orlova. [On the issue of the detection of pregabalin and lorazepam in the cases of their joint presence for the purpose of chemical toxicological studies]. Sudebno-meditsinskaia ekspertiza. 2020; 63(1):36-41. doi: 10.17116/sudmed20206301136. [PMID: 32040086]
  • Ömer Karaca, Hüseyin Ulaş Pinar, Ahmet Fevzi Özgür, Sevsen Kulaksizoğlu, Rafi Doğan. The effect of pregabalin on tourniquet-induced ischemia-reperfusion injury: a prospective randomized study. Turkish journal of medical sciences. 2019 12; 49(6):1693-1700. doi: 10.3906/sag-1902-230. [PMID: 31655508]
  • David A Goldfarb. Re: Prospective, Double-Blind, Randomized Clinical Trial Comparing an ERAS Pathway with Ketorolac and Pregabalin versus Standard of Care plus Placebo during Live Donor Nephrectomy for Kidney Transplant. The Journal of urology. 2019 12; 202(6):1087-1088. doi: 10.1097/01.ju.0000585200.72782.6a. [PMID: 31518191]
  • Renuka Verma, Jasmine Sharma, Nirmal Singh, Amteshwar Singh Jaggi. Investigating the possible pain attenuating mechanisms of pregabalin in chronic constriction injury-induced neuropathic pain in rats. The International journal of neuroscience. 2019 Dec; 129(12):1155-1165. doi: 10.1080/00207454.2019.1638783. [PMID: 31256739]
  • Z Gao, H Wei, Z Chen, N Jalava, A Koivisto, A Pertovaara. Ongoing pain in streptozotocin model of diabetes in the rat: correlation with cutaneous cheminociception. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2019 Dec; 70(6):. doi: 10.26402/jpp.2019.6.14. [PMID: 32203940]
  • Katarzyna Socała, Elżbieta Wyska, Małgorzata Szafarz, Dorota Nieoczym, Piotr Wlaź. Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies. Neuropharmacology. 2019 11; 158(?):107733. doi: 10.1016/j.neuropharm.2019.107733. [PMID: 31377197]
  • Marci Chew, Guangli Ma, Rujia Xie, Howard Bockbrader, Sunny Chapel, Scott Marshall. Population Pharmacokinetics of Pregabalin Extended-Release in Healthy Volunteers and Patients With Postherpetic Neuralgia, Fibromyalgia, and Partial-Onset Seizures. Journal of clinical pharmacology. 2019 11; 59(11):1527-1542. doi: 10.1002/jcph.1450. [PMID: 31183879]
  • Shazia Akram Ghumman, Sajid Bashir, Sobia Noreen, Abdul Muqeet Khan, Muhammad Zubair Malik. Taro-corms mucilage-alginate microspheres for the sustained release of pregabalin: In vitro &in vivo evaluation. International journal of biological macromolecules. 2019 Oct; 139(?):1191-1202. doi: 10.1016/j.ijbiomac.2019.08.100. [PMID: 31415852]
  • Ilker Gunyeli, Mustafa Saygin, Ozlem Ozmen. The impact of the sepsis on female urogenital system: the role of pregabalin. Archives of gynecology and obstetrics. 2019 10; 300(4):1067-1082. doi: 10.1007/s00404-019-05285-8. [PMID: 31529363]
  • Nozomi Yoshikawa, Takafumi Naito, Tatsuya Yagi, Junichi Kawakami. Impact of Cachexia and Opioid Analgesic Cotreatment on Pregabalin Pharmacokinetics and Central Nervous System Symptoms in Cancer Patients. Therapeutic drug monitoring. 2019 10; 41(5):591-597. doi: 10.1097/ftd.0000000000000634. [PMID: 30986807]
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