Metolazone (BioDeep_00000018025)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulphonamide

化学式: C16H16ClN3O3S (365.0600856)
中文名称: 美托拉宗
谱图信息: 最多检出来源 Homo sapiens(blood) 25%

分子结构信息

SMILES: Cc1ccccc1N1C(=O)c2cc(S(N)(=O)=O)c(Cl)cc2NC1C
InChI: InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)

描述信息

Metolazone is only found in individuals that have used or taken this drug. It is a quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. [PubChem]The actions of metolazone result from interference with the renal tubular mechanism of electrolyte reabsorption. Metolazone acts primarily to inhibit sodium reabsorption at the cortical diluting site and to a lesser extent in the proximal convoluted tubule. Sodium and chloride ions are excreted in approximately equivalent amounts. The increased delivery of sodium to the distal tubular exchange site results in increased potassium excretion. Metolazone does not inhibit carbonic anhydrase. The antihypertensive mechanism of action of metolazone is not fully understood but is presumed to be related to its saluretic and diuretic properties.
C - Cardiovascular system > C03 - Diuretics > C03B - Low-ceiling diuretics, excl. thiazides > C03BA - Sulfonamides, plain
D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D049990 - Membrane Transport Modulators

同义名列表

16 个代谢物同义名

7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulphonamide; 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-O-tolyl-6-quinazolinesulphonamide; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-O-tolyl-6-quinazolinesulfonamide; 2-Methyl-3-O-tolyl-6-sulphamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone; 2-Methyl-3-O-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone; Celltech pharmaceuticals brand OF metolzone; UCB pharma brand OF metolazone; Metolazonum; metolazone; Metolazona; Zaroxolyn; Mykrox; Microx; Diulo



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kristen M Ahlschwede, Edward Ofori, Terrick Andey, Anita Osei, John S Somberg. Formulation, Characterization, and the Diuretic Effects of a New Intravenous Metolazone Emulsion. Drug research. 2022 Jul; 72(6):299-305. doi: 10.1055/a-1813-9489. [PMID: 35537450]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Taylor D Steuber, Kristin M Janzen, Meredith L Howard. A Systematic Review and Meta-Analysis of Metolazone Compared to Chlorothiazide for Treatment of Acute Decompensated Heart Failure. Pharmacotherapy. 2020 09; 40(9):924-935. doi: 10.1002/phar.2440. [PMID: 32639593]
  • Zachary L Cox, Rebecca Hung, Daniel J Lenihan, Jeffrey M Testani. Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial. JACC. Heart failure. 2020 03; 8(3):157-168. doi: 10.1016/j.jchf.2019.09.012. [PMID: 31838029]
  • Shaurya Srivastava, Tyler Kemnic, Kyle R Hildebrandt. BRASH syndrome. BMJ case reports. 2020 Feb; 13(2):. doi: 10.1136/bcr-2019-233825. [PMID: 32094236]
  • Momin Salahudin, Hammad Shah, Muneeb Ullah Jan, Afrasyab Altaf. Comparing the sodium excreting efficacy of furosemide and indapamide combination against furosemide and metolazone combination in congestive heart failure patients: A randomized control trial. JPMA. The Journal of the Pakistan Medical Association. 2019 Dec; 69(12):1794-1799. doi: 10.5455/jpma.3401. [PMID: 31853105]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Russell T Wise, Brady S Moffett, Ayse Akcan-Arikan, Marianne Galati, Natasha Afonso, Paul A Checchia. Enhancement of diuresis with metolazone in infant paediatric cardiac intensive care patients. Cardiology in the young. 2018 Jan; 28(1):27-31. doi: 10.1017/s1047951117001330. [PMID: 28889825]
  • Xueqing Li, Rutao Wang, Yang Liu, Yun Liu, Heng Zheng, Yabo Feng, Na Zhao, Hongbin Geng, Wanzhi Zhang, Aidong Wen. Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population. BMC pharmacology & toxicology. 2017 11; 18(1):73. doi: 10.1186/s40360-017-0178-x. [PMID: 29145890]
  • Jiezhao Zhou, Meiling Chen, Ying Li, Fanglin Yu, Xiaohui Cheng, Yang Yang, Yan Liu, Xiangyang Xie, Zhiping Li, Hui Zhang, Xingguo Mei. Simultaneous determination of metolazone and valsartan in plasma by on-line SPE coupled with liquid chromatography/tandem mass spectrometry. European journal of mass spectrometry (Chichester, England). 2017 Oct; 23(5):305-312. doi: 10.1177/1469066717716726. [PMID: 29028382]
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  • Christopher J Michaud, Kendall C Mintus. Intravenous Chlorothiazide Versus Enteral Metolazone to Augment Loop Diuretic Therapy in the Intensive Care Unit. The Annals of pharmacotherapy. 2017 Apr; 51(4):286-292. doi: 10.1177/1060028016683971. [PMID: 28228057]
  • Maria Cardinale, Jerry Altshuler, Jeffrey M Testani. Efficacy of Intravenous Chlorothiazide for Refractory Acute Decompensated Heart Failure Unresponsive to Adjunct Metolazone. Pharmacotherapy. 2016 08; 36(8):843-51. doi: 10.1002/phar.1787. [PMID: 27321568]
  • Christine E Shulenberger, Anthony Jiang, Sandeep Devabhakthuni, Vijay Ivaturi, Tao Liu, Brent N Reed. Efficacy and Safety of Intravenous Chlorothiazide versus Oral Metolazone in Patients with Acute Decompensated Heart Failure and Loop Diuretic Resistance. Pharmacotherapy. 2016 08; 36(8):852-60. doi: 10.1002/phar.1798. [PMID: 27393709]
  • Ramkumar Dubey, Manik Ghosh, Barij Nayan Sinha, Venkateswari Muthukrishnan. Simultaneous Determination and Pharmacokinetics of Metolazone, Losartan and Losartan Carboxylic Acid in Rat Plasma by HPLC-ESI-MS-MS. Journal of chromatographic science. 2015 Oct; 53(9):1520-7. doi: 10.1093/chromsci/bmv047. [PMID: 25947361]
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  • Hon Wai Benjamin Cheng, Mau-Kwong Sham, Kwok-Ying Chan, Cho-Wing Li, Ho-Yan Au, Terence Yip. Combination therapy with low-dose metolazone and furosemide: a 'needleless' approach in managing refractory fluid overload in elderly renal failure patients under palliative care. International urology and nephrology. 2014 Sep; 46(9):1809-13. doi: 10.1007/s11255-014-0724-z. [PMID: 24824145]
  • Mohammed I Walash, Nahed M El-Enany, Manal I Eid, Mona E Fathy. Simultaneous determination of metolazone and losartan potassium in their binary mixtures using high-performance liquid chromatography with fluorimetric detection: application to combined tablets and spiked human plasma. Luminescence : the journal of biological and chemical luminescence. 2014 Aug; 29(5):462-70. doi: 10.1002/bio.2570. [PMID: 23996979]
  • Bijin Thajudeen, Mario F Rubin. Hemodynamic acute kidney injury in immunoglobulin A nephropathy: nephrosarca theory revisited. The American journal of medicine. 2013 Dec; 126(12):e13-4. doi: 10.1016/j.amjmed.2013.07.033. [PMID: 24140146]
  • Tien M H Ng, Erica Konopka, Alifiya F Hyderi, Shenche Hshieh, Yuki Tsuji, Brian J Kim, Song Y Han, Duc H Phan, Aaron I Jeng, Mimi Lou, Uri Elkayam. Comparison of bumetanide- and metolazone-based diuretic regimens to furosemide in acute heart failure. Journal of cardiovascular pharmacology and therapeutics. 2013 Jul; 18(4):345-53. doi: 10.1177/1074248413482755. [PMID: 23538300]
  • Yanyan Jia, Yan Zhang, Chao Wang, Zhirui Wang, Yu Liu, Jingwen Wang, Aidong Wen. An improved LC-MS/MS method for quantitative determination of metolazone in human plasma and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2011 Oct; 25(10):1138-43. doi: 10.1002/bmc.1583. [PMID: 21387350]
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