hydroxyitraconazole (BioDeep_00000018005)
human metabolite Endogenous blood metabolite Chemicals and Drugs
代谢物信息卡片
4-{4-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-1-(3-hydroxybutan-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one
化学式: C35H38Cl2N8O5 (720.2342077999999)
中文名称: 羟基依他康唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
InChI: InChI=1S/C35H38Cl2N8O5/c1-24(25(2)46)45-34(47)44(23-40-45)29-6-4-27(5-7-29)41-13-15-42(16-14-41)28-8-10-30(11-9-28)48-18-31-19-49-35(50-31,20-43-22-38-21-39-43)32-12-3-26(36)17-33(32)37/h3-12,17,21-25,31,46H,13-16,18-20H2,1-2H3
描述信息
hydroxyitraconazole is a metabolite of itraconazole. Itraconazole, invented in 1984, is a triazole antifungal agent that is prescribed to patients with fungal infections. The drug may be given orally or intravenously. (Wikipedia)
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
同义名列表
4 个代谢物同义名
4-{4-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-1-(3-hydroxybutan-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one; 4-{4-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one; Hydroxy Itraconazole; hydroxyitraconazole
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Yuya Matsuda, Shunsaku Nakagawa, Ikuko Yano, Satohiro Masuda, Satoshi Imai, Atsushi Yonezawa, Takashi Yamamoto, Mitsuhiro Sugimoto, Masahiro Tsuda, Tetsunori Tsuzuki, Tomohiro Omura, Takayuki Nakagawa, Toyofumi Fengshi Chen-Yoshikawa, Miki Nagao, Hiroshi Date, Kazuo Matsubara. Effect of Itraconazole and Its Metabolite Hydroxyitraconazole on the Blood Concentrations of Cyclosporine and Tacrolimus in Lung Transplant Recipients.
Biological & pharmaceutical bulletin.
2022; 45(4):397-402. doi:
10.1248/bpb.b21-00738. [PMID: 35370263] - David E Gerber, William C Putnam, Farjana J Fattah, Kemp H Kernstine, Rolf A Brekken, Ivan Pedrosa, Rachael Skelton, Jessica M Saltarski, Robert E Lenkinski, Richard D Leff, Chul Ahn, Chyndhri Padmanabhan, Vaidehi Chembukar, Sahba Kasiri, Raja Reddy Kallem, Indhumathy Subramaniyan, Qing Yuan, Quyen N Do, Yin Xi, Scott I Reznik, Lorraine Pelosof, Brandon Faubert, Ralph J DeBerardinis, James Kim. Concentration-dependent Early Antivascular and Antitumor Effects of Itraconazole in Non-Small Cell Lung Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2020 11; 26(22):6017-6027. doi:
10.1158/1078-0432.ccr-20-1916. [PMID: 32847935] - Katharina R Beck, Lucija Telisman, Chris J van Koppen, George R Thompson, Alex Odermatt. Molecular mechanisms of posaconazole- and itraconazole-induced pseudohyperaldosteronism and assessment of other systemically used azole antifungals.
The Journal of steroid biochemistry and molecular biology.
2020 05; 199(?):105605. doi:
10.1016/j.jsbmb.2020.105605. [PMID: 31982514] - Yaeko Nakamura, Kana Matsumoto, Atsuo Sato, Kunihiko Morita. Effective plasma concentrations of itraconazole and its active metabolite for the treatment of pulmonary aspergillosis.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2020 Feb; 26(2):170-174. doi:
10.1016/j.jiac.2019.08.002. [PMID: 31481305] - Viktorija Dragojević-Simić, Aleksandra Kovačević, Vesna Jaćević, Nemanja Rančić, Snežana Djordjević, Vesna Kilibarda, Momir Mikov, Dubravko Bokonjić. Bioequivalence study of two formulations of itraconazole 100 mg capsules in healthy volunteers under fed conditions: a randomized, three-period, reference-replicated, crossover study.
Expert opinion on drug metabolism & toxicology.
2018 Sep; 14(9):979-988. doi:
10.1080/17425255.2018.1503649. [PMID: 30028640] - Nicole Jenkins, Marion Black, Hans G Schneider. Simultaneous determination of voriconazole, posaconazole, itraconazole and hydroxy-itraconazole in human plasma using LCMS/MS.
Clinical biochemistry.
2018 Mar; 53(?):110-115. doi:
10.1016/j.clinbiochem.2018.01.004. [PMID: 29325818] - Yosuke Suzuki, Ryota Tanaka, Nobuhiro Oyama, Ko Nonoshita, Kazuhiko Hashinaga, Kenji Umeki, Yuhki Sato, Kazufumi Hiramatsu, Jun-Ichi Kadota, Hiroki Itoh. Sensitive and selective quantification of total and free itraconazole and hydroxyitraconazole in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry.
Clinical biochemistry.
2017 Dec; 50(18):1228-1236. doi:
10.1016/j.clinbiochem.2017.09.011. [PMID: 28928005] - Sankha S Basu, Athena Petrides, Donald S Mason, Petr Jarolim. A rapid UPLC-MS/MS assay for the simultaneous measurement of fluconazole, voriconazole, posaconazole, itraconazole, and hydroxyitraconazole concentrations in serum.
Clinical chemistry and laboratory medicine.
2017 May; 55(6):836-844. doi:
10.1515/cclm-2016-0418. [PMID: 27866173] - Katharina R Beck, Murielle Bächler, Anna Vuorinen, Sandra Wagner, Muhammad Akram, Ulrich Griesser, Veronika Temml, Petra Klusonova, Hideaki Yamaguchi, Daniela Schuster, Alex Odermatt. Inhibition of 11β-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole.
Biochemical pharmacology.
2017 04; 130(?):93-103. doi:
10.1016/j.bcp.2017.01.010. [PMID: 28131847] - Ahmad Y Abuhelwa, David J R Foster, Stuart Mudge, David Hayes, Richard N Upton. Population pharmacokinetic modeling of itraconazole and hydroxyitraconazole for oral SUBA-itraconazole and sporanox capsule formulations in healthy subjects in fed and fasted states.
Antimicrobial agents and chemotherapy.
2015 Sep; 59(9):5681-96. doi:
10.1128/aac.00973-15. [PMID: 26149987] - Jin Seok Kim, June-Won Cheong, Yeo-Kyeoung Kim, Jinny Park, Yeung-Chul Mun, Hye Jin Kang, Hyeon Gyu Yi, Je-Hwan Lee, Yang Soo Kim, Hun-Mo Ryoo, Sung-Hyun Kim, Ho Young Kim, Jin Young Kim, Dong-Gun Lee, Hoon-Gu Kim, Hawk Kim, Young-Don Joo, Yoo Hong Min. The relationship between the success rate of empirical antifungal therapy with intravenous itraconazole and clinical parameters, including plasma levels of itraconazole, in immunocompromised patients receiving itraconazole oral solution as prophylaxis: a multicenter, prospective, open-label, observational study in Korea.
Annals of hematology.
2014 Jan; 93(1):33-42. doi:
10.1007/s00277-013-1826-x. [PMID: 23807252] - Emilio Cendejas-Bueno, Manuel Cuenca-Estrella, Alicia Gomez-Lopez. A simple, sensitive HPLC-PDA method for the quantification of itraconazole and hydroxy itraconazole in human serum: a reference laboratory experience.
Diagnostic microbiology and infectious disease.
2013 Jul; 76(3):314-20. doi:
10.1016/j.diagmicrobio.2013.03.012. [PMID: 23588004] - Xin Xiong, Suodi Zhai, Jingli Duan. Validation of a fast and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) with atmospheric pressure chemical ionization method for simultaneous quantitation of voriconazole, itraconazole and its active metabolite hydroxyitraconazole in human plasma.
Clinical chemistry and laboratory medicine.
2013 Feb; 51(2):339-46. doi:
10.1515/cclm-2012-0364. [PMID: 23095205] - Mei Zhang, Grant A Moore, Murray L Barclay, Evan J Begg. A simple high-performance liquid chromatography method for simultaneous determination of three triazole antifungals in human plasma.
Antimicrobial agents and chemotherapy.
2013 Jan; 57(1):484-9. doi:
10.1128/aac.00768-12. [PMID: 23147736] - Tiina Karonen, Jouko Laitila, Mikko Niemi, Pertti J Neuvonen, Janne T Backman. Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations.
European journal of clinical pharmacology.
2012 May; 68(5):681-8. doi:
10.1007/s00228-011-1158-5. [PMID: 22108774] - Sara L Buckner, M Mansour Ceesay, Antonio Pagliuca, Phillip E Morgan, Robert J Flanagan. Measurement of posaconazole, itraconazole, and hydroxyitraconazole in plasma/serum by high-performance liquid chromatography with fluorescence detection.
Therapeutic drug monitoring.
2011 Dec; 33(6):735-41. doi:
10.1097/ftd.0b013e3182381bb1. [PMID: 22105591] - Tuija Tapaninen, Janne T Backman, Kaisa J Kurkinen, Pertti J Neuvonen, Mikko Niemi. Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren.
Journal of clinical pharmacology.
2011 Mar; 51(3):359-67. doi:
10.1177/0091270010365885. [PMID: 20400651] - Laurent Arthur Decosterd, Bertrand Rochat, Benoît Pesse, Thomas Mercier, Frédéric Tissot, Nicolas Widmer, Jacques Bille, Thierry Calandra, Boris Zanolari, Oscar Marchetti. Multiplex ultra-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification in human plasma of fluconazole, itraconazole, hydroxyitraconazole, posaconazole, voriconazole, voriconazole-N-oxide, anidulafungin, and caspofungin.
Antimicrobial agents and chemotherapy.
2010 Dec; 54(12):5303-15. doi:
10.1128/aac.00404-10. [PMID: 20855739] - M Miura, N Takahashi, M Nara, N Fujishima, H Kagaya, Y Kameoka, H Saitoh, H Tagawa, K Sawada. A simple, sensitive high-performance liquid chromatography -ultraviolet method for the quantification of concentration and steady-state pharmacokinetics of itraconazole and hydroxyitraconazole.
Annals of clinical biochemistry.
2010 Sep; 47(Pt 5):432-9. doi:
10.1258/acb.2010.010029. [PMID: 20595406] - Jing-Ying Jia, Chuan Lu, Gang-Yi Liu, Meng-Qi Zhang, Yan-Mei Liu, Wei Wang, Li-Ping Weng, Shui-Jun Li, Chen Yu. Simultaneous determination of itraconazole and hydroxyitraconazole in human plasma by liquid chromatography-isotope dilution tandem mass spectrometry method.
Biomedical chromatography : BMC.
2010 Jun; 24(6):648-54. doi:
10.1002/bmc.1341. [PMID: 19813178] - A Toi, H Ohtani, M Tsujimoto, Y Sawada. Pharmacokinetic modeling of the dosing interval dependency for the interaction between itraconazole and triazolam.
International journal of clinical pharmacology and therapeutics.
2010 Jun; 48(6):356-66. doi:
10.5414/cpp48356. [PMID: 20497744] - Unji Lee, Young H Choi, So H Kim, Byung K Lee. Pharmacokinetics of itraconazole in diabetic rats.
Antimicrobial agents and chemotherapy.
2010 Feb; 54(2):931-3. doi:
10.1128/aac.01145-09. [PMID: 19995926] - Elizabeth M Bunting, Noha Abou-Madi, Sherry Cox, Tomas Martin-Jimenez, Henry Fox, George V Kollias. Evaluation of oral itraconazole administration in captive Humboldt penguins (Spheniscus humboldti).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2009 Sep; 40(3):508-18. doi:
10.1638/2009-0045.1. [PMID: 19746867] - Tomasz Grabowski, Anna Swierczewska, Beata Borucka, Renata Sawicka, Małgorzata Sasinowska-Motyl, Stanisław Witold Gumułka. Chromatographic/mass spectrometric method for the estimation of itraconazole and its metabolite in human plasma. Application to a bioequivalence study.
Arzneimittel-Forschung.
2009; 59(8):422-8. doi:
10.1055/s-0031-1296418. [PMID: 19813466] - Roger J M Brüggemann, Daan J Touw, Rob E Aarnoutse, Paul E Verweij, David M Burger. International interlaboratory proficiency testing program for measurement of azole antifungal plasma concentrations.
Antimicrobial agents and chemotherapy.
2009 Jan; 53(1):303-5. doi:
10.1128/aac.00901-08. [PMID: 19015363] - D Vijaya Bharathi, Kishore Kumar Hotha, P V Vidya Sagar, Sanagapati Sirish Kumar, Pandu Ranga Reddy, A Naidu, Ramesh Mullangi. Development and validation of a highly sensitive and robust LC-MS/MS with electrospray ionization method for simultaneous quantitation of itraconazole and hydroxyitraconazole in human plasma: application to a bioequivalence study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Jun; 868(1-2):70-6. doi:
10.1016/j.jchromb.2008.04.029. [PMID: 18485840] - Paul O Gubbins, Bill J Gurley, David K Williams, Scott R Penzak, Scott A McConnell, Amy M Franks, Michael Saccente. Examining sex-related differences in enteric itraconazole metabolism in healthy adults using grapefruit juice.
European journal of clinical pharmacology.
2008 Mar; 64(3):293-301. doi:
10.1007/s00228-007-0417-y. [PMID: 18172627] - I E Templeton, K E Thummel, E D Kharasch, K L Kunze, C Hoffer, W L Nelson, N Isoherranen. Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo.
Clinical pharmacology and therapeutics.
2008 Jan; 83(1):77-85. doi:
10.1038/sj.clpt.6100230. [PMID: 17495874] - Susan M Abdel-Rahman, Richard F Jacobs, Joseph Massarella, Ralph E Kauffman, John S Bradley, Hui C Kimko, Gregory L Kearns, Kevin Shalayda, Christopher Curtin, Samuel D Maldonado, Jeffrey L Blumer. Single-dose pharmacokinetics of intravenous itraconazole and hydroxypropyl-beta-cyclodextrin in infants, children, and adolescents.
Antimicrobial agents and chemotherapy.
2007 Aug; 51(8):2668-73. doi:
10.1128/aac.00297-07. [PMID: 17517842] - B Schneider, R Gerdsen, J Plat, S Dullens, I Björkhem, U Diczfalusy, P J Neuvonen, T Bieber, K von Bergmann, D Lütjohann. Effects of high-dose itraconazole treatment on lipoproteins in men.
International journal of clinical pharmacology and therapeutics.
2007 Jul; 45(7):377-84. doi:
10.5414/cpp45377. [PMID: 17725244] - Tsukasa Uno, Mikiko Shimizu, Kazunobu Sugawara, Tomonori Tateishi. Sensitive determination of itraconazole and its active metabolite in human plasma by column-switching high-performance liquid chromatography with ultraviolet detection.
Therapeutic drug monitoring.
2006 Aug; 28(4):526-31. doi:
10.1097/00007691-200608000-00007. [PMID: 16885720] - Stefanie Redmann, Bruce G Charles. A rapid HPLC method with fluorometric detection for determination of plasma itraconazole and hydroxy-itraconazole concentrations in cystic fibrosis children with allergic bronchopulmonary aspergillosis.
Biomedical chromatography : BMC.
2006 Apr; 20(4):343-8. doi:
10.1002/bmc.569. [PMID: 16161186] - Stefanie Hennig, Claire E Wainwright, Scott C Bell, Hugh Miller, Lena E Friberg, Bruce G Charles. Population pharmacokinetics of itraconazole and its active metabolite hydroxy-itraconazole in paediatric cystic fibrosis and bone marrow transplant patients.
Clinical pharmacokinetics.
2006; 45(11):1099-114. doi:
10.2165/00003088-200645110-00004. [PMID: 17048974] - GholamAli Khoschsorur, Franz Fruehwirth, Sieglinde Zelzer. Isocratic high-performance liquid chromatographic method with ultraviolet detection for simultaneous determination of levels of voriconazole and itraconazole and its hydroxy metabolite in human serum.
Antimicrobial agents and chemotherapy.
2005 Aug; 49(8):3569-71. doi:
10.1128/aac.49.8.3569-3571.2005. [PMID: 16048987] - John E Conte, Jeffrey A Golden, Juliana Kipps, Marina McIver, Elisabeth Zurlinden. Intrapulmonary pharmacokinetics and pharmacodynamics of itraconazole and 14-hydroxyitraconazole at steady state.
Antimicrobial agents and chemotherapy.
2004 Oct; 48(10):3823-7. doi:
10.1128/aac.48.10.3823-3827.2004. [PMID: 15388441] - Paul O Gubbins, Scott A McConnell, Bill J Gurley, Timothy K Fincher, Amy M Franks, David K Williams, Scott R Penzak, Michael Saccente. Influence of grapefruit juice on the systemic availability of itraconazole oral solution in healthy adult volunteers.
Pharmacotherapy.
2004 Apr; 24(4):460-7. doi:
10.1592/phco.24.5.460.33350. [PMID: 15098799] - V Srivatsan, A K Dasgupta, Prashant Kale, Rama Raju Datla, Devangi Soni, Mahendra Patel, Rakesh Patel, Chandrakant Mavadhiya. Simultaneous determination of itraconazole and hydroxyitraconazole in human plasma by high-performance liquid chromatography.
Journal of chromatography. A.
2004 Mar; 1031(1-2):307-13. doi:
10.1016/j.chroma.2003.11.061. [PMID: 15058598] - H Stass, J Nagelschmitz, J G Moeller, H Delesen. Pharmacokinetics of moxifloxacin are not influenced by a 7-day pretreatment with 200 mg oral itraconazole given once a day in healthy subjects.
International journal of clinical pharmacology and therapeutics.
2004 Jan; 42(1):23-9. doi:
10.5414/cpp42023. [PMID: 14756383] - Michael C Breadmore, Andrea Procházková, Regula Theurillat, Wolfgang Thormann. Determination of itraconazole and hydroxyitraconazole in human serum and plasma by micellar electrokinetic chromatography.
Journal of chromatography. A.
2003 Oct; 1014(1-2):57-70. doi:
10.1016/s0021-9673(03)00573-9. [PMID: 14558612] - Michael C Breadmore, Wolfgang Thormann. Capillary electrophoresis evidence for the stereoselective metabolism of itraconazole in man.
Electrophoresis.
2003 Aug; 24(15):2588-97. doi:
10.1002/elps.200305494. [PMID: 12900871] - Michael Vogeser, Ute Spöhrer, Xaver Schiel. Determination of itraconazole and hydroxyitraconazole in plasma by use of liquid chromatography-tandem mass spectrometry with on-line solid-phase extraction.
Clinical chemistry and laboratory medicine.
2003 Jul; 41(7):915-20. doi:
10.1515/cclm.2003.139. [PMID: 12940518] - Cees H W Koks, Rolf W Sparidans, Georgette Lucassen, Kristel M L Crommentuyn, Jos H Beijnen. Selective high-performance liquid chromatographic assay for itraconazole and hydroxyitraconazole in plasma from human immunodeficiency virus-infected patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Feb; 767(1):103-10. doi:
10.1016/s0378-4347(01)00550-3. [PMID: 11865826] - S Al-Rawithi, R Hussein, I Al-Moshen, D Raines. Expedient microdetermination of itraconazole and hydroxyitraconazole in plasma by high-performance liquid chromatography with fluorescence detection.
Therapeutic drug monitoring.
2001 Aug; 23(4):445-8. doi:
10.1097/00007691-200108000-00021. [PMID: 11477331] - B Lebrun-Vignes, V C Archer, B Diquet, J C Levron, O Chosidow, A J Puech, D Warot. Effect of itraconazole on the pharmacokinetics of prednisolone and methylprednisolone and cortisol secretion in healthy subjects.
British journal of clinical pharmacology.
2001 May; 51(5):443-50. doi:
10.1046/j.1365-2125.2001.01372.x. [PMID: 11422002] - P Kubalec, E Brandsteterová. Column-switching chromatographic determination of itraconazole and its metabolite hydroxy-itraconazole in human serum.
Die Pharmazie.
2001 May; 56(5):397-400. doi:
NULL. [PMID: 11400556] - A Carrier, J Parent. Liquid chromatographic-mass spectrometric determination of itraconazole and its major metabolite, hydroxyitraconazole, in dog plasma.
Journal of chromatography. B, Biomedical sciences and applications.
2000 Aug; 745(2):413-20. doi:
10.1016/s0378-4347(00)00309-1. [PMID: 11043759] - M Mochizuki, S Murase, K Takahashi, S Shimada, H Kume, T Iizuka, M Fukuda. Serum itraconazole and hydroxyitraconazole concentrations and interaction with digoxin in a case of chronic hypertrophic pachymenigitis caused by Aspergillus flavus.
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology.
2000; 41(1):33-9. doi:
10.3314/jjmm.41.33. [PMID: 10660641] - F C Odds, B Dupont, M G Rinaldi, D A Stevens, D W Warnock, R Woestenborghs. Bioassays for itraconazole blood levels: an interlaboratory collaborative study.
The Journal of antimicrobial chemotherapy.
1999 May; 43(5):723-7. doi:
10.1093/jac/43.5.723. [PMID: 10382898] - G Suarez-Kurtz, F A Bozza, F L Vicente, C G Ponte, C J Struchiner. Limited-sampling strategy models for itraconazole and hydroxy-itraconazole based on data from a bioequivalence study.
Antimicrobial agents and chemotherapy.
1999 Jan; 43(1):134-40. doi:
10.1128/aac.43.1.134. [PMID: 9869578] - T Kantola, K T Kivistö, P J Neuvonen. Effect of itraconazole on cerivastatin pharmacokinetics.
European journal of clinical pharmacology.
1999 Jan; 54(11):851-5. doi:
10.1007/s002280050566. [PMID: 10027660] - H Zhou, M Goldman, J Wu, R Woestenborghs, A E Hassell, P Lee, A Baruch, L Pesco-Koplowitz, J Borum, L J Wheat. A pharmacokinetic study of intravenous itraconazole followed by oral administration of itraconazole capsules in patients with advanced human immunodeficiency virus infection.
Journal of clinical pharmacology.
1998 Jul; 38(7):593-602. doi:
10.1002/j.1552-4604.1998.tb04465.x. [PMID: 9702843] - J A Barone, B L Moskovitz, J Guarnieri, A E Hassell, J L Colaizzi, R H Bierman, L Jessen. Enhanced bioavailability of itraconazole in hydroxypropyl-beta-cyclodextrin solution versus capsules in healthy volunteers.
Antimicrobial agents and chemotherapy.
1998 Jul; 42(7):1862-5. doi:
10.1128/aac.42.7.1862. [PMID: 9661037] - J A Barone, B L Moskovitz, J Guarnieri, A E Hassell, J L Colaizzi, R H Bierman, L Jessen. Food interaction and steady-state pharmacokinetics of itraconazole oral solution in healthy volunteers.
Pharmacotherapy.
1998 Mar; 18(2):295-301. doi:
NULL. [PMID: 9545149] - P O Gubbins, B J Gurley, J Bowman. Rapid and sensitive high performance liquid chromatographic method for the determination of itraconazole and its hydroxy-metabolite in human serum.
Journal of pharmaceutical and biomedical analysis.
1998 Feb; 16(6):1005-12. doi:
10.1016/s0731-7085(97)00062-9. [PMID: 9547703] - L de Repentigny, J Ratelle, J M Leclerc, G Cornu, E M Sokal, P Jacqmin, K De Beule. Repeated-dose pharmacokinetics of an oral solution of itraconazole in infants and children.
Antimicrobial agents and chemotherapy.
1998 Feb; 42(2):404-8. doi:
10.1128/aac.42.2.404. [PMID: 9527794] - K Vandewoude, D Vogelaers, J Decruyenaere, P Jaqmin, K De Beule, A Van Peer, R Woestenborghs, K Groen, F Colardyn. Concentrations in plasma and safety of 7 days of intravenous itraconazole followed by 2 weeks of oral itraconazole solution in patients in intensive care units.
Antimicrobial agents and chemotherapy.
1997 Dec; 41(12):2714-8. doi:
10.1128/aac.41.12.2714. [PMID: 9420044] - J Reynes, C Bazin, F Ajana, A Datry, J P Le Moing, E Chwetzoff, J C Levron. Pharmacokinetics of itraconazole (oral solution) in two groups of human immunodeficiency virus-infected adults with oral candidiasis.
Antimicrobial agents and chemotherapy.
1997 Nov; 41(11):2554-8. doi:
10.1128/aac.41.11.2554. [PMID: 9371367] - J D Cartledge, J Midgely, B G Gazzard. Itraconazole solution: higher serum drug concentrations and better clinical response rates than the capsule formulation in acquired immunodeficiency syndrome patients with candidosis.
Journal of clinical pathology.
1997 Jun; 50(6):477-80. doi:
10.1136/jcp.50.6.477. [PMID: 9378812] - J M Poirier, G Cheymol. A rapid and specific liquid chromatographic assay for the determination of itraconazole and hydroxyitraconazole in plasma.
Therapeutic drug monitoring.
1997 Apr; 19(2):247-8. doi:
10.1097/00007691-199704000-00026. [PMID: 9108662] - D Compas, D J Touw, P N de Goede. Rapid method for the analysis of itraconazole and hydroxyitraconazole in serum by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications.
1996 Dec; 687(2):453-6. doi:
10.1016/s0378-4347(96)00245-9. [PMID: 9017471] - A Böhme, G Just-Nübling, L Bergmann, P M Shah, W Stille, D Hoelzer. Itraconazole for prophylaxis of systemic mycoses in neutropenic patients with haematological malignancies.
The Journal of antimicrobial chemotherapy.
1996 Dec; 38(6):953-61. doi:
10.1093/jac/38.6.953. [PMID: 9023642] - M P Ducharme, R L Slaughter, L H Warbasse, P H Chandrasekar, V Van de Velde, G Mannens, D J Edwards. Itraconazole and hydroxyitraconazole serum concentrations are reduced more than tenfold by phenytoin.
Clinical pharmacology and therapeutics.
1995 Dec; 58(6):617-24. doi:
10.1016/0009-9236(95)90017-9. [PMID: 8529326] - J W Hülsewede, H Dermoumi, R Ansorg. Determination of itraconazole and hydroxy-itraconazole in sera using high-performance-liquid-chromatography and a bioassay.
Zentralblatt fur Bakteriologie : international journal of medical microbiology.
1995 Oct; 282(4):457-64. doi:
10.1016/s0934-8840(11)80719-x. [PMID: 9810671] - E Brandsteterová, P Kubalec, A Rády, V Krcméry. Determination of itraconazole and its metabolite in plasma using SPE-HPLC.
Die Pharmazie.
1995 Sep; 50(9):597-9. doi:
NULL. [PMID: 7480094] - C Lacroix, F Wojciechowski, P Danger. Simultaneous determination of itraconazole, hydroxy-itraconazole and amphotericin B in human plasma by HPLC with photodiode array detection.
Annales de biologie clinique.
1995; 53(5):293-7. doi:
NULL. [PMID: 7574117] - J M Poirier, M Lebot, P Descamps, M Levy, G Cheymol. Determination of itraconazole and its active metabolite in plasma by column liquid chromatography.
Therapeutic drug monitoring.
1994 Dec; 16(6):596-601. doi:
10.1097/00007691-199412000-00011. [PMID: 7878700] - B Coronel, F Persat, D Dorez, J F Moskovtchenko, M A Peins, A Mercatello. Itraconazole concentrations during continuous haemodiafiltration.
The Journal of antimicrobial chemotherapy.
1994 Sep; 34(3):448-9. doi:
10.1093/jac/34.3.448. [PMID: 7829423] - D Law, C B Moore, D W Denning. Bioassay for serum itraconazole concentrations using hydroxyitraconazole standards.
Antimicrobial agents and chemotherapy.
1994 Jul; 38(7):1561-6. doi:
10.1128/aac.38.7.1561. [PMID: 7979289] - C M Conway. Editorial: 'Old lamps for new'.
British journal of anaesthesia.
1975 Aug; 47(8):811-2. doi:
NULL. [PMID: 27]