4-[[2-(2-Acetylsulfanylethyl)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-5-yl]oxy]-4-oxobutanoic acid (BioDeep_00000180106)
human metabolite blood metabolite
代谢物信息卡片
化学式: C19H24O6S (380.1293524)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)SCCC1CC2=C(C)C(OC(=O)CCC(O)=O)=C(C)C(C)=C2O1
InChI: InChI=1S/C19H24O6S/c1-10-11(2)19-15(9-14(24-19)7-8-26-13(4)20)12(3)18(10)25-17(23)6-5-16(21)22/h14H,5-9H2,1-4H3,(H,21,22)
描述信息
同义名列表
6 个代谢物同义名
4-({2-[2-(acetylsulfanyl)ethyl]-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-5-yl}oxy)-4-oxobutanoic acid; 4-[[2-(2-Acetylsulphanylethyl)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-5-yl]oxy]-4-oxobutanoic acid; 4-[[2-(2-Acetylsulfanylethyl)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-5-yl]oxy]-4-oxobutanoic acid; 4-[[2-(2-Acetylsulphanylethyl)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-5-yl]oxy]-4-oxobutanoate; 4-[[2-(2-Acetylsulfanylethyl)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-5-yl]oxy]-4-oxobutanoate; IRFI 042
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- M Calò, H Marini, A Bitto, D Altavilla, F Polito, L Minutoli, P Lo Cascio, S Antoci, F Squadrito. Protective effects of IRFI-042 in monensin induced neurotoxicity in chicks.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2008 Nov; 46(11):3528-33. doi:
10.1016/j.fct.2008.09.009. [PMID: 18834916] - Sonia Messina, Domenica Altavilla, M'hammed Aguennouz, Paolo Seminara, Letteria Minutoli, Maria C Monici, Alessandra Bitto, Anna Mazzeo, Herbert Marini, Francesco Squadrito, Giuseppe Vita. Lipid peroxidation inhibition blunts nuclear factor-kappaB activation, reduces skeletal muscle degeneration, and enhances muscle function in mdx mice.
The American journal of pathology.
2006 Mar; 168(3):918-26. doi:
10.2353/ajpath.2006.050673. [PMID: 16507907] - Margherita Calò, Domenica Altavilla, Paolo Seminara, Herbert Marini, Letteria Minutoli, Alessandra Bitto, Francesco Naccari, Francesco Squadrito. Inhibition of lipid peroxidation by IRFI 042, a vitamin E analogue, decreases monensin cardiotoxicity in chicks.
Toxicology and applied pharmacology.
2005 Oct; 208(2):137-44. doi:
10.1016/j.taap.2005.01.016. [PMID: 16183387] - Francesco Squadrito, Letteria Minutoli, Maria Esposito, Alessandra Bitto, Herbert Marini, Paolo Seminara, Alessandra Crisafulli, Mariolina Passaniti, Elena Bianca Adamo, Rolando Marini, Salvatore Guarini, Domenica Altavilla. Lipid peroxidation triggers both c-Jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK) activation and neointimal hyperplasia induced by cessation of blood flow in the mouse carotid artery.
Atherosclerosis.
2005 Feb; 178(2):295-302. doi:
10.1016/j.atherosclerosis.2004.10.013. [PMID: 15694937] - Herbert Marini, Domenica Altavilla, Maria Bellomo, Elena Bianca Adamo, Rolando Marini, Floriana Laureanti, Maria Carmela Bonaccorso, Paolo Seminara, Maria Passaniti, Letteria Minutoli, Alessandra Bitto, Gioacchino Calapai, Francesco Squadrito. Modulation of IL-1 beta gene expression by lipid peroxidation inhibition after kainic acid-induced rat brain injury.
Experimental neurology.
2004 Jul; 188(1):178-86. doi:
10.1016/j.expneurol.2004.03.023. [PMID: 15191814] - Domenica Altavilla, Giovanni Squadrito, Letteria Minutoli, Barbara Deodato, Antonino Bova, Aurora Sardella, Paolo Seminara, Maria Passaniti, Giuseppe Urna, Saverio F Venuti, Achille P Caputi, Francesco Squadrito. Inhibition of nuclear factor-kappaB activation by IRFI 042, protects against endotoxin-induced shock.
Cardiovascular research.
2002 Jun; 54(3):684-93. doi:
10.1016/s0008-6363(02)00276-6. [PMID: 12031715] - D Altavilla, A Saitta, S Guarini, M Galeano, G Squadrito, D Cucinotta, L B Santamaria, A T Mazzeo, G M Campo, M Ferlito, L Minutoli, C Bazzani, A Bertolini, A P Caputi, F Squadrito. Oxidative stress causes nuclear factor-kappaB activation in acute hypovolemic hemorrhagic shock.
Free radical biology & medicine.
2001 May; 30(10):1055-66. doi:
10.1016/s0891-5849(01)00492-0. [PMID: 11369495] - G M Campo, F Squadrito, S Ceccarelli, M Calò, A Avenoso, S Campo, G Squadrito, D Altavilla. Reduction of carbon tetrachloride-induced rat liver injury by IRFI 042, a novel dual vitamin E-like antioxidant.
Free radical research.
2001 Apr; 34(4):379-93. doi:
10.1080/10715760100300321. [PMID: 11328674] - D Altavilla, B Deodato, G M Campo, M Arlotta, M Miano, G Squadrito, A Saitta, D Cucinotta, S Ceccarelli, M Ferlito, M Tringali, L Minutoli, A P Caputi, F Squadrito. IRFI 042, a novel dual vitamin E-like antioxidant, inhibits activation of nuclear factor-kappaB and reduces the inflammatory response in myocardial ischemia-reperfusion injury.
Cardiovascular research.
2000 Aug; 47(3):515-28. doi:
10.1016/s0008-6363(00)00124-3. [PMID: 10963724]