Baratol (BioDeep_00000180024)
human metabolite blood metabolite
代谢物信息卡片
N-{1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl}benzenecarboximidic acid
化学式: C22H25N3O (347.1998)
中文名称: 吲哌胺
谱图信息:
最多检出来源 Mus musculus(blood) 76.09%
分子结构信息
SMILES: C1CN(CCC1NC(=O)C2=CC=CC=C2)CCC3=CNC4=CC=CC=C43
InChI: InChI=1S/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26)
描述信息
C - Cardiovascular system > C02 - Antihypertensives > C02C - Antiadrenergic agents, peripherally acting > C02CA - Alpha-adrenoreceptor antagonists
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α1A-adrenoceptor[1].
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:135470
- PubChem: 33625
- HMDB: HMDB0253479
- DrugBank: DB08950
- ChEMBL: CHEMBL279516
- Wikipedia: Indoramin
- MeSH: Indoramin
- chemspider: 31014
- CAS: 26844-12-2
- medchemexpress: HY-12760
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Ronald Mathison, Eldon Shaffer. Increased cholinergic contractions of jejunal smooth muscle caused by a high cholesterol diet are prevented by the 5-HT4 agonist--tegaserod.
BMC gastroenterology.
2006 Feb; 6(?):8. doi:
10.1186/1471-230x-6-8. [PMID: 16504074] - A A Nasher, A A Qirbi, M A Ghafoor, A Catterall, A Thompson, J W Ramsay, I M Murray-Lyon. Khat chewing and bladder neck dysfunction. A randomized controlled trial of alpha 1-adrenergic blockade.
British journal of urology.
1995 May; 75(5):597-8. doi:
10.1111/j.1464-410x.1995.tb07415.x. [PMID: 7613796] - M A Stott, P Abrams. Indoramin in the treatment of prostatic bladder outflow obstruction.
British journal of urology.
1991 May; 67(5):499-501. doi:
10.1111/j.1464-410x.1991.tb15194.x. [PMID: 1710162] - D M Pierce. A review of the clinical pharmacokinetics and metabolism of the alpha 1-adrenoceptor antagonist indoramin.
Xenobiotica; the fate of foreign compounds in biological systems.
1990 Dec; 20(12):1357-67. doi:
10.3109/00498259009046634. [PMID: 1981634] - D M Pierce, S J Warrington, R A Franklin. Pharmacokinetics of indoramin and its 6-hydroxylated metabolite after repeated oral dosing.
Biopharmaceutics & drug disposition.
1988 Mar; 9(2):147-57. doi:
10.1002/bod.2510090204. [PMID: 2897212] - D M Pierce, S M Abrams, R A Franklin. Intra- and inter-subject variation in the pharmacokinetics of indoramin and its 6-hydroxylated metabolite.
European journal of clinical pharmacology.
1988; 35(2):195-8. doi:
10.1007/bf00609252. [PMID: 3191938] - D M Pierce, S E Smith, R A Franklin. The pharmacokinetics of indoramin and 6-hydroxyindoramin in poor and extensive hydroxylators of debrisoquine.
European journal of clinical pharmacology.
1987; 33(1):59-65. doi:
10.1007/bf00610381. [PMID: 3691597] - D M Pierce, S M Abrams, R A Franklin. Pharmacokinetics and systemic availability of the antihypertensive agent indoramin and its metabolite 6-hydroxyindoramin in healthy subjects.
European journal of clinical pharmacology.
1987; 32(6):619-23. doi:
10.1007/bf02455999. [PMID: 3653231] - M T Olivari, T B Levine, J N Cohn. Acute hemodynamic and hormonal effects of central versus peripheral sympathetic inhibition in patients with congestive heart failure.
Journal of cardiovascular pharmacology.
1986 Sep; 8(5):973-7. doi:
10.1097/00005344-198609000-00014. [PMID: 2429099] - G S Butrous, A J Camm. Clinical cardiac electrophysiology of indoramin, a post-synaptic alpha blocker.
European heart journal.
1986 Jul; 7(7):576-83. doi:
10.1093/oxfordjournals.eurheartj.a062108. [PMID: 3758091] - D E Leelavathi, E F Soffer, D E Dressler, J Knowles. Liquid chromatographic assay using electrochemical detection for the quantitation of indoramin in human plasma.
Journal of pharmaceutical sciences.
1986 Apr; 75(4):421-3. doi:
10.1002/jps.2600750423. [PMID: 3723366] - K E Britton, M K Nawaz, C C Nimmon, E Mlodkowska, M Carroll, T Horne, M Granowska. Total and intrarenal flow distribution in healthy subjects: technique, acute effects of ibopamine and of indoramin.
Nephron.
1986; 43(4):265-73. doi:
10.1159/000183852. [PMID: 3736737] - G S Butrous, A J Camm. Clinical cardiac electrophysiological assessment of indoramin.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 2(?):S137-43. doi:
10.1097/00005344-198600082-00028. [PMID: 2423787] - G Neumann, G Wilke, W V Reimold, D M Pierce, M Giesing. Pharmacokinetics of indoramin and its metabolite 6-hydroxyindoramin after single and multiple doses to cirrhotic liver patients.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 2(?):S20-4. doi:
10.1097/00005344-198600082-00005. [PMID: 2423791] - J L Archibald. Recent developments in the pharmacology and pharmacokinetics of indoramin.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 2(?):S16-9. doi:
10.1097/00005344-198600082-00004. [PMID: 2423790] - V P Sood, M Stannard, G Beastall, R J Weir. Indoramin in the hypertensive diabetic patient.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 2(?):S80-3. doi:
10.1097/00005344-198600082-00017. [PMID: 2423805] - J H Laragh. Potential of alpha blockade in treating human hypertension: a role for indoramin.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 2(?):S37-42. doi:
10.1097/00005344-198600082-00008. [PMID: 2423795] - T L Martinez, C R Auriemo, A M Machado, M A Cunha, M C Feres, S Maldjian, A Wortsman, F O Delboni. Effects of indoramin and metoprolol on plasma lipids and lipoproteins.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 2(?):S76-9. doi:
10.1097/00005344-198600082-00016. [PMID: 2423803] - B Silke, G I Nelson, S P Verma, M A Frais, G Reynolds, N Jackson, S H Taylor. Haemodynamic dose-response effects of intravenous indoramin in acute heart failure complicating myocardial infarction.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 2(?):S102-6. doi:
10.1097/00005344-198600082-00022. [PMID: 2423781] - G Morrison, B Spar, B R Walker, S Goldfarb. The acute and chronic effects of indoramin on renal function, hemodynamics, and transport.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 2(?):S25-9. doi:
10.1097/00005344-198600082-00006. [PMID: 2423792] - J W Strandhoy. Comparison of the renal effects of indoramin and prazosin.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 2(?):S151-5. doi:
10.1097/00005344-198600082-00030. [PMID: 2423789] - C Rosendorff. Indoramin in the hypertensive patient with concomitant disease: clinical experience.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 2(?):S93-7. doi:
10.1097/00005344-198600082-00020. [PMID: 2423808] - A Overlack, K O Stumpe. Comparison of the effect of indoramin and prazosin on blood pressure and lipid profiles in essential hypertension.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 2(?):S53-5. doi:
10.1097/00005344-198600082-00011. [PMID: 2423798] - M E Robbins, J W Hopewell. Physiological factors effecting renal radiation tolerance: a guide to the treatment of late effects.
The British journal of cancer. Supplement.
1986; 7(?):265-7. doi:
NULL. [PMID: 3521705] - V Pierce, N B Shepperson, A West-Watson. The effect of indoramin on plasma lipids in hypercholesterolemic patas monkeys.
The Journal of pharmacy and pharmacology.
1985 Mar; 37(3):200-2. doi:
10.1111/j.2042-7158.1985.tb05041.x. [PMID: 2858569] - M A Weber, J I Drayer. Central and peripheral blockade of the sympathetic nervous system.
The American journal of medicine.
1984 Oct; 77(4A):110-8. doi:
10.1016/s0002-9343(84)80046-7. [PMID: 6148889] - M T Olivari, V R Garberg, T Selby, J N Cohn, T B Levine. Acute hemodynamic and hormonal response to indoramin in congestive heart failure.
Clinical pharmacology and therapeutics.
1984 Sep; 36(3):297-301. doi:
10.1038/clpt.1984.178. [PMID: 6380878] - D P Nicholls, J McNeill, P C O'Connor, D W Harron, W J Leahey, R G Shanks. Effect of indoramin, labetalol and alinidine on sympathetic function in normal man.
British journal of clinical pharmacology.
1984 Aug; 18(2):215-21. doi:
10.1111/j.1365-2125.1984.tb02455.x. [PMID: 6386022] - D P Nicholls, P C O'Connor, D W Harron, W J Leahey, R G Shanks. Differential blockade of alpha-adrenoceptors by indoramin.
British journal of clinical pharmacology.
1984 Jun; 17(6):719-28. doi:
10.1111/j.1365-2125.1984.tb02409.x. [PMID: 6146328] - J H Bauer, L B Jones, P Gaddy. Effects of indoramin therapy on BP, renal function, and body fluid composition.
Archives of internal medicine.
1984 Feb; 144(2):308-12. doi:
NULL. [PMID: 6696567] - R M Graham. Selective alpha 1-adrenergic antagonists: therapeutically relevant antihypertensive agents.
The American journal of cardiology.
1984 Jan; 53(3):16A-20A. doi:
10.1016/0002-9149(84)90829-4. [PMID: 6141721] - H M Norbury, R A Franklin, P K Marrott, S J Warrington. Pharmacokinetics of oral indoramin in elderly and middle-aged female volunteers.
European journal of clinical pharmacology.
1984; 27(2):247-9. doi:
10.1007/bf00544054. [PMID: 6499905] - S Vaidyanathan, M S Rao, P L Sharma, K S Chary, R P Swamy. Possible use of indoramin in patients with chronic neurogenic bladder dysfunction.
The Journal of urology.
1983 Jan; 129(1):96-101. doi:
10.1016/s0022-5347(17)51938-2. [PMID: 6827693] - H M Norbury, R A Franklin, P K Marrott, S J Warrington. Pharmacokinetics of intravenous indoramin in middle-aged male and female volunteers.
European journal of clinical pharmacology.
1983; 25(2):243-6. doi:
10.1007/bf00543798. [PMID: 6628508] - R A Franklin, P Robson, D Stevenson. Studies on the metabolism of the new anti-hypertensive agent, indoramin, in man.
European journal of clinical pharmacology.
1983; 24(5):629-34. doi:
10.1007/bf00542212. [PMID: 6873141] - G N Volans, D Jeffereys, A N Latham, T Frost. Pharmacokinetics of oral indoramin.
Current medical research and opinion.
1982; 8(1):51-3. doi:
10.1185/03007998209109757. [PMID: 7105823] - R A Franklin, D M Pierce. Studies on the biotransformation of indoramin in the patas monkey.
Xenobiotica; the fate of foreign compounds in biological systems.
1981 Nov; 11(11):755-62. doi:
10.3109/00498258109045879. [PMID: 7336756] - S H Unger, G H Chiang. Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity.
Journal of medicinal chemistry.
1981 Mar; 24(3):262-70. doi:
10.1021/jm00135a006. [PMID: 6167716] - L D Waterbury, R R Dean. Effects of alpha agonists and alpha blocking drugs on mouse plasma renin activity.
Proceedings of the Western Pharmacology Society.
1980; 23(?):57-61. doi:
NULL. [PMID: 6105666] - G H Draffan, P J Lewis, J L Firmin, T W Jordan, C T Dollery. Pharmacokinetics of indoramin in man.
British journal of clinical pharmacology.
1976 Jun; 3(3):489-95. doi:
10.1111/j.1365-2125.1976.tb00626.x. [PMID: 788751]
