Inositol nicotinate (BioDeep_00000180034)

   

human metabolite blood metabolite


代谢物信息卡片


2,3,4,5,6-pentakis(pyridine-3-carbonyloxy)cyclohexyl pyridine-3-carboxylate

化学式: C42H30N6O12 (810.192162)
中文名称: 肌醇烟酸酯
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: C1=CC(=CN=C1)C(=O)OC2C(C(C(C(C2OC(=O)C3=CN=CC=C3)OC(=O)C4=CN=CC=C4)OC(=O)C5=CN=CC=C5)OC(=O)C6=CN=CC=C6)OC(=O)C7=CN=CC=C7
InChI: InChI=1S/C42H30N6O12/c49-37(25-7-1-13-43-19-25)55-31-32(56-38(50)26-8-2-14-44-20-26)34(58-40(52)28-10-4-16-46-22-28)36(60-42(54)30-12-6-18-48-24-30)35(59-41(53)29-11-5-17-47-23-29)33(31)57-39(51)27-9-3-15-45-21-27/h1-24,31-36H

描述信息

C - Cardiovascular system > C04 - Peripheral vasodilators > C04A - Peripheral vasodilators > C04AC - Nicotinic acid and derivatives
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98151 - Niacin-based Antilipidemic Agent
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

17 个代谢物同义名

2,3,4,5,6-pentakis(pyridine-3-carbonyloxy)cyclohexyl pyridine-3-carboxylate; meso-Inositol hexanicotinate; Inositol hexanicotinic acid; Inositol hexanicotinate; Inositol nicotinic acid; Hexanicotinoyl inositol; Inositol niacinic acid; inositol nicotinate; Inositol niacinate; Inositolniacinate; Phorilingual; Hämovannad; Hexanicit; Tolanate; Hexopal; Nicolip; Palohex



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lei Zheng, Chen Sun, Xingyi Zhu, Wenhao Xu, Jingbo Yu, Qihong Zhang, Alexandr V Dushkin, Weike Su. Inositol hexanicotinate self-micelle solid dispersion is an efficient drug delivery system in the mouse model of non-alcoholic fatty liver disease. International journal of pharmaceutics. 2021 Jun; 602(?):120576. doi: 10.1016/j.ijpharm.2021.120576. [PMID: 33839223]
  • Shirlette G Milton, Keila Robinson, Jing Ma, Bo Wei, Ivy O Poon, Dong Liang. Biotransformation and pharmacokinetics of inositol hexanicotinate in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2013 Sep; 43(9):817-22. doi: 10.3109/00498254.2012.762591. [PMID: 23347001]
  • Joseph M Keenan. Wax-matrix extended-release niacin vs inositol hexanicotinate: a comparison of wax-matrix, extended-release niacin to inositol hexanicotinate 'no-flush' niacin in persons with mild to moderate dyslipidemia. Journal of clinical lipidology. 2013 Jan; 7(1):14-23. doi: 10.1016/j.jacl.2012.10.004. [PMID: 23351578]
  • Douglas MacKay, John Hathcock, Erminia Guarneri. Niacin: chemical forms, bioavailability, and health effects. Nutrition reviews. 2012 Jun; 70(6):357-66. doi: 10.1111/j.1753-4887.2012.00479.x. [PMID: 22646128]
  • Qinghua Shang, Zhaolan Liu, Keji Chen, Hao Xu, Jianping Liu. A systematic review of xuezhikang, an extract from red yeast rice, for coronary heart disease complicated by dyslipidemia. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):636547. doi: 10.1155/2012/636547. [PMID: 22567033]
  • Huimin Qi, Xiaolei Liu, Jinbao Zhang, Yu Duan, Xiaolan Wang, Quanbin Zhang. Synthesis and antihyperlipidemic activity of acetylated derivative of ulvan from Ulva pertusa. International journal of biological macromolecules. 2012 Jan; 50(1):270-2. doi: 10.1016/j.ijbiomac.2011.11.006. [PMID: 22115715]
  • Zhao Lan Liu, Jian Ping Liu, Anthony Lin Zhang, Qiong Wu, Yao Ruan, George Lewith, Denise Visconte. Chinese herbal medicines for hypercholesterolemia. The Cochrane database of systematic reviews. 2011 Jul; ?(7):CD008305. doi: 10.1002/14651858.cd008305.pub2. [PMID: 21735427]
  • Yao Yao, Xiao-Bo Li, Wei Zhao, Yan-Yan Zeng, Hong Shen, Hua Xiang, Hong Xiao. Anti-obesity effect of an isoflavone fatty acid ester on obese mice induced by high fat diet and its potential mechanism. Lipids in health and disease. 2010 May; 9(?):49. doi: 10.1186/1476-511x-9-49. [PMID: 20482839]
  • V S Kamanna, S H Ganji, M L Kashyap. The mechanism and mitigation of niacin-induced flushing. International journal of clinical practice. 2009 Sep; 63(9):1369-77. doi: 10.1111/j.1742-1241.2009.02099.x. [PMID: 19691622]
  • Vaijinath S Kamanna, Moti L Kashyap. Mechanism of action of niacin. The American journal of cardiology. 2008 Apr; 101(8A):20B-26B. doi: 10.1016/j.amjcard.2008.02.029. [PMID: 18375237]
  • Dong Liang, Jing Ma, Bo Wei, Ivy O Poon, Edward C Bell, Theodore R Bates. Determination of inositol hexanicotinate in rat plasma by high performance liquid chromatography with UV detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Feb; 863(1):172-6. doi: 10.1016/j.jchromb.2007.12.024. [PMID: 18207467]
  • Anbu Pandian, Anjali Arora, Laurence S Sperling, Bobby V Khan. Targeting multiple dyslipidemias with fixed combinations--focus on extended release niacin and simvastatin. Vascular health and risk management. 2008; 4(5):1001-9. doi: 10.2147/vhrm.s3460. [PMID: 19183748]
  • Jianping Liu, Jing Zhang, Yi Shi, Sameline Grimsgaard, Terje Alraek, Vinjar Fønnebø. Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials. Chinese medicine. 2006 Nov; 1(?):4. doi: 10.1186/1749-8546-1-4. [PMID: 17302963]
  • Si-Yuan Pan, Rong Yang, Yi-Fan Han, Hang Dong, Xu-Dong Feng, Na Li, Wei Geng, Kam-Ming Ko. High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice: animal models of acute hypertriglyceridemia. Acta pharmacologica Sinica. 2006 Jun; 27(6):673-8. doi: 10.1111/j.1745-7254.2006.00332.x. [PMID: 16723084]
  • Paul L Canner, Curt D Furberg, Michael L Terrin, Mark E McGovern. Benefits of niacin by glycemic status in patients with healed myocardial infarction (from the Coronary Drug Project). The American journal of cardiology. 2005 Jan; 95(2):254-7. doi: 10.1016/j.amjcard.2004.09.013. [PMID: 15642562]
  • Fredrik Karpe, Keith N Frayn. The nicotinic acid receptor--a new mechanism for an old drug. Lancet (London, England). 2004 Jun; 363(9424):1892-4. doi: 10.1016/s0140-6736(04)16359-9. [PMID: 15183629]
  • Yu Pengzhan, Li Ning, Liu Xiguang, Zhou Gefei, Zhang Quanbin, Li Pengcheng. Antihyperlipidemic effects of different molecular weight sulfated polysaccharides from Ulva pertusa (Chlorophyta). Pharmacological research. 2003 Dec; 48(6):543-9. doi: 10.1016/s1043-6618(03)00215-9. [PMID: 14527817]
  • Shobha H Ganji, Vaijinath S Kamanna, Moti L Kashyap. Niacin and cholesterol: role in cardiovascular disease (review). The Journal of nutritional biochemistry. 2003 Jun; 14(6):298-305. doi: 10.1016/s0955-2863(02)00284-x. [PMID: 12873710]
  • V S Kamanna, M L Kashyap. Mechanism of action of niacin on lipoprotein metabolism. Current atherosclerosis reports. 2000 Jan; 2(1):36-46. doi: 10.1007/s11883-000-0093-1. [PMID: 11122723]
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  • L Harthon, R Brattsand. Enzymatic hydrolysis of pentaerythritoltetranicotinate and meso-inositolhexanicotinate in blood and tissues. Arzneimittel-Forschung. 1979; 29(12):1859-62. doi: NULL. [PMID: 546424]