Ioxaglic acid (BioDeep_00000180083)

   

human metabolite blood metabolite


代谢物信息卡片


3-[(2-hydroxyethyl)carbamoyl]-2,4,6-triiodo-5-(2-{[2,4,6-triiodo-3-(methylcarbamoyl)-5-(N-methylacetamido)phenyl]formamido}acetamido)benzoic acid

化学式: C24H21I6N5O8 (1268.5658686000002)
中文名称: 异草酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)N(C)C1=C(C(=C(C(=C1I)C(=O)NCC(=O)NC2=C(C(=C(C(=C2I)C(=O)O)I)C(=O)NCCO)I)I)C(=O)NC)I
InChI: InChI=1S/C24H21I6N5O8/c1-7(37)35(3)20-17(29)10(21(39)31-2)13(25)11(18(20)30)23(41)33-6-8(38)34-19-15(27)9(22(40)32-4-5-36)14(26)12(16(19)28)24(42)43/h36H,4-6H2,1-3H3,(H,31,39)(H,32,40)(H,33,41)(H,34,38)(H,42,43)

描述信息

V - Various > V08 - Contrast media > V08A - X-ray contrast media, iodinated > V08AB - Watersoluble, nephrotropic, low osmolar x-ray contrast media
D006133 - Growth Substances > D010937 - Plant Growth Regulators > D014283 - Triiodobenzoic Acids

同义名列表

19 个代谢物同义名

3-[(2-hydroxyethyl)carbamoyl]-2,4,6-triiodo-5-(2-{[2,4,6-triiodo-3-(methylcarbamoyl)-5-(N-methylacetamido)phenyl]formamido}acetamido)benzoic acid; N-(2-Hydroxyethyl)-2,4,6-triiodo-5-(2-(2,4,6-triiodo-3-(N-methylacetamido)-5-(methylcarbamoyl)benzamido)acetamido)isophthalamic acid; N-(2-Hydroxyethyl)-2,4,6-triiodo-5-(2-(2,4,6-triiodo-3-(N-methylacetamido)-5-(methylcarbamoyl)benzamido)acetamido)isophthalamate; Ioxaglic acid, calcium salt (2:1); Ioxaglic acid monosodium salt; Ioxaglate, methylglucamine; Methylglucamine ioxaglate; p-286 (Contrast media); P286 (Contrast media); Meglumine, ioxaglate; Ioxaglate meglumine; Acidum ioxaglicum; Acide ioxaglique; Ioxaglate sodium; Acido ioxaglico; ioxaglic acid; Hexabrix 320; Ioxaglate; Hexabrix



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Omur Ozturk, Huseyin Avni Eroglu, Sefer Ustebay, Mehmet Kuzucu, Yasemen Adali. An experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy. Acta cirurgica brasileira. 2018 Jun; 33(6):508-517. doi: 10.1590/s0102-865020180060000005. [PMID: 30020312]
  • Gennaro Giustino, Usman Baber, Ioannis Mastoris, Georgios J Vlachojannis, Jennifer Yu, Paul S Teirstein, William E Downey, Wayne B Batchelor, Peter J Casterella, Eugenia Nikolsky, S Chiu Wong, Kleanthis N Theodoropoulos, George D Dangas, Roxana Mehran. One-year results of the ICON (Ionic versus non-ionic Contrast to Obviate worsening Nephropathy after angioplasty in chronic renal failure patients) Study. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2016 Mar; 87(4):703-9. doi: 10.1002/ccd.26106. [PMID: 26481591]
  • Lu-Ping Li, Jon Thacker, Jing Lu, Tammy Franklin, Ying Zhou, Maria V Papadopoulou, Richard Solomon, Pottumarthi V Prasad. Efficacy of preventive interventions for iodinated contrast-induced acute kidney injury evaluated by intrarenal oxygenation as an early marker. Investigative radiology. 2014 Oct; 49(10):647-52. doi: 10.1097/rli.0000000000000065. [PMID: 24872003]
  • Lu-Ping Li, Jing Lu, Ying Zhou, Maria V Papadopoulou, Tammy Franklin, Ujala Bokhary, Richard Solomon, Anindya Sen, Pottumarthi V Prasad. Evaluation of intrarenal oxygenation in iodinated contrast-induced acute kidney injury-susceptible rats by blood oxygen level-dependent magnetic resonance imaging. Investigative radiology. 2014 Jun; 49(6):403-10. doi: 10.1097/rli.0000000000000031. [PMID: 24566288]
  • Diana Constanze Lenhard, Anna-Lena Frisk, Philipp Lengsfeld, Hubertus Pietsch, Gregor Jost. The effect of iodinated contrast agent properties on renal kinetics and oxygenation. Investigative radiology. 2013 Apr; 48(4):175-82. doi: 10.1097/rli.0b013e31827b70f9. [PMID: 23262792]
  • Emre Aslanger, Bora Uslu, Cansu Akdeniz, Nihat Polat, Yasar Cizgici, Huseyin Oflaz. Intrarenal application of N-acetylcysteine for the prevention of contrast medium-induced nephropathy in primary angioplasty. Coronary artery disease. 2012 Jun; 23(4):265-70. doi: 10.1097/mca.0b013e328351aacc. [PMID: 22343798]
  • S J Park. Retention of iodinated contrast material within renal cysts in a patient with autosomal dominant polycystic kidney disease. The British journal of radiology. 2012 Mar; 85(1011):e53-5. doi: 10.1259/bjr/24588919. [PMID: 22391500]
  • Noboru Maeda, Keigo Osuga, Kouki Shimazu, Eiichi Morii, Koji Mikami, Shinichi Hori, Tetsuro Nakazawa, Hiroki Higashihara, Kaname Tomoda, Hironobu Nakamura, Noriyuki Tomiyama. In vivo evaluation of cisplatin-loaded superabsorbent polymer microspheres for use in chemoembolization of VX2 liver tumors. Journal of vascular and interventional radiology : JVIR. 2012 Mar; 23(3):397-404.e1. doi: 10.1016/j.jvir.2011.10.024. [PMID: 22209264]
  • Martin Zo'o, Marcus Hoermann, Csilla Balassy, Francis Brunelle, Robin Azoulay, Danièle Pariente, Michel Panuel, Patrick Le Dosseur. Renal safety in pediatric imaging: randomized, double-blind phase IV clinical trial of iobitridol 300 versus iodixanol 270 in multidetector CT. Pediatric radiology. 2011 Nov; 41(11):1393-400. doi: 10.1007/s00247-011-2164-6. [PMID: 21713440]
  • Hsiang-Chun Lee, Jan-Gowth Chang, Hsueh-Wei Yen, I-Hsin Liu, Wen-Ter Lai, Sheng-Hsiung Sheu. Ionic contrast media induced more apoptosis in diabetic kidney than nonionic contrast media. Journal of nephrology. 2011 May; 24(3):376-80. doi: 10.5301/jn.2010.5784. [PMID: 20890877]
  • Laura Calvi, Gilbert H Daniels. Acute thyrotoxicosis secondary to destructive thyroiditis associated with cardiac catheterization contrast dye. Thyroid : official journal of the American Thyroid Association. 2011 Apr; 21(4):443-9. doi: 10.1089/thy.2010.0300. [PMID: 21385076]
  • Doron Sudarsky, Eugenia Nikolsky. Contrast-induced nephropathy in interventional cardiology. International journal of nephrology and renovascular disease. 2011; 4(?):85-99. doi: 10.2147/ijnrd.s21393. [PMID: 21912486]
  • Steven D Weisbord, Paul M Palevsky. Strategies for the prevention of contrast-induced acute kidney injury. Current opinion in nephrology and hypertension. 2010 Nov; 19(6):539-49. doi: 10.1097/mnh.0b013e32833d42e3. [PMID: 20625289]
  • Mauricio Sendeski, Andreas Patzak, Pontus B Persson. Constriction of the vasa recta, the vessels supplying the area at risk for acute kidney injury, by four different iodinated contrast media, evaluating ionic, nonionic, monomeric and dimeric agents. Investigative radiology. 2010 Aug; 45(8):453-7. doi: 10.1097/rli.0b013e3181d77eed. [PMID: 20458252]
  • J P Fägerstam, A K Ostberg, A C Eriksson, S-G Fransson, P A Whiss. Similar inhibition of platelet adhesion, P-selectin expression and plasma coagulation by ioversol, iodixanol and ioxaglate. The British journal of radiology. 2010 May; 83(989):401-10. doi: 10.1259/bjr/71758045. [PMID: 19546176]
  • Shih-Ping Hsu, Tun-Jun Tsai, Chiang-Ting Chien. Ioxitalamate induces renal tubular apoptosis via activation of renal efferent nerve-mediated adrenergic signaling, renin activity, and reactive oxygen species production in rats. Toxicological sciences : an official journal of the Society of Toxicology. 2010 Mar; 114(1):149-58. doi: 10.1093/toxsci/kfp290. [PMID: 19945959]
  • A Barlak, H Akar, Y Yenicerioglu, C Yenisey, I Meteoğlu, O Yilmaz. Effect of sodium bicarbonate in an experimental model of radiocontrast nephropathy. Renal failure. 2010; 32(8):992-9. doi: 10.3109/0886022x.2010.502282. [PMID: 20722568]
  • Denis Angoulvant, Michel Cucherat, Gilles Rioufol, Gérard Finet, Jacques Beaune, Didier Revel, Maurice Laville, Michel Ovize, Xavier André-Fouët. Preventing acute decrease in renal function induced by coronary angiography (PRECORD): a prospective randomized trial. Archives of cardiovascular diseases. 2009 Nov; 102(11):761-7. doi: 10.1016/j.acvd.2009.07.001. [PMID: 19944392]
  • Michael Reed, Pascal Meier, Umesh U Tamhane, Kathy B Welch, Mauro Moscucci, Hitinder S Gurm. The relative renal safety of iodixanol compared with low-osmolar contrast media: a meta-analysis of randomized controlled trials. JACC. Cardiovascular interventions. 2009 Jul; 2(7):645-54. doi: 10.1016/j.jcin.2009.05.002. [PMID: 19628188]
  • V Agrawal, A Swami, R Kosuri, M Alsabbagh, M Agarwal, D Samarapungavan, L L Rocher, P A McCullough. Contrast-induced acute kidney injury in renal transplant recipients after cardiac catheterization. Clinical nephrology. 2009 Jun; 71(6):687-96. doi: 10.5414/cnp71687. [PMID: 19473638]
  • Roxana Mehran, Eugenia Nikolsky, Ajay J Kirtane, Adriano Caixeta, S Chiu Wong, Paul S Teirstein, William E Downey, Wayne B Batchelor, Peter J Casterella, Young-Hak Kim, Martin Fahy, George D Dangas. Ionic low-osmolar versus nonionic iso-osmolar contrast media to obviate worsening nephropathy after angioplasty in chronic renal failure patients: the ICON (Ionic versus non-ionic Contrast to Obviate worsening Nephropathy after angioplasty in chronic renal failure patients) study. JACC. Cardiovascular interventions. 2009 May; 2(5):415-21. doi: 10.1016/j.jcin.2009.03.007. [PMID: 19463464]
  • Francesco Busetti, Kathryn L Linge, Justin W Blythe, Anna Heitz. Rapid analysis of iodinated X-ray contrast media in secondary and tertiary treated wastewater by direct injection liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2008 Dec; 1213(2):200-8. doi: 10.1016/j.chroma.2008.10.021. [PMID: 18980771]
  • Sang-Ho Jo, Bon-Kwon Koo, Tae-Jin Youn, Hyo-Soo Kim. Conclusion of recent 'osmolality trials' in preventing contrast-induced nephropathy by NAC--what is the standard?. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2008 Jul; 23(7):2424; author reply 2424-5. doi: 10.1093/ndt/gfn163. [PMID: 18445639]
  • Motoki Osawa, Fumiko Satoh, Hidekazu Horiuchi, Wei Tian, Nobuko Kugota, Iwao Hasegawa. Postmortem diagnosis of fatal anaphylaxis during intravenous administration of therapeutic and diagnostic agents: evaluation of clinical laboratory parameters and immunohistochemistry in three cases. Legal medicine (Tokyo, Japan). 2008 May; 10(3):143-7. doi: 10.1016/j.legalmed.2007.10.002. [PMID: 18035583]
  • Esther de Luis, Jose I Bilbao, Jose A García Jalón de Ciércoles, Antonio Martínez-Cuesta, Alba de Martino Rodríguez, María D Lozano. In vivo evaluation of a new embolic spherical particle (HepaSphere) in a kidney animal model. Cardiovascular and interventional radiology. 2008 Mar; 31(2):367-76. doi: 10.1007/s00270-007-9240-1. [PMID: 18167024]
  • Haim D Danenberg, Chaim Lotan, Boris Varshitski, Shimon Rosenheck, A Teddy Weiss. Removal of contrast medium from the coronary sinus during coronary angiography: feasibility of a simple and available technique for the prevention of nephropathy. Cardiovascular revascularization medicine : including molecular interventions. 2008 Jan; 9(1):9-13. doi: 10.1016/j.carrev.2007.05.003. [PMID: 18206631]
  • Pamela S Reed, Simon R Dixon, Judith A Boura, William W O'Neill, Joel K Kahn. Comparison of the usefulness of gadodiamide and iodine mixture versus iodinated contrast alone for prevention of contrast-induced nephropathy in patients with chronic kidney disease undergoing coronary angiography. The American journal of cardiology. 2007 Oct; 100(7):1090-3. doi: 10.1016/j.amjcard.2007.04.055. [PMID: 17884368]
  • Gilbert Deray. Visipaque (iodixanol) and hexabrix (ioxaglate) in renal insufficiency. Journal of the American College of Cardiology. 2007 Apr; 49(15):1668. doi: 10.1016/j.jacc.2007.02.005. [PMID: 17433961]
  • Pontus Persson, Per Liss, Peter Hansell. Evaluation and comparison between visipaque (iodixanol) and hexabrix (ioxaglate) in coronary angiography. Journal of the American College of Cardiology. 2007 Apr; 49(15):1668-1669. doi: 10.1016/j.jacc.2007.02.006. [PMID: 17433962]
  • S-H Jo, B-K Koo, T-J Youn, H-S Kim. Iodixanol vs ioxaglate for preventing contrast nephropathy: who is winner?. Kidney international. 2007 Apr; 71(8):828; author reply 828-9. doi: 10.1038/sj.ki.5002211. [PMID: 17429424]
  • Andrezza Sanches Garofalo, Fernanda Teixeira Borges, Maria Aparecida Dalboni, Oscar Fernando Pavão dos Santos. Reactive oxygen species independent cytotoxicity induced by radiocontrast agents in tubular cells (LLC-PK1 and MDCK). Renal failure. 2007; 29(2):121-31. doi: 10.1080/08860220601095892. [PMID: 17365925]
  • P Liss, P B Persson, P Hansell, B Lagerqvist. Renal failure in 57 925 patients undergoing coronary procedures using iso-osmolar or low-osmolar contrast media. Kidney international. 2006 Nov; 70(10):1811-7. doi: 10.1038/sj.ki.5001887. [PMID: 17003814]
  • Bertrand Dussol, Sophie Morange, Anderson Loundoun, Pascal Auquier, Yvon Berland. A randomized trial of saline hydration to prevent contrast nephropathy in chronic renal failure patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2006 Aug; 21(8):2120-6. doi: 10.1093/ndt/gfl133. [PMID: 16611682]
  • Hsiang-Chun Lee, Hsueh-Wei Yen, Sheng-Hsiung Sheu. Effects of different contrast media on glutathione peroxidase and superoxide dismutase activities in the heart and kidneys of normal and streptozotocin-induced diabetic rats. Journal of the Formosan Medical Association = Taiwan yi zhi. 2006 Jul; 105(7):530-5. doi: 10.1016/s0929-6646(09)60146-7. [PMID: 16877231]
  • V O Gomes, C E Poli de Figueredo, P Caramori, R Lasevitch, L C Bodanese, A Araújo, A P Röedel, A P Caramori, F S Brito, H G Bezerra, P Nery, A Brizolara. N-acetylcysteine does not prevent contrast induced nephropathy after cardiac catheterisation with an ionic low osmolality contrast medium: a multicentre clinical trial. Heart (British Cardiac Society). 2005 Jun; 91(6):774-8. doi: 10.1136/hrt.2004.039636. [PMID: 15894775]
  • Fredrik Palm, David Bergqvist, Per-Ola Carlsson, Olof Hellberg, Rickard Nyman, Peter Hansell, Per Liss. The effects of carbon dioxide versus ioxaglate in the rat kidney. Journal of vascular and interventional radiology : JVIR. 2005 Feb; 16(2 Pt 1):269-74. doi: 10.1097/01.rvi.0000146174.98151.2b. [PMID: 15713929]
  • George Dangas, Ioannis Iakovou, Eugenia Nikolsky, Eve D Aymong, Gary S Mintz, Nicholas N Kipshidze, Alexandra J Lansky, Issam Moussa, Gregg W Stone, Jeffrey W Moses, Martin B Leon, Roxana Mehran. Contrast-induced nephropathy after percutaneous coronary interventions in relation to chronic kidney disease and hemodynamic variables. The American journal of cardiology. 2005 Jan; 95(1):13-9. doi: 10.1016/j.amjcard.2004.08.056. [PMID: 15619387]
  • Per Liss, Hampus Eklöf, Olof Hellberg, Anders Hägg, Annika Boström-Ardin, Anne-Marie Löfberg, Ulf Olsson, Per Orndahl, Helena Nilsson, Peter Hansell, Lars-Gunnar Eriksson, David Bergqvist, Richard Nyman. Renal effects of CO2 and iodinated contrast media in patients undergoing renovascular intervention: a prospective, randomized study. Journal of vascular and interventional radiology : JVIR. 2005 Jan; 16(1):57-65. doi: 10.1097/01.rvi.0000144807.81633.79. [PMID: 15640411]
  • Walter H Reinhart, Beat Pleisch, Llinos G Harris, Marcus Lütolf. Influence of contrast media (iopromide, ioxaglate, gadolinium-DOTA) on blood viscosity, erythrocyte morphology and platelet function. Clinical hemorheology and microcirculation. 2005; 32(3):227-39. doi: NULL. [PMID: 15851842]
  • Azzam A Khankan, Keigo Osuga, Shinichi Hori, Eiichi Morii, Takamichi Murakami, Hironobu Nakamura. Embolic effects of superabsorbent polymer microspheres in rabbit renal model: comparison with tris-acryl gelatin microspheres and polyvinyl alcohol. Radiation medicine. 2004 Nov; 22(6):384-90. doi: NULL. [PMID: 15648453]
  • Yoshinori Itoh, Toshiaki Sendo, Toshio Hirakawa, Takeshi Goromaru, Naoko Sakai, Hitoo Nakano, Ryozo Oishi. Similarity and difference in the acute lung injury induced by a radiographic contrast medium and an anticancer agent paclitaxel in rats. Toxicology letters. 2004 Aug; 152(1):27-34. doi: 10.1016/j.toxlet.2004.03.022. [PMID: 15294344]
  • Ki-Nam Lee, Seong Kuk Yoon, Jin Wha Lee, Ki Nam Kim, Byung-Ho Park, Jong Young Kwak, Jin Sook Jeong, Young Hoon Kim. Hepatopulmonary syndrome induced by common bile duct ligation in a rabbit model: correlation between pulmonary vascular dilatation on thin-section CT and angiography and serum nitrite concentration or endothelial nitric oxide synthase (eNOS)1 expression. Korean journal of radiology. 2004 Jul; 5(3):149-56. doi: 10.3348/kjr.2004.5.3.149. [PMID: 15467411]
  • Luciane Ribeiro, Fábio de Assunção e Silva, Rose Saemi Kurihara, Nestor Schor, Elisa Mieko, Suemitsu Higa. Evaluation of the nitric oxide production in rat renal artery smooth muscle cells culture exposed to radiocontrast agents. Kidney international. 2004 Feb; 65(2):589-96. doi: 10.1111/j.1523-1755.2004.00408.x. [PMID: 14717929]
  • R El Mahmoud, C Le Feuvre, K H Le Quan Sang, G Helft, F Beygui, J P Batisse, J P Metzger. [Absence of nephro-protective effect of acetylcysteine in patients with chronic renal failure investigated by coronary angiography]. Archives des maladies du coeur et des vaisseaux. 2003 Dec; 96(12):1157-61. doi: NULL. [PMID: 15248440]
  • W K Laskey, J Gellman. Inflammatory markers increase following exposure to radiographic contrast media. Acta radiologica (Stockholm, Sweden : 1987). 2003 Sep; 44(5):498-503. doi: 10.1034/j.1600-0455.2003.00119.x. [PMID: 14510756]
  • Amir Peer, Zhan Averbukh, Sylvia Berman, David Modai, Michael Averbukh, Joshua Weissgarten. Contrast media augmented apoptosis of cultured renal mesangial, tubular, epithelial, endothelial, and hepatic cells. Investigative radiology. 2003 Mar; 38(3):177-82. doi: 10.1097/01.rli.0000054529.61167.84. [PMID: 12595799]
  • R Al Dieri, S Béguin, H C Hemker. The ionic contrast medium ioxaglate interferes with thrombin-mediated feedback activation of factor V, factor VIII and platelets. Journal of thrombosis and haemostasis : JTH. 2003 Feb; 1(2):269-74. doi: 10.1046/j.1538-7836.2003.00026.x. [PMID: 12871500]
  • Maria A Cunha, Nestor Schor. Effects of gentamicin, lipopolysaccharide, and contrast media on immortalized proximal tubular cells. Renal failure. 2002 Nov; 24(6):687-90. doi: 10.1081/jdi-120015662. [PMID: 12472192]
  • J Sainte-Laudy. [Specific antibodies to iodinated contrast media. Research techniques, specificity]. Allergie et immunologie. 2002 Sep; 34(7):259-60. doi: . [PMID: 12389451]
  • Maria A Cunha, Nestor Schor. Effects of gentamicin, lipopolysaccharide, and contrast media on immortalized proximal tubular cells. Renal failure. 2002 Sep; 24(5):655-8. doi: 10.1081/jdi-120013970. [PMID: 12380912]
  • Eric Lancelot, Jean-Marc Idée, Christine Laclédère, Robin Santus, Claire Corot. Effects of two dimeric iodinated contrast media on renal medullary blood perfusion and oxygenation in dogs. Investigative radiology. 2002 Jul; 37(7):368-75. doi: 10.1097/00004424-200207000-00002. [PMID: 12068157]
  • Katsumi Hayakawa, Tatsuo Nakamura, Yasuhiko Shimizu. Iodinated contrast medium-induced potassium release: the effect of mixing ratios. Radiation medicine. 2002 Jul; 20(4):195-9. doi: NULL. [PMID: 12296436]
  • Yanhong Zhu, Richard Tomasiak, William P Fay. Do clinically relevant circulating concentrations of radiographic contrast agents inhibit platelet-dependent arterial thrombosis?. Thrombosis research. 2002 Mar; 105(5):413-8. doi: 10.1016/s0049-3848(02)00039-7. [PMID: 12062543]
  • Cornelia Sonja Schick, Renate Bangert, Wolfgang Kübler, Christlieb Haller. Ionic radiocontrast media disrupt intercellular contacts via an extracellular calcium-independent mechanism. Experimental nephrology. 2002; 10(3):209-15. doi: 10.1159/000058347. [PMID: 12053122]
  • Rosa-Maria Rodriguez, J-L Guéant, I Aimone-Gastin, P Gérard, F Amoghly, A Bellou, Y Jullière, G Faure, N Danchin, A Romano. The increased histamine release in ischaemic heart disease patients undergoing coronaroangiography is not mediated by specific IgE. Allergy. 2002; 57 Suppl 72(?):61-6. doi: 10.1034/j.1398-9995.57.s72.17.x. [PMID: 12144558]
  • P M Farrehi, Y Zhu, W P Fay. An analysis of mechanisms underlying the antifibrinolytic properties of radiographic contrast agents. Journal of thrombosis and thrombolysis. 2001 Dec; 12(3):273-81. doi: 10.1023/a:1015283210156. [PMID: 11981110]
  • Y Cağlar, U O Mete, M Kaya. Ultrastructural evaluation of the effects of the contrast media on the rat kidney. Journal of submicroscopic cytology and pathology. 2001 Oct; 33(4):443-51. doi: NULL. [PMID: 11989778]
  • C Donadio, A Lucchesi, M Ardini, G Tramonti, P Chella, E Magagnini, C Bianchi. Renal effects of cardiac angiography with different low-osmolar contrast media. Renal failure. 2001 May; 23(3-4):385-96. doi: 10.1081/jdi-100104722. [PMID: 11499554]
  • H K Galtung, M Løken, K S Sakariassen. Effect of radiologic contrast media on cell volume regulation in rabbit proximal renal tubules. Academic radiology. 2001 May; 8(5):398-404. doi: 10.1016/s1076-6332(03)80547-0. [PMID: 11345270]
  • M Brezinski, K Saunders, C Jesser, X Li, J Fujimoto. Index matching to improve optical coherence tomography imaging through blood. Circulation. 2001 Apr; 103(15):1999-2003. doi: 10.1161/01.cir.103.15.1999. [PMID: 11306530]
  • D C Desai, T M O'Dorisio, W J Schirmer, S S Jung, H Khabiri, V Villanueva, E W Martin. Serum pancreastatin levels predict response to hepatic artery chemoembolization and somatostatin analogue therapy in metastatic neuroendocrine tumors. Regulatory peptides. 2001 Jan; 96(3):113-7. doi: 10.1016/s0167-0115(00)00167-1. [PMID: 11111016]
  • H K Galtung, M Løken, K S Sakariassen. Effect of radiologic contrast material on cell volume regulation in proximal renal tubules from trout (Salmo trutta). Academic radiology. 2000 Nov; 7(11):911-9. doi: 10.1016/s1076-6332(00)80172-5. [PMID: 11089693]
  • B Scheller, B Hennen, T Thünenkötter, C Mrowietz, T Markwirth, H Schieffer, F Jung. Effect of X-ray contrast media on blood flow properties after coronary angiography. Thrombosis research. 1999 Nov; 96(4):253-60. doi: 10.1016/s0049-3848(99)00108-5. [PMID: 10593427]
  • P V Sergeev, N K Sviridov, Iu A Poliaev, N L Shimanovskiĭ. [Diagnostic effectiveness and safety of currently available X-ray contrast media]. Vestnik rentgenologii i radiologii. 1999 Nov; ?(6):45-9. doi: NULL. [PMID: 10714233]
  • E Lancelot, J M Idée, V Couturier, V Vazin, C Corot. Influence of the viscosity of iodixanol on medullary and cortical blood flow in the rat kidney: a potential cause of Nephrotoxicity. Journal of applied toxicology : JAT. 1999 Sep; 19(5):341-6. doi: 10.1002/(sici)1099-1263(199909/10)19:5<341::aid-jat584>3.0.co;2-u. [PMID: 10513679]
  • J Ueda, T Furukawa, K Higashino, T Yamamoto, H Ujita, K Sakaguchi, Y Araki. Permeability of iodinated and MR contrast media through two types of hemodialysis membrane. European journal of radiology. 1999 Jul; 31(1):76-80. doi: 10.1016/s0720-048x(98)00090-4. [PMID: 10477103]
  • S Roy, F Laerum, F Brosstad, K Kvernebo, K S Sakariassen. Selective venous thrombolysis with the nipple-balloon catheter: comparative evaluation in vivo. Journal of vascular and interventional radiology : JVIR. 1999 Jun; 10(6):817-24. doi: 10.1016/s1051-0443(99)70121-1. [PMID: 10392954]
  • C S Schick, C Haller. Comparative cytotoxicity of ionic and non-ionic radiocontrast agents on MDCK cell monolayers in vitro. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1999 Feb; 14(2):342-7. doi: 10.1093/ndt/14.2.342. [PMID: 10069186]
  • G Deray. Effects of iodixanol on renal function immediately after abdominal angiography. Clinical comparison with iomeprol and ioxaglate. Acta radiologica (Stockholm, Sweden : 1987). 1999 Jan; 40(1):111-2. doi: 10.1080/02841859909174415. [PMID: 9973915]
  • K Hayakawa, T Nakamura, Y Shimizu. Role of hemolysis in potassium release by iodinated contrast medium. European radiology. 1999; 9(7):1357-61. doi: 10.1007/s003300050848. [PMID: 10460374]
  • G Deray, C Bagnis, C Jacquiaud, M Dubois, Y Adabra, C Jaudon. Renal effects of low and isoosmolar contrast media on renal hemodynamic in a normal and ischemic dog kidney. Investigative radiology. 1999 Jan; 34(1):1-4. doi: 10.1097/00004424-199901000-00001. [PMID: 9888047]
  • M Gyoten. [Activation of the complement system and cytokine production by radiographic contrast media in vascular endothelial cells in vitro]. Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica. 1998 Dec; 58(14):811-5. doi: NULL. [PMID: 10028833]
  • H Mita, K Tadokoro, K Akiyama. Detection of IgE antibody to a radiocontrast medium. Allergy. 1998 Dec; 53(12):1133-40. doi: 10.1111/j.1398-9995.1998.tb03832.x. [PMID: 9930588]
  • S Heptinstall, A White, N Edwards, J Pascoe, H M Sanderson, S C Fox, R A Henderson. Differential effects of three radiographic contrast media on platelet aggregation and degranulation: implications for clinical practice?. British journal of haematology. 1998 Dec; 103(4):1023-30. doi: 10.1046/j.1365-2141.1998.01118.x. [PMID: 9886314]
  • W P Fay, A C Parker. Effects of radiographic contrast agents on thrombin formation and activity. Thrombosis and haemostasis. 1998 Aug; 80(2):266-72. doi: 10.1055/s-0037-1615186. [PMID: 9716151]
  • R Murakami, H Tajima, T Kumazaki, K Yamamoto. Effect of iodixanol on renal function immediately after abdominal angiography. Clinical comparison with iomeprol and ioxaglate. Acta radiologica (Stockholm, Sweden : 1987). 1998 Jul; 39(4):368-71. doi: 10.1080/02841859809172446. [PMID: 9685820]
  • Y X Wang, P Chan, S K Morcos. The effect of radiographic contrast media on human vascular smooth muscle cells. The British journal of radiology. 1998 Apr; 71(844):376-80. doi: 10.1259/bjr.71.844.9659129. [PMID: 9659129]
  • M Suzuki, T Yamaguchi. [Experimental study on efficacy of myocardial opacification owing to difference of echocardiographic contrast agents]. Nihon rinsho. Japanese journal of clinical medicine. 1998 Apr; 56(4):909-13. doi: NULL. [PMID: 9577607]
  • P Liss, A Nygren, U Erikson, H R Ulfendahl. Injection of low and iso-osmolar contrast medium decreases oxygen tension in the renal medulla. Kidney international. 1998 Mar; 53(3):698-702. doi: 10.1046/j.1523-1755.1998.00811.x. [PMID: 9507216]
  • J Ueda, A Nygren, M Sjöquist, E Jacobsson, H R Ulfendahl, Y Araki. Iodine concentrations in the rat kidney measured by X-ray microanalysis. Comparison of concentrations and viscosities in the proximal tubules and renal pelvis after intravenous injections of contrast media. Acta radiologica (Stockholm, Sweden : 1987). 1998 Jan; 39(1):90-5. doi: 10.1080/02841859809172157. [PMID: 9498878]
  • K Narasaki. [Contrast-associated nephrotoxicity: ultrastructural and biochemical study in diabetic rats]. Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica. 1997 Aug; 57(9):586-95. doi: NULL. [PMID: 9293757]
  • R Mikkonen, T Lehto, V Koistinen, H J Aronen, L Kivisaari, S Meri. Suppression of alternative complement pathway activity by radiographic contrast media. Scandinavian journal of immunology. 1997 Apr; 45(4):371-7. doi: 10.1046/j.1365-3083.1997.d01-414.x. [PMID: 9105424]
  • S M Laranja, H Ajzen, N Schor. Nephrotoxicity of low-osmolality contrast media. Renal failure. 1997 Mar; 19(2):307-14. doi: 10.3109/08860229709026294. [PMID: 9101609]
  • T Furukawa, J Ueda, S Takahashi, K Sakaguchi. Elimination of low-osmolality contrast media by hemodialysis. Acta radiologica (Stockholm, Sweden : 1987). 1996 Nov; 37(6):966-71. doi: 10.1177/02841851960373p2104. [PMID: 8995475]
  • R E Vlietstra, C M Nunn, J Narvarte, K F Browne. Contrast nephropathy after coronary angioplasty in chronic renal insufficiency. American heart journal. 1996 Nov; 132(5):1049-50. doi: 10.1016/s0002-8703(96)90021-6. [PMID: 8892783]
  • H Yamazaki, H Oi, M Matsushita, T Inoue, S Murayama, M Koizumi, T Nose, E Tanaka, T Teshima, K Kagawa, T Inoue. Renal cortical retention of contrast medium after angiography as assessed by delayed CT: a multivariate analysis. Radiation medicine. 1996 Sep; 14(5):247-50. doi: NULL. [PMID: 8988503]
  • E L Siegel, J D Rosenblum, D A Eckard, J Leef, J Bergh, M B Parsa, M L Redick. Comparison of iodixanol and ioxaglate for adult aortography and renal/visceral angiography: a phase III clinical trial. Academic radiology. 1996 Sep; 3 Suppl 3(?):S507-13. doi: 10.1016/s1076-6332(05)80367-8. [PMID: 8883529]
  • A Lesnik, J Chabriais, H Benali, J M Guinebretiere, R Di Paola, J F Moreau. Early renal transit of an iodinated contrast medium: factor-analytic dynamic computed tomography scanning study in rabbits. Academic radiology. 1996 Aug; 3 Suppl 2(?):S248-50. doi: 10.1016/s1076-6332(96)80548-4. [PMID: 8796573]
  • K Hayakawa, Y Shimizu. Do iodinated contrast media increase serum potassium levels?. Radiology. 1996 Aug; 200(2):407-11. doi: 10.1148/radiology.200.2.8685334. [PMID: 8685334]
  • C Stellato, G de Crescenzo, V Patella, P Mastronardi, B Mazzarella, G Marone. Human basophil/mast cell releasability. XI. Heterogeneity of the effects of contrast media on mediator release. The Journal of allergy and clinical immunology. 1996 Mar; 97(3):838-50. doi: 10.1016/s0091-6749(96)80162-x. [PMID: 8613641]
  • S F Millward, B E Burbridge, N G Hartman, D Moher, M J Chamberlain. Nephrotoxicity of ioxaglate and ioversol assessed by glomerular filtration rate: a pilot study. Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes. 1996 Feb; 47(1):24-9. doi: NULL. [PMID: 8548465]
  • A Genovese, C Stellato, V Patella, B Lamparter-Schummert, G de Crescenzo, M Adt, G Marone. Contrast media are incomplete secretagogues acting on human basophils and mast cells isolated from heart and lung, but not skin tissue. International journal of clinical & laboratory research. 1996; 26(3):192-8. doi: 10.1007/bf02592981. [PMID: 8905451]
  • W Krause, D Niehues. Biochemical characterization of x-ray contrast media. Investigative radiology. 1996 Jan; 31(1):30-42. doi: 10.1097/00004424-199601000-00006. [PMID: 8850363]
  • G Deray, C Mouquet, S Ourhama, M F Bellin, C Jacquiaud, J Luciani, M O Bitker, C Jacobs. Effects on renal haemodynamics and tubular function of the contrast medium Ioxaglate in renal transplant patients. Clinical radiology. 1995 Jul; 50(7):476-8. doi: 10.1016/s0009-9260(05)83164-2. [PMID: 7614794]
  • J Karstoft, L Bååth, I Jansen, L Edvinsson. Vasoconstriction of isolated arteries induced by angiographic contrast media. A comparison of ionic and non-ionic contrast media iso-osmolar with plasma. Acta radiologica (Stockholm, Sweden : 1987). 1995 May; 36(3):312-6. doi: NULL. [PMID: 7742129]
  • J M Idee, R Bourbouze. Effects of iodinated X-ray contrast media on renal epithelial cells in culture. Investigative radiology. 1995 May; 30(5):323-4. doi: NULL. [PMID: 7558738]
  • A Tamura, C Ohata, Y Hirakakiuchi, T Sato. [Suppressive effects of iodinated contrast media on human platelet aggregation]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1995 Mar; 115(3):250-5. doi: 10.1248/yakushi1947.115.3_250. [PMID: 7738783]
  • A Verbaeys, S Ringoir, D Kesteloot, G Van Maele, N Lameire. Evaluation of renal function before and after intravenous injection of non-cholangiographic water soluble contrast media in rats. Acta urologica Belgica. 1995 Mar; 63(1):103-8. doi: NULL. [PMID: 7725984]