Flunitrazepam (BioDeep_00000018000)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


5-(O-Fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one

化学式: C16H12FN3O3 (313.0862654)
中文名称: 氟硝西泮
谱图信息: 最多检出来源 Homo sapiens(blood) 6.67%

分子结构信息

SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)[N+](=O)[O-])C3=CC=CC=C3F
InChI: InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3

描述信息

A benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug. [PubChem]
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CD - Benzodiazepine derivatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

47 个代谢物同义名

5-(O-Fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one; 1,3-Dihydro-5-(O-fluorophenyl)-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one; 5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one; 1-Methyl-7-nitro-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2(1H)-one; CT-Arzneimittel brand OF flunitrazepam; CT Arzneimittel brand OF flunitrazepam; Neuraxpharm brand OF flunitrazepam; Ratiopharm brand OF flunitrazepam; Merck dura brand OF flunitrazepam; Betapharm brand OF flunitrazepam; Roche brand OF flunitrazepam; Hexal brand OF flunitrazepam; Teva brand OF flunitrazepam; Flunitrazepam neuraxpharm; Flunitrazepam-neuraxpharm; 1a Brand OF flunitrazepam; Flunitrazepam-ratiopharm; Flunitrazepam ratiopharm; Flunitrazepam-teva; Flunitrazepam teva; Von CT, flunizep; Fluni 1a pharma; Flunizep von CT; Flunitrazepamum; flunitrazepam; Fluridrazepam; Flunidazepam; Hipnosedon; Flunimerck; Flunibeta; RO 5-4200; Hypnodorm; RO-5-4200; Rohypnol; Narcozep; Rohipnol; Fluscand; Flunipam; RO-54200; Fluninoc; RO54200; Valsera; Flunita; Roipnol; Silece; Hypnor; Primum



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Anna Carfora, Carlo Pietro Campobasso, Paola Cassandro, Raffaella Petrella, Renata Borriello. Long-Term Detection in Hair of Zolpidem, Oxazepam and Flunitrazepam in a Case of Drug-Facilitated Sexual Assault. Journal of analytical toxicology. 2022 Feb; 46(1):e16-e20. doi: 10.1093/jat/bkaa174. [PMID: 33180140]
  • Misato Ota, Hao Ni, Yasuhito Maki, Daiki Kato, Shohei Moriguchi, Shuto Nakayama, Yuki Oiwa, Kan'ichiro Ishiuchi, Toshiaki Makino. Binding activity of Valeriana fauriei root extract on GABAA receptor flunitrazepam sites and distribution of its active ingredients in the brain of mice - A comparison with that of V. officinalis root. Journal of ethnopharmacology. 2021 Oct; 278(?):114262. doi: 10.1016/j.jep.2021.114262. [PMID: 34116188]
  • David Tolulope Oluwole, Roland Eghoghosoa Akhigbe, Ayodeji Folorunsho Ajayi. Rohypnol-induced sexual dysfunction is via suppression of hypothalamic-pituitary-testicular axis: An experimental study in rats. Andrologia. 2021 Mar; 53(2):e13931. doi: 10.1111/and.13931. [PMID: 33378084]
  • Xenia Simeone, Filip Koniuszewski, Markus Müllegger, Andreas Smetka, Friederike Steudle, Roshan Puthenkalam, Margot Ernst, Petra Scholze. A Benzodiazepine Ligand with Improved GABAA Receptor α5-Subunit Selectivity Driven by Interactions with Loop C. Molecular pharmacology. 2021 01; 99(1):39-48. doi: 10.1124/molpharm.120.000067. [PMID: 33268553]
  • Hong Joon Ahn, Won Joon Jeong, Kwan Jae Kim, Sun Cheun Kim, Dong Woo Kim, Hye Jin Chang, Chang Shin Kang, Se Kwang Oh, Sung Uk Cho, Jin Hong Min, Yong Chul Cho, Jung Soo Park, Seung Ryu, Yeon Ho You, Jing Woong Lee, Min Su Kim. Serial plasma and urine measurements of a patient with acute intoxication of zolpidem and flunitrazepam resulting in QT prolongation and ventricular tachycardia. Clinical toxicology (Philadelphia, Pa.). 2020 06; 58(6):501-503. doi: 10.1080/15563650.2019.1663206. [PMID: 31512527]
  • Ali Y Benkherouf, Nora Logrén, Tamara Somborac, Maaria Kortesniemi, Sanna L Soini, Baoru Yang, Outi M H Salo-Ahen, Oskar Laaksonen, Mikko Uusi-Oukari. Hops compounds modulatory effects and 6-prenylnaringenin dual mode of action on GABAA receptors. European journal of pharmacology. 2020 Apr; 873(?):172962. doi: 10.1016/j.ejphar.2020.172962. [PMID: 32001220]
  • Mehran Haidari, Sravan Mansani, Dezaray Ponds, Lissett Romero, Christine Cobb, Saad Alsaab. Storage of urine specimens in point of care (POC) urine drug testing cups reduces concentrations of many drugs. Clinica chimica acta; international journal of clinical chemistry. 2019 Dec; 499(?):81-86. doi: 10.1016/j.cca.2019.09.001. [PMID: 31491368]
  • Tse-Wei Chen, Umamaheswari Rajaji, Shen-Ming Chen, Akilarasan Muthumariyappan, Muneerah Mogren Al Mogren, R Jothi Ramalingam, Majdi Hochlaf. Facile synthesis of copper(II) oxide nanospheres covered on functionalized multiwalled carbon nanotubes modified electrode as rapid electrochemical sensing platform for super-sensitive detection of antibiotic. Ultrasonics sonochemistry. 2019 Nov; 58(?):104596. doi: 10.1016/j.ultsonch.2019.05.013. [PMID: 31450358]
  • Shiyang Qin, Guobin Xin, Yuanfeng Wang, Jing Qiao, Wenfang Zhang, Duoqi Xu, Zizhen Xu, Yongtao Liu, Ying Zhang, Jianghai Lu. Characterization and tentative identification of new flunitrazepam metabolites in authentic human urine specimens using liquid chromatography-Q exactive-HF hybrid quadrupole-Orbitrap-mass spectrometry (LC-QE-HF-MS). Journal of mass spectrometry : JMS. 2019 Aug; 54(8):704-715. doi: 10.1002/jms.4383. [PMID: 31233253]
  • Zenggen Liu, A Kerstin Lindemeyer, Jing Liang, Martin Wallner, Xuesi M Shao, Yun Shao, Yanduo Tao, Richard W Olsen. Flavonoids isolated from Tibetan medicines, binding to GABAA receptor and the anticonvulsant activity. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Nov; 50(?):1-7. doi: 10.1016/j.phymed.2018.09.198. [PMID: 30466968]
  • Yu-Ru Wu, Hsiang-Yu Liu, Shu-Ling Lin, Ming-Ren Fuh. Quantification of 7-aminoflunitrazepam in human urine by polymeric monolith-based capillary liquid chromatography coupled to tandem mass spectrometry. Talanta. 2018 Jan; 176(?):293-298. doi: 10.1016/j.talanta.2017.08.040. [PMID: 28917754]
  • Ricardo Jorge Dinis-Oliveira. Metabolic Profile of Flunitrazepam: Clinical and Forensic Toxicological Aspects. Drug metabolism letters. 2017 11; 11(1):14-20. doi: 10.2174/1872312811666170407164216. [PMID: 28403803]
  • Koutaro Hasegawa, Amin Wurita, Kayoko Minakata, Kunio Gonmori, Hideki Nozawa, Itaru Yamagishi, Kanako Watanabe, Osamu Suzuki. Postmortem distribution of flunitrazepam and its metabolite 7-aminoflunitrazepam in body fluids and solid tissues in an autopsy case: Usefulness of bile for their detection. Legal medicine (Tokyo, Japan). 2015 Sep; 17(5):394-400. doi: 10.1016/j.legalmed.2015.06.002. [PMID: 26173614]
  • Baiqiu Xu, Min Chen, Jinxing Hou, Xi Chen, Xu Zhang, Shufen Cui. Calibration of pre-equilibrium HF-LPME and its application to the rapid determination of free analytes in biological fluids. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Feb; 980(?):28-33. doi: 10.1016/j.jchromb.2014.12.022. [PMID: 25579112]
  • Wen C Shan, Ya L Cui, Xin He, Lei Zhang, Jing Liu, Jian P Wang. Production of monoclonal antibody against clonazepam for immunoassay of benzodiazepine drugs in swine tissues. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2015; 50(1):15-22. doi: 10.1080/03601234.2015.964620. [PMID: 25421624]
  • Valentina Pastore, Cristina Wasowski, Josefina Higgs, Irene C Mangialavori, Luis E Bruno-Blanch, Mariel Marder. A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2014 Aug; 24(8):1405-14. doi: 10.1016/j.euroneuro.2014.04.005. [PMID: 24846538]
  • Oliver Lerch, Oliver Temme, Thomas Daldrup. Comprehensive automation of the solid phase extraction gas chromatographic mass spectrometric analysis (SPE-GC/MS) of opioids, cocaine, and metabolites from serum and other matrices. Analytical and bioanalytical chemistry. 2014 Jul; 406(18):4443-51. doi: 10.1007/s00216-014-7815-7. [PMID: 24788888]
  • Mayuko Uehara, Masami Inaoka, Yasuko Miyaki, Shinji Nakashima, Akira Fuzii, Tetsuya Higami. [Neuroleptic malignant syndrome after cardiac surgery]. Kyobu geka. The Japanese journal of thoracic surgery. 2013 Nov; 66(12):1052-5. doi: NULL. [PMID: 24322311]
  • Benjamín Caruso, Julieta M Sánchez, Daniel A García, Eneida de Paula, María A Perillo. Probing the combined effect of flunitrazepam and lidocaine on the stability and organization of bilayer lipid membranes. A differential scanning calorimetry and dynamic light scattering study. Cell biochemistry and biophysics. 2013 Jul; 66(3):461-75. doi: 10.1007/s12013-012-9494-3. [PMID: 23269502]
  • Yang-Hee Jung, Ri-Ra Ha, Seung-Hwan Kwon, Sa-Ik Hong, Kun-Ho Lee, Sun-Yeou Kim, Seok-Yong Lee, Choon-Gon Jang. Anxiolytic effects of Julibroside C1 isolated from Albizzia julibrissin in mice. Progress in neuro-psychopharmacology & biological psychiatry. 2013 Jul; 44(?):184-92. doi: 10.1016/j.pnpbp.2013.02.012. [PMID: 23481219]
  • Lea R Chioca, Marcelo M Ferro, Irinéia P Baretta, Sara M Oliveira, Cássia R Silva, Juliano Ferreira, Estela M Losso, Roberto Andreatini. Anxiolytic-like effect of lavender essential oil inhalation in mice: participation of serotonergic but not GABAA/benzodiazepine neurotransmission. Journal of ethnopharmacology. 2013 May; 147(2):412-8. doi: 10.1016/j.jep.2013.03.028. [PMID: 23524167]
  • Hei Hwa Lee, Jong Feng Lee, Sin Yu Lin, Yan Yin Lin, Chia Fang Wu, Ming Tsang Wu, Bai Hsiun Chen. Simultaneous quantification of urine flunitrazepam, nimetazepam and nitrazepam by using liquid chromatography tandem mass spectrometry. Clinica chimica acta; international journal of clinical chemistry. 2013 May; 420(?):134-9. doi: 10.1016/j.cca.2012.10.023. [PMID: 23085494]
  • Britta Haenisch, Michael Huber, Thomas Wilhelm, Michael Steffens, Gerhard J Molderings. Investigation into mechanisms mediating the inhibitory effect of 1,4-benzodiazepines on mast cells by gene expression profiling. Life sciences. 2013 Mar; 92(6-7):345-51. doi: 10.1016/j.lfs.2013.01.010. [PMID: 23352970]
  • Akira Namera, Ryosuke Makita, Tatsuro Saruwatari, Aiko Hatano, Hiroaki Shiraishi, Masataka Nagao. Acute intoxication caused by overdose of flunitrazepam and triazolam: high concentration of metabolites detected at autopsy examination. The American journal of forensic medicine and pathology. 2012 Dec; 33(4):293-6. doi: 10.1097/paf.0b013e31820f1514. [PMID: 21372658]
  • Josipa Vlainić, Maja Jazvinšćak Jembrek, Toni Vlainić, Dubravka Švob Strac, Danka Peričić. Differential effects of short- and long-term zolpidem treatment on recombinant α1β2γ2s subtype of GABA(A) receptors in vitro. Acta pharmacologica Sinica. 2012 Dec; 33(12):1469-76. doi: 10.1038/aps.2012.89. [PMID: 22922343]
  • Shufen Cui, Gangfeng Ouyang, Guijiao Duan, Jinxing Hou, Tiangang Luan, Xu Zhang. The mass transfer dynamics of hollow fiber liquid-phase microextraction and its application for rapid analysis of biological samples. Journal of chromatography. A. 2012 Nov; 1266(?):10-6. doi: 10.1016/j.chroma.2012.10.024. [PMID: 23116799]
  • Béla Kiss, Catalina Bogdan, Anca Pop, Felicia Loghin. A rapid UPLC-MS/MS method for simultaneous determination of flunitrazepam, 7-aminoflunitrazepam, methadone and EDDP in human, rat and rabbit plasma. Talanta. 2012 Sep; 99(?):649-59. doi: 10.1016/j.talanta.2012.06.070. [PMID: 22967607]
  • Ruth Verplaetse, Eva Cuypers, Jan Tytgat. The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in urine and blood. Journal of chromatography. A. 2012 Aug; 1249(?):147-54. doi: 10.1016/j.chroma.2012.06.023. [PMID: 22749457]
  • Anahí V Turina, Shirley Schreier, María A Perillo. Coupling between GABA(A)-R ligand-binding activity and membrane organization in β-cyclodextrin-treated synaptosomal membranes from bovine brain cortex: new insights from EPR experiments. Cell biochemistry and biophysics. 2012 May; 63(1):17-33. doi: 10.1007/s12013-012-9338-1. [PMID: 22311134]
  • Yi-Chi Ho, Mei-Chun Tseng, Ying-Wei Lu, Chun-Cheng Lin, Yu-Ju Chen, Ming-Ren Fuh. Nanoparticle-assisted MALDI-TOF MS combined with seed-layer surface preparation for quantification of small molecules. Analytica chimica acta. 2011 Jul; 697(1-2):1-7. doi: 10.1016/j.aca.2011.04.008. [PMID: 21641411]
  • Cristina Wasowski, Mariel Marder. Central nervous system activities of two diterpenes isolated from Aloysia virgata. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 Mar; 18(5):393-401. doi: 10.1016/j.phymed.2010.08.017. [PMID: 21036579]
  • Tharaka Dassanayake, Patricia Michie, Gregory Carter, Alison Jones. Effects of benzodiazepines, antidepressants and opioids on driving: a systematic review and meta-analysis of epidemiological and experimental evidence. Drug safety. 2011 Feb; 34(2):125-56. doi: 10.2165/11539050-000000000-00000. [PMID: 21247221]
  • Takeshi Suzuki, Kazuo Mihara, Akifumi Nakamura, Goyo Nagai, Shoko Kagawa, Kenji Nemoto, Ikuya Ohta, Hajime Arakaki, Tsukasa Uno, Tsuyoshi Kondo. Effects of the CYP2D6*10 allele on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in Japanese patients with schizophrenia. Therapeutic drug monitoring. 2011 Feb; 33(1):21-4. doi: 10.1097/ftd.0b013e3182031021. [PMID: 21157400]
  • Matthew W Peterson, Steven Z Fairchild, Tamara C Otto, Mojdeh Mohtashemi, Douglas M Cerasoli, Wenling E Chang. VX hydrolysis by human serum paraoxonase 1: a comparison of experimental and computational results. PloS one. 2011; 6(5):e20335. doi: 10.1371/journal.pone.0020335. [PMID: 21655255]
  • John C Fløvig, Arne E Vaaler, Gunnar Morken. Effects of legal and illegal use of benzodiazepines at acute admission to a psychiatric acute department. BMC research notes. 2010 Oct; 3(?):263. doi: 10.1186/1756-0500-3-263. [PMID: 20958975]
  • Beate Beer, Kathrin Libiseller, Herbert Oberacher, Marion Pavlic. A fatal intoxication case involving topiramate. Forensic science international. 2010 Oct; 202(1-3):e9-11. doi: 10.1016/j.forsciint.2010.04.035. [PMID: 20494535]
  • Hsin-Yu Bai, Shu-Ling Lin, Shen-An Chan, Ming-Ren Fuh. Characterization and evaluation of two-dimensional microfluidic chip-HPLC coupled to tandem mass spectrometry for quantitative analysis of 7-aminoflunitrazepam in human urine. The Analyst. 2010 Oct; 135(10):2737-42. doi: 10.1039/c0an00355g. [PMID: 20820494]
  • Josipa Vlainić, Maja Jazvinsćak Jembrek, Dubravka Svob Strac, Danka Pericić. The effects of zolpidem treatment and withdrawal on the in vitro expression of recombinant alpha1beta2gamma2s GABA(A) receptors expressed in HEK 293 cells. Naunyn-Schmiedeberg's archives of pharmacology. 2010 Sep; 382(3):201-12. doi: 10.1007/s00210-010-0539-0. [PMID: 20652804]
  • Mariano A Ostuni, Leeyah Issop, Gabriel Péranzi, Francine Walker, Magali Fasseu, Carole Elbim, Vassilios Papadopoulos, Jean-Jacques Lacapere. Overexpression of translocator protein in inflammatory bowel disease: potential diagnostic and treatment value. Inflammatory bowel diseases. 2010 Sep; 16(9):1476-87. doi: 10.1002/ibd.21250. [PMID: 20222126]
  • Monique A J Mets, Edmund R Volkerts, Berend Olivier, Joris C Verster. Effect of hypnotic drugs on body balance and standing steadiness. Sleep medicine reviews. 2010 Aug; 14(4):259-67. doi: 10.1016/j.smrv.2009.10.008. [PMID: 20171127]
  • Marjorie Chèze, Aurélie Muckensturm, Guillaume Hoizey, Gilbert Pépin, Marc Deveaux. A tendency for re-offending in drug-facilitated crime. Forensic science international. 2010 Mar; 196(1-3):14-7. doi: 10.1016/j.forsciint.2009.12.037. [PMID: 20116946]
  • Josh Gunn, Scott Kriger, Andrea R Terrell. Simultaneous determination and quantification of 12 benzodiazepines in serum or whole blood using UPLC/MS/MS. Methods in molecular biology (Clifton, N.J.). 2010; 603(?):107-19. doi: 10.1007/978-1-60761-459-3_10. [PMID: 20077063]
  • Christian Mutz, Valbona Mirakaj, Dierk A Vagts, Phillipp Westermann, Kristina Waibler, Klemens König, Thomas Iber, Gabriele Nöldge-Schomburg, Peter Rosenberger. The neuronal guidance protein netrin-1 reduces alveolar inflammation in a porcine model of acute lung injury. Critical care (London, England). 2010; 14(5):R189. doi: 10.1186/cc9301. [PMID: 20969752]
  • Malin Forsman, Ingrid Nyström, Markus Roman, Liselotte Berglund, Johan Ahlner, Robert Kronstrand. Urinary detection times and excretion patterns of flunitrazepam and its metabolites after a single oral dose. Journal of analytical toxicology. 2009 Oct; 33(8):491-501. doi: 10.1093/jat/33.8.491. [PMID: 19874658]
  • Sabine Pompéia, Bruno H C Grego, Marcia Pradella-Hallinan, Helena Hachul, Sergio Tufik, Vânia D'Almeida. Acute benzodiazepine administration induces changes in homocysteine metabolism in young healthy volunteers. Progress in neuro-psychopharmacology & biological psychiatry. 2009 Aug; 33(6):933-8. doi: 10.1016/j.pnpbp.2009.04.017. [PMID: 19409441]
  • Nancy A Salvatierra, Mariana P Cid, Augusto Arce. Neonatal acute stress by novelty in the absence of social isolation decreases fearfulness in young chicks. Stress (Amsterdam, Netherlands). 2009 Jul; 12(4):328-35. doi: 10.1080/10253890802455433. [PMID: 19005874]
  • X Laqueille, C Launay, A Dervaux, M Kanit. [Abuse of alcohol and benzodiazepine during substitution therapy in heroin addicts: a review of the literature]. L'Encephale. 2009 Jun; 35(3):220-5. doi: 10.1016/j.encep.2008.05.005. [PMID: 19540407]
  • Rikke Søgaard, Bjarke Ebert, Dan Klaerke, Thomas Werge. Triton X-100 inhibits agonist-induced currents and suppresses benzodiazepine modulation of GABA(A) receptors in Xenopus oocytes. Biochimica et biophysica acta. 2009 May; 1788(5):1073-80. doi: 10.1016/j.bbamem.2009.02.001. [PMID: 19366585]
  • Mahaveer B Melwanki, Wei-Shan Chen, Hsin-Yu Bai, Tzuen-Yeuan Lin, Ming-Ren Fuh. Determination of 7-aminoflunitrazepam in urine by dispersive liquid-liquid microextraction with liquid chromatography-electrospray-tandem mass spectrometry. Talanta. 2009 Apr; 78(2):618-22. doi: 10.1016/j.talanta.2008.12.021. [PMID: 19203634]
  • Jürgen Kempf, Thomas Wuske, Rolf Schubert, Wolfgang Weinmann. Pre-analytical stability of selected benzodiazepines on a polymeric oral fluid sampling device. Forensic science international. 2009 Apr; 186(1-3):81-5. doi: 10.1016/j.forsciint.2009.02.004. [PMID: 19282117]
  • Mitsuhiro Nakamura, Tomofumi Ohmori, Yoshinori Itoh, Masato Terashita, Kazuyuki Hirano. Simultaneous determination of benzodiazepines and their metabolites in human serum by liquid chromatography-tandem mass spectrometry using a high-resolution octadecyl silica column compatible with aqueous compounds. Biomedical chromatography : BMC. 2009 Apr; 23(4):357-64. doi: 10.1002/bmc.1122. [PMID: 18937304]
  • Shufen Cui, Shuo Tan, Gangfeng Ouyang, Janusz Pawliszyn. Automated polyvinylidene difluoride hollow fiber liquid-phase microextraction of flunitrazepam in plasma and urine samples for gas chromatography/tandem mass spectrometry. Journal of chromatography. A. 2009 Mar; 1216(12):2241-7. doi: 10.1016/j.chroma.2009.01.022. [PMID: 19185867]
  • Agata Dziuban', Anna Ratecka, Piotr Brzyski, Zofia Foryś, Ewa Gomółka, Dorota Ogonowska. [The knowledge about 'date rape drugs' among Polish students]. Przeglad lekarski. 2009; 66(6):301-10. doi: NULL. [PMID: 19788134]
  • Dubravka Svob Strac, Josipa Vlainić, Maja Jazvinsćak Jembrek, Danka Pericić. Differential effects of diazepam treatment and withdrawal on recombinant GABAA receptor expression and functional coupling. Brain research. 2008 Dec; 1246(?):29-40. doi: 10.1016/j.brainres.2008.09.093. [PMID: 18955034]
  • Jay Liu, Tongming Chen, Tyrell Norris, Kathy Knappenberger, Julie Huston, Michael Wood, Robert Bostwick. A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells. Assay and drug development technologies. 2008 Dec; 6(6):781-6. doi: 10.1089/adt.2008.161. [PMID: 19090692]
  • Mohammad Nasir Uddin, Victoria F Samanidou, Ioannis N Papadoyannis. Validation of SPE-HPLC determination of 1,4-benzodiazepines and metabolites in blood plasma, urine, and saliva. Journal of separation science. 2008 Dec; 31(21):3704-17. doi: 10.1002/jssc.200800342. [PMID: 19003810]
  • Stéphane Pirnay, Bruno Megarbane, Xavier Declèves, Patricia Risède, Stephen W Borron, Stéphane Bouchonnet, Bérangère Perrin, Marcel Debray, Nathalie Milan, Tania Duarte, Ivan Ricordel, Frédéric J Baud. Buprenorphine alters desmethylflunitrazepam disposition and flunitrazepam toxicity in rats. Toxicological sciences : an official journal of the Society of Toxicology. 2008 Nov; 106(1):64-73. doi: 10.1093/toxsci/kfn163. [PMID: 18703559]
  • Ruta Muceniece, Kristine Saleniece, Juris Rumaks, Liga Krigere, Zane Dzirkale, Rudolfs Mezhapuke, Olga Zharkova, Vija Klusa. Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice. Pharmacology, biochemistry, and behavior. 2008 Oct; 90(4):712-6. doi: 10.1016/j.pbb.2008.05.015. [PMID: 18582921]
  • Maja Jazvinsćak Jembrek, Dubravka Svob Strac, Josipa Vlainić, Danka Pericić. The role of transcriptional and translational mechanisms in flumazenil-induced up-regulation of recombinant GABA(A) receptors. Neuroscience research. 2008 Jul; 61(3):234-41. doi: 10.1016/j.neures.2008.03.005. [PMID: 18453026]
  • Caryl M Beynon, Clare McVeigh, Jim McVeigh, Conan Leavey, Mark A Bellis. The involvement of drugs and alcohol in drug-facilitated sexual assault: a systematic review of the evidence. Trauma, violence & abuse. 2008 Jul; 9(3):178-88. doi: 10.1177/1524838008320221. [PMID: 18541699]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Yves Denizot, Alexandre Leguyader, Elisabeth Cornu, Marc Laskar, Isabelle Orsel, Christelle Vincent, Nathalie Nathan. Alterations in plasma soluble vascular endothelial growth factor receptor-1 (sFlt-1) concentrations during coronary artery bypass graft surgery: relationships with post-operative complications. Journal of cardiothoracic surgery. 2008 Apr; 3(?):16. doi: 10.1186/1749-8090-3-16. [PMID: 18423019]
  • Subrat Kumar Bhattamisra, Vinay Kumar Khanna, Ashok Kumar Agrawal, Paras Nath Singh, Sushil Kumar Singh. Antidepressant activity of standardised extract of Marsilea minuta Linn. Journal of ethnopharmacology. 2008 Apr; 117(1):51-7. doi: 10.1016/j.jep.2008.01.012. [PMID: 18299179]
  • Marc Deveaux, Marjorie Chèze, Gilbert Pépin. The role of liquid chromatography-tandem mass spectrometry (LC-MS/MS) to test blood and urine samples for the toxicological investigation of drug-facilitated crimes. Therapeutic drug monitoring. 2008 Apr; 30(2):225-8. doi: 10.1097/ftd.0b013e3181676186. [PMID: 18367985]
  • Kei Zaitsu, Akihiro Miki, Munehiro Katagi, Hitoshi Tsuchihashi. Long-term stability of various drugs and metabolites in urine, and preventive measures against their decomposition with special attention to filtration sterilization. Forensic science international. 2008 Jan; 174(2-3):189-96. doi: 10.1016/j.forsciint.2007.04.224. [PMID: 17555899]
  • Sergio Abanades, Magi Farré, Diego Barral, Marta Torrens, Neus Closas, Klaus Langohr, Antoni Pastor, Rafael de la Torre. Relative abuse liability of gamma-hydroxybutyric acid, flunitrazepam, and ethanol in club drug users. Journal of clinical psychopharmacology. 2007 Dec; 27(6):625-38. doi: 10.1097/jcp.0b013e31815a2542. [PMID: 18004131]
  • Anita Holmgren, Per Holmgren, Fredrik C Kugelberg, A Wayne Jones, Johan Ahlner. Predominance of illicit drugs and poly-drug use among drug-impaired drivers in Sweden. Traffic injury prevention. 2007 Dec; 8(4):361-7. doi: 10.1080/15389580701329344. [PMID: 17994489]
  • A S Reece. Psychosocial and treatment correlates of opiate free success in a clinical review of a naltrexone implant program. Substance abuse treatment, prevention, and policy. 2007 Nov; 2(?):35. doi: 10.1186/1747-597x-2-35. [PMID: 18036213]
  • Matthew P Juhascik, Adam Negrusz, Diana Faugno, Linda Ledray, Pam Greene, Alice Lindner, Barbara Haner, R E Gaensslen. An estimate of the proportion of drug-facilitation of sexual assault in four U.S. localities. Journal of forensic sciences. 2007 Nov; 52(6):1396-400. doi: 10.1111/j.1556-4029.2007.00583.x. [PMID: 18093069]
  • Yves Denizot, Alexandre Leguyader, Elisabeth Cornu, Marc Laskar, Isabelle Orsel, Christelle Vincent, Nathalie Nathan. Release of soluble vascular endothelial growth factor receptor-1 (sFlt-1) during coronary artery bypass surgery. Journal of cardiothoracic surgery. 2007 Sep; 2(?):38. doi: 10.1186/1749-8090-2-38. [PMID: 17888151]
  • Andrew Pike, Susan M Cook, Alan P Watt, Paul Scott-Stevens, Thomas W Rosahl, Ruth M McKernan, Luanda J Pym, Alec Guiblin, Christopher Moyes, Bindi Sohal, John R Atack. Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands. Biopharmaceutics & drug disposition. 2007 Sep; 28(6):275-82. doi: 10.1002/bdd.553. [PMID: 17570124]
  • Jaime M Monti, S R Pandi-Perumal. Eszopiclone: its use in the treatment of insomnia. Neuropsychiatric disease and treatment. 2007 Aug; 3(4):441-53. doi: NULL. [PMID: 19300573]
  • Xuejing Li, David R Serwanski, Celia P Miralles, Ben A Bahr, Angel L De Blas. Two pools of Triton X-100-insoluble GABA(A) receptors are present in the brain, one associated to lipid rafts and another one to the post-synaptic GABAergic complex. Journal of neurochemistry. 2007 Aug; 102(4):1329-45. doi: 10.1111/j.1471-4159.2007.04635.x. [PMID: 17663755]
  • Ming-Ren Fuh, Shi-Wei Lin, Li-Lung Chen, Tzuen-Yeuan Lin. Determination of flunitrazepam and 7-aminoflunitrazepam in human urine by on-line solid phase extraction liquid chromatography-electrospray-tandem mass spectrometry. Talanta. 2007 Jun; 72(4):1329-35. doi: 10.1016/j.talanta.2007.01.040. [PMID: 19071765]
  • Hossam Ebaid, Mohamed A Dkhil, Mohamed A Danfour, Amany Tohamy, Mohamed S Gabry. Piroxicam-induced hepatic and renal histopathological changes in mice. The Libyan journal of medicine. 2007 Jun; 2(2):82-9. doi: 10.4176/070130. [PMID: 21503258]
  • J Macek, J Klíma, P Ptácek. Rapid determination of omeprazole in human plasma by protein precipitation and liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jun; 852(1-2):282-7. doi: 10.1016/j.jchromb.2007.01.026. [PMID: 17293174]
  • Danka Pericić, Dubravka Svob Strac, Maja Jazvinsćak Jembrek, Josipa Vlainić. Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors. Naunyn-Schmiedeberg's archives of pharmacology. 2007 May; 375(3):177-87. doi: 10.1007/s00210-007-0152-z. [PMID: 17377772]
  • Victoria F Samanidou, Anastasia P Pechlivanidou, Ioannis N Papadoyannis. Development of a validated HPLC method for the determination of four 1,4-benzodiazepines in human biological fluids. Journal of separation science. 2007 Mar; 30(5):679-87. doi: 10.1002/jssc.200600365. [PMID: 17461106]
  • Ivano Marchi, Serge Rudaz, Maurice Selman, Jean-Luc Veuthey. Evaluation of the influence of protein precipitation prior to on-line SPE-LC-API/MS procedures using multivariate data analysis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jan; 845(2):244-52. doi: 10.1016/j.jchromb.2006.08.045. [PMID: 17030156]
  • Lutea A A de Jong, C Margot Jeronimus-Stratingh, Thomas I F H Cremers. Development of a multiplex non-radioactive receptor assay: the benzodiazepine receptor, the serotonin transporter and the beta-adrenergic receptor. Rapid communications in mass spectrometry : RCM. 2007; 21(4):567-72. doi: 10.1002/rcm.2869. [PMID: 17245793]
  • Bruno Mégarbane, Xavier Declèves, Vanessa Bloch, Christophe Bardin, François Chast, Frédéric J Baud. Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships. Critical care (London, England). 2007; 11(1):R5. doi: 10.1186/cc5150. [PMID: 17224045]
  • He Zhu, Beata Karolewicz, Emily Nail, Craig A Stockmeier, Katalin Szebeni, Gregory A Ordway. Normal [3H]flunitrazepam binding to GABAA receptors in the locus coeruleus in major depression and suicide. Brain research. 2006 Dec; 1125(1):138-46. doi: 10.1016/j.brainres.2006.09.082. [PMID: 17118347]
  • Euguenia Bouairi, Harriet Kamendi, Xin Wang, Christopher Gorini, David Mendelowitz. Multiple types of GABAA receptors mediate inhibition in brain stem parasympathetic cardiac neurons in the nucleus ambiguus. Journal of neurophysiology. 2006 Dec; 96(6):3266-72. doi: 10.1152/jn.00590.2006. [PMID: 16914614]
  • Franz E Dussy, Cornelia Hamberg, Thomas A Briellmann. Quantification of benzodiazepines in whole blood and serum. International journal of legal medicine. 2006 Nov; 120(6):323-30. doi: 10.1007/s00414-005-0042-1. [PMID: 16220317]
  • Karsten Müssig, Elisabeth Friess, Stefan A Wudy, Klaus Mörike, Hans-Ulrich Häring, Dietrich Overkamp. Secondary adrenal failure due to long-term treatment with flunitrazepam. Clinical endocrinology. 2006 Oct; 65(4):549-50. doi: 10.1111/j.1365-2265.2006.02622.x. [PMID: 16984251]
  • José G Ortiz, Nicole Rassi, Patricia M Maldonado, Silvia González-Cabrera, Igmeris Ramos. Commercial valerian interactions with [3H]Flunitrazepam and [3H]MK-801 binding to rat synaptic membranes. Phytotherapy research : PTR. 2006 Sep; 20(9):794-8. doi: 10.1002/ptr.1960. [PMID: 16819753]
  • M C Hellión-Ibarrola, D A Ibarrola, Y Montalbetti, M L Kennedy, O Heinichen, M Campuzano, J Tortoriello, S Fernández, C Wasowski, M Marder, T C M De Lima, S Mora. The anxiolytic-like effects of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in mice. Journal of ethnopharmacology. 2006 May; 105(3):400-8. doi: 10.1016/j.jep.2005.11.013. [PMID: 16386395]
  • Chiung-Wei Huang, Hsiu-Ping Jen, Ren-De Wang, You-Zung Hsieh. Sweeping technique combined with micellar electrokinetic chromatography for the simultaneous determination of flunitrazepam and its major metabolites. Journal of chromatography. A. 2006 Mar; 1110(1-2):240-4. doi: 10.1016/j.chroma.2006.01.070. [PMID: 16483590]
  • Jeffery Hackett, Albert A Elian. Extraction and analysis of flunitrazepam/7-aminoflunitrazepam in blood and urine by LC-PDA and GC-MS using butyl SPE columns. Forensic science international. 2006 Mar; 157(2-3):156-62. doi: 10.1016/j.forsciint.2005.03.019. [PMID: 15955650]
  • Pauline Saint-Martin, Yves Furet, Patrick O'Byrne, Marie Bouyssy, Gilles Paintaud, Elisabeth Autret-Leca. [Chemical submission: a literature review]. Therapie. 2006 Mar; 61(2):145-50. doi: 10.2515/therapie:2006028. [PMID: 16886708]
  • H L Lord, M Rajabi, S Safari, J Pawliszyn. Development of immunoaffinity solid phase microextraction probes for analysis of sub ng/mL concentrations of 7-aminoflunitrazepam in urine. Journal of pharmaceutical and biomedical analysis. 2006 Feb; 40(3):769-80. doi: 10.1016/j.jpba.2005.10.003. [PMID: 16352414]
  • T Ohshima. A case of drug-facilitated sexual assault by the use of flunitrazepam. Journal of clinical forensic medicine. 2006 Jan; 13(1):44-5. doi: 10.1016/j.jcfm.2005.05.006. [PMID: 16087387]
  • Peter Ondra, Katerina Zedníková, Radek Matlach. Possibilities and problems with identification and determination of "new" hypnotics. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 2005 Dec; 149(2):469-72. doi: 10.5507/bp.2005.082. [PMID: 16601812]
  • Ilsemarie Kurzthaler, Markus Wambacher, Karl Golser, Gernot Sperner, Barbara Sperner-Unterweger, Alexander Haidekker, Marion Pavlic, Georg Kemmler, W Wolfgang Fleischhacker. Alcohol and/or benzodiazepine use: different accidents--different impacts?. Human psychopharmacology. 2005 Dec; 20(8):583-9. doi: 10.1002/hup.736. [PMID: 16317801]
  • Gregory A O'Sullivan, Matthias Kneussel, Zvulun Elazar, Heinrich Betz. GABARAP is not essential for GABA receptor targeting to the synapse. The European journal of neuroscience. 2005 Nov; 22(10):2644-8. doi: 10.1111/j.1460-9568.2005.04448.x. [PMID: 16307606]
  • Dong-Liang Lin, Rea-Ming Yin, Cheng-Hsing Chen, Ya-Lei Chen, Ray H Liu. Performance characteristics of 7-aminoflunitrazepam specific enzyme-linked immunosorbent assays. Journal of analytical toxicology. 2005 Oct; 29(7):718-23. doi: 10.1093/jat/29.7.718. [PMID: 16419407]
  • Emiko Kurisaki, Makiko Hayashida, Makoto Nihira, Youkichi Ohno, Hirobumi Mashiko, Takaaki Okano, Shin-ichi Niwa, Kouichi Hiraiwa. Diagnostic performance of Triage for benzodiazepines: urine analysis of the dose of therapeutic cases. Journal of analytical toxicology. 2005 Sep; 29(6):539-43. doi: NULL. [PMID: 16168176]
  • Roland Baur, Urs Simmen, Martin Senn, Urs Séquin, Erwin Sigel. Novel plant substances acting as beta subunit isoform-selective positive allosteric modulators of GABAA receptors. Molecular pharmacology. 2005 Sep; 68(3):787-92. doi: 10.1124/mol.105.011882. [PMID: 15939801]
  • Ritu Chadda, Leslie L Devaud. Differential effects of mild repeated restraint stress on behaviors and GABA(A) receptors in male and female rats. Pharmacology, biochemistry, and behavior. 2005 Aug; 81(4):854-63. doi: 10.1016/j.pbb.2005.06.009. [PMID: 16039700]