3-{1-[6,7-Diethoxy-2-(morpholin-4-yl)quinazolin-4-yl]piperidin-4-yl}-1,6-dimethyl-1,2,3,4-tetrahydroquinazoline-2,4-dione (BioDeep_00000180273)

   

human metabolite blood metabolite


代谢物信息卡片


3-{1-[6,7-Diethoxy-2-(morpholin-4-yl)quinazolin-4-yl]piperidin-4-yl}-1,6-dimethyl-1,2,3,4-tetrahydroquinazoline-2,4-dione

化学式: C31H38N6O5 (574.2903537999999)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 95.45%

分子结构信息

SMILES: CCOC1=C(C=C2C(=C1)C(=NC(=N2)N3CCOCC3)N4CCC(CC4)N5C(=O)C6=C(C=CC(=C6)C)N(C5=O)C)OCC
InChI: InChI=1S/C31H38N6O5/c1-5-41-26-18-22-24(19-27(26)42-6-2)32-30(36-13-15-40-16-14-36)33-28(22)35-11-9-21(10-12-35)37-29(38)23-17-20(3)7-8-25(23)34(4)31(37)39/h7-8,17-19,21H,5-6,9-16H2,1-4H3



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Natalia Grañe-Boladeras, Declan Williams, Zlatina Tarmakova, Katarina Stevanovic, Linda A Villani, Pedram Mehrabi, K W Michael Siu, Marçal Pastor-Anglada, Imogen R Coe. Oligomerization of equilibrative nucleoside transporters: a novel regulatory and functional mechanism involving PKC and PP1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 03; 33(3):3841-3850. doi: 10.1096/fj.201800440rr. [PMID: 30521377]
  • Sumeeta Warraich, Derek B J Bone, Diana Quinonez, Hisataka Ii, Doo-Sup Choi, David W Holdsworth, Maria Drangova, S Jeffrey Dixon, Cheryle A Séguin, James R Hammond. Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in humans. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2013 May; 28(5):1135-49. doi: 10.1002/jbmr.1826. [PMID: 23184610]
  • Tohru Noji, Ken-ichiro Nan-ya, Mirai Mizutani, Chikako Katagiri, Jun-ichi Sano, Chie Takada, Satoshi Nishikawa, Akira Karasawa, Hideaki Kusaka. KF24345, an adenosine uptake inhibitor, ameliorates the severity and mortality of lethal acute pancreatitis via endogenous adenosine in mice. European journal of pharmacology. 2002 Nov; 454(1):85-93. doi: 10.1016/s0014-2999(02)02476-7. [PMID: 12409009]
  • Tohru Noji, Ken-ichiro Nan-ya, Chikako Katagiri, Mirai Mizutani, Jun-ichi Sano, Satoshi Nishikawa, Akira Karasawa, Hideaki Kusaka. Adenosine uptake inhibition ameliorates cerulein-induced acute pancreatitis in mice. Pancreas. 2002 Nov; 25(4):387-92. doi: 10.1097/00006676-200211000-00011. [PMID: 12409834]
  • Tohru Noji, Hitoshi Sato, Jun-ichi Sano, Satoshi Nishikawa, Hideaki Kusaka, Akira Karasawa. Treatment with an adenosine uptake inhibitor attenuates glomerulonephritis in mice. European journal of pharmacology. 2002 Aug; 449(3):293-300. doi: 10.1016/s0014-2999(02)02039-3. [PMID: 12167472]
  • Tohru Noji, Makoto Takayama, Mirai Mizutani, Yuko Okamura, Haruki Takai, Akira Karasawa, Hideaki Kusaka. KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production and leukopenia via endogenous adenosine in mice. The Journal of pharmacology and experimental therapeutics. 2002 Jan; 300(1):200-5. doi: 10.1124/jpet.300.1.200. [PMID: 11752117]
  • L Ekelund, W Månsson, A M Olsson, L Stigsson. Palliative embolization of arterial renal tumour supply. Results in 10 cases. Acta radiologica: diagnosis. 1979; 20(2):323-36. doi: 10.1177/028418517902000205. [PMID: 91307]