ISOPROPYL METHYLPHOSPHONATE (BioDeep_00000180175)
human metabolite blood metabolite
代谢物信息卡片
methyl(propan-2-yloxy)phosphinic acid
化学式: C4H11O3P (138.0446)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 62.5%
分子结构信息
SMILES: CC(C)OP(=O)(C)O
InChI: InChI=1S/C4H11O3P/c1-4(2)7-8(3,5)6/h4H,1-3H3,(H,5,6)
描述信息
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- PubChem: 15778
- HMDB: HMDB0253676
- chemspider: 15003
- CAS: 133415-68-6
- CAS: 25040-35-1
- CAS: 24975-09-5
- CAS: 26272-48-0
- CAS: 24975-04-0
- CAS: 11086-88-7
- CAS: 1832-54-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Junfei Ma, Shachinthaka D Dissanayaka Mudiyanselage, Woong June Park, Mo Wang, Ryuta Takeda, Bin Liu, Ying Wang. A nuclear import pathway exploited by pathogenic noncoding RNAs.
The Plant cell.
2022 09; 34(10):3543-3556. doi:
10.1093/plcell/koac210. [PMID: 35877068] - Merav Blanca, Avital Shifrovitch, Shlomit Dachir, Shlomi Lazar, Maor Elgarisi, Hagit Prihed, Shlomi Baranes, Inbal Egoz, Meir Avraham, Hani Dekel Jaoui, Ohad Mazor, Shai Dagan, Avi Weissberg. Extended retrospective detection of regenerated sarin (GB) in rabbit blood and the IMPA metabolite in urine: a pharmacokinetics study.
Archives of toxicology.
2021 07; 95(7):2403-2412. doi:
10.1007/s00204-021-03085-1. [PMID: 34032868] - Dan Loewenthal, Avi Weissberg, Shai Dagan. Enantioselective in-vitro elimination kinetics of nerve agents in blood monitored by derivatization and LC-MS/MS analysis.
Archives of toxicology.
2020 11; 94(11):3751-3757. doi:
10.1007/s00204-020-02854-8. [PMID: 32720193] - Merav Blanca, Avital Shifrovitch, Shlomit Dachir, Shlomi Lazar, Maor Elgarisi, Dana Marder, Tamar Shamai Yamin, Shlomi Baranes, Meir Avraham, Hani Dekel Jaoui, Shai Dagan, Avi Weissberg. Highly sensitive retrospective determination of organophosphorous nerve agent biomarkers in human urine implemented in vivo in rabbit.
Archives of toxicology.
2020 09; 94(9):3033-3044. doi:
10.1007/s00204-020-02827-x. [PMID: 32627075] - Amanda S Appel, John H McDonough, Joseph D McMonagle, Brian A Logue. Analysis of Nerve Agent Metabolites from Hair for Long-Term Verification of Nerve Agent Exposure.
Analytical chemistry.
2016 06; 88(12):6523-30. doi:
10.1021/acs.analchem.6b01274. [PMID: 27161086] - Alper Coban, Russell L Carr, Howard W Chambers, Kenneth O Willeford, Janice E Chambers. Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase.
Toxicology letters.
2016 Apr; 248(?):39-45. doi:
10.1016/j.toxlet.2016.03.002. [PMID: 26965078] - Ying Lin, Jia Chen, Long Yan, Lei Guo, Bidong Wu, Chunzheng Li, Jianlin Feng, Qin Liu, Jianwei Xie. Determination of nerve agent metabolites in human urine by isotope-dilution gas chromatography-tandem mass spectrometry after solid phase supported derivatization.
Analytical and bioanalytical chemistry.
2014 Aug; 406(21):5213-20. doi:
10.1007/s00216-014-7695-x. [PMID: 24633564] - R A Evans, E M Jakubowski, W T Muse, K Matson, S W Hulet, R J Mioduszewski, S A Thomson, A L Totura, J A Renner, C L Crouse. Quantification of sarin and cyclosarin metabolites isopropyl methylphosphonic acid and cyclohexyl methylphosphonic acid in minipig plasma using isotope-dilution and liquid chromatography- time-of-flight mass spectrometry.
Journal of analytical toxicology.
2008 Jan; 32(1):78-85. doi:
10.1093/jat/32.1.78. [PMID: 18269798] - Douglas D Richardson, Joseph A Caruso. Derivatization of organophosphorus nerve agent degradation products for gas chromatography with ICPMS and TOF-MS detection.
Analytical and bioanalytical chemistry.
2007 Jun; 388(4):809-23. doi:
10.1007/s00216-007-1164-8. [PMID: 17356819] - D Noort, A G Hulst, D H Platenburg, M Polhuijs, H P Benschop. Quantitative analysis of O-isopropyl methylphosphonic acid in serum samples of Japanese citizens allegedly exposed to sarin: estimation of internal dosage.
Archives of toxicology.
1998 Oct; 72(10):671-5. doi:
10.1007/s002040050559. [PMID: 9851684] - M Minami, D M Hui, M Katsumata, H Inagaki, C A Boulet. Method for the analysis of the methylphosphonic acid metabolites of sarin and its ethanol-substituted analogue in urine as applied to the victims of the Tokyo sarin disaster.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Aug; 695(2):237-44. doi:
10.1016/s0378-4347(97)00203-x. [PMID: 9300859] - D J Weiss, R S Geary, W Wustenberg, T J Bucci, V Perman, I P Baumel, J C Dacre. The comparative metabolism of diisopropyl methylphosphonate in mink and rats.
Archives of environmental contamination and toxicology.
1994 Oct; 27(3):420-5. doi:
10.1007/bf00213181. [PMID: 7944557] - M L Shih, J R Smith, J D McMonagle, T W Dolzine, V C Gresham. Detection of metabolites of toxic alkylmethylphosphonates in biological samples.
Biological mass spectrometry.
1991 Nov; 20(11):717-23. doi:
10.1002/bms.1200201111. [PMID: 1799583] - P J Little, M L Reynolds, E R Bowman, B R Martin. Tissue disposition of [3H]sarin and its metabolites in mice.
Toxicology and applied pharmacology.
1986 May; 83(3):412-9. doi:
10.1016/0041-008x(86)90223-1. [PMID: 3705071]
