isopropyl unoprostone (BioDeep_00000180176)
human metabolite blood metabolite
代谢物信息卡片
化学式: C25H44O5 (424.3188574)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCC(=O)CCC1C(O)CC(O)C1CC=CCCCC(=O)OC(C)C
InChI: InChI=1S/C25H44O5/c1-4-5-6-7-10-13-20(26)16-17-22-21(23(27)18-24(22)28)14-11-8-9-12-15-25(29)30-19(2)3/h8,11,19,21-24,27-28H,4-7,9-10,12-18H2,1-3H3
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nobuhiro Nagai, Shinji Yamada, Junichi Kawasaki, Eri Koyanagi, Saaya Saijo, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Toshiaki Abe. Pharmacokinetic and Safety Evaluation of a Transscleral Sustained Unoprostone Release Device in Monkey Eyes.
Investigative ophthalmology & visual science.
2018 02; 59(2):644-652. doi:
10.1167/iovs.17-22429. [PMID: 29392308] - John Cuppoletti, Danuta H Malinowska, Kirti P Tewari, Jayati Chakrabarti, Ryuji Ueno. Unoprostone isopropyl and metabolite M1 activate BK channels and prevent ET-1-induced [Ca²⁺]i increases in human trabecular meshwork and smooth muscle.
Investigative ophthalmology & visual science.
2012 Aug; 53(9):5178-89. doi:
10.1167/iovs.11-9046. [PMID: 22786902] - John Cuppoletti, Danuta H Malinowska, Kirti P Tewari, Jayati Chakrabarti, Ryuji Ueno. Cellular and molecular effects of unoprostone as a BK channel activator.
Biochimica et biophysica acta.
2007 May; 1768(5):1083-92. doi:
10.1016/j.bbamem.2006.12.015. [PMID: 17307133] - Bo Gao, Robert D Huber, Andreas Wenzel, Stephan R Vavricka, Manfred G Ismair, Charlotte Remé, Peter J Meier. Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium.
Experimental eye research.
2005 Jan; 80(1):61-72. doi:
10.1016/j.exer.2004.08.013. [PMID: 15652527] - Hirokazu Mukuno, Makoto Nakamura, Akiyasu Kanamori, Azusa Nagai, Akira Negi, Gail Seigel. Unoprostone isopropyl rescues retinal progenitor cells from apoptosis in vitro.
Current eye research.
2004 Dec; 29(6):457-64. doi:
10.1080/02713680490889465. [PMID: 15764090] - N A Sharif, C R Kelly, J Y Crider, G W Williams, S X Xu. Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2003 Dec; 19(6):501-15. doi:
10.1089/108076803322660422. [PMID: 14733708] - Curtis R Kelly, Gary W Williams, Najam A Sharif. Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors.
The Journal of pharmacology and experimental therapeutics.
2003 Jan; 304(1):238-45. doi:
10.1124/jpet.102.042556. [PMID: 12490597] - Kenji Kashiwagi, Naoaki Kanai, Takayuki Tsuchida, Michihiro Suzuki, Yoko Iizuka, Yuko Tanaka, Shigeo Tsukahara. Comparison between isopropyl unoprostone and latanoprost by prostaglandin E(2)induction, affinity to prostaglandin transporter, and intraocular metabolism.
Experimental eye research.
2002 Jan; 74(1):41-9. doi:
10.1006/exer.2001.1104. [PMID: 11878817] - C Lindén, A Alm. Prostaglandin analogues in the treatment of glaucoma.
Drugs & aging.
1999 May; 14(5):387-98. doi:
10.2165/00002512-199914050-00006. [PMID: 10408738] - A Alm. Prostaglandin derivates as ocular hypotensive agents.
Progress in retinal and eye research.
1998 Jul; 17(3):291-312. doi:
10.1016/s1350-9462(97)00003-7. [PMID: 9695796] - I Azuma. [Progress in medical treatment for glaucoma].
Nippon Ganka Gakkai zasshi.
1993 Dec; 97(12):1353-69. doi:
NULL. [PMID: 7904790]