Ipronidazole (BioDeep_00000180097)

   

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


1-methyl-5-nitro-2-(propan-2-yl)-1H-imidazole

化学式: C7H11N3O2 (169.0851226)
中文名称: 异丙硝唑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C1=NC=C(N1C)N(=O)=O
InChI: InChI=1S/C7H11N3O2/c1-5(2)7-8-4-6(9(7)3)10(11)12/h4-5H,1-3H3

描述信息

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent

同义名列表

4 个代谢物同义名

1-methyl-5-nitro-2-(propan-2-yl)-1H-imidazole; ro-71554Ipronidazole; IPRONIDAZOLE; Ipronidazole



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Astrid Solvåg Nesse, Stine Göransson Aanrud, Jan Ludvig Lyche, Trine Sogn, Roland Kallenborn. Confirming the presence of selected antibiotics and steroids in Norwegian biogas digestate. Environmental science and pollution research international. 2022 Dec; 29(57):86595-86605. doi: 10.1007/s11356-022-21479-1. [PMID: 35796924]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Stéphanie Fraselle, Veerle Derop, Jean-Marie Degroodt, Joris Van Loco. Validation of a method for the detection and confirmation of nitroimidazoles and the corresponding hydroxy metabolites in pig plasma by high performance liquid chromatography-tandem mass spectrometry. Analytica chimica acta. 2007 Mar; 586(1-2):383-93. doi: 10.1016/j.aca.2007.01.009. [PMID: 17386738]
  • Tao Ding, Jinzhong Xu, Chongyu Shen, Yuan Jiang, Huilan Chen, Bin Wu, Zengyun Zhao, Gonghai Li, Jing Zhang, Fei Liu. [Determination of three nitroimidazole residues in royal jelly by high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2006 Jul; 24(4):331-4. doi: ". [PMID: 17017153]
  • R M Aerts, I M Egberink, C A Kan, H J Keukens, W M Beek. Liquid chromatographic multicomponent method for determination of residues of ipronidazole, ronidazole, and dimetridazole and some relevant metabolites in eggs, plasma, and feces and its use in depletion studies in laying hens. Journal - Association of Official Analytical Chemists. 1991 Jan; 74(1):46-55. doi: NULL. [PMID: 2026576]
  • G L Biagi, G Cantelli-Forti, A M Barbaro, M C Guerra, P Hrelia, P A Borea. The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles. Journal of medicinal chemistry. 1987 Feb; 30(2):420-3. doi: 10.1021/jm00385a027. [PMID: 3806622]
  • G Cantelli-Forti, M C Guerra, A M Barbaro, P Hrelia, G L Biagi, P A Borea. Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats. Journal of medicinal chemistry. 1986 Apr; 29(4):555-61. doi: 10.1021/jm00154a021. [PMID: 3959031]
  • G Weiss, N Rose, P Duke, T H Williams. A major rat faecal metabolite of ipronidazole. Xenobiotica; the fate of foreign compounds in biological systems. 1981 Mar; 11(3):207-15. doi: 10.3109/00498258109045293. [PMID: 7293217]
  • E G Schildknecht, R L Squibb. The effect of vitamins A, E and K on experimentally induced histomoniasis in turkeys. Parasitology. 1979 Feb; 78(1):19-31. doi: 10.1017/s0031182000048551. [PMID: 570265]
  • A Assandri, A Perazzi, L F Zerilli, P Ferrari, E Martinelli. Metabolism of 5-isopropyl-1-methyl-2-nitro-1H-imidazole. Identification of some urinary metabolites in the dog. Drug metabolism and disposition: the biological fate of chemicals. 1978 Mar; 6(2):109-13. doi: NULL. [PMID: 26523]