Istradefylline (BioDeep_00000180212)

   

human metabolite blood metabolite


代谢物信息卡片


8-[2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

化学式: C20H24N4O4 (384.1797464)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN1C2=C(N(C)C(C=CC3=CC(OC)=C(OC)C=C3)=N2)C(=O)N(CC)C1=O
InChI: InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3

描述信息

同义名列表

2 个代谢物同义名

8-[2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; Istradefylline



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • William Knebel, Niranjan Rao, Tatsuo Uchimura, Akihisa Mori, Jeannine Fisher, Marc R Gastonguay, Philip Chaikin. Population pharmacokinetic analysis of istradefylline in healthy subjects and in patients with Parkinson's disease. Journal of clinical pharmacology. 2011 Jan; 51(1):40-52. doi: 10.1177/0091270010363809. [PMID: 20200269]
  • Ndidi Ngwuluka, Viness Pillay, Lisa C Du Toit, Valence Ndesendo, Yahya Choonara, Girish Modi, Dinesh Naidoo. Levodopa delivery systems: advancements in delivery of the gold standard. Expert opinion on drug delivery. 2010 Feb; 7(2):203-24. doi: 10.1517/17425240903483166. [PMID: 20095943]
  • N Rao, B Dvorchik, N Sussman, H Wang, K Yamamoto, A Mori, T Uchimura, P Chaikin. A study of the pharmacokinetic interaction of istradefylline, a novel therapeutic for Parkinson's disease, and atorvastatin. Journal of clinical pharmacology. 2008 Sep; 48(9):1092-8. doi: 10.1177/0091270008320924. [PMID: 18552277]
  • Guy A Higgins, Michael E Grzelak, Annamarie J Pond, Mary E Cohen-Williams, Robert A Hodgson, Geoffrey B Varty. The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors. Behavioural brain research. 2007 Dec; 185(1):32-42. doi: 10.1016/j.bbr.2007.07.013. [PMID: 17707919]
  • Cornelis J Van der Schyf, Shunit Gal, Werner J Geldenhuys, Moussa B H Youdim. Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases. Expert opinion on investigational drugs. 2006 Aug; 15(8):873-86. doi: 10.1517/13543784.15.8.873. [PMID: 16859391]
  • E Hirani, J Gillies, A Karasawa, J Shimada, H Kase, J Opacka-Juffry, S Osman, S K Luthra, S P Hume, D J Brooks. Evaluation of [4-O-methyl-(11)C]KW-6002 as a potential PET ligand for mapping central adenosine A(2A) receptors in rats. Synapse (New York, N.Y.). 2001 Dec; 42(3):164-76. doi: 10.1002/syn.1110. [PMID: 11746713]