Meprobamate (BioDeep_00000018023)

   

human metabolite blood metabolite


代谢物信息卡片


2-[(carbamoyloxy)methyl]-2-methylpentyl carbamate

化学式: C9H18N2O4 (218.1267)
中文名称: 甲丙氨酯
谱图信息: 最多检出来源 Homo sapiens(blood) 21.15%

分子结构信息

SMILES: CCCC(C)(COC(=N)O)COC(=N)O
InChI: InChI=1S/C9H18N2O4/c1-3-4-9(2,5-14-7(10)12)6-15-8(11)13/h3-6H2,1-2H3,(H2,10,12)(H2,11,13)

描述信息

A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Meprobamate is a controlled substance in the U.S.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BC - Carbamates
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants

同义名列表

28 个代谢物同义名

2-[(carbamoyloxy)methyl]-2-methylpentyl carbamate; Sanofi synthelabo brand OF meprobamate; Reid rowell brand OF meprobamate; Reid-rowell brand OF meprobamate; Wallace brand 2 OF meprobamate; Wallace brand 1 OF meprobamate; Meprobamate reid-rowell brand; Richard brand OF meprobamate; Wyeth brand OF meprobamate; Alter brand OF meprobamate; Kade brand OF meprobamate; Meprobamate richard brand; Meprobamate alter brand; Meprobamate wyeth brand; Meprobamate kade brand; Méprobamate richard; Meprobamic acid; DEA no. 2820; Procarbamide; meprobamate; Meprospan; Miltown; Equanil; Tranmep; Visano; sowell; Dapaz; Meprobamate



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Hany Ibrahim, Abdallah M Hamdy, Hanan A Merey, Ahmed S Saad. Simultaneous Determination of Paracetamol, Propyphenazone and Caffeine in Presence of Paracetamol Impurities Using Dual-Mode Gradient HPLC and TLC Densitometry Methods. Journal of chromatographic science. 2021 Jan; 59(2):140-147. doi: 10.1093/chromsci/bmaa088. [PMID: 33221830]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Matthew H Slawson, Kamisha L Johnson-Davis. Quantitation of Carisoprodol and Meprobamate in Urine and Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Methods in molecular biology (Clifton, N.J.). 2016; 1383(?):105-14. doi: 10.1007/978-1-4939-3252-8_12. [PMID: 26660179]
  • Jessica L Knittel, Shawn P Vorce, Barry Levine, Rhome L Hughes, Thomas Z Bosy. Multidrug toxicity involving sumatriptan. Journal of analytical toxicology. 2015 Jan; 39(1):75-9. doi: 10.1093/jat/bku120. [PMID: 25324526]
  • Xingrong Liu, Matthew Wright, Cornelis E C A Hop. Rational use of plasma protein and tissue binding data in drug design. Journal of medicinal chemistry. 2014 Oct; 57(20):8238-48. doi: 10.1021/jm5007935. [PMID: 25099658]
  • Fabien Bévalot, Charline Bottinelli, Nathalie Cartiser, Laurent Fanton, Jérôme Guitton. Quantification of five compounds with heterogeneous physicochemical properties (morphine, 6-monoacetylmorphine, cyamemazine, meprobamate and caffeine) in 11 fluids and tissues, using automated solid-phase extraction and gas chromatography-tandem mass spectrometry. Journal of analytical toxicology. 2014 Jun; 38(5):256-64. doi: 10.1093/jat/bku029. [PMID: 24790060]
  • Stephanie A Tse, Rabia S Atayee, Joseph D Ma, Brookie M Best. Factors affecting carisoprodol metabolism in pain patients using urinary excretion data. Journal of analytical toxicology. 2014 Apr; 38(3):122-8. doi: 10.1093/jat/bku002. [PMID: 24488112]
  • Xiaoqin Wu, Frederick Ernst, Jeremy L Conkle, Jay Gan. Comparative uptake and translocation of pharmaceutical and personal care products (PPCPs) by common vegetables. Environment international. 2013 Oct; 60(?):15-22. doi: 10.1016/j.envint.2013.07.015. [PMID: 23973619]
  • Alessandro Ceschi, David Berger, Michael Dickenmann, Michael Bodmer. Pharmacokinetics of meprobamate in overdose treated with continuous venovenous hemodiafiltration (CVVHDF). Hemodialysis international. International Symposium on Home Hemodialysis. 2013 Oct; 17(4):656-9. doi: 10.1111/hdi.12047. [PMID: 23615322]
  • Gudrun Høiseth, Umair Majid, Jørg Mørland, Jørgen G Bramness, Espen Molden. CYP2C19 genetics in fatal carisoprodol intoxications. European journal of clinical pharmacology. 2012 Nov; 68(11):1561-5. doi: 10.1007/s00228-012-1278-6. [PMID: 22527345]
  • Ulrike Hass, Uwe Dünnbier, Gudrun Massmann. Occurrence of psychoactive compounds and their metabolites in groundwater downgradient of a decommissioned sewage farm in Berlin (Germany). Environmental science and pollution research international. 2012 Jul; 19(6):2096-106. doi: 10.1007/s11356-011-0707-x. [PMID: 22227832]
  • J Lee, I C Choi, K T Kim, S H Cho, J Y Yoo. Response of dietary substitution of fishmeal with various protein sources on growth, body composition and blood chemistry of olive flounder (Paralichthys olivaceus, Temminck & Schlegel, 1846). Fish physiology and biochemistry. 2012 Jun; 38(3):735-44. doi: 10.1007/s10695-011-9555-3. [PMID: 21892790]
  • Stephanie A Tse, Rabia S Atayee, Brookie M Best, Amadeo J Pesce. Evaluating the relationship between carisoprodol concentrations and meprobamate formation and inter-subject and intra-subject variability in urinary excretion data of pain patients. Journal of analytical toxicology. 2012 May; 36(4):221-31. doi: 10.1093/jat/bks018. [PMID: 22511696]
  • V Härmä, M Knuuttila, J Virtanen, T Mirtti, P Kohonen, P Kovanen, A Happonen, S Kaewphan, I Ahonen, O Kallioniemi, R Grafström, J Lötjönen, M Nees. Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models. Oncogene. 2012 Apr; 31(16):2075-89. doi: 10.1038/onc.2011.396. [PMID: 21996742]
  • Sarah Lebeer, Ingmar J J Claes, Crina I A Balog, Geert Schoofs, Tine L A Verhoeven, Kris Nys, Ingemar von Ossowski, Willem M de Vos, Hanne L P Tytgat, Patrizia Agostinis, Airi Palva, Els J M Van Damme, André M Deelder, Sigrid C J De Keersmaecker, Manfred Wuhrer, Jos Vanderleyden. The major secreted protein Msp1/p75 is O-glycosylated in Lactobacillus rhamnosus GG. Microbial cell factories. 2012 Feb; 11(?):15. doi: 10.1186/1475-2859-11-15. [PMID: 22297095]
  • Jean-Claude Alvarez, Charlotte Duverneuil, Khémais Zouaoui, Emuri Abe, Philippe Charlier, Geoffroy Lorin de la Grandmaison, Stanislas Grassin-Delyle. Evaluation of the first immunoassay for the semi-quantitative measurement of meprobamate in human whole blood or plasma using biochip array technology. Clinica chimica acta; international journal of clinical chemistry. 2012 Jan; 413(1-2):273-7. doi: 10.1016/j.cca.2011.10.025. [PMID: 22057036]
  • Marc W Schmid, Anja Schmidt, Ulrich C Klostermeier, Matthias Barann, Philip Rosenstiel, Ueli Grossniklaus. A powerful method for transcriptional profiling of specific cell types in eukaryotes: laser-assisted microdissection and RNA sequencing. PloS one. 2012; 7(1):e29685. doi: 10.1371/journal.pone.0029685. [PMID: 22291893]
  • Casper Søgaard, Anne Stenbæk, Sophie Bernard, Masood Hadi, Azeddine Driouich, Henrik Vibe Scheller, Yumiko Sakuragi. GO-PROMTO illuminates protein membrane topologies of glycan biosynthetic enzymes in the Golgi apparatus of living tissues. PloS one. 2012; 7(2):e31324. doi: 10.1371/journal.pone.0031324. [PMID: 22363620]
  • Ali Mobasheri, Yves Henrotin, Hans-Konrad Biesalski, Mehdi Shakibaei. Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. International journal of molecular sciences. 2012; 13(4):4202-4232. doi: 10.3390/ijms13044202. [PMID: 22605974]
  • Makoto Hirano, Bruce Y Ma, Nobuko Kawasaki, Shogo Oka, Toshisuke Kawasaki. Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney. Glycobiology. 2012 Jan; 22(1):84-95. doi: 10.1093/glycob/cwr107. [PMID: 21835783]
  • Bai-Liang He, Ji-Min Yuan, Lu-Yun Yang, Jun-Feng Xie, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He. The viral TRAF protein (ORF111L) from infectious spleen and kidney necrosis virus interacts with TRADD and induces caspase 8-mediated apoptosis. PloS one. 2012; 7(5):e37001. doi: 10.1371/journal.pone.0037001. [PMID: 22615868]
  • Hongyu Zhao, Matthew R Avenarius, Peter G Gillespie. Improved biolistic transfection of hair cells. PloS one. 2012; 7(10):e46765. doi: 10.1371/journal.pone.0046765. [PMID: 23049715]
  • Honggang Li, Shiyun Huang, Cuicui Guo, Huangtao Guan, Chengliang Xiong. Cell-free seminal mRNA and microRNA exist in different forms. PloS one. 2012; 7(4):e34566. doi: 10.1371/journal.pone.0034566. [PMID: 22506029]
  • Pei-Shiue J Tsai, Ian A Brewis, Jillis van Maaren, Bart M Gadella. Involvement of complexin 2 in docking, locking and unlocking of different SNARE complexes during sperm capacitation and induced acrosomal exocytosis. PloS one. 2012; 7(3):e32603. doi: 10.1371/journal.pone.0032603. [PMID: 22412896]
  • Melisande L Addison, James S Minnion, Joy C Shillito, Keisuke Suzuki, Tricia M Tan, Benjamin C T Field, Natacha Germain-Zito, Christoph Becker-Pauly, Mohammad A Ghatei, Stephen R Bloom, Kevin G Murphy. A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36. Endocrinology. 2011 Dec; 152(12):4630-40. doi: 10.1210/en.2011-1195. [PMID: 21952244]
  • Alison M Mondul, Kai Yu, William Wheeler, Hong Zhang, Stephanie J Weinstein, Jacqueline M Major, Marilyn C Cornelis, Satu Männistö, Aditi Hazra, Ann W Hsing, Kevin B Jacobs, Heather Eliassen, Toshiko Tanaka, Douglas J Reding, Sara Hendrickson, Luigi Ferrucci, Jarmo Virtamo, David J Hunter, Stephen J Chanock, Peter Kraft, Demetrius Albanes. Genome-wide association study of circulating retinol levels. Human molecular genetics. 2011 Dec; 20(23):4724-31. doi: 10.1093/hmg/ddr387. [PMID: 21878437]
  • Jenny Wegert, Sabrina Bausenwein, Susanne Kneitz, Sabine Roth, Norbert Graf, Eva Geissinger, Manfred Gessler. Retinoic acid pathway activity in Wilms tumors and characterization of biological responses in vitro. Molecular cancer. 2011 Nov; 10(?):136. doi: 10.1186/1476-4598-10-136. [PMID: 22067876]
  • Kuniyasu Soda. The mechanisms by which polyamines accelerate tumor spread. Journal of experimental & clinical cancer research : CR. 2011 Oct; 30(?):95. doi: 10.1186/1756-9966-30-95. [PMID: 21988863]
  • Elimelda Moige Ongeri, Odinaka Anyanwu, W Brian Reeves, Judith S Bond. Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion. American journal of physiology. Renal physiology. 2011 Oct; 301(4):F871-82. doi: 10.1152/ajprenal.00703.2010. [PMID: 21795642]
  • Marianne Jaubert, Saikat Bhattacharjee, Alexandre F S Mello, Keith L Perry, Peter Moffett. ARGONAUTE2 mediates RNA-silencing antiviral defenses against Potato virus X in Arabidopsis. Plant physiology. 2011 Jul; 156(3):1556-64. doi: 10.1104/pp.111.178012. [PMID: 21576511]
  • Hakan Dortay, Usha Madhuri Akula, Christin Westphal, Marie Sittig, Bernd Mueller-Roeber. High-throughput protein expression using a combination of ligation-independent cloning (LIC) and infrared fluorescent protein (IFP) detection. PloS one. 2011 Apr; 6(4):e18900. doi: 10.1371/journal.pone.0018900. [PMID: 21541323]
  • Jérôme Bellenger, Sandrine Bellenger, Amandine Bataille, Karen A Massey, Anna Nicolaou, Mickaël Rialland, Christian Tessier, Jing X Kang, Michel Narce. High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibition. Diabetes. 2011 Apr; 60(4):1090-9. doi: 10.2337/db10-0901. [PMID: 21330635]
  • Dorota Scieglinska, Wojciech Piglowski, Mykola Chekan, Agnieszka Mazurek, Zdzisław Krawczyk. Differential expression of HSPA1 and HSPA2 proteins in human tissues; tissue microarray-based immunohistochemical study. Histochemistry and cell biology. 2011 Apr; 135(4):337-50. doi: 10.1007/s00418-011-0791-5. [PMID: 21373891]
  • Guohong Wang, Kim Huynh, Rekha Barhate, Warren Rodrigues, Christine Moore, Cynthia Coulter, Michael Vincent, James Soares. Validation of a new homogeneous immunoassay for the detection of carisoprodol in urine. Journal of analytical toxicology. 2011 Mar; 35(2):108-12. doi: 10.1093/anatox/35.2.108. [PMID: 21396230]
  • Zhen Wang, Christian Herzog, Gur P Kaushal, Neriman Gokden, Philip R Mayeux. Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis. Shock (Augusta, Ga.). 2011 Feb; 35(2):141-7. doi: 10.1097/shk.0b013e3181ec39cc. [PMID: 20577148]
  • Sanjita Banerjee, Ge Jin, S Gaylen Bradley, Gail L Matters, Ryan D Gailey, Jacqueline M Crisman, Judith S Bond. Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease. American journal of physiology. Gastrointestinal and liver physiology. 2011 Feb; 300(2):G273-82. doi: 10.1152/ajpgi.00504.2009. [PMID: 21071511]
  • Jason R Gerstner, William M Vanderheyden, Paul J Shaw, Charles F Landry, Jerry C P Yin. Fatty-acid binding proteins modulate sleep and enhance long-term memory consolidation in Drosophila. PloS one. 2011 Jan; 6(1):e15890. doi: 10.1371/journal.pone.0015890. [PMID: 21298037]
  • Xavier Delavenne, Jean Pierre Gay-Montchamp, Thierry Basset. HPLC MS/MS method for quantification of meprobamate in human plasma: application to 24/7 clinical toxicology. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Jan; 879(2):215-8. doi: 10.1016/j.jchromb.2010.11.034. [PMID: 21185792]
  • Agata Budkowska, Athanassios Kakkanas, Eric Nerrienet, Olga Kalinina, Patrick Maillard, Srey Viseth Horm, Geena Dalagiorgou, Niki Vassilaki, Urania Georgopoulou, Michelle Martinot, Amadou Alpha Sall, Penelope Mavromara. Synonymous mutations in the core gene are linked to unusual serological profile in hepatitis C virus infection. PloS one. 2011 Jan; 6(1):e15871. doi: 10.1371/journal.pone.0015871. [PMID: 21283512]
  • Gabriella Aviello, Jasna M Canadanovic-Brunet, Natasa Milic, Raffaele Capasso, Ernesto Fattorusso, Orazio Taglialatela-Scafati, Ines Fasolino, Angelo A Izzo, Francesca Borrelli. Potent antioxidant and genoprotective effects of boeravinone G, a rotenoid isolated from Boerhaavia diffusa. PloS one. 2011; 6(5):e19628. doi: 10.1371/journal.pone.0019628. [PMID: 21625488]
  • Vance L Albaugh, Ravi Singareddy, David Mauger, Christopher J Lynch. A double blind, placebo-controlled, randomized crossover study of the acute metabolic effects of olanzapine in healthy volunteers. PloS one. 2011; 6(8):e22662. doi: 10.1371/journal.pone.0022662. [PMID: 21857944]
  • Leigh Breen, Andrew Philp, Christopher S Shaw, Asker E Jeukendrup, Keith Baar, Kevin D Tipton. Beneficial effects of resistance exercise on glycemic control are not further improved by protein ingestion. PloS one. 2011; 6(6):e20613. doi: 10.1371/journal.pone.0020613. [PMID: 21701685]
  • Agustin Garcia-Caballero, Susan S Ishmael, Yan Dang, Daniel Gillie, Judith S Bond, Sharon L Milgram, M Jackson Stutts. Activation of the epithelial sodium channel by the metalloprotease meprin β subunit. Channels (Austin, Tex.). 2011 Jan; 5(1):14-22. doi: 10.4161/chan.5.1.13759. [PMID: 20953144]
  • Francesca Belleudi, Cristina Scrofani, Maria Rosaria Torrisi, Patrizia Mancini. Polarized endocytosis of the keratinocyte growth factor receptor in migrating cells: role of SRC-signaling and cortactin. PloS one. 2011; 6(12):e29159. doi: 10.1371/journal.pone.0029159. [PMID: 22195012]
  • Maria Eldh, Karin Ekström, Hadi Valadi, Margareta Sjöstrand, Bob Olsson, Margareta Jernås, Jan Lötvall. Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA. PloS one. 2010 Dec; 5(12):e15353. doi: 10.1371/journal.pone.0015353. [PMID: 21179422]
  • Antonio Díaz-López, Pilar Iniesta, Alberto Morán, Paloma Ortega, Tamara Fernández-Marcelo, Andrés Sánchez-Pernaute, Antonio J Torres, Manuel Benito, Carmen De Juan. Expression of Human MDGA1 Increases Cell Motility and Cell-Cell Adhesion and Reduces Adhesion to Extracellular Matrix Proteins in MDCK Cells. Cancer microenvironment : official journal of the International Cancer Microenvironment Society. 2010 Nov; 4(1):23-32. doi: 10.1007/s12307-010-0055-2. [PMID: 21505559]
  • Ffolliott M Fisher, Patricia C Chui, Patrick J Antonellis, Holly A Bina, Alexei Kharitonenkov, Jeffrey S Flier, Eleftheria Maratos-Flier. Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes. 2010 Nov; 59(11):2781-9. doi: 10.2337/db10-0193. [PMID: 20682689]
  • G Bobe, G Murphy, P S Albert, L B Sansbury, E Lanza, A Schatzkin, N H Colburn, A J Cross. Serum cytokine concentrations, flavonol intake and colorectal adenoma recurrence in the Polyp Prevention Trial. British journal of cancer. 2010 Oct; 103(9):1453-61. doi: 10.1038/sj.bjc.6605915. [PMID: 20924374]
  • Zhigang Xu, Kazuo Oshima, Stefan Heller. PIST regulates the intracellular trafficking and plasma membrane expression of cadherin 23. BMC cell biology. 2010 Oct; 11(?):80. doi: 10.1186/1471-2121-11-80. [PMID: 20958966]
  • Jana Hedrich, Daniel Lottaz, Katharina Meyer, Irene Yiallouros, Willi Jahnen-Dechent, Walter Stöcker, Christoph Becker-Pauly. Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases. Biochemistry. 2010 Oct; 49(39):8599-607. doi: 10.1021/bi1004238. [PMID: 20806899]
  • Deborah M Dickey, Lincoln R Potter. Human B-type natriuretic peptide is not degraded by meprin A. Biochemical pharmacology. 2010 Oct; 80(7):1007-11. doi: 10.1016/j.bcp.2010.06.015. [PMID: 20599787]
  • Patrick Cosson, Luc Sofer, Valérie Schurdi-Levraud, Frédéric Revers. A member of a new plant gene family encoding a meprin and TRAF homology (MATH) domain-containing protein is involved in restriction of long distance movement of plant viruses. Plant signaling & behavior. 2010 Oct; 5(10):1321-3. doi: 10.4161/psb.5.10.13244. [PMID: 20930558]
  • Jens Mittag, Thomas Behrends, Carolin S Hoefig, Björn Vennström, Lutz Schomburg. Thyroid hormones regulate selenoprotein expression and selenium status in mice. PloS one. 2010 Sep; 5(9):e12931. doi: 10.1371/journal.pone.0012931. [PMID: 20877559]
  • Matthias Becker, Wolf-Eberhard Siems, Reinhart Kluge, Florian Gembardt, Heinz-Peter Schultheiss, Michael Schirner, Thomas Walther. New function for an old enzyme: NEP deficient mice develop late-onset obesity. PloS one. 2010 Sep; 5(9):. doi: 10.1371/journal.pone.0012793. [PMID: 20862277]
  • Nuwan U Sella Kapu, Daniel J Cosgrove. Changes in growth and cell wall extensibility of maize silks following pollination. Journal of experimental botany. 2010 Sep; 61(14):4097-107. doi: 10.1093/jxb/erq225. [PMID: 20656797]
  • Patrick Cosson, Luc Sofer, Quang Hien Le, Valérie Léger, Valérie Schurdi-Levraud, Steven A Whitham, Miki L Yamamoto, Suresh Gopalan, Olivier Le Gall, Thierry Candresse, James C Carrington, Frédéric Revers. RTM3, which controls long-distance movement of potyviruses, is a member of a new plant gene family encoding a meprin and TRAF homology domain-containing protein. Plant physiology. 2010 Sep; 154(1):222-32. doi: 10.1104/pp.110.155754. [PMID: 20584941]
  • Vijay Paul, Patrick Guertler, Steffi Wiedemann, Heinrich H D Meyer. Degradation of Cry1Ab protein from genetically modified maize (MON810) in relation to total dietary feed proteins in dairy cow digestion. Transgenic research. 2010 Aug; 19(4):683-9. doi: 10.1007/s11248-009-9339-z. [PMID: 19888668]
  • D Lee Hamilton, Andrew Philp, Matthew G MacKenzie, Keith Baar. Prolonged activation of S6K1 does not suppress IRS or PI-3 kinase signaling during muscle cell differentiation. BMC cell biology. 2010 May; 11(?):37. doi: 10.1186/1471-2121-11-37. [PMID: 20507574]
  • Lili Zheng, Jing Zheng, Donna S Whitlon, Jaime García-Añoveros, James R Bartles. Targeting of the hair cell proteins cadherin 23, harmonin, myosin XVa, espin, and prestin in an epithelial cell model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 May; 30(21):7187-201. doi: 10.1523/jneurosci.0852-10.2010. [PMID: 20505086]
  • Hakan Dortay, Bernd Mueller-Roeber. A highly efficient pipeline for protein expression in Leishmania tarentolae using infrared fluorescence protein as marker. Microbial cell factories. 2010 May; 9(?):29. doi: 10.1186/1475-2859-9-29. [PMID: 20459748]
  • Ville Härmä, Johannes Virtanen, Rami Mäkelä, Antti Happonen, John-Patrick Mpindi, Matias Knuuttila, Pekka Kohonen, Jyrki Lötjönen, Olli Kallioniemi, Matthias Nees. A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses. PloS one. 2010 May; 5(5):e10431. doi: 10.1371/journal.pone.0010431. [PMID: 20454659]
  • Maria V Yusenko, Thomas Ruppert, Gyula Kovacs. Analysis of differentially expressed mitochondrial proteins in chromophobe renal cell carcinomas and renal oncocytomas by 2-D gel electrophoresis. International journal of biological sciences. 2010 Apr; 6(3):213-24. doi: 10.7150/ijbs.6.213. [PMID: 20440404]
  • Tsun-Thai Chai, Daina Simmonds, David A Day, Timothy D Colmer, Patrick M Finnegan. Photosynthetic performance and fertility are repressed in GmAOX2b antisense soybean. Plant physiology. 2010 Mar; 152(3):1638-49. doi: 10.1104/pp.109.149294. [PMID: 20097793]
  • Eric J R Jansen, Nick H M van Bakel, Anthon J M Coenen, Sander H van Dooren, Hermina A M van Lith, Gerard J M Martens. An isoform of the vacuolar (H(+))-ATPase accessory subunit Ac45. Cellular and molecular life sciences : CMLS. 2010 Feb; 67(4):629-40. doi: 10.1007/s00018-009-0200-6. [PMID: 19946730]
  • Filomena Giorno, Mieke Wolters-Arts, Stefania Grillo, Klaus-Dieter Scharf, Wim H Vriezen, Celestina Mariani. Developmental and heat stress-regulated expression of HsfA2 and small heat shock proteins in tomato anthers. Journal of experimental botany. 2010; 61(2):453-62. doi: 10.1093/jxb/erp316. [PMID: 19854799]
  • Somayeh Kazemi, Sedigheh Asgary, Jamal Moshtaghian, Mahmoud Rafieian, Azadeh Adelnia, Fatemeh Shamsi. Liver-protective effects of hydroalcoholic extract of allium hirtifolium boiss. In rats with alloxan-induced diabetes mellitus. ARYA atherosclerosis. 2010; 6(1):11-5. doi: NULL. [PMID: 22577407]
  • Pan Gao, Rui-wei Guo, Jian-fei Chen, Yang Chen, Hong Wang, Yang Yu, Lan Huang. A meprin inhibitor suppresses atherosclerotic plaque formation in ApoE-/- mice. Atherosclerosis. 2009 Nov; 207(1):84-92. doi: 10.1016/j.atherosclerosis.2009.04.036. [PMID: 19464686]
  • Marcelo M Samsa, Juan A Mondotte, Nestor G Iglesias, Iranaia Assunção-Miranda, Giselle Barbosa-Lima, Andrea T Da Poian, Patricia T Bozza, Andrea V Gamarnik. Dengue virus capsid protein usurps lipid droplets for viral particle formation. PLoS pathogens. 2009 Oct; 5(10):e1000632. doi: 10.1371/journal.ppat.1000632. [PMID: 19851456]
  • Suresh Shastry, Leighton R James. Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK. Journal of inflammation (London, England). 2009 Sep; 6(?):27. doi: 10.1186/1476-9255-6-27. [PMID: 19781090]
  • Juha Isosomppi, Hanna Västinsalo, Scott F Geller, Elise Heon, John G Flannery, Eeva-Marja Sankila. Disease-causing mutations in the CLRN1 gene alter normal CLRN1 protein trafficking to the plasma membrane. Molecular vision. 2009 Sep; 15(?):1806-18. doi: . [PMID: 19753315]
  • Maria G E G Bremer, Nathalie G E Smits, Willem Haasnoot. Biosensor immunoassay for traces of hazelnut protein in olive oil. Analytical and bioanalytical chemistry. 2009 Sep; 395(1):119-26. doi: 10.1007/s00216-009-2720-1. [PMID: 19263041]
  • Robert E Feldmann, Gottfried Kranz, Nicole Praschak-Rieder, Siegfried Kasper. Psycho-pharmacotherapy for anxiety and obsessive-compulsive disorder: the issue of prolonged barbiturate retention. Current medical research and opinion. 2009 Sep; 25(9):2281-5. doi: 10.1185/03007990903116172. [PMID: 19630487]
  • Maria V Yusenko, Dmitry Zubakov, Gyula Kovacs. Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours. International journal of biological sciences. 2009 Jul; 5(6):517-27. doi: 10.7150/ijbs.5.517. [PMID: 19680475]
  • Françoise Thibaud-Nissen, Shu Ouyang, C Robin Buell. Identification and characterization of pseudogenes in the rice gene complement. BMC genomics. 2009 Jul; 10(?):317. doi: 10.1186/1471-2164-10-317. [PMID: 19607679]
  • Anne-Claire Buire, Fabien Vitry, Guillaume Hoizey, Denis Lamiable, Thierry Trenque. Overdose of meprobamate: plasma concentration and Glasgow Coma Scale. British journal of clinical pharmacology. 2009 Jul; 68(1):126-7. doi: 10.1111/j.1365-2125.2009.03406.x. [PMID: 19660012]
  • Guido Boerrigter, Lisa C Costello-Boerrigter, Gail J Harty, Brenda K Huntley, Alessandro Cataliotti, Harald Lapp, John C Burnett. B-type natriuretic peptide 8-32, which is produced from mature BNP 1-32 by the metalloprotease meprin A, has reduced bioactivity. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 Jun; 296(6):R1744-50. doi: 10.1152/ajpregu.00059.2009. [PMID: 19386989]
  • Zhou Du, Xin Zhou, Li Li, Zhen Su. plantsUPS: a database of plants' Ubiquitin Proteasome System. BMC genomics. 2009 May; 10(?):227. doi: 10.1186/1471-2164-10-227. [PMID: 19445698]
  • Pamela J Plant, Judy Correa, Neil Goldenberg, James Bain, Jane Batt. The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. The Biochemical journal. 2009 Apr; 419(1):57-63. doi: 10.1042/bj20081866. [PMID: 19125695]
  • Jing Zheng, Charles T Anderson, Katharine K Miller, MaryAnn Cheatham, Peter Dallos. Identifying components of the hair-cell interactome involved in cochlear amplification. BMC genomics. 2009 Mar; 10(?):127. doi: 10.1186/1471-2164-10-127. [PMID: 19320974]
  • Christian Herzog, Randy S Haun, Varsha Kaushal, Philip R Mayeux, Sudhir V Shah, Gur P Kaushal. Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta. Biochemical and biophysical research communications. 2009 Feb; 379(4):904-8. doi: 10.1016/j.bbrc.2008.12.161. [PMID: 19135030]
  • Gavin D Perkins, Nazim Nathani, Alex G Richter, Daniel Park, Murali Shyamsundar, Ritva Heljasvaara, Taina Pihlajaniemi, Mav Manji, W Tunnicliffe, Danny McAuley, Fang Gao, David R Thickett. Type XVIII collagen degradation products in acute lung injury. Critical care (London, England). 2009; 13(2):R52. doi: 10.1186/cc7779. [PMID: 19358707]
  • Vasiliki Koliaraki, Martha Marinou, Theodoros P Vassilakopoulos, Eustathios Vavourakis, Emmanuel Tsochatzis, Gerassimos A Pangalis, George Papatheodoridis, Alexandra Stamoulakatou, Dorine W Swinkels, George Papanikolaou, Avgi Mamalaki. A novel immunological assay for hepcidin quantification in human serum. PloS one. 2009; 4(2):e4581. doi: 10.1371/journal.pone.0004581. [PMID: 19238200]
  • Renee E Yura, S Gaylen Bradley, Ganesan Ramesh, W Brian Reeves, Judith S Bond. Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge. American journal of physiology. Renal physiology. 2009 Jan; 296(1):F135-44. doi: 10.1152/ajprenal.90524.2008. [PMID: 18971209]
  • Yu Jin, Venkata S Kotakadi, Lei Ying, Anne B Hofseth, Xiangli Cui, Patricia A Wood, Anthony Windust, Lydia E Matesic, Edsel A Pena, Codruta Chiuzan, Narendra P Singh, Mitzi Nagarkatti, Prakash S Nagarkatti, Michael J Wargovich, Lorne J Hofseth. American ginseng suppresses inflammation and DNA damage associated with mouse colitis. Carcinogenesis. 2008 Dec; 29(12):2351-9. doi: 10.1093/carcin/bgn211. [PMID: 18802031]
  • Sanjita Banerjee, Judith S Bond. Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation. The Journal of biological chemistry. 2008 Nov; 283(46):31371-7. doi: 10.1074/jbc.m802814200. [PMID: 18786924]
  • Erwin E Sterchi, Walter Stöcker, Judith S Bond. Meprins, membrane-bound and secreted astacin metalloproteinases. Molecular aspects of medicine. 2008 Oct; 29(5):309-28. doi: 10.1016/j.mam.2008.08.002. [PMID: 18783725]
  • D M Pritchard, D Berry, S M C Przemeck, F Campbell, S W Edwards, A Varro. Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor. American journal of physiology. Gastrointestinal and liver physiology. 2008 Oct; 295(4):G798-805. doi: 10.1152/ajpgi.00015.2008. [PMID: 18719002]
  • Daniel Ambort, Daniel Stalder, Daniel Lottaz, Maya Huguenin, Beatrice Oneda, Manfred Heller, Erwin E Sterchi. A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin. The FEBS journal. 2008 Sep; 275(18):4490-509. doi: 10.1111/j.1742-4658.2008.06592.x. [PMID: 18671728]
  • Vian Azzu, Nadeene Parker, Martin D Brand. High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation. The Biochemical journal. 2008 Jul; 413(2):323-32. doi: 10.1042/bj20080321. [PMID: 18426390]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Beatrice Oneda, Nadège Lods, Daniel Lottaz, Christoph Becker-Pauly, Walter Stöcker, Jeffrey Pippin, Maya Huguenin, Daniel Ambort, Hans-Peter Marti, Erwin E Sterchi. Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis. PloS one. 2008 May; 3(5):e2278. doi: 10.1371/journal.pone.0002278. [PMID: 18509531]
  • Maya Huguenin, Eliane J Müller, Sandra Trachsel-Rösmann, Beatrice Oneda, Daniel Ambort, Erwin E Sterchi, Daniel Lottaz. The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion. PloS one. 2008 May; 3(5):e2153. doi: 10.1371/journal.pone.0002153. [PMID: 18478055]
  • Hiromitsu Yoshimura, Masayoshi Ito, Yusuke Kuwahara, Aiko Ishii, Katsuki Tsuritani, Atsushi Nakamura, Yasushi Hirasawa, Tadashi Nagamatsu. Downregulated expression in high IgA (HIGA) mice and the renal protective role of meprinbeta. Life sciences. 2008 Apr; 82(15-16):899-908. doi: 10.1016/j.lfs.2008.02.006. [PMID: 18355876]
  • Magdalena Winiarska, Jacek Bil, Ewa Wilczek, Grzegorz M Wilczynski, Malgorzata Lekka, Patrick J Engelberts, Wendy J M Mackus, Elzbieta Gorska, Lukasz Bojarski, Tomasz Stoklosa, Dominika Nowis, Zuzanna Kurzaj, Marcin Makowski, Eliza Glodkowska, Tadeusz Issat, Piotr Mrowka, Witold Lasek, Anna Dabrowska-Iwanicka, Grzegorz W Basak, Maria Wasik, Krzysztof Warzocha, Maciej Sinski, Zbigniew Gaciong, Marek Jakobisiak, Paul W H I Parren, Jakub Golab. Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. PLoS medicine. 2008 Mar; 5(3):e64. doi: 10.1371/journal.pmed.0050064. [PMID: 18366248]
  • Cong-jun Li, Robert W Li. Butyrate induced cell cycle arrest in bovine cells through targeting gene expression relevant to DNA replication apparatus. Gene regulation and systems biology. 2008 Mar; 2(?):113-23. doi: 10.4137/grsb.s465. [PMID: 19787080]
  • G A Broderick, M J Stevenson, R A Patton, N E Lobos, J J Olmos Colmenero. Effect of supplementing rumen-protected methionine on production and nitrogen excretion in lactating dairy cows. Journal of dairy science. 2008 Mar; 91(3):1092-102. doi: 10.3168/jds.2007-0769. [PMID: 18292265]
  • John Bylander, Qing Li, Ganesan Ramesh, Binzhi Zhang, W Brian Reeves, Judith S Bond. Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice. American journal of physiology. Renal physiology. 2008 Mar; 294(3):F480-90. doi: 10.1152/ajprenal.00214.2007. [PMID: 18172000]
  • Junji Takayama, Masanori Takaoka, Shinya Yamamoto, Asami Nohara, Mamoru Ohkita, Yasuo Matsumura. Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats. European journal of pharmacology. 2008 Feb; 581(1-2):157-63. doi: 10.1016/j.ejphar.2007.11.044. [PMID: 18093581]
  • Prasad Devarajan. Proteomics for the investigation of acute kidney injury. Contributions to nephrology. 2008; 160(?):1-16. doi: 10.1159/000125893. [PMID: 18401157]