Kemptide (BioDeep_00000180259)

   

human metabolite blood metabolite


代谢物信息卡片


2-{2-[2-(2-{2-[2-(2-amino-4-methylpentanamido)-5-[(diaminomethylidene)amino]pentanamido]-5-[(diaminomethylidene)amino]pentanamido}propanamido)-3-hydroxypropanamido]-4-methylpentanamido}acetic acid

化学式: C32H61N13O9 (771.4714976)
中文名称: 肯普肽 乙酸盐
谱图信息: 最多检出来源 Mus musculus(blood) 33.33%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NCC(=O)O)N
InChI: InChI=1S/C32H61N13O9/c1-16(2)12-19(33)26(50)42-21(9-7-11-39-32(36)37)29(53)43-20(8-6-10-38-31(34)35)28(52)41-18(5)25(49)45-23(15-46)30(54)44-22(13-17(3)4)27(51)40-14-24(47)48/h16-23,46H,6-15,33H2,1-5H3,(H,40,51)(H,41,52)(H,42,50)(H,43,53)(H,44,54)(H,45,49)(H,47,48)(H4,34,35,38)(H4,36,37,39)

描述信息

Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase (PKA).

同义名列表

5 个代谢物同义名

2-{2-[2-(2-{2-[2-(2-amino-4-methylpentanamido)-5-[(diaminomethylidene)amino]pentanamido]-5-[(diaminomethylidene)amino]pentanamido}propanamido)-3-hydroxypropanamido]-4-methylpentanamido}acetic acid; {2-[2-(2-{2-[2-(2-amino-4-methylpentanamido)-5-[(diaminomethylidene)amino]pentanamido]-5-[(diaminomethylidene)amino]pentanamido}propanamido)-3-hydroxypropanamido]-4-methylpentanamido}acetic acid; Leucyl-arginyl-arginyl-alanyl-seryl-leucyl-glycine; Leu-arg-arg-ala-ser-leu-gly; Kemptide



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shuai He, Yi Mon Ei Kyaw, Eddie Khay Ming Tan, Laurent Bekale, Malvin Wei Cherng Kang, Susana Soo-Yeon Kim, Ivan Tan, Kong-Peng Lam, James Chen Yong Kah. Quantitative and Label-Free Detection of Protein Kinase A Activity Based on Surface-Enhanced Raman Spectroscopy with Gold Nanostars. Analytical chemistry. 2018 05; 90(10):6071-6080. doi: 10.1021/acs.analchem.7b05417. [PMID: 29697974]
  • Nathan Sandbo, Yimin Qin, Sebastien Taurin, D Kyle Hogarth, Barry Kreutz, Nickolai O Dulin. Regulation of serum response factor-dependent gene expression by proteasome inhibitors. Molecular pharmacology. 2005 Mar; 67(3):789-97. doi: 10.1124/mol.104.006874. [PMID: 15550677]
  • Rong Xiang, Csaba Horváth, James A Wilkins. Elution-modified displacement chromatography coupled with electrospray ionization-MS: on-line detection of trace peptides at low-femtomole level in peptide digests. Analytical chemistry. 2003 Apr; 75(8):1819-27. doi: 10.1021/ac026232t. [PMID: 12713039]
  • Robert G K Donald, Paul A Liberator. Molecular characterization of a coccidian parasite cGMP dependent protein kinase. Molecular and biochemical parasitology. 2002 Apr; 120(2):165-75. doi: 10.1016/s0166-6851(01)00451-0. [PMID: 11897122]
  • F Karege, M Schwald, C Lambercy, J J Murama, M Cisse, A Malafosse. A non-radioactive assay for the cAMP-dependent protein kinase activity in rat brain homogenates and age-related changes in hippocampus and cortex. Brain research. 2001 Jun; 903(1-2):86-93. doi: 10.1016/s0006-8993(01)02409-x. [PMID: 11382391]
  • Y S Cho, Y N Lee, Y S Cho-Chung. Biochemical characterization of extracellular cAMP-dependent protein kinase as a tumor marker. Biochemical and biophysical research communications. 2000 Nov; 278(3):679-84. doi: 10.1006/bbrc.2000.3853. [PMID: 11095968]
  • A Kondrashin, M Nesterova, Y S Cho-Chung. Cyclic adenosine 3':5'-monophosphate-dependent protein kinase on the external surface of LS-174T human colon carcinoma cells. Biochemistry. 1999 Jan; 38(1):172-9. doi: 10.1021/bi982090e. [PMID: 9890895]
  • L J MacAla, J P Hayslett, J I Smallwood. TECHNICAL NOTE: measurement of cAMP-dependent protein kinase activity using a fluorescent-labeled kemptide. Kidney international. 1998 Nov; 54(5):1746-50. doi: 10.1046/j.1523-1755.1998.00140.x. [PMID: 9844154]
  • A Zelada, S Passeron, S Lopes Gomes, M L Cantore. Isolation and characterisation of cAMP-dependent protein kinase from Candida albicans. Purification of the regulatory and catalytic subunits. European journal of biochemistry. 1998 Mar; 252(2):245-52. doi: 10.1046/j.1432-1327.1998.2520245.x. [PMID: 9523695]
  • M Hatmi, J M Gavaret, I Elalamy, B B Vargaftig, C Jacquemin. Evidence for cAMP-dependent platelet ectoprotein kinase activity that phosphorylates platelet glycoprotein IV (CD36). The Journal of biological chemistry. 1996 Oct; 271(40):24776-80. doi: 10.1074/jbc.271.40.24776. [PMID: 8798748]
  • M Hasmeda, G M Polya. Inhibition of cyclic AMP-dependent protein kinase by curcumin. Phytochemistry. 1996 Jun; 42(3):599-605. doi: 10.1016/0031-9422(96)00091-x. [PMID: 8768315]
  • P Fernández Murray, P Hammerschmidt, A Samela, S Passeron. Peptide degradation: effect of substrate phosphorylation on aminopeptidasic hydrolysis. The international journal of biochemistry & cell biology. 1996 Apr; 28(4):451-6. doi: 10.1016/1357-2725(95)00158-1. [PMID: 9026356]
  • B H Wang, G M Polya. The fungal teratogen secalonic acid D is an inhibitor of protein kinase C and of cyclic AMP-dependent protein kinase. Planta medica. 1996 Apr; 62(2):111-4. doi: 10.1055/s-2006-957829. [PMID: 8657739]
  • S Dieterich, T Herget, G Link, H Böttinger, K Pfizenmaier, F J Johannes. In vitro activation and substrates of recombinant, baculovirus expressed human protein kinase C mu. FEBS letters. 1996 Mar; 381(3):183-7. doi: 10.1016/0014-5793(96)00116-0. [PMID: 8601451]
  • D D Schlaepfer, J Jones, H T Haigler. Inhibition of protein kinase C by annexin V. Biochemistry. 1992 Feb; 31(6):1886-91. doi: 10.1021/bi00121a043. [PMID: 1310621]
  • A G Craig, A Engström, H Bennich, E Hoffmann-Posorske, H E Meyer. Plasma desorption mass spectrometry of phosphopeptides: an investigation to determine the feasibility of quantifying the degree of phosphorylation. Biological mass spectrometry. 1991 Sep; 20(9):565-74. doi: 10.1002/bms.1200200910. [PMID: 1723626]
  • D Kübler, W Pyerin, O Bill, A Hotz, J Sonka, V Kinzel. Evidence for ecto-protein kinase activity that phosphorylates Kemptide in a cyclic AMP-dependent mode. The Journal of biological chemistry. 1989 Aug; 264(24):14549-55. doi: 10.1016/s0021-9258(18)71713-4. [PMID: 2547801]
  • M M Behrens, M J Mazón. Yeast cAMP-dependent protein kinase can be associated to the plasma membrane. Biochemical and biophysical research communications. 1988 Feb; 151(1):561-7. doi: 10.1016/0006-291x(88)90631-6. [PMID: 2831892]